YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis of Melandrin Derivatives

Melandrin 유도체의 합성

  • Lim, Jung-Ki (College of Pharmary, Sung Kyun Kwan University) ;
  • Woo, Won-Sick (Natural Products Research Institute, Seoul National University) ;
  • Lee, Kang-Ro (College of Pharmary, Sung Kyun Kwan University) ;
  • Ma, Eun-Sook (College of Pharmary, Hyosung Women's University)
  • 임중기 (성균관대학교 약학대학) ;
  • 우원식 (서울대학교 천연물과학연구소) ;
  • 이강노 (성균관대학교 약학대학) ;
  • 마은숙 (효성여자대학교 약학대학)
  • Published : 1994.06.30
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Abstract

Melandrin was isolated from the Melandrium firmum(Caryophyllaceae), its structure was N-(p-hydroxybenzoyl)-5-hydroxyanthranilic acid. Fourteen melandrin derivatives(I-XIV) were synthesized and according to MME calculation by the computer, optimized three dimensional structure of compounds was obtained. The space orientation of compounds was cis-form as a indomethacin.

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