• 과학기술학연구
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• 제8권1호
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• pp.1-28
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• 2008

이 글에서는 새롭게 등장하고 있는 사회적 목표를 지향하는 혁신정책의 특성들을 살펴보고 그것이 우리의 혁신정책에 주는 함의를 살펴보았다. 우선 이 정책들은 지속가능성과 같은 목표를 제시하고 그것에 경제성장보다 앞서는 우선권을 부여하고 있다. 또 이 정책들은 개별적인 기술개발이나 국지적인 문제해결을 넘어 사회 기술시스템 전체의 전환(system transition)을 염두에 두고 있다. 그리고 시스템 전환을 위해, 새로운 내용을 갖는 기술과 사회제도를 실험하여 기술적 지식을 확충하고 정당성을 향상시키는 '전략적 니치 관리' 방식을 채택하고 있다. 장기적이고 근본적인 변화 방향과 구체적이고 국지적인 정책과 사업들을 학습 과정을 통해 연계시키고 있는 것이다. 이와 함께 정책들의 기획 및 집행과정에서 공공적 참여자의 역할을 확대하고 있다. 이런 정책이 우리에게 주는 함의는 2007년에 발표된 "기술기반 삶의 질 향상 종합대책"을 중심으로 논의하였다. 이 대책은 경제성장 중심 혁신정책의 틀을 넘어서는 새로운 정책이었지만 기존 정책들의 관성으로 인해 몇 가지 한계가 있음을 지적하였다. 특히 과거 산업화 과정에서 형성된 타겟팅적 경향 때문에 장기적 관점에서 시스템 전환을 고려하는 관점이 도입되는 데 어려움이 있다는 것을 논의하였다.

• 대한치과의사협회지
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• 제54권10호
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• pp.811-819
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• 2016

범안면골 골절은 안면부 손상 그 자체로도 치료가 까다롭고 어렵지만, 동반된 다른 신체 중요 장기의 손상 등과 함께 치료 후 에도 남을 수 있는 안면의 심미적, 기능적 문제들 때문에 더욱 치료가 힘들어 질 수 있다. 뇌손상 등의 중요 장기 손상으로 인해 수술이 빠른 시일 내에 시행되지 못할 때에는 관련 의학분과와의 긴밀한 협진 하에 수술 전 처치가 이루어질 수 있도록 하여야 하며, 연조직을 포함한 골절편 등 안면 구조물들이 손상되지 않고 전체적인 형태를 유지할 수 있도록 응급 처치가 되어야 한다. 3D CT 등의 영상진단을 통해 안면골 골절을 치료하기 위한 전체적인 계획을 수립해야 한다. 이 계획에는 수술을 위한 기도확보 방법, 골절의 정복 고정 순서, 접근 방법, 안구, 코 등의 재건 방법 그리고 연조직에 손상에 대한 처치가 포함된다. 수술 시에는 환자 개개인의 상황에 맞춰 되도록 정확한 정복과 고정이 가능한 안면구조물에서 부터 시작하여 교합을 형성하고, 안면골의 유기적인 관계에 유의하여 삼차원적인 구조를 재위치 시킬 수 있도록 해야 한다. 연조직 봉합 시에는 얼굴 피부의 처짐 등을 방지하기 위해 골막, 근막 및 중요 안면 인대들을 고려하여 시행하여야 한다.

• 한국전문물리치료학회지
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• 제19권2호
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• pp.48-58
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• 2012

The objective of this study was to evaluate the effects of mirror therapy on motor function recovery following a stroke through a systemic review and meta-analysis. In total, nine of the 48 studies were identified from search engines between 1997 and 2011, as well as from a review of the reference lists of each identified study. The quality of each study was assessed using Jadad scale, and the effect size was calculated as a Cohen's effect size using MetaAnalyst (Beta 3.13). The overall effect size of the mirror therapy was 2.005 (95% confidence interval=1.041~2.970) in a random-effects model. This finding suggests that mirror therapy is beneficial for improving motor function following a stroke. The results from the subgroup analysis according to categorical variables were as follows: First, the effect size was larger for an onset time of less than 1 year (1.166) than for a duration of 1 year or more (.668). Second, the effect size of unpublished dissertations (1.610) was larger than published articles (1.221). Third, motor recovery of upper extremities (1.609) had a greater effect than motor recovery of lower extremities (.903). The major limitation of this study is the relatively small study population. Therefore, further individual studies of mirror therapy should be conducted in order to generalize the effects. In addition, mirror therapy supervised by a physical therapist should be recognized as a potential approach to manage motor function following a stroke and recommended to patients to improve their motor function.

