• Progress in Medical Physics
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• v.23 no.2
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• pp.81-90
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• 2012

The effect of setup uncertainties on CTV dose and the correlation between setup uncertainties and setup margin were evaluated by Monte Carlo based numerical simulation. Patient specific information of IMRT treatment plan for rectal cancer designed on the VARIAN Eclipse planning system was utilized for the Monte Carlo simulation program including the planned dose distribution and tumor volume information of a rectal cancer patient. The simulation program was developed for the purpose of the study on Linux environment using open source packages, GNU C++ and ROOT data analysis framework. All misalignments of patient setup were assumed to follow the central limit theorem. Thus systematic and random errors were generated according to the gaussian statistics with a given standard deviation as simulation input parameter. After the setup error simulations, the change of dose in CTV volume was analyzed with the simulation result. In order to verify the conventional margin recipe, the correlation between setup error and setup margin was compared with the margin formula developed on three dimensional conformal radiation therapy. The simulation was performed total 2,000 times for each simulation input of systematic and random errors independently. The size of standard deviation for generating patient setup errors was changed from 1 mm to 10 mm with 1 mm step. In case for the systematic error the minimum dose on CTV $D_{min}^{stat{\cdot}}$ was decreased from 100.4 to 72.50% and the mean dose $\bar{D}_{syst{\cdot}}$ was decreased from 100.45% to 97.88%. However the standard deviation of dose distribution in CTV volume was increased from 0.02% to 3.33%. The effect of random error gave the same result of a reduction of mean and minimum dose to CTV volume. It was found that the minimum dose on CTV volume $D_{min}^{rand{\cdot}}$ was reduced from 100.45% to 94.80% and the mean dose to CTV $\bar{D}_{rand{\cdot}}$ was decreased from 100.46% to 97.87%. Like systematic error, the standard deviation of CTV dose ${\Delta}D_{rand}$ was increased from 0.01% to 0.63%. After calculating a size of margin for each systematic and random error the "population ratio" was introduced and applied to verify margin recipe. It was found that the conventional margin formula satisfy margin object on IMRT treatment for rectal cancer. It is considered that the developed Monte-carlo based simulation program might be useful to study for patient setup error and dose coverage in CTV volume due to variations of margin size and setup error.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.1
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• pp.125-132
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• 2017

Objective: Along with increasing livestock products via intensive rearing, the accumulation of livestock manure has become a serious issue due to the fact that there is finite land for livestock manure recycling via composting. The nutrients from livestock manure accumulate on agricultural land and the excess disembogues into streams causing eutrophication. In order to systematically manage nutrient loading on agricultural land, quantifying the amount of nutrients according to their respective sources is very important. However, there is a lack of research concerning nutrient loss from livestock manure during composting or storage on farms. Therefore, in the present study we quantified the nutrients from dairy cattle manure that were imparted onto agricultural land. Methods: Through investigation of 41 dairy farms, weight reduction and volatile solids (VS), total nitrogen (TN), and total phosphorus (TP) changes of dairy cattle manure during the storage and composting periods were analyzed. In order to support the direct investigation and survey on site, the three cases of weight reduction during the storing and composting periods were developed according to i) experiment, ii) reference, and iii) theoretical changes in phosphorus content (${\Delta}P=0$). Results: The data revealed the nutrient loading coefficients (NLCs) of VS, TN, and TP on agricultural land were 1.48, 0.60, and 0.66, respectively. These values indicated that the loss of nitrogen and phosphorus was 40% and 34%, respectively, and that there was an increase of VS since bedding materials were mixed with excretion in the barn. Conclusion: As result of nutrient-footprint analyses, the amounts of TN and TP particularly entered on arable land have been overestimated if applying the nutrient amount in fresh manure. The NLCs obtained in this study may assist in the development of a database to assess the accurate level of manure nutrient loading on soil and facilitate systematic nutrient management.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.35 no.4
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• pp.126-133
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• 2017

