• 한국임상약학회지
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• 제17권1호
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• pp.38-45
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• 2007

Background: The multitude of the therapeutic usefulness of intra-articular injection of hyaluronate on oateoarthritis of the knee is still in question. The objective of this systemic review was to elucidate both the therapeutic efficacy and the safety of intra-articular administration of hyaluronic acid for degenerative osteoarthritis of the knee joints. Methods: I searched MEDLINE and Korea Medical Database (KMbase) from January 1990 to April 2007 using a combination search terms for knee osteoarthritis and hyaluronic acid and a filter for randomized controlled trials. I extracted data on pain at rest, and during or just after movement, on joint function, and on adverse events. Results: Ten trials that reported usable quantitative information on any of the predefined end points were identified and included in the systemic review. Intra-articular injection of hyaluronic acid can decrease symptoms of osteoarthritis of the knee. The study revealed significant improvements in pain and functional outcomes with few adverse effects. However, there was significant between-study heterogeneity in the estimates of the efficacy of hyaluronic acid. Sub-group analysis showed that lower methodological quality such as a single-blind or single-center design resulted in higher estimates hyaluronic acid efficacy, and that patients older than sixty years of age and those with the most advanced radiographic stage of osteoarthritis were less likely to benefit from intra-articular injection of hyaluronic acid. Conclusion: According to the currently available evidence, intra-articular hyaluronic acid has been proven clinically effective for the patients bearing the knee osteoarthritis with NSAID-induced GI troubles or inapplicable to any surgery, and may be associated with lower risk of adverse events.

• IMMUNE NETWORK
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• 제14권3호
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• pp.138-148
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• 2014

MicroRNAs (miRNAs) are endogenous small RNA molecules best known for their function in post-transcriptional gene regulation. Immunologically, miRNA regulates the differentiation and function of immune cells and its malfunction contributes to the development of various autoimmune diseases including systemic lupus erythematosus (SLE). Over the last decade, accumulating researches provide evidence for the connection between dysregulated miRNA network and autoimmunity. Interruption of miRNA biogenesis machinery contributes to the abnormal T and B cell development and particularly a reduced suppressive function of regulatory T cells, leading to systemic autoimmune diseases. Additionally, multiple factors under autoimmune conditions interfere with miRNA generation via key miRNA processing enzymes, thus further skewing the miRNA expression profile. Indeed, several independent miRNA profiling studies reported significant differences between SLE patients and healthy controls. Despite the lack of a consistent expression pattern on individual dysregulated miRNAs in SLE among these studies, the aberrant expression of distinct groups of miRNAs causes overlapping functional outcomes including perturbed type I interferon signalling cascade, DNA hypomethylation and hyperactivation of T and B cells. The impact of specific miRNA-mediated regulation on function of major immune cells in lupus is also discussed. Although research on the clinical application of miRNAs is still immature, through an integrated approach with advances in next generation sequencing, novel tools in bioinformatics database analysis and new in vitro and in vivo models for functional evaluation, the diagnostic and therapeutic potentials of miRNAs may bring to fruition in the future.

• Journal of Periodontal and Implant Science
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• 제49권4호
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• pp.248-257
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• 2019

Purpose: The purpose of this retrospective study was to investigate the relationships of types of dental insurance coverage in Korea with sociodemographic characteristics and the prevalence of systemic and oral diseases, as well as to evaluate the socioeconomic impact of Korean dental insurance policies. Methods: Sample cohort data from 2006 to 2015 were obtained from the National Health Insurance Service. Patients were divided into 2 groups. The exposed group comprised patients who received insurance benefits for complete dentures, removable partial dentures, and implant care, while the control group comprised patients who did not receive these benefits. The type of insurance coverage and the prevalence of systemic and oral diseases were compared between the 2 groups. Results: Patients who received benefits in the form of complete dentures, removable partial dentures, and implants had similar sociodemographic characteristics in terms of sex, age, income quintile, and type of insurance coverage to the control group. The prevalence of hypertension, anemia, renal disease, rheumatoid arthritis, osteoporosis, asthma, and cerebral infarction was higher in the exposed group than in the control group (P<0.05). The prevalence of periodontal diseases and dental caries was also higher in the exposed group. Conclusions: Korean dental health insurance policy has been beneficial for the medical expenses of low-income and elderly people suffering from a cost burden due to systemic diseases. However, since there is a tendency to avoid invasive interventions in older patients due to the high risk of systemic diseases, insurance coverage of dentures may be more helpful from a socioeconomic perspective than coverage of dental implant treatments.