• 한국컴퓨터정보학회논문지
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• 제13권6호
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• pp.87-94
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• 2008

홍채진단은 홍채의 패턴, 색, 기타 다른 특징들을 조사하여 환자의 병을 진단하는 대체의학이다. 그러나 기존의 연구는 흑백 홍채영상을 이용하여 홍채 내의 특정 패턴을 검출하는 알고리즘 연구로 홍채의 칼라 정보로부터 건강상태를 체크하는 진단시스템으로 사용하기에는 부족하다. 본 논문에서는 칼라 홍채영상과 의료정보 데이터베이스를 이용하는 홍채진단시스템을 개발하였다. 개발한 시스템은 홍채카메라는 갖는 입력모듈, 홍채병소징후 검출 모듈, 의료정보 데이터베이스, 출력 모듈 등 4가지 모듈로 되어있다. 칼라 홍채영상으로부터 7가지 주요 홍채병소징후를 추출하고 검진의 정확도를 위해 병소 수동 편집 기능을 제공한다. 병소를 분석하는 단계에서는 홍채학에 기반한 의료정보와 개인 이력 관리 모듈을 이용한다. 제안한 시스템은 기존 시스템의 비해 다양한 기능이 추가되어 홍채진단 시스템으로 활용 가능하다.

• 근관절건강학회지
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• 제10권1호
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• pp.54-61
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• 2003

Due to the development in computer mediated communication, there are many homepages on the web, which provide medical on health counseling and education. The internet is becoming increasingly important and essential in medicine. But little was known about what problems can be counseled and what difficulties are met during the computer mediated counseling. This study was performed to investigate the content and purpose of health counseling on the web. The data were collected from March 1st, 2002 to February 28th, 2003, from 199 questioners visited one rheumatic center homepage questionary/answering(Q/A) site. Most of the questioners consulted health problems of their own or their families. The 51.3% of them were diagnosed medically Rheumatoid arthritis was the most frequent disease and followed systemic lupus erythematosus, gout and ankylosing spondylitis. Most of the questioners needed to know treatment principles, diagnosing process, and information regarding the clinic. During the one-year period, the average number of users questioning was 29.4 cases and answering was 44.8 cases. Above findings suggest that computer mediated health counseling of rheumatic patients may be useful supplement of health education for them. Communication using internet has become popular, but this kind of approach needs a proper guideline. It is highly recommended that nurses be familiar with the e-health and e-medicine.

• Journal of Genetic Medicine
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• 제8권1호
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• pp.17-27
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• 2011

자간전증은 전세계적으로 모성 및 주산기 사망과 이환의 주된 원인이나 아직까지 병인기전은 명확하게 규명되지 않은 실정이다. 자간전증은 일반적으로 두 단계 질환으로 알려져 있으며, 그 임상의 첫 단계는 모체의 나선동맥의 얕은 세포영양아층 침투에 의한 태반 부전이 발생한다. 태반 부전에 의한 허혈성 태반이 모체의 순환 혈류 내로 용해성 인자와 싸이토카인, 영양막 조직파편을 유리하면, 전신적인 내피세포 손상 및 기능 부전을 야기하고, 이로 인하여 자간전증 이차 단계인 모체 증후군이 나타난다. 역학적 연구에서 자간전증에 대한 유전적 소인이 일관되게 증명되었다. 집중적 연구 노력에 의한 감수성 유전자 발견은 자간전증의 병태생리를 이해하는데 있어서 유용한 정보를 줄 것이며 자간전증의 치료 및 예방 방법에 대한 방향을 제시할 것이다. 본 주제에서는 자간전증의 병태생리에 있어서 유전적 요인의 역할에 대한 최신 이해를 요약하고 자간전증의 유전적 실마리를 찾기 위한 분자적 접근에 대해 설명하고자 한다.