This study analyzed hydrological changes of stormwater runoff of Seolleung Jeongneung zone according to the application of LID system based on landscape Architectural technology. The results are as follows. First, when flooding occurred in Gwanghwamun in July 27, 2011, the maximum instantaneous rainfall amount was 183 mm/hr recorded at 10:00 on 27th for 10 minutes, and it was confirmed that rainfall intensity more than three times as high as the maximum rainfall of 57.5 mm/hr. Second, it is possible to control peak flow rate in the case of 1,500mm of soil thickness, so that it is possible to improve the vulnerability of flood damage in Seolleung and Jeongneung zone when applying the LID system. Third, in the berm height scenario, peak flow rate control was not controled in all depth level models, but the first stormwater runoff was delayed by 4 hours and 10 minutes compared to the soil thickness scenario. It was interpreted as a relatively important indicator the soil thickness for the initial stromwater runoff reduction and the berm height for the peak runoff. Through this, the systematic adaptation of landscape-friendly ecological factors within the cultural property protection zone could theoretically confirm the effects of flood disaster prevention.

• Korean Institute of Interior Design Journal
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• v.21 no.1
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• pp.78-85
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• 2012

The relevance between organisms and their external environment covers everything including humans, natural and artificial surroundings, regarding which academic and scientific understanding has continued. Relevant elements established by inter-dependence between humans and environment and the unity of life should be translated from the perspective of a whole, not of unit elements or reduction. That is, a space is formed by its own program and assumes sustainable relevance based on interactions between internal and external spaces, not building an independent system. The present study aims to present the feasibility of a potential mutant space formed by invisible arenas between individuals and evolutionary space formation based on an ecological paradigm Accordingly, this study suggested that evolutionary attributes as the major power source of biological changes could verify the virtual multiplicity of a new space formation, and that the potential form generation of hybrid mutant space of emergence and infinite formative capability could be supported. The suggestions made here will hopefully contribute to extending applicability of evolutionary space generation in the field of space design. To derive the potential mutant forms from biological space, a preliminary study was conducted regarding the characteristics of evolutionary form generation. For the purpose of this study, three evolutionary perspectives of reproduction, mutation (variation) and selection were taken. First, the theory of evolution was defined and characterized. Also, the relevance between the characteristics generated and hybrid mutant space was analyzed to consider relevant characteristics. The present study helped to understand that the hybrid mutant space had an evolutionary space structure based on a biological paradigm. It was also found that the mutant space structure built by mutant polymorphism assumed a systematic correlation between space and environment.

• YAKHAK HOEJI
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• v.50 no.6
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• pp.386-392
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• 2006

Pramlintide, a synthetic analogue of human hormone amylin, is the first of a new class of amylinomimetic compounds. Present study was undertaken to compile and analyze the clinical trials of pramlintide, and thereby to facilitate the design of the bridging study for the earlier introduction of the drug, which might be needed by diabetes patients in Korea. Sixty-two articles from Pubmed and MEDLINE search were used to analyze the trials of pramlintide along with prescribing information and New Drug Application packet obtained form the manufacturer. The efficacy of the new drug was attributed to three mechanisms: delay of gastric emptying time, inhibition of post-prandial glucagon secretion, and reduction of food intake by enhanced satiety. Clinical trials consistently identified the effectiveness of the drug for the treatment of type 1and type 2 diabetes who have failed to achieve glycemic control despite optimal therapy with insulin. However, the six pivotal Phase III clinical trials were peformed with mostly caucasian and some black and hispanic people. None of the trials documented the proportion of either Asian or Korean participants. Since Korean diabetes patients show different epidemiology and characteristics in their disease state, it appears that the bridging study of pramlintide should be designed in the level of full scale Phase III clinical trial along with pharmacokinetic and pbarmacodynamic studies.

