• 한국안광학회지
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• 제10권3호
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• pp.241-246
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• 2005

본 연구는 굴절이상을 가진 피검자의 단안에서 Netspeg lens를 착용 후 시력 개선의 상태를 P-VEP의 파형 분석을 통해서 검증하고자 하였다. P-VEP는 3 channel의 Bausch Lomb system으로 기록하였다. 10명의 성인 피검자(남성 5인, 여성 5명; 평균 21세, 연령은 19세와 23세 사이)의 눈을 검사하였다. 피검자는 전신건강, 약물복용, 유전, 알레르기 그리고 안질환을 포함하는 문진 등을 조사하였다. 시력과 굴절검사는 Netspeg lens를 사용하여 피검자의 단안을 기록하였다. 피검자는 P-VEP 기록을 하는 동안 교정된 시력을 통해서 단안의 P-VEP 자극을 본다. 연구의 결과 Netspeg lens를 사용한 단안은 사용하지 않는 눈에 비해서 시력 결상이 선영하게 자각되었다. 한편 P-VEP 검사에서는 Netspeg lens를 사용한 눈이 높은 진폭 나타 내었다. 그러나 P-VEP의 장복시간은 오히려 늦게 나타났다. 그러나 P-VEP이 형태에서는 Netspeg lens를 사용한 눈이 안정된 파형을 유지하였다. 한편 오른 눈과 왼눈의 유의성은 거의 없었다. 따라서 본 연구에서는 Netspeg lens를 사용한 단안에서는 그렇지 않는 눈에 비해서 시력과 시기능이 기능이 우수함을 나타내었다.

• Journal of Microbiology and Biotechnology
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• 제26권10호
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• pp.1817-1823
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• 2016

Areca nut (AN) chewing is a habit in many countries in Central, Southern, and Southeast Asia. It is strongly associated with the occurrence of oral, pharyngeal, and esophageal cancer as well as systemic inflammation. However, the association between AN intake and the development of gastric lesions has not yet been identified. The aim of this study was to investigate the effect of AN on gastric diseases using a mouse model for Helicobacter pylori infection. We studied four groups of mice: those fed a normal diet (ND), those fed a diet containing 2.5% AN (AD), those fed ND and infected with H. pylori PMSS1 strain (ND/HP), and those fed AD and infected with H. pylori PMSS1 strain (AD/HP). Food intake and body weight were monitored weekly during the experiments. At 10 weeks, the mice were sacrificed, and the stomach weight, H. pylori colonization, and gastric inflammation were evaluated. The stomach weight had increased significantly in the ND/HP and AD/HP groups along with increases in H. pylori colonization; however, there was no significant difference between these two groups with respect to stomach weight and colonization. On histological grading, mononuclear cell infiltration was severer in the AD/HP group than in the ND/HP group. These data suggest that chronic gastric inflammation was aggravated by AN treatment in the mice with H. pylori-induced gastric lesions. Furthermore, as previously suggested, this animal model is useful to determine the effect of potential carcinogens on gastric lesions induced by H. pylori infection.

• 한국콘텐츠학회논문지
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• 제10권8호
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• pp.274-282
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• 2010

본 연구는 부산지역 S치과에 내원한 임플란트 시술을 받은 299명이 식립한 871개의 임플라트를 대상으로 임플란트의 종류, 골 이식 종류, 치주상태, 임플란트 분포를 조사하여 임플란트 구강위생관리 및 환자관리에 기초 자료를 마련하고자 하였다. 임플란트의 종류는 국산 임플란트 83.6%, 수입 임플란트 16.4%로 나타났다. 골 이식에서는 혼합 뼈로 골 이식을 한 환자가 17.1%로 가장 많았으며, 질병이 없는 환자는 있는 환자보다 자가 뼈로 골 이식을 많이 하였다($X^2$=14.66, p<.01). 치주상태는 남자보다는 여자가 좋았으며(t=-2.73, p<.01), 연령별에서는 연령이 적을수록(F=14.20, p<.001), 질병 유 무에서는 질병이 없는 환자(t=-4.67, p<.001)에서 치주상태가 좋았다. 치아별 임플란트 분포에서 하악에 많았고, 하악 좌측 임플란트가 2개 있는 환자가 16.1%로 가장 많았다($X^2$=33.14, p<.01). 총 치아의 임플란트 유 무에서 연령별로는 20대의 경우 1개, 60대 이상은 2개 로 나타나 연령이 증가할수록 개수가 많아짐을 보였다($X^2$=74.09, p<.001). 또한 치주상태에 따라서도 양호한 경우 1개를 식립한 경우가 많았고 불량할수록 2개 가 많았다($X^2$=38.28, p<.01). 이상의 결과에서 임플란트의 식립 상태 및 치주 상태를 정확히 파악하여 환자 상태에 맞는 1:1 맞춤 구강위생관리 프로그램 개발이 조속히 마련되어야 할 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7251-7256
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• 2013

