• 한국수소및신에너지학회논문집
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• 제28권2호
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• pp.190-199
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• 2017

Air-blown Gasification of coal and torrefied biomass mixture is conducted on fixed-bed gasifier. The various ratio (9:1, 8:2, 7:3) of coal and torrefied biomass mixture are used. The contents of $H_2$, CO in the syngas were increased with gasification temperature. Carbon conversion tend to increase with temperature and equivalence ratio (ER). However, cold gas efficiency showed maximum point in ER range of 0.26-0.36. The torrefied biomass showed highest cold gas efficiency of 67.5% at $934^{\circ}C$, ER 0.36. Gasification of 8:2 mixture showed the highest carbon conversion and cold gas efficiency and synergy effect.

• 기술혁신연구
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• 제5권1호
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• pp.15-43
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• 1997

This paper investigates empirically the relationship between various business portfolio properties (particularly technological properties) and chaebol's performance using data on the 50largest chaebols in Korea. In addition to the traditional indexes to measure diversification such as entropy index, we calculated inter-industry technological similarity using R'||'&'||'D expenditure data by industry and 1990 Input-output Table in korea, and obtained chaebol-level technological relatedness and internal transaction proportion from chaebols' business profile, inter-inustry technological similarity and 1990 input-output table. We applied factor analysis on 13 business portfolio property indexes and showed that they could be grouped into 3 dimensions. diversification scope, inter-business relatedness and degree of vertical integration. In this paper, using 50 largest chaebols' financial data (1989-1994), we analyzed empirically the effect of business portfolio properties on ROS(Return On Sales) which is conventional index for firm performance and on TFP(Total Factor Productivity) growth which is a pure measure of firm performance. To utilize the advantage of panel data, FEM(Fixed Effect Model) and REM(Random Effect Model) were used. The empirical result shows that the entropy index as a measurement of inter-business relatedness in not significant but technological relatedness index is significant. OLS estimates on pooled data were considerably different from FEM or REM estimates on panel data. By introducing interaction effect among the three variables for business portfolio properties, we obtained three findings. First, only VI(Vertical integration) has a significant positive correlation with ROS. Second, when using TFP growth as an dependent variable, both TR(Technological Relatedness) and VI are significant and positively related to the dependent variable. Third, the interaction term between TR and VI is significant and negatively affects TFP growth, meaning that TR and VI are substitutes. These results suggest strategic directions on restructuring business portfolio. As VI is increased, chaebols will get more profit. A higher level of either TR or VI will increase TFP growth rate, but increase in both TR and VI will have a negative effect on TFP growth. To summarize, certain business portfolio properties such as VI and TR can be considered "resources" themselves since they can affect profit rate and productivity growth. VI and TR have a synergy effect of change in profit rate and productivity growth. VI increases ROS and productivity growth, while TR increases productivity growth representing a technological synergy effect.t.

• 대한본초학회지
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• 제31권5호
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• pp.93-98
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• 2016

Objectives : Hwangheuk-san is a complex prescription composed of oriental traditional medicine and has been reported for antioxidant, antimicrobial and anticancer effects in the recent study. Methicillin-resistant Staphylococcus aureus (MRSA) is one of important causes of fatal infectious diseases such as septicemia, endocarditis, toxic shock syndrome, pneumonia, skin and soft tissue infections (SSTIs). S. aureus is reported as being for a variety of human diseases and its epidemiological relevance is mainly due to their ability of becoming highly resistant to common antimicrobials such as tetracycline, penicillin, cphalosporin and aminoglycoside. The objective of this study is to determine the antimicrobial effect of Hwangheuk-san ethanol extracts (HHS) and synergistic effects with antibiotics oxacillin against MRSA.Methods : The antimicrobial activity of HHS was measured by the disc diffusion method, broth microdilution method and the checkerboard dilution test, time-kill curve assay was performed to investigate synergistic effects with antibiotics oxacillin against MRSA.Results : HHS showed antimicrobial activity against MRSA with a MIC value of 125 ㎍/㎖. In the checkerboard test, the interaction of HHS with antibiotics oxacillin produced almost synergy or partial synergy against MRSA. This study showed that HHS reduced the MICs of oxacillin tested, and a remarkable antibacterial effect of HHS, with membrane permeability enhancers.Conclusions : These results suggest that HHS has the antimicrobial effect and synergistic effects with antibiotics oxacillin against MRSA. This study thus can be a valuable source for the development of a new drug with low MRSA resistance.