• Journal of Microbiology and Biotechnology
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• 제24권1호
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• pp.119-126
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• 2014

Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disorder that primarily affects the flexible joints and may also affect a number of tissues and organs. The progression of RA involves an inflammatory response of the capsule around the joint, swelling of synovial cells with excess synovial fluid (SF), and the development of fibrous tissue in the synovium. Since the progressive pathology of the disease often leads to the irreversible destruction of articular cartilage and ankylosis of the joint, early diagnosis of RA is essential. Thus, we undertook a comparative proteomic approach to investigate novel biomarkers for early diagnosis using SFs and serums from RA patients. As a result, we identified 32 differentially expressed spots in SFs and 34 spots in serums. The differential expression of the STEAP4 and ZNF 658 proteins were validated using immunoblotting of the SFs and serums, respectively. These data suggest that differentially expressed proteins in SFs and serums could be used as RA-specific biomarkers for the diagnosis and monitoring of RA. Furthermore, these findings advance our understanding of the molecular etiopathogenesis of RA.

• Journal of Acupuncture Research
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• 제23권2호
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• pp.173-179
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• 2006

Objectives : In this study, we investigated the SNP (single-nucleotide polymorphism) of IL10 in patients with stroke. The present study was undertaken to see if specific genotypic and allelic variations are associated with stroke in the Korean population. Methods : Blood samples from all subjects were obtained for DNA extraction and collected in EDTA tube. Genomic DNA was extracted using DNA isolation kit for Mammalian Blood (Boehringer Mannheim, IN, USA). The extracted DNA was amplified by polymerase chain reaction (PCR). Pyrosequencing was performed according to manufacturer's standard protocol. Results : There was no statistically significant genotypic distribution difference between control and stroke group. The frequencies of A/A homozygotes and A/C heterozygotes among control subjects were 91 (87.5%) and 13 (12.5%). The frequencies of A/A and A/C among the stroke patients were 85 (89.5%) and 10 (10.5%). There was not statistically significant allelic frequency difference between control and stroke group. The allelic frequency of A and C was 195 (93.8%) and 13 (6.2%) among the control subjects and 180 (94.7%) and 10 (5.3%) in stroke patients, respectively. Conclusion : The cytokine IL10 may not be pathogenetic factors in stroke. But further studies including different cytokine gene can be a useful for predicting stroke. Establishment of more systemic approach and high quality of prospective cohorts will be necessary for the good prediction of genetic markers.

• 한국임상약학회지
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• 제3권1호
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• pp.31-43
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• 1993

The influence of phenobarbital(PB) pretreatment(75mg/kg/day, Lp. for 4 days) on the hepatic clearance of indocyanine green(ICG) as a model compound of organic anionic drugs was investigated in rats in order to elucidate the relative contributions of change in the hepatic blood flow versus increase in the hepatic intrinsic activity to remove ICG due to PB pretreatment. ICG(1mg/kg) was injected single bolus via femoral or portal vein to the control and the PB-pretreated rats. The initial hepatic uptake clearance$(V_{d.c.}K_{12})$ obtained from plasma concentration-time data was increased by $38.4\% in the PB-pretreated rats, which may be due to the increased hepatic blood flow by PB pretreatment. Using a pharmacokinetic approach, hepatic blood flows were estimated of 67.5ml/min/kg in control rats and 91.9ml/min/kg in PB-pretreated rats. They were in good agreement with other's blood flow estimates observed experimentally. It may be concluded that the $38\%$ increased initial hepatic uptake clearance of ICG was due to the $36\%$ increased hepatic blood flow with phenobarbital, and that the increased hepatic blood flow and the activated hepatic intrinsic clearance with phenobarbital contributed to $49\%\;and\;51\%$ of the increased systemic clearance of ICG, respectively.

• 산업경영시스템학회지
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• 제33권1호
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• pp.17-23
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• 2010

The corporate R&D(Research and Development) has a primary role of new product development and its potential is the most crucial factor to estimate corporate future value. However, its systemic inadequacies and inefficiencies, the shorten product life-cycle to satisfy customer needs, the global operations by outsourcing strategy, and the reduction of product cost, are starting to expose to R&D business processes. The three-phased execution strategy for R&D innovation is introduced to establish master plan for new R&D model. From information technology point of view, PLM(Product Life-cycle Management) is one of the business total solutions in product development area. It is not a system, but the strategic business approach that collaboratively manage the product from beginning stage to end of life in all business areas PLM functions and capabilities are usually used as references to re-design new R&D process. BPA(Business Process Assessment) and 5DP(Design Parameters) in PI6sigma developed by Samsung SDS Consulting division are introduced to establish R&D master plan and re-design process respectively. This research provides a case study for R&D process innovation. How process assessment and PMM(Process Maturity Model) can be applied in business processes, and also it explains process re-design by 5DP method.