Objectives: To estimate the proportion of liver cancer cases and deaths due to infection with hepatitis B virus (HBV), hepatitis C virus (HCV), aflatoxin exposure, alcohol drinking and smoking in China in 2005. Study design: Systemic assessment of the burden of five modifiable risk factors on the occurrence of liver cancer in China using the population attributable fraction. Methods: We estimated the population attributable fraction of liver cancer caused by five modifiable risk factors using the prevalence data around 1990 and data on relative risks from meta-analyses, and large-scale observational studies. Liver cancer mortality data were from the 3rd National Death Causes Survey, and data on liver cancer incidence were estimated from the mortality data from cancer registries in China and a mortality/incidence ratio calculated. Results: We estimated that HBV infection was responsible for 65.9% of liver cancer deaths in men and 58.4% in women, while HCV was responsible for 27.3% and 28.6% respectively. The fraction of liver cancer deaths attributable to aflatoxin was estimated to be 25.0% for both men and women. Alcohol drinking was responsible for 23.4% of liver cancer deaths in men and 2.2% in women. Smoking was responsible for 18.7% and 1.0%. Overall, 86% of liver cancer mortality and incidence (88% in men and 78% in women) was attributable to these five modifiable risk factors. Conclusions: HBV, HCV, aflatoxin, alcohol drinking and tobacco smoking were responsible for 86% of liver cancer mortality and incidence in China in 2005. Our findings provide useful data for developing guidelines for liver cancer prevention and control in China and other developing countries.

• 한국안광학회지
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• 제18권4호
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• pp.473-479
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• 2013

목적: 스마트폰 시청과 알코올 섭취에 따른 눈의 변화와 상관관계를 알아보고자 하였다. 방법: 안질환, 정신질환, 전신질환 그리고 알코올 대사에 관련된 약물복용의 병력이 없는 평소 건전한 음주습관을 가진 대상자 31명(남 18명, 여 13명)을 굴절검사, 각막곡률반경, 안압측정, 각막두께를 측정하고 분석하였다. 결과: 스마트폰 시청에 따른 호흡 중 혈중 알코올의 농도 변화는 15분, 30분, 45분, 60분 그리고 회복기에서 유의하게 감소하였다(p<0.01, p<0.001). 알코올 섭취 후 스마트폰 시청 전과 시청 후, 굴절검사 비교 결과 원주굴절력과 축에서 유의한 변화가 있었다(p=0.005, p=0.001). 알코올 섭취 후 스마트폰 시청에 따른 안압의 변화는 30분부터 유의하게 감소하였으며(p<0.001), 알코올을 섭취 한 상태에서 경과시간에 따른 스마트폰 시청은 각막두께에 유의한 변화를 주지 않았다. 결론: 스마트폰 시청과 알코올 섭취는 원주굴절력과 축 그리고 안압에 유의한 변화를 보인다. 시기능 피로를 초래할 수 있는 스마트폰 시청 및 알코올 섭취는 굴절검사 전 반드시 고려해야 할 요인이다.