• 경영정보학연구
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• 제10권3호
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• pp.1-20
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• 2008

1990년대 이래 신경 제라는 제목 하에 다양한 경제 사회적 현상들이 관찰되고 논의되어왔다. 문헌에 기록된 대부분의 신경제 현상들은 단편적 일화적으로 묘사되고 있어 신경제의 본질에 대한 논리적이고 체계적인 설명이 부족하다. 본 연구는 시스템 관점에서 신경제 현상의 특성을 분석하였다. 구체적으로 신경제를 하나의 시스템 현상으로 놓고 아래 5가지 시스템적 속성에 대한 답을 구하였다. 1) 신경제 시스템의 구성요소는 무엇이며 그것들은 어떻게 상호 연관되어 있는가? 2) 신경제 시스템은 기능적으로 어떻게 작동하는가? 3) 신경제 시스템에서 생산되는 재화와 서비스는 무엇인가? 4) 신경제가 시스템으로서 가지는 가치는 무엇인가? 5) 신경제 시스템의 총체적 체계적 특성은 무엇인가? 본 연구는 상기 각 시스템 측면에서 신경제가 가지는 핵심 속성을 도출하고, 이를 종합하여 시스템 관점에서의 신경제 이해를 도모하고 있다. 아울러 신경제의 시스템적 특성이 기업의 전략에 시사하는 바가 무엇인지를 논의하고 앞으로의 연구과제들을 제시하고 있다.

• 한국콘텐츠학회논문지
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• 제18권8호
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• pp.607-615
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• 2018

본 연구에서는 A치과에 내원하는 환자 중 20-60세에 해당하는 환자 110명을 대상으로 설문조사를 통해 전신질환과 구강건강 간 연관성에 관한 인식 수준과 교육 현황을 파악하였고, 최종 분석에는 92명의 응답을 포함하였다. 연구대상자 중 두 건강상태의 연관성을 인식하고 있는 비율은 48.9%로 나타났다. 또한 연구대상자 중 39.1%는 전신질환과 구강건강의 연관성에 대한 교육을 받은 경험이 있는 것으로 나타났고, 68.5%는 교육이 필요한 것으로 인식하였다. 전신질환과 구강건강의 연관성과 교육 필요성 인식 수준과 관련된 요인을 확인하기 위하여, 로지스틱회귀분석을 실시한 결과 정기적으로 치과를 내원하는 경우 두 질환의 연관성을 인식할 가능성이 3.94배 높았고, 주관적 구강건강수준이 나쁜 경우 교육의 필요성을 인지할 가능성이 5.20배 높았으며, 과거 교육경험 여부는 두 질환의 연관성 인식 및 교육 필요성 인식 수준에 유의한 영향을 미치는 것으로 나타났다. 치과에 내원하는 환자들을 대상으로 치과의료전문가는 교육주체자로서 보다 체계적인 교육방식을 통하여 전신질환과 구강건강 간 연관성에 관한 교육을 필수적으로 수행해야 할 것이다. 이를 위해 치과의료전문가는 진료실 구강보건교육 매뉴얼 및 다양한 매체를 개발해야 하고, 효과적인 교육방법을 모색해야 한다.

• 한국치위생학회지
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• 제14권3호
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• pp.371-379
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• 2014

Objectives : The purpose of this study is to investigate the correlation between quality of sleep and dental fear in implant surgery patients. Methods : A self-reported questionnaire was filled out by 153 implant patients from December 2012 to February 2013 in dental clinics and hospitals in Busan and Changwon. Data were analyzed by descriptive analysis, t-test, ANOVA and multiple regression analysis using SAS version 9.20. Results : The quality of sleep in the implant patients was $41.0{\pm}6.0$. The systemic diseases influenced on the quality of sleep and dental fear also affected the quality of sleep. Conclusions : The results of the analysis of a relationship between the fear perception of dental implant surgery patients and the quality of their sleep showed that the patients with systemic diseases, the patients with a fear by the physical stimulation relating to implant treatment showed the low quality of sleep.