• Journal of the Korean Institute of Landscape Architecture
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• v.28 no.1
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• pp.70-82
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• 2000

This is a study to generate a theoretical base for the development of wildlife corridor as a solution to the problems of wildlife population size reduction and declining bio-diversity resulting from the fragmented habitats caused by road constructions. This study seeks to examine and define techniques in very aspect of wildlife corridor including planning, site selection, design and development, and maintenance through an actual application. The results of this study are as follows. 1) The wildlife corridor should be developed in an approach supplementing a landscape ecological approach and a restoration ecological approach bilaterally. To this end, systematic methodology and process are required. 2) It was restored an ecosystem as close as possible go to the forest ecosystem before road development. In addition, in order to allow it to function as an ecological corridor, topography restoration, stream development, and ecological plantation were implemented. 3) The result of monitoring activities that continued for one year since the development confirmed the migration and inhabitation of a number of animals including small mammals. It is judged that it functions as a corridor in fragmented habitats as initially expected. 4) Through continuous monitoring in the future, the effects of corridor development on ecological restoration need to be reviewed in a long-term perspective. There is also a need to develop and refine a comprehensive maintenance plan for wildlife corridors and their surroundings. Based on such study results, actual data on the development of wildlife corridor should be accumulated. In follow-up studies, after continuous monitoring for a long period of time, the effects of wildlife corridor development should be evaluated comprehensively and wildlife corridor applicable to Korea should be standardized by correcting disclosed problems.

• Journal of The Korean Society of Integrative Medicine
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• v.9 no.1
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• pp.141-150
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• 2021

Purpose : The purpose of this study was to investigate the effect of case-based learning application in human growth development classes on nursing students' problem-solving ability, self-directed learning ability, and academic self-efficacy. Methods : The research method was a self-report questionnaire before and after case-based learning for second-year nursing students who took the human growth development course at U University in K city. The collected data were statistically processed using SPSS WIN 21.0. Results : The results of the study showed that after case-based learning, problem-solving ability, self-directed learning ability, and academic self-efficacy were all significantly improved. In addition, as a result of examining the correlation between each variable after case-based learning, problem solving ability score and self-directed learning ability score (r=.54, ｐ<.01), and problem solving ability scores and academic self-efficacy scores (r=.44, ｐ<.01), were significantly correlated with self-directed learning ability scores and the academic self-efficacy reduction scores (r=.76, ｐ<.01). Conclusion : The results of this study suggested the need for various learning programs such as case-based learning to improve nursing students' problem-solving abilities and self-directed learning abilities and their application. In addition, to improve the learning self-efficacy of nursing students, a continuous and systematic study is suggested to develop and apply customized educational programs according to the learners' preferences. Since the sample group in this study was limited to one university, there were few cases and no control group, so there are limitations in generalizing the test effect, However, significant differences a were verified in the case-based learning pre-tests and post-tests.

• Knowledge Management Research
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• v.14 no.5
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• pp.15-34
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• 2013

In a turbulent environment, it is important for a firm to obtain competitiveness through acquiring new technologies and new knowledge. Many studies has shown that R&D has positive effects on innovation and performance. However, the limitation of resources and research personnel for SMEs leads to the needs of collaboration between government R&D and SMEs. The quantitative results of government R&D comes in the form of patents or publication of papers while the qualitative results comes in the form of commercialization (revenue increase or cost reduction) of the SMEs acquiring the technology through technology transfer. Korean government invested 16.9 Trillion Won in 2013 and achieved remarkable quantitative results but the qualitative results are still yet to be improved. The technology transfer rate in 2011 was 26.0% while the success rate of commercialization of the transferred technology is only 23.6%. Therefore it is meaningful to study the success factors of the technology commercialization in Korea. In this study, a case of technology commercialization between ETRI and Initech is studied. Initech was a venture firm which started in 1997 with 2 employees and after transfer of technology from ETRI in 1999, it has grown to a firm of 238 employees. In this study, Jolly's commercialization model was used to analyze the success factors of the commercialization. It was shown that four main factors that leads to the success are (1) mobilizing interest and endorsement through customer oriented R&D by ETRI, (2) mobilizing resources for demonstration through systematic technology commercialization process by ETRI, (3) mobilizing market constitutents through government standardization that leads to the reliability of the participants, and (4) mobilizing complementary assets for delivery by management strategies of Initech.