• 대한영양사협회학술지
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• 제6권2호
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• pp.161-170
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• 2000

This study was conducted to find biochemical status, dietary habits and dietary behaviors according to the degree of obesity among obese children, and to provide baseline data for nutrition education. The number of subjects was 64 obese children(Mildly obesed : MI 19, Moderately obese : Mo 30, Severely obese : SI 15) participated in '98 Summer Nutrition Camp'. The results of this study were as follows. 1. Weight and body fat rate was increased according to obesity degree(p<0.05). Total cholesterol and TG also was increased according to obesity degree but it was statistically significant. 2. In dietary habits, it wasn't statistically significant but MI tended to eat fast and to eat the snacks before sleeping. MO tended to skip the breakfast. SI tended to eat more snacks and dinner and they tended to overeat. 3. In cognition of self-weight, most obese children(93.7%) worried about their weight but 73.4% of obese children thought that it was possible for losing weight. There were no difference by the obesity degree. 4. In dietary behaviors, there were no statistically significant difference but MI and SI than MO tended to had worse dietary behaviors. 5. In life styles, SI than the others have tendency to have more regular exercise but they had more indoor activities than outdoor activities. 6. In foods intake frequency, SI than MI and MO ate instant foods more frequently and MI than the others ate hot and salty foods more frequently(p<0.05). With these result, MI and SI than MO tended to have undesirable dietary habits and behaviors. Many obese children worried about the weight but they had positive thought about losing weight. SI tended to do regularly exercise but they had more indoor activities than outdoor activities. Therefore, only with this study, it is difficult to say that there is the clear difference by the obesity degree. Because, in this study, we can have some difference among these groups, we should study more about these difference for effective, systemic and practical nutrition education in the future.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제34권5호
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• pp.332-336
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• 2012

Purpose: The third molar extraction is one of the mostly performed procedures in the department of oral and maxillofacial surgery. In most of dental clinic or hospital, the third molar extraction used to be frequently performed in an office-based surgery, and most patients did not have specific medical history with young ages. Medical history taking are dependent on the only way by asking to the patients about their individual conditions. Therefore, as the specialists of the oral and maxillofacial surgery in the field of dentistry, we suggest a new policy that the preoperative lab must be performed routinely before extraction of the third molar. Methods: This study is based on 1,096 patients who have been managed with third molar extractions, from March 2008 to September 2011 by a single surgeon. The preoperative lab, including complete blood count, coagulation panel, chemistry and serology, was performed before any surgical procedures. The results were informed to the patients regardless of their abnormalities, and any abnormalities related to the surgical procedures, such as platelet count and coagulation factors, were checked and corrected safely. Results: Through the preoperative blood test, systemic diseases that the patients had not recognized before, such as anemia, leukopenia, fatty liver and chronic renal disease, were identified. Patients with acute or chronic leukemia, Hepatitis B, and HIV positive, were also detected as a small number. Also, the possibilities of the cross-infection between dentists and patients or between patients and patients, and any other emergency situations can be prevented; as well as the public health condition can be improved, too. The patients were satisfied with low cost preventive blood test and high quality of medical services. Conclusion: Therefore, routine medical lab testing, including history taking are needed before an office-based minor surgery, such as third molar extractions, and these results were suggested as a new policy in the field of dentistry.

• 대한소아치과학회지
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• 제47권3호
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• pp.344-351
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• 2020

법랑질 형성부전증은 단독으로 나타나거나 다른 구강내 이상 또는 전신질환과 동반되어 나타난다. 신석회증을 동반한 법랑질 형성 부전증은 Enamel Renal Syndrome (ERS; OMIM #204690)으로 불리며, 법랑질의 심각한 저형성, 다수의 치아 맹출 장애, 치수내 석회화, 치은 증식, 신석회증을 특징으로 한다. 신석회증이란 칼슘 결정이 신장 조직 내에 침착되어 심각한 신장 합병증을 일으키게 되는 질환이다. 이 증후군은 특징적인 구강내 소견을 보이므로 신장 증상이 나타나기 전에 조기에 발견될 수 있으며, 이러한 조기발견으로 추후 심각한 신장 질환 합병증을 예방할 수 있다. 따라서 소아치과 의사는 ERS가 의심된다면 신장 평가를 위해 소아과 의사에게 의뢰하여야 하고, 또한 관련 원인 유전자 탐색을 위해 유전학자에게 의뢰를 하는 역할을 할 수 있다.