• 디지털융복합연구
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• 제10권11호
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• pp.403-418
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• 2012

본 논문에서는 IT와 서비스 산업의 디지털융합 모델의 가치 창출요소의 시너지 효과를 이론적으로 정형화하고 실증분석을 통하여 시사점을 도출하였다. 경영전략 분야의 상황적합 이론에 기반 하여 IT융합의 근원적 가치요소를 고정형, 이동형으로 구분하고 이들 가치의 전략적 적합과 서비스 프로세스 제약완화 기여 등을 시너지 효과에 초점을 맞추어 탐색하였다. 본 논문에서 도출된 융합 시너지 연구 모델은 실증분석을 통하여 계층적 회귀분석 방법을 통하여 검증하였으며, 분석 결과 융합 모델의 가치 창출 요소의 유용성은 산업 별로 확연하게 구분되며 혁신에 의한 상대적 이점과 함께 일상생활 습관과의 부합성이 채택의 중요한 영향을 미치는 것이 발견되었다. IPTV 등에 기반 한 고정형 가치와 스마트 폰 등 모바일 기반 응용에 대한 시너지 효과와 프로세스 제약완화 등에 대한 시너지 효과가 제한적으로 나타났으며 이는 이들 가치가 서로 독립적으로 존재하며 융합 산업의 고유 특성과의 조화가 핵심적이라는 시사점이 도출되었다. 본 연구 결과는 향후 IT기반 산업 융합 모델 비즈니스 모델 연구에 유용한 시사점을 제공한다.

• Journal of Genetic Medicine
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• 제3권1호
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• pp.29-32
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• 1999

The Apolipoprotein E type 4 allele (ApoE ${\varepsilon}4$) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease. The BchE-k variant, which is the common variant of the BchE gene, has been reported to show allelic association with AD in subjects who are also carriers of the ${\varepsilon}4$ allele of the ApoE, especially in subjects over the age of 75. This study was performed to evaluate the distribution of the ApoE and the BchE genotypes in the healthy and AD groups and to evaluate the synergy between the BchE-k variant and the ApoE ${\varepsilon}4$ in AD. The ApoE and the BchE genotypes were determined in DNA samples from 610 healthy people and 60 LOAD patients by using ARMS by standard agarose gel electrophoresis. The effect of the ApoE ${\varepsilon}4$ was closely related to AD(p<0.05). A comparison between the AD patients and the healthy individuals, both with the ${\varepsilon}4$ allele, indicated an interaction between the BchE-k and the ApoE ${\varepsilon}4$(p<0.05). The association of the BchE-k with AD was limited to carriers of the ApoE ${\varepsilon}4$ allele, among whom the presence of the BchE-k gave an odds ratio of AD 3.48 (95% C.I. 1.3-9.2). Therefore, these results suggested that further evidence of an association between the ApoE ${\varepsilon}4$ and LOAD, and the BchE-k acts in synergy with the ApoE ${\varepsilon}4$ as a susceptibility gene for AD.

• Journal of Microbiology and Biotechnology
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• 제26권4호
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• pp.784-789
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• 2016

We evaluated the synergistic antibacterial effect in combination with the chitosan-ferulic acid conjugate (CFA) and β-lactam antibiotics, such as ampicillin, penicillin, and oxacillin, against methicillin-resistant Staphylococcus aureus (MRSA) using fractional inhibitory concentration (FIC) indices. CFA clearly reversed the antibacterial activity of ampicillin, penicillin, and oxacillin against MRSA in the combination mode. Among these antibiotics, the combination of oxacillin-CFA resulted in a ΣFIC_min range of 0.250 and ΣFIC_max of 0.563, suggesting that the oxacillin-CFA combination resulted in an antibacterial synergy effect against MRSA. In addition, we determined that CFA inhibited the mRNA expression of gene mecA and the production of PBP2a, which is a key determinant for β-lactam antibiotic resistance, in a dose-dependent manner. Thus, the results obtained in this study supported the idea on the antibacterial action mechanism that oxacillin will restore the antibacterial activity against MRSA through the suppression of PBP2a production by CFA.