• Journal of Korean society of Dental Hygiene
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• v.17 no.3
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• pp.395-404
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• 2017

Objectives: The purpose of this study was to identify the effects of music intervention on the patient's fear and anxiety during scaling. Methods: 360 patients who had visited W University dental hygiene laboratory were selected as study subjects and divided into experiment group and control group. Results: Study results showed that the control group (71.9%) and the experimental group (75.1%) had experiences avoiding dental treatment due to fear. In the control group (37.6%) and experimental group (40.6%), the highest influencing factor was the sound of machine and followed by pain. The experimental group preferred classical music, followed by pop songs, trot music and instrumental music. In the experimental group (83.3%), fear and anxiety were alleviated by music, and 77.9% of the patients mentioned they would recommend music for scaling to other patients. There was an interaction effect (p=0.014) between the groups before and after the measurement of the lowest blood pressure. There was a significant difference in pulse before and after pulse measurement (p=0.000). There was a significant difference in respiration between groups (p=0.042) and before and after respiration (p=0.030). Conclusions: Study results showed that music intervention that utilizes music during scaling showed significant effects on the alleviation of fear and anxiety, affecting Pulse number among vital signs. Therefore, more systematic program is to be required to alleviate dental fear and anxiety with music therapy not only for scaling, but also for dental clinic in the future.

• Korea journal of population studies
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• v.11 no.1
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• pp.14-31
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• 1988

The national family planning program in Korea, which was instituted as an integral part of the nation's economic development plans since 1962, has contributed greatly to a reduction in the fertility and population growth rate. The total fertility rate dipped from 6.0 births per women in 1960 to 2.0 in 1985, and the population growth rate rom 2.84 percent per year to 1.25 percent during the same period, while the contraceptive practice rate for the 15-44 married women increased from 9 percent in 1965 to 70 percent in 1985. Study findings indicate that the fertility reduction in the past 26 years is largely attributed to the virgorous implementation of the national family planning program, rising age at marriage, wide-spread use of induced abortion, and the changes in attitude regarding the value of children that came into being in the wake of the rapid socio-economic development over the period. Among the strengths of the national family planning program are the following : 1) a pluralistic system of program manageent with active participation of various government and voluntary organizations, 2) utilization of a large corps of family planning field workers to conduct face-to-face communication and motivation activities, 3) use of private physicians with government support to provide contraceptive services, 4) a systematic program management system including program planning of traget allocation, evaluation, and supervision with a broad MIS and award system, 5) numerous incentive and disincentive schemes for stimulating the small family norm and contraceptive use, and 6) strong commitments to the family planning program by political leaders. The new demographic targets during the Sixth Five-Year Economic and Social Development plan period(1987-91) have been set for a further reduction in the population growth rate to 1.0 percent by 1993, assuming that the TFR will decline to 1.75 level in 1995. This target is, however, not easy to achieve due to anticipated unfavorable factors like the strong boy preference, high discontinuation rates of reversible contraceptive methods, fertility termination-oriented contraceptive use, a plateau level of contraceptive practice rate that has mostly accounted for a sterilization, shortened length of birth intervals, and the changing patterns of contraceptive mix. The recent changes in contraceptive and fertility behaviors clearly indicate that the past quantity-oriented management system of the national program should be redirected toward a quality-oriented approach. Particularly, program efforts should be expanded to recruit new contraceptive users in the 20s of younger age groups, both for birth spacing and controlling their fertility since the women aged 20 to 29 account for more than 80 percent of the total annual births in recent years. In addition, the current contraceptive fee system of the national family planning program should be gradually shifted from free contraceptive services to a acceptor's charge system, and the provision of contraceptive services through the medical insurance system, which will cover the entire population by 1989, should be accelerated as a means of integration of family planning program with other health programs.