• 한국식품영양과학회지
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• 제42권10호
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• pp.1608-1617
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• 2013

본 연구는 과체중 및 비만인 직장인을 대상으로 체중관리 프로그램을 실시하여 체중감량 및 체지방의 감소, 혈액생화학적 변화, 영양지식 및 운동 능력에 대한 효과를 알아보고자 하였다. 전라북도 내 공공기관의 BMI 23 이상 과체중 및 비만인 직원 39명을 연구대상자로 하여 6개월간 프로그램을 실시하였다. 연구결과 남자그룹에서 삼두근 피부두겹 두께가 유의적으로 감소하였고(P<0.05), 남녀 그룹 모두에서 허리둘레, 엉덩이 둘레가 유의적으로 감소하였다(P<0.05). 혈액 생화학적 검사에서는 남자그룹에서 총콜레스테롤(P<0.05)과 LDL-콜레스테롤(P<0.01)이 유의적으로 감소하였다. 복부 컴퓨터단층촬영 결과에서는 남자그룹에서 복부피하지방조직이 유의적으로 감소하였으며(P<0.01), 영양소 섭취 조사결과 여자 그룹에서 철, 비타민 B2와 나이 아신 섭취량이 유의적으로 증가하였다(P<0.05). 영양지식 점수는 남자 그룹에서 유의적으로 증가하였으며(P<0.05), 운동능력 검사에서는 근지구력이 유의적으로 증가하였다(P<0.01). 직장인들의 건강증진뿐만 아니라 근무 능률과 삶의 질 향상을 위해 사업장에도 건강 및 비만관리가 이루어질 수 있는 체계적인 프로그램이 필요하며, 교육 후에도 비만개선의 긍정적인 변화가 지속될 수 있도록 근로 현장과 국가차원의 프로그램이 개발 지원되어야 할 것이다.

• 대한의생명과학회지
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• 제12권3호
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• pp.289-301
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• 2006

Cardiopulmonary bypass (CPB) for cardiac surgery triggers the production and release of numerous chemotactic substances and cytokines, ensuing systemic inflammatory response that leads to postoperative major organ dysfunction. Traditionally, corticosteroids (steroid) have been administered to patients undergoing cardiac surgery to ward off these detrimental physiologic alterations. However, the majority of the studies have been performed on adult patients with high-dose steroid. We carried out a randomized, prospective, double-blind study to compare the efficacy of low-dose steroid with that of high-dose steroid and to determine the adequate dose of pretreated-steroid for prophylactic effects in pediatric cardiac surgery. Thirty pediatric patients scheduled for elective cardiac surgery were randomly assigned to two groups; fifteen patients received low-dose methylprednisolone (10mg/kg intravenously, n=15, low-dose group) and the others received high-dose methylprednisolone (30mg/kg intravenously, n=15, high-dose group) 1 hour prior to CPB. Arterial blood samples were taken before CPB (Pre-CPB), 10 minutes after start of CPB (CPB-10), and immediately after CPB-end (CPB-OFF) for measuring total leukocyte counts (T-WBC) and diff-counts, platelet counts, interleukin-6 (IL-6), myeloperoxidase (MPO), total antioxidant (TAO), neuron-specific enolase (NSE), troponin I (TNI), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, and blood urea nitrogen (BUN) levels. Other parameters such as volumes of urine output, pulmonary index $(PI,\;PaO_2/FiO_2)$, mechanical ventilating period, intensive care unit (ICU)-staying period, postoperative complications (fever, wound problem), postoperative 24 hrs and total volumes in blood loss, and hospitalized days were also assessed. All parameters were compared between two groups. There were no significant differences in T-WBC counts, monocyte fraction, platelet counts, TA levels, NSE levels, creatinine levels, BUN levels, the volumes of total urine output, PI, the incidences of fever and wound problem, postoperative 24hrs- and total-blood loss volumes and ICU-staying period between two groups (P>0.05). At CPB-OFF, neutrophil fraction, MPO level, TNI level, and AST level were higher in the high-dose group than in the low-dose group (P<0.05). IL-6 level at CPB-10 was higher in the high dose-group than in the low-dose group (P<0.05). Furthermore, mechanical ventilating periods and hospitalized days of the high-dose group were significantly longer than those of low-dose group (P<0.05). The high-dose group had significantly low lymphocyte fi-action at CPB-OFF compared with the low-dose group (P<0.001). These findings suggest that pretreatment of high-dose steroid is not superior to that of low-dose steroid regrading its potential benefits in pediatric cardiac surgery. Therefore, the conventional strategy of steroid treatment, high-dose pretreatment, should be modified in the cardiac surgery with CPB. However, further studies must be performed on the larger number of patients in as much as small number of patients in this study.