• 한국콘텐츠학회논문지
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• 제9권3호
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• pp.91-98
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• 2009

복잡하고 빠르게 돌아가는 현대사회의 사회적 대상관계의 특징은 개인주의 팽배와 획일적 인간 관계속의 주체성 상실 등을 들 수 있다. 이러한 구조상의 무관심속에 아동들은 혼자서 텔레비전을 보거나 컴퓨터에 빠져 지내는 경우가 늘어나고 있다. 또한 어머니들의 과보호, 불규칙적인 양육태도, 정서적 외상 및 유전적 영향으로 인해 아동기 정신 발달 장애 빈도가 높아지고 있는 추세이다. 이러한 추세에 발맞추어서 미술치료에 대한 연구와 사례들이 많이 발표되고 있으며 미술치료의 중요성이 대두되고 있다. 이에 본 연구에서는 가장 인간과 밀접한 관계가 있는 자연 매체인 점토를 통한 치료가 발달 장애(자폐아)를 가지고 있는 아동에게 미치는 영향과 효과에 대하여 고찰해보고 또한 점토치료가 이러한 장애를 가진 아동들의 사회적 대상관계와 정화작용의 발전에 미치는 영향에 대해 제시하며 이를 바탕으로 생기는 시너지 (Synergy Effect) 효과와 이러한 효과를 극대화 시킬 수 있는 교육 프로그램 개발 연구에 대해서 제시하려한다.

• 한방재활의학과학회지
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• 제28권2호
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• pp.21-35
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• 2018

Objectives The objective of this study is to determine the antimicrobial effect of Daehwanggyeonu-san(Dahwangqianniu-san,DGE) and synergistic effects with antibiotics oxacillin, ampicillin, and gentamicin against Methicillin-Resistant Staphylococcus aureus(MRSA). Methods The antibacterial activity of DGE extract was evaluated againest MRSA strains by using the Disc diffusion method, broth microdilution method(minimal inhibitory concentration; MIC), checkerboard dilution test. The checkerboard dilution test was used to examined synergetic effect of oxacillin, ampicillin, gentamicin, ciprofloxacin with DGE extract. Results DGE showed antimicrobial activity against MRSA with an MIC value of $125{\sim}250{\mu}g/mL$. In the checkerboard test, the interation of DGE with all tested antibiotics produced almost synergy or partial synergy against MRSA. Conclusions This study shows that DGE reduced the MICs of several antibiotics tested, and a remarkable antibacterial effect of DGE, with membrane permeability enhancers and ATP synthase inhibitors. This study can be a valuable source for the development of a new drug with low MRSA resistance.

• 무역학회지
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• 제47권6호
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• pp.377-393
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• 2022

This study aims to identify the effect of growth of the land transportation industry on economic growth and to provide implications for Korea's metropolitan region policy. The effect of each metropolitan region on the integrated region where each metropolitan region is integrated is as follows. First, The integrated region where each metropolitan region was integrated with the Southeast region and the Daegyeong region had the greatest economic growth effect due to the growth of the land transportation industry in terms of value added, but the effect of the integrated region with the Chungcheong region was the least. In the case of capital such as roads, the integrated metropolitan regions with the Chungcheong region showed the greatest economic effect. However, the impact of the integrated regions with Jeolla region and the Seoul metropolitan region is insignificant. These results suggest that the synergy effect of metropolitan regional integration by spillover effect such as networks should be considered in the land transportation industry policy.

• 대한화장품학회지
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• 제41권3호
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• pp.229-235
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• 2015

피부 노화는 피부 표면에 나타나는 현상으로 피부 표면의 미세구조와 연관이 있다. 피부 미세구조의 변화는 주름형성, 피부 톤 저하 등 다양한 피부 노화 현상을 유발하는 요인이 된다. 본 연구는 주름 기능성 성분인 세드롤(Cedrol)과 콜라겐 유래 펩타이드 성분을 이용하여 시험관 수준(in vitro)에서 타입III 콜라겐 합성 시너지 효과를 평가하였다. 여성 피시험자를 대상으로 4주 동안 상기 원료가 함유된 크림제품을 사용한 후 피부 미세구조, 스타 형상(star configurations), 보습, 탄력, 피부 밝기, 윤기, 피부 톤, 투명도를 평가하였다. 시험관 수준의 세드롤과 펩타이드를 동시에 처리하면 우수한 수준의 타입III 콜라겐 합성 시너지효과를 나타내었다. 그리고 크림제형을 이용한 인체적용 시험에서는 사용 4주 후부터 피부 미세구조, 스타형상, 윤기, 피부 톤, 보습, 탄력을 개선시켰으나, 피부 밝기 개선 효능은 나타나지 않았다. 본 연구를 통하여 기존 주름 기능성 성분인 세드롤과 콜라겐 유래 펩타이드는 세포 수준에서 타입III 콜라겐 합성 시너지 효과가 있음을 확인하였고 이를 화장품에 적용하여 시험한 결과 피부 노화 개선에 도움을 주는 성분임을 확인하였다.