• 대한한방내과학회지
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• 제44권4호
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• pp.603-620
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• 2023

Objectives: This study reviewed randomized controlled trials (RCTs) investigating the efficacy of herbal medicine on sleep disorders associated with Parkinson's disease and suggests a better research process. Methods: We searched for RCTs for herbal medicine treatments for sleep disorders related to Parkinson's disease on July 31, 2023 using eight databases (PubMed, Embase, the Cochrane library, China National Knowledge Infrastructure [CNKI], the Research Information Service System [RISS], Science ON, the Oriental Medicine Advanced Searching Integrated System [OASIS], and the Korea Citation Index [KCI]). Cochrane's risk of bias tool was used to assess the quality of the RCTs. Results: A total of 16 RCTs met all the inclusion criteria, and in most reports, the treatment group showed a significant improvement in sleep disorders compared to the control group. Total effective rate (TER), Pittsburgh Sleep Quality Index (PSQI), Unified Parkinson's Disease Rating Scale (UPDRS), TCM Symptom Score (TSS), Parkinson's Disease Sleep Scale (PDSS), etc., were used as evaluation indicators. Conclusion: Herbal medicine is a potential treatment for sleep disorders associated with Parkinson's disease. However, the selected RCTs were of poor quality, and it is necessary to perform more systematic studies.

• 한국컴퓨터정보학회논문지
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• 제28권10호
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• pp.207-215
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• 2023

선박 시스템은 복잡하고 고도화되어 있으며, 각 요소 간 업무연관성이 굉장히 높다 보니 관련된 사고를 예방하기 위해서는 사고를 분석할 때 사고의 직접적 원인을 찾아 제거하는 전통적인 순차적 접근방법에 더하여 전반적이고 통합적인 시스템의 측면에서 접근할 필요가 있다. 이에 본 연구에서는 전통적인 사고분석 기법과는 다른 STAMP 방법론을 사용하여 선박에서 발생한 화재사고를 분석한다. 이 분석을 통해 선박 내 화재를 예방하기 위한 안전 요구 사항, 부적절한 결정과 조치, 상황, 장비 결함 및 사고분석 결과에서 도출된 권고 사항을 포함한 다양한 요소를 검토한다. STAMP를 이용한 사고 예방에 대한 종합적인 접근을 통해 선박이라는 전체 시스템 내에서 구성 요소 수준에서 대안 평가를 제시하고, 단순한 사고분석 뿐만 아니라 사고 예방 및 위험 평가에도 체계적으로 활용하고자 한다.

• 한방재활의학과학회지
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• 제33권4호
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• pp.79-93
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• 2023

Objectives The purpose of this study is to investigate therapeutic exercise and to provide the evidence of daoyin exercise for shoulder pain. Methods Electronic databases including PubMed, EMBASE, China National Knowledge Infrastructure, Science ON, Oriental Medicine Advanced Searching Integrated System were searched up to October 2022. We selected randomized controlled trials. The quality of studies was assessed by Cochrane risk of bias tool. Meta-analysis were perfomed by Review Manager software. Results Eighteen randomized controlled trials were collected in accordance with the selection and exclusion criteria. Among the 18 trials, 7 trials used strengthening exercise, 4 trials used stablilization exercise, 5 trials used both types of intervention, and 2 trials used daoyin exercise. The study characteristics, results and method of intervention were analyzed. Meta-analysis showed that therapeutic exercise appeared to more effective than no treatment group for shoulder pain (standardized mean difference=-1.18, 95% confidence interval=-1.44 to 0.91, Z=8.82, p<0.00001; chi²=2.71, p=0.61; I²=0%). Conclusions All of 18 selected studies reported the effectiveness of therapeutic exercise for shoulder pain. Combining strengthening and stablilization exercise is considered the most efficient way for shoulder pain. Based on this study, well-designed studies should be performed to be evidence of the use of daoyin exercise for shoulder pain.

• 동의신경정신과학회지
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• 제34권4호
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• pp.403-420
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• 2023

