• International Journal of Computer Science & Network Security
• /
• v.23 no.12
• /
• pp.175-180
• /
• 2023

The main purpose of the study is to identify the key aspects of the formation of legal and professional competence of students of higher educational institutions in the context of the COVID-19 pandemic. The modern system of public relations tightens the requirements for the professional and legal competence of specialists in all spheres of life. The development of a unified nationwide strategy in the field of education focused on the formation and development of young people's skills for life in the information society, is aimed at finding ways to form an active position of a future specialist, developing an experience of a holistic understanding of the professional activity, systemic action in solving new problems and tasks. The methodology includes a number of theoretical methods. Based on the results of the study, the main elements of the formation of legal and professional competence of students of higher educational institutions in the context of the COVID-19 pandemic.

• Journal of Intelligence and Information Systems
• /
• v.9 no.1
• /
• pp.139-155
• /
• 2003

This paper presents the new methodology of analyzing and classifying patterns of customers in mobile telecommunication market to enhance the performance of predicting the credit information based on the decision tree and neural network. With the application of variance selection process from decision tree, the systemic process of defining input vector's value and the rule generation were developed. In point of customer management, this research analyzes current customers and produces the patterns of them so that the company can maintain good customer relationship and makes special management on the customer who has huh potential of getting out of contract in advance. The real implementation of proposed method shows that the predicted accuracy is higher than existing methods such as decision tree(CART, C4.5), regression, neural network and combined model(CART and NN).

• Journal of Ginseng Research
• /
• v.47 no.3
• /
• pp.479-491
• /
• 2023

Background: Hepatocellular carcinoma (HCC) has a high incidence and is one of the highest mortality cancers when advanced stage is proceeded. However, Anti-cancer drugs available for treatment are limited and new anti-cancer drugs and new ways to treat them are minimal. We examined that the effects and possibility of Red Ginseng (RG, Panax ginseng Meyer) as new anti-cancer drug on HCC by combining network pharmacology and molecular biology. Materials and Methods: Network pharmacological analysis was employed to investigate the systems-level mechanism of RG focusing on HCC. Cytotoxicity of RG was determined by MTT analysis, which were also stained by annexin V/PI staining for apoptosis and acridine orange for autophagy. For the analyze mechanism of RG, we extracted protein and subjected to immunoblotting for apoptosis or autophagy related proteins. Results: We constructed compound-target network of RG and identified potential pathways related to HCC. RG inhibited growth of HCC through acceleration of cytotoxicity and reduction of wound healing ability of HCC. RG also increased apoptosis and autophagy through AMPK induction. In addition, its ingredients, 20S-PPD (protopanaxadiol) and 20S-PPT (protopanaxatriol), also induced AMPK mediated apoptosis and autophagy. Conclusion: RG effectively inhibited growth of HCC cells inducing apoptosis and autophagy via ATG/AMPK in HCC cells. Overall, our study suggests possibility as new anti-cancer drug on HCC by proof for the mechanism of the anti-cancer action of RG.

• Electronics and Telecommunications Trends
• /
• v.35 no.6
• /
• pp.129-136
• /
• 2020

Korea launched the world's first commercial 5G services in April 2019. Mobile traffic is expected to increase further with the acceleration of mobile-centric data utilization. It is one of the most important indexes of the growth of the mobile communications market, and it has a close relationship with frequency demand and supply, network management, and information communication policy. To overcome the limitations of an analytical solution due to the high complexity of the real world, this paper estimates the diffusion of 5G users using systemic thinking and the behavior of individual agents. Based on these demand forecasts, contributions to the establishment of strategic policies are suggested. For better understanding, global 5G predictions of subscribers and mobile traffic are also compared.

• Korean Journal of Veterinary Research
• /
• v.48 no.3
• /
• pp.363-367
• /
• 2008

A 4-year-old female Cocker spaniel was presented with respiratory distress and abdominal distension. Pleural effusion, ascites, hepatosplenomegaly, and superficial lymphadenopathy were observed and multicentric lymphoma was diagnosed by cytological examination. Immunophenotyping of lymph node and bone marrow using polymerase chain reaction for antigen receptor rearrangement identified a stage V lymphoma originating from T-cell. Despite of systemic chemotherapy using L-asparagenase, vincristine, cyclophoaphamide and prednisolone, neurologic deficits came out and progressed. Cerebrospinal fluid analysis revealed neoplastic lymphocytic pleocytosis indicating central nervous system involvement of lymphoma. The postmortem diagnosis was confirmed based on the histology and imunohistochemistry.

