• The Journal of Korean Medical History
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• v.27 no.1
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• pp.87-112
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• 2014

Purpose : "The Part of Cold damage in Uihakipmun" is the collection of the books on Cold damage which follow the way of description focusing on symptoms before Ming dynasty. "The chapter of First symptom" in this part is the first chapter which described focusing on the symptoms in earnest. This research is to discover the reference books of "The chapter of First symptom" in detail. Methods : I compared the books presented in the reference list of "The Part of Cold damage in Uihakipmun" with the sentences of "The chapter of First symptom". Results & Conclusions : "The chapter of First symptom" referred to "Sanghanyukseo(傷寒六書)" and "Injaesanghanryuseo(仁齋傷寒類書)" mainly, and the rest were supplemented with other books like "Hwalinseo(活人書)". And the books which were not listed on the reference like "Sanghanmyeongriron(傷寒明理論)", "Yupyeonhwalinseogwaljijangdoron(類編活人書括指掌圖論)" were also referred in part. Among the reference list of "The Part of Cold damage in Uihakipmun", "Baekmun(百問)" doesn't indicate "Sanghanbaekmun(傷寒百問)" but "Sanghanbaekmunga(傷寒百問歌)". As for the history of the books on cold damage which described focusing on symptoms, "Injaesanghanryuseo" added new contents on the basis of "Hwalinseo" and after that, it had a large influence on "Sanghanyukseo" and "The Part of Cold damage in Uihakipmun". In case of 33.4% of the chapter of first symptom, the reference books were not found. It includes the part that the reference books were not found and also the part that Lee Cheon added his personal opinion. For this parts, the in-depth study is needed afterwards.

• The Journal of Korean Medicine
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• v.41 no.3
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• pp.1-8
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• 2020

Objectives: This paper aims to investigate the Donguibogam-based pattern diagnosis by applying natural language processing and machine learning. Methods: A database has been constructed by gathering symptoms and pattern diagnosis from Donguibogam. The symptom sentences were tokenized with nouns, verbs, and adjectives with natural language processing tool. To apply symptom sentences into machine learning, Word2Vec model has been established for converting words into numeric vectors. Using the pair of symptom's vector and pattern diagnosis, a pattern prediction model has been trained through Logistic Regression. Results: The Word2Vec model's maximum performance was obtained by optimizing Word2Vec's primary parameters -the number of iterations, the vector's dimensions, and window size. The obtained pattern diagnosis regression model showed 75% (chance level 16.7%) accuracy for the prediction of Six-Qi pattern diagnosis. Conclusions: In this study, we developed pattern diagnosis prediction model based on the symptom and pattern diagnosis from Donguibogam. The prediction accuracy could be increased by the collection of data through future expansions of oriental medicine classics.

• Journal of Medicine and Life Science
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• v.20 no.3
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• pp.107-114
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• 2023

Epidemiological control of coronavirus disease 2019 (COVID-19) is needed to estimate the infection period of confirmed cases and identify potential cases. The present study, targeting confirmed cases for which the time of COVID-19 symptom onset was disclosed, aimed to investigate the relationship between intervals (day) from symptom onset to testing the cycle threshold (CT) values of real-time reverse transcription-polymerase chain reaction. Of the COVID-19 confirmed cases, those for which the date of suspected symptom onset in the epidemiological investigation was specifically disclosed were included in this study. Interval was defined as the number of days from symptom onset (as disclosed by the patient) to specimen collection for testing. A locally weighted regression smoothing (LOWESS) curve was applied, with intervals as explanatory variables and CT values (CTR for RdRp gene and CTE for E gene) as outcome variables. After finding its non-linear relationship, a polynomial regression model was applied to estimate the 95% confidence interval values of CTR and CTE by interval. The application of LOWESS in 331 patients identified a U-shaped curve relationship between the CTR and CTE values according to the number of interval days, and both CTR and CTE satisfied the quadratic model for interval days. Active application of these results to epidemiological investigations would minimize the chance of failing to identify individuals who are in contact with COVID-19 confirmed cases, thereby reducing the potential transmission of the virus to local communities.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1905-1909
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• 2013

Objective: The aim of the current study was to evaluate changes in treatment outcomes in terms of health-related quality of life (HRQoL) and symptom burden at zero, one, three, and six months after an initial diagnosis of colorectal cancer. The demographic and clinical characteristics that account for outcome changes in patients were investigated using a repeated measures framework. Methods and Materials: A cohort study was performed of 134 colorectal cancer patients followed from diagnosis to 6 months post-treatment in Central Taiwan. HRQoL and symptoms were assessed at diagnosis and one, three, and six months thereafter. The Functional Assessment of Cancer Therapy-Colon (FACT-C) questionnaire, VAS pain, and the Memorial Symptom Assessment Scale (MSAS) were used for data collection. A generalized estimating equation (GEE) was applied for statistical analysis. Results: The majority of the patients were male (55%) and married (91.5%). The mean age was 60.4 years (SD = 11.71). Most were diagnosed stage III and IV colorectal cancer (54.5%). All underwent surgery; some also received chemotherapy (CT) or concurrent chemoradiation therapy (CCRT). The results of the GEE showed that overall, the HRQoL, pain, and symptoms of the patients significantly improved over the treatment period. Patients with stage IV disease who had received surgery and CCRT showed the worst HRQoL. Females, patients with comorbidity, and stage IV patients had higher pain scores over time. Female and stage IV patients had more severe physical symptoms, whereas stage II and IV patients had worse psychological symptoms over time. Conclusion: The patients' HRQoL, pain, and symptoms significantly improved over the 6-month treatment period. Certain patient and clinical variables accounted for changes in treatment outcomes regarding HRQoL and symptom burden in colorectal cancer patients.