• 한국학교보건학회지
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• 제29권2호
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• pp.63-70
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• 2016

Purpose: The purpose of this study was to find the factors influencing adolescents' adult media engagement. The study is based on Agnew's General Strain Theory (GST) and a micro-systemic perspective. Methods: The study examined 479 middle school freshmen who participated in the fourth wave of the Korean Children & Youth Panel Survey (KCYPS) conducted by National Youth Policy Institute. Data were analyzed through descriptive statistics, factor analysis, and reliability analysis using SPSS 22.0 Ver. Also, hypothesis testing was performed via covariance-based structure equation modeling (CB-SEM) using Amos 21.0 Ver. Results: Strain factors had positive effects on adolescent depression, and depression had a positive effect on adult media engagement. Also, cell-phone dependency had a positive mediation effect between depression and adult media engagement. Conclusion: The study's result identified the factors affecting adult media engagement. Therefore, we suggest intervention programs considering adolescents' strains, depression and cell-phone dependency to improve their health.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7277-7280
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• 2014

This analysis was conducted to evaluate the efficacy and safety of carboplatin based chemotherapy in treating pediatric patients with Wilms tumors. Methods: Clinical studies evaluating the efficacy and safety of carboplatin based regimens on response and safety for pediatric patients with Wilms tumors were identified using a predefined search strategy. Pooled response rates (RRs) of treatment were calculated. Results: In carboplatin based regimens, 4 clinical studies which including 127 patients with advanced Wilms tumors were considered eligible for inclusion. With this carboplatin based chemotherapy, 2 clinical studies included carboplatin, ifosfamide and etoposide. Systemic analysis suggested that, in all patients, the pooled PR was 64.5% (82/127) in carboplatin based regimens. Thrombocytopenia and leukocytopenia were the main side effects. No grade III or IV renal or liver toxicity was observed. No treatment related death occurred with carboplatin based treatment. Conclusion: This systemic analysis suggests that carboplatine based regimens are associated with a reasonable response rate and accepted toxicities for treating pediatric patients with Wilms tumors.

• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10745-10748
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• 2015

Background: This analysis was conducted to evaluate the efficacy and safety of irinotecan based chemotherapy for treatment of patients with metastatic breast cancer (MBC) who experienced disease progression after one to three chemotherapy regimens, including at least one anthracycline- or taxane-based. Methods: Clinical studies were identified using a predefined search strategy. Pooled response rates (RR) to treatment were calculated. Results: As irinotecan based regimens, 5 clinical studies which including 217 patients with refractory MBC were considered eligible for inclusion, with irinotecan, cisplatin, capecitabine, or TS-1. Systemic analysis suggested that, in all patients, pooled RR was 48.8% (106/217) with irinotecan based regimens. Thrombocytopenia and leukocytopenia were the main side effects. No grade III or IV renal or liver toxicity was observed. No treatment related deaths occurred. Conclusion: This systemic analysis suggests that irinotecan based regimens are beneficial and safe for treating patients with MBC after other chemotherapy.

• 음성과학
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• 제13권4호
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• pp.187-200
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• 2006

The speech synthesis technology is widely used and its application area is also being broadened to an automatic response service, a learning system for handicapped person, etc. However, the sound quality of the speech synthesizer has not yet reached to the satisfactory level of users. To make a synthesized speech, the existing synthesizer generates rhythms only by the interval information such as space and comma or by several punctuation marks such as a question mark and an exclamation mark so that it is not easy to generate natural rhythms of people even though it is based on mass speech database. To make up for the problem, there is a way to select rhythms after processing language from a higher level information. This paper proposes a method for generating tags for controling rhythms by analyzing the meaning of sentence with speech situation information. We use the Systemic Functional Grammar (SFG) [4] which analyzes the meaning of sentence with speech situation information considering the sentence prior to the given one, the situation of a conversation, the relationship among people in the conversation, etc. In this study, we generate Semantic Speech Control Tag (SSCT) by the result of SFG's meaning analysis and the voice wave analysis.