• Korean Journal of Veterinary Service
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• v.34 no.2
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• pp.191-193
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• 2011

A 3-month-old intact male, Labrador retriever was presented with the history of coagulopathy and anemia. The results of initial screening tests of the hemostatic system yielded a tentative diagnosis of hemophilia. Activated partial thromboplastin time (APTT) was distinctly prolonged (106 seconds) and prothrombin time (PT) was not detected due to markedly prolonged test time. Whole blood transfusions (20 me l/kg body weight) were carried out prior to assays of coagulation factor. After transfusion, the patient recovered well and hemorrhage ceased. Blood samples were assessed for coagulation factor activity. The patient showed markedly low factor IX coagulation activity (5%, reference range: 7~140%) and was diagnosed with hemophilia B. After recovery, the patient was discharged from the hospital. However, 4 months later the patient was re-hospitalized for recurrence of the initial symptoms. The owner did not want to pursue further treatment and the patient died of respiratory distress two days later.

• Journal of Korean Society for Quality Management
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• v.41 no.4
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• pp.725-735
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• 2013

Purpose: The purpose of this study is to propose an Integrated Safety Evaluation Process (ISEP) that can enhances the safety aspect of the safety-critical system. This process utilizes the advantages of the iterative Systems Engineering process combined with the safety assessment process that is commonly and well defined in many standards and/or guidelines for railway, aerospace, and other safety-critical systems. Methods: The proposed process model is based on the predefined system lifecycle, in each phase of which the appropriate safety assessment activities and the safety data are identified. The interfaces between Systems Engineering process and the safety assessment process are identified before the two processes are integrated. For the integration, the elements at lower level of Systems Engineering process are combined with the relevant elements of safety assessment process. This combined process model is represented as Enhanced Functional Flow Block Diagram (EFFBD) by using CORE(R) that is commercial modelling tool. Results: The proposed model is applied to the lifecycle and management process of the United States aircraft system. The US aircraft systems engineering process are composed of twelve key elements, among which the requirements management, functional analysis, and Synthesis processes are considered for examplenary application of the proposed process. To synchronize the Systems Engineering process and the safety assessment process, the Systems Engineering milestones are utilized, where the US aircraft system has thirteen milestones. Taking into account of the nine steps in the maturity level, the integrated process models are proposed in some phases of lifecycle. The flows of processes are simulated using CORE(R), confirming the flows are timelined without any conflict between the Systems Engineering process and the safety assessment process. Conclusion: ISEP allows the timeline analysis for identifying activity and data flows. Also, the use of CORE(R) is shown to be effective in the management and change of process data, which helps for the ISEP to apply for the development of safety critical system. In this study, only the first few phases of lifecyle are considered, however, the implementation through operation phases can be revised by combining the elements of safety activities regarding those phases.

• Journal of the Korean Society of Safety
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• v.35 no.3
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• pp.24-31
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• 2020

The duty of construction clients in WSH (Workplace Safety and Health) system was included in the amendment of Occupational Safety and Health Act (enforced on 16 January 2020), which was estimated the shift of paradigm in the prevention of construction accidents. The purpose of this paper is to introduce the analysis results of construction clients' role in the construction project, which were performed by authors over the recent years in order to impose the duty on construction clients, and to suggest their role according the plan, design, and construction stage. Utilizing the systematic literature review process based on Meta analysis, the related papers were selected. For the selected papers, related domestic and foreign regulations, and other prominent report, the construction clients' role was analyzed by reflecting the experts' advice. Results show that the construction clients should control the designer and contractor for implementing the WHS system during the whole process of the construction project. They should supply sufficient source and time to ensure the workers' safety. In the plan stage, the key role of construction clients is to identify intensively controlled hazard and risk reduction plan and to transfer the results. In the design stage, their key role is to select the designer with the capacity in WSH and to assist the designer for the safety design. The main key role of construction clients in the costruction stage is to select the contractor with specialty in WSH including a contract reflecting the WSH requirement and to check implementation of WSH plan, WSH cost, WSH education, and accident report. In addition, it is thought that the construction clients' participations in the site WSH activity and adjustment of safety and health problem among contractors can be effect in the prevention of construction accidents.

• Proceedings of the KSR Conference
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• 2007.05a
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• pp.936-940
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• 2007

This paper is about the study on the verification method for railway system SIL which is frequency of hazard, composing Risk, one of the measurement standards for railway system safety. Frequency of hazard can be identified by using FMECA, or HAZOP, and the assessment of identified dangerous failure rate should be done by systematic methods such as FTA. Therefore, this paper provides the hazard identification level for SIL verification and the requirements necessary to verify the integrity of analysis activity.