Objectives: This study investigated the effectiveness of herbal medicine for generalized anxiety disorder (GAD) based on recent clinical studies. Methods: Studies were searched through four databases. Clinical research studies on herbal medicine treatment for GAD patients were included. The studies were analyzed according to study design, diagnostic criteria, population, and intervention. A risk of bias assessment was performed to assess the quality of the included randomized controlled trials (RCT). If the intervention applied to the treatment and control groups was the same and two or more studies were reporting the same items as outcome indicators, a meta-analysis was performed. Results: A total of 19 studies, including 12 RCTs were selected. The most common pattern identification was 'Phlegm fire disturbing upward' (痰熱上擾), and the most used herb for therapeutic purposes was 'Rhizome of Poria cocos' (茯苓). Meta-analysis results of three studies showed that there were no significant differences in effectiveness between the herbal medicine intervention and the Western medicine intervention. Meta-analysis results of five studies showed that the Hamilton Anxiety Rating Scale was significantly reduced in the case of herbal medicine intervention compared to Western medicine intervention. Conclusions: The results of our study demonstrated that herbal medicine treatment for GAD is effective in alleviating anxiety symptoms and chief symptoms of GAD. However, this study has several limitations; there was a lack of placebo-controlled RCT and an absence of objective diagnostic criteria in case reports. Therefore, further well-designed clinical studies, conducted based on the results of this study, are recommended.

• Safety and Health at Work
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• 제15권1호
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• pp.1-8
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• 2024

Background: The International Agency for Research on Cancer (IARC) Monograph conducted a systematic review of the relationship between asbestos and ovarian cancer. However, there may have been information bias due to the undue weight given to few articles. To address this limitation, the present study performed a meta-analysis integrating studies published both before and after the 2012 IARC Monograph on Asbestos, with the aim of investigating the association between asbestos exposure and ovarian cancer. Methods: A comprehensive search of major journal databases was conducted to identify studies examining the relationship between asbestos exposure and ovarian cancer, including those featured in the 2012 IARC Monograph on Asbestos. A meta-analysis on asbestos exposure and cancer risk was performed. Results: The meta-analysis of studies published after the 2012 IARC Monograph on Asbestos found a summary Standardized Mortality Ratio (SMR) of 2.04 (95% CI: 1.03-4.05; p = 0.0123; 5 studies), with a significant degree of heterogeneity among the studies (I² = 72.99%). The combined analysis of 15 studies before and after the 2012 IARC Monograph showed an overall summary SMR of 1.72 (95% CI: 1.43-2.06; p = 0.0349; 15 studies), with a moderate degree of heterogeneity (I² = 42.99%). Conclusion: This meta-analysis provides evidence of a significant association between asbestos exposure and ovarian cancer mortality. While the possibility of misdiagnosis in earlier studies cannot be completely ruled out, recent findings suggest a robust correlation between asbestos exposure and ovarian cancer. This highlights the importance of sustained efforts to minimize asbestos exposure and protect public health.

• Hip & pelvis
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• 제35권4호
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• pp.217-227
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• 2023

Purpose: Periprosthetic femoral fracture (PFF) is a common complication after total hip arthroplasty, and open reduction and internal fixation (ORIF) is a common surgical treatment. We conducted a meta-analysis to compare the outcomes of ORIF in patients with different fracture patterns (Vancouver B1 and B2). Materials and Methods: We conducted a systematic search of PubMed, Embase, Cochrane Library and KoreaMed from inception to August 2022. We conducted a pair-wise meta-analysis (with a fixed-effects model) on the 10 comparative studies and a proportional meta-analysis on the data from the 39 articles to determine a consensus. The outcomes were the incidence of reoperations that included osteosynthesis, irrigation/debridement and revision arthroplasty. Results: The pair-wise meta-analysis showed similar outcomes between two groups; the risk of reoperation (odds ratio [OR]=0.82, confidence interval [CI] 0.43-1.55, P=0.542), nonunion (OR=0.49; CI 0.22-1.10, P=0.085) and deep infection (OR=1.89, CI 0.48-7.46, P=0.361). In proportion meta-analysis, pooled prevalence of reoperation was 9% (95% CI, 6-12) in B1 and 8% (95% CI, 2-15) in B2 (heterogeneity between two groups (Q), P=0.772). The pooled prevalence of nonunion was same as of 4% in B1 and B2 (Q, P=0.678), and deep infection was 2% (95% CI, 1-3) in B1 and 4% (95% CI, 2-7) in B2 (Q, P=0.130). Conclusion: ORIF is a feasible treatment for B1 and B2 periprosthetic femoral fractures, with acceptable outcomes in terms of, nonunion and infection. The results of this study would help clinicians and provide baseline data for further studies validating PFF.