• Journal of Korean Academy of Nursing
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• v.39 no.4
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• pp.528-538
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• 2009

Purpose: This study was done to develop and test a palliative care program based on home care nursing. Methods: A quasi-experimental design was employed. Changes in the variables were evaluated to test effects of the developed program. Participants were patients with terminal cancer and their families receiving home care nursing from six hospitals (experimental group: 24 and control group: 22). Data collection was conducted from February to October, 2006. Chi-square test, Fisher's exact test, t-test, Mann-Whitney U test and repeated measures ANOVA were used to analyse the data. Results: Hypothesis 1, the experimental group receiving this program will experience less pain (severe, average, weak pain) than the control group, was supported. Hypothesis 2, the experimental group will have less symptom experience than the control group, was supported. Hypothesis 3, the experimental group will have higher QOL than the control group, was supported and the last hypothesis 4, family burden in the experimental group will be less than the control group, was supported. Conclusion: The home care nursing based palliative program developed in this study was found to be an effective program to reduce patient pain and symptom experience, to improve patient QOL and to decrease family burden.

• Korean Journal Plant Pathology
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• v.11 no.1
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• pp.90-93
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• 1995

Leaf blotch of Welsh onion was observed at a farmer's field at Kangnung in July 1990. Further collection o the diseased materials was made in 1993 and 1994. The symptom initially appeared as discolored spot and later yellowish blotch with the long axis parallel to the leaf veins, which turned to sooty colored concentric lesion due to heavy production of conidiophores and conidia. Cladosporium allii-cepae (Ranojevic) M. B. Ellis was repeatedly isolated from the leaf lesions. Healthy Welsh onion inoculated with conidial suspension of the fungus produced the typical symptom 10 days after inoculation. Koch's postulates were fulfilled by reisolation of the fungus. This is the first report of a Cladosporium leaf blotch of Welsh onion in Korea.

• Journal of Korean Academy of Nursing
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• v.33 no.4
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• pp.471-477
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• 2003

Purpose. This cross-sectional survey research was undertaken to examine the degree of depression in post-menopausal women and to analyze the factors affecting that depression. Method. 325 people from public health center in Inchon were surveyed as the subject of this study. Data collection was conducted through the use of questionnaires. Results. The above half of these sampled people were in depressed state (64.0%) and the mean score of depression was 12.71. There were significant differences in the depression state according to presence of spouse, economic level, exercise, and smoking. A positive correlation was found between depression and climacteric symptoms. Stepwise multiple regression analysis revealed that the most powerful predictor was climacteric symptom. Climacteric symptom, presence of spouse, smoking, and exercise accounted for 45 % of the variance in postmenopausal women's depression. Conclusion. Nurses are able to use these results to plan and implement nursing interventions for decreasing depression and consequent the improved quality of life in Korean postmenopausal women. Also, the nurses have to be more aware of the following groups; solitary women, low-income group and smokers, that they have higher mean score of depression.

• Herbal Formula Science
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• v.15 no.1
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• pp.49-105
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• 2007

Objectives : Select and analyze the case record of dyspnea and wheezing asthma recorded in Xu Ming Yi Lei An that is the most abundant and wide in contents in existing case records that are systematic, comprehending relatively modern Traditional Chinese Medicine to secure more deep and objective basis of Traditional Chinese Medicine approach for dyspnea and wheezing asthma to analyze and review possibility for clinical application in this study. Methods: The study was conducted with the case records of dyspnea and wheezing asthma in whole Xu Ming Yi Lei An. Pattern identify and classify selected case records and again classified with deficiency syndrome and excess syndrome. Also analyzed prescriptions and herbs used in the case records. Nature of herbs and properties and flavors that were used in the case records were classified and frequency of each nature of herbs were analyzed. Applicable case records were interpreted and suggested prescriptions, pulse feelings, pattern classification were analyzed and described. Results : Among the 5254 case records stated on the complete collection, it is researched that there are 63 case records for the symptom complex of dyspnea as 1.2% of the whole case records, and the case records on the symptom complex of wheezing asthma are 14 as the 0.27% of the total examples. 63 case record examples related with symptom complex of dyspnea were pattern identified and classified. As a result, deficiency syndrome of the Kidney(33 %), deficiency syndrome of the Spleen(26.0%), Wind-Cold(12.3%), phlegm turbidity(12.3%), Heat in the Lung(8.2%), asthenia of the Lung(8.2%) were investigated as above order. 14 case record examples related with wheezing asthma were pattern identified and classified. As a result, phlegm-Heat(26.3%), upper excess and lower deficiency(26.3%), external affections Wind-Cold(15.8%), Dampness-phlegm(10.5%), Lung asthenia(10.5%), Cold phlegm(5.3%), mutual deficiency and detriment of Heart and Kidneys(5.3%) were investigated as above order. Symptom complex of dyspnea has 67.1% of deficiency syndrome, 32.9% of excess syndrome resulting more deficiency syndrome than excess syndrome. Symptom complex of wheezing asthma has 42.1 % of deficiency syndrome and 57.9% of excess syndrome resulting more excess syndrome than deficiency syndrome. In case of symptom complex of dyspnea prescription used in the case record, the order of frequency is as following. Palmijihwang-tang, Bojung-ikgitang, Yungmijihwang-tang, Ijintang, Sojaganggitang, Igongsan. In case of symptom complex of wheezing asthma prescription in the case record, Yungmijihwang-tang, Ohotang, Dodamtang were mostly used. Herbs used in case records of