• IMMUNE NETWORK
• /
• v.13 no.3
• /
• pp.81-85
• /
• 2013

The mucosal surfaces are constantly exposed to incoming pathogens which can cause infections that result in severe morbidity and/or mortality. Studies have reported that mucosal immunity is important for providing protection against these pathogens and that mucosal vaccination is effective in preventing local infections. For many years, the sublingual mucosa has been targeted to deliver immunotherapy to treat allergic hypersensitivities. However, the potential of vaccine delivery via sublingual mucosal has received little attention until recently. Recent studies exploring such potential have documented the safety and effectiveness of sublingual immunization, demonstrating the ability of sublingual immunization to induce both systemic and mucosal immune responses against a variety of antigens, including soluble proteins, inter particulate antigens, and live-attenuated viruses. This review will summarize the recent findings that address the promising potential of sublingual immunization in proving protection against various mucosal pathogens.

• Proceedings of the KSR Conference
• /
• 2002.10a
• /
• pp.414-423
• /
• 2002

Keep pace with economic development, the quality of transportation means such as railway, road, harbors has changed and those changes have affected to economic activities. It means that economic development and the changes of transportation quality have an inter-systemic relationship. So to speak, transportation means are major factor of national economic activities to implement economic and consumption activities by promoting supply of goods through the network between regions and industries. Currently, it is needed to connect railway and road between South and North Korea due to the economic cooperation of two sides and meeting of separated families based on the peacemaking mood. Moreover, to connect to T.C.R. and T.S.R. route will contribute to save time and cost of transporting freight to Europe comparing with shipping when South-North railway is connected. The possibility and method of connecting railway between South and North Korea will be introduced in this paper.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
• /
• 2022.06a
• /
• pp.361-362
• /
• 2022

As the importance of maritime communication in a cross-cultural onboard working environment grows, the importance of developing systematic supporting aids both for learning and teaching maritime English has been emphasized. Given that English communication proficiency is one of the most critical factors in determining a seafarer's competency, a systemic supporting system for enhancing maritime English communication capabilities is essential not only for them to professionally carry out and conduct assigned duties onboard, but also for them to navigate success in their lives through increased labour mobility both at sea and onshore. The APEC Seafarers Excellence Network initiates the production of Maritime English Communication Packages for seafarers in APEC regions, under the leadership of the Republic of Korea. This paper introduces the design of APEC SEN Maritime English Communication Packages, which include textbooks, audio-lingual materials, online/mobile life-long learning platform and testing aids, ultimately for upand re-skilling of seafarers to increase their employability, mobility and preparedness for the future shipping industry where globalisation is expected to further accelerate.

• IMMUNE NETWORK
• /
• v.22 no.1
• /
• pp.12.1-12.13
• /
• 2022

Allergen-specific immunotherapy (AIT) is presumed to modulate the natural course of allergic disease by inducing immune tolerance. However, conventional AITs, such as subcutaneous immunotherapy and sublingual immunotherapy, require long treatment durations and often provoke local or systemic hypersensitivity reactions. Therefore, only <5% of allergy patients receive AIT as second-line therapy. Novel administration routes, such as intralymphatic, intradermal and epicutaneous immunotherapies, and synthetic recombinant allergen preparations have been evaluated to overcome these limitations. We will review the updated views of diverse AIT methods, and discuss the limitations and opportunities of the AITs for the treatment of allergic diseases in humans.

• IMMUNE NETWORK
• /
• v.20 no.4
• /
• pp.30.1-30.10
• /
• 2020

Systemic infections due to Fusobacterium may originate in the tonsillar/internal jugular veins or from the abdomen. We encountered a patient who presented with bacteremia, fulminant septic shock, and extensive soft tissue pyogenic infection due to Fusobacterium necrophorum. In addition, there was widespread metastatic colon cancer with the unique finding of pre-mortem co-localization of F. necrophorum and cancer cells at a site distant from the colon. We reviewed the literature of the association of F. necrophorum and colon cancer, and discuss the evidence of how each of these 2 distinct entities may mutually augment the development or progression of the other.