• 지질공학
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• 제34권2호
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• pp.317-327
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• 2024

대규모 암반 사면에서 비연속성의 절리계가 발달할 때, 계단상 활동면에 의한 사면 파괴가 발생할 수 있다. 계단상 활동면은 절리-절리 활동면 또는 절리-암교 활동면으로 구분할 수 있으며, 절리-암교 활동면에서 암교는 절리와 평행한 전단 저항과 절리에 수직인 인장 저항을 제공한다. 계단 경로 파괴는 활동 암괴의 하중에 의해 암교의 파괴가 발생하여 암교 양단의 두 절리가 연결되며 발생한다. 암교의 길이가 동일하다면 암석의 인장강도가 전단강도에 비해 낮으므로 절리에 수직으로 형성된 암교가 파괴에 취약하며, 불연속면 간격/길이의 비가 작을수록 계단 경로 파괴의 가능성이 커진다. 비연속성의 절리가 발달하는 암반 사면의 계단상 활동 파괴 위험에 대한 평가를 위해서는 체계적인 불연속면 조사 및 분석을 통해 계단 경로 파괴면을 구성하여 한계 평형 해석 또는 수치 해석 등의 안정성 평가를 수행하여야 한다.

• 한국간담췌외과학회지
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• 제27권1호
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• pp.20-27
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• 2023

There are many variations and unclear definitions of the appropriate timing of laparoscopic cholecystectomy (LC) after endoscopic retrograde cholangiopancreatography (ERCP), and there is still a lack of consistency about the appropriate timing. Inappropriate timing can be associated with serious comorbidity and can affect the patients. This meta-analysis was conducted to assess the operative outcomes and morbidity to provide a benefit to the patients based on the best timing of LC after ERCP. Randomized controlled trials (RCTs) and retrospective studies were identified from the PubMed and Scopus databases from inception to July 2021. A meta-analysis was performed to estimate the treatment effects on operative outcomes and morbidity. Four RCTs and four retrospective studies met our inclusion criteria. A meta-analysis indicated that patients who received LC after ERCP on the same day or within 72 hours had about 0.354 days shorter length of hospital stay with a shorter operative time of about 0.111-1.835 minutes and a lower risk of complications around 37%-73%. Our evidence suggests that the appropriate timing of LC after ERCP is either the same day or within 72 hours for treating cholelithiasis patients based on the severity of disease.

• 한국항행학회논문지
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• 제28권2호
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• pp.185-192
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• 2024

항공산업은 기술적인 혁신을 통해 안전성을 향상했으며, 항공 당국의 안전 규제와 감독을 통해 비행안전을 강화해 왔다. 항공산업의 안전 접근 방식이 항공기 시스템 전체에 대한 체계적인 접근 방식으로 발전함으로써 항공사는 새로운 안전 관리시스템을 구축하게 되었다. 항공기의 기술적 결함이나 비정상적인 데이터는 사고로 이어질 수 있는 전조 징후가 될 수 있으며, 이러한 징후를 조기에 식별하고 대처함으로써 사고 발생의 위험을 감소시킬 수 있다. 따라서 비정상적인 전조 징후의 관리는 데이터 기반 의사결정을 촉진하고, 항공사의 운영 효율성 및 안전수준을 강화하는 데 있어 필수적인 요소이다. 본 연구에서는 항공기 착륙 시에 활주로 이탈로 이어질 수 있는 크랩랜딩 이벤트의 패턴과 원인 분석을 위한 사전적 분석 단계에서 QAR (quick access recorder) 비행 데이터 통계 분석 모델을 제시하여 착륙 이벤트의 전조 징후와 원인을 식별 및 제거하는 안전관리의 효율성을 제고하고자 한다.

• Anatomy and Cell Biology
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• 제57권1호
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• pp.31-44
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• 2024

The exocrine part of the pancreas has a duct system called the pancreatic ductal system (PDS). Its mechanism of development is complex, and any reorganization during early embryogenesis can give rise to anatomical variants. The aim of this study is to collect, classify, and analyze published evidence on the importance of anatomical variants of the PDS, addressing gaps in our understanding of such variations. The MEDLINE, Web of Science, Embase, and Google Scholar databases were searched to identify publications relevant to this review. R studio with meta-package was used for data extraction, risk of bias estimation, and statistical analysis. A total of 64 studies out of 1,778 proved suitable for this review and metanalysis. The meta-analysis computed the prevalence of normal variants of the PDS (92% of 10,514 subjects). Type 3 variants and "descending" subtypes of the main pancreatic duct (MPD) predominated in the pooled samples. The mean lengths of the MPD and accessory pancreatic duct (APD) were 16.53 cm and 3.36 cm, respectively. The mean diameters of the MPD at the head and the APD were 3.43 mm and 1.69 mm, respectively. The APD was present in only 41% of samples, and the long type predominated. The pancreatic ductal anatomy is highly variable, and the incorrect identification of variants may be challenging for surgeons during ductal anastomosis with gut, failure to which may often cause ductal obstruction or pseudocysts formation.