• Journal of Food Hygiene and Safety
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• v.2 no.1
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• pp.9-14
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• 1987

With the market of food products, the use of food additives is on the increase. The dye as food additives, can be used for some foods which are difficult to preserve their own colors. It can be also classified as tar dye, vegetable dye and mineral dye. Because tar dye has dense toxicity, only 15 articles among them are legally allowed to be used. Among the allowed articles, the azo compound amaranth, tartrazine, sunset yellow, and allura red, were used in determining and comparing rat hepatic azo reductase activity and we observed the flavin's effects as follows: 1. Investigation with amaranth as substrate gave an apparent Km of $645\;\mu\textrm{M}$ and Vmax of 50 n mol/min/mg protein. 2. On investigation using a fixed amaranth concentration over a range of flavin concentration, FAD significantly increased the activity of the azo reductase compared with only minor increases in reaction mediated by the NADPH-generating system alone. 3. On investigation with amaranth, tartrazine, sunset yellow allura red as electron acceptor in the absence or presence of 300 mM-FAD, sunset yellow was reduced at a rat similar to amaranth, tartrazine was reduced at a slower rate and allura red was reduced a little more rapidly.

• Journal of Korean Society of Transportation
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• v.6 no.1
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• pp.33-41
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• 1988

The Wisconsin Department of Transportation currently has a Datalog Information System which facilitates the collection of geometric characteristics at every 0.01 mile high way section. The objectives of this study are to develop the plan and profile drawing of a highway section utilizing the Datalog Information system and to develop a methodology of investigating the safety aspects associated with the highway section being considered. For this purpose, two of the highway design elements, the minimum stoping sight distance as well as passing sight distance based on the AASHTO requirements, were applied in this study. A computer program was also developed to facilitate the data processing activity. The results from the computer program and from a manual analysis which adopted the identical methodology used in the computer program were in a good agreement. a few discrepancies between the two results were due to the data collection error and they were believed to be negligible. Using the computerized methodology developed in this study one does not need the plan and profile drawing to investigate the safety of a highway section, which appears to be an essential progress to the Computer Aided design and Draft in highway engineering field.

• Fire Science and Engineering
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• v.17 no.2
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• pp.50-55
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• 2003

The lower flash points for the binary system, n-butanol+n-decane, were measured by Pensky-Martens closed cup tester. The experimental results showed the minimum in the flash point versus composition curve. The experimental data were compared with the values calculated by the reduced model under an ideal solution assumption and the flash point-prediction models based on the Van Laar and Wilson equations. The predictive curve based upon the reduced model deviated form the experimental data for this system. The experimental results were in good agreement with the predictive curves, which use the Van Laar and Wilson equations to estimate activity coefficients. However, the predictive curve of the flash point prediction model based on the Willson equation described the experimentally-derived data more effectively than that of the flash point prediction model based on the Van Laar equation.

• Journal of the Korea Safety Management & Science
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• v.16 no.1
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• pp.201-206
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• 2014

GCM(Green Chain Management) is being spread by that companies which apply with eco-friendly concept in entire SCM(Supply Chain Management) perspective is being increased for resolving some recent environmental problems. There are reasons that numerous companies focus on GCM. At first various governments began to directly manage components and material contents about various noxious substances. Second, environment problem management in the entire logistics process from procurement of product materials to distribution of product became to be important according to introduction of certification system that evaluate the environmental impact throughout life-cycle of products. Purposes of this paper are 1) to analyze the GCM process whose important is more increasing in the recent logistics environment change, 2) to comprehend places and sources that generate environmental elements like energy consumption and greenhouse gas emissions in elements of logistics function, and 3) to construct integrated GCM system for observing activity of logistics function throughout life-cycle of products.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.22 no.3
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• pp.1-7
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• 2014

The base of leisure air activities are consistently expanding and its demand is expected to increase attributed to GDP growth and people's interest in its activity. Utilizing Visual Flight Rule, light sport aircrafts and ultra-light aircrafts are not under the effect of air traffic control center, which resulted in passenger injury due to emergency landing for adverse weather conditions and technical issues after pulling into mountain area, ocean and even urban area. Such events encouraged safety consciousness toward leisure aircraft activities and developing a measure to prevent a recurrence of the accident. This research focuses on suggesting compositive system for preventive safety management system by providing user based Flight information service and operating effective system, necessary for leisure aircraft activities.

• Proceedings of the Safety Management and Science Conference
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• 2004.05a
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• pp.61-65
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• 2004

As technique that can contribute in quality improvement in design process to overcome shortcoming of traditional quality control, call design or development department quality control activity that is achieved to reduce gun damage shuddering at circle minimizing change or side effect of product performance as off-line quality control. This paper discuss optimal process design of investment projects expansion and replacement investment on each line or individual in the production. Generally optimal plant design has add to a few method by Subsidiary means with use a especial method. And then in this paper, a Robust design is presented, which may be effective to the processes appraisal or improvement. We propose that should make a optimal plant design model for reducing field failure rate to assign by real data on different factors in plant system. Using this model, robust design of taguchi method used in this comprehensive method for reducing field failure rate in plant system.