• YAKHAK HOEJI
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• v.35 no.4
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• pp.332-334
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• 1991

The synthesis of melandrin has been accomplished in good yield by the reaction of 5-tosyloxyanthranilic acid ethyl ester with p-acetoxybenzoyl chloride, followed by removal of protecting groups with methanolic ammonia.

• YAKHAK HOEJI
• /
• v.38 no.3
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• pp.281-285
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• 1994

Melandrin was isolated from the Melandrium firmum(Caryophyllaceae), its structure was N-(p-hydroxybenzoyl)-5-hydroxyanthranilic acid. Fourteen melandrin derivatives(I-XIV) were synthesized and according to MME calculation by the computer, optimized three dimensional structure of compounds was obtained. The space orientation of compounds was cis-form as a indomethacin.

• YAKHAK HOEJI
• /
• v.37 no.3
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• pp.243-246
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• 1993

Six N-substituted-5-hydroxyanthranilic acids were synthesized by the coupling reaction of 5-tosyloxyanthranilic acid ethyl ester with corresponding acid chlorides. The structure of the obtained compounds was proved by NMR and IR. These compounds did not inhibit the growth of micro-organisms while suppressed HSV-1 replication in vero cell at 100 $\mu\textrm{g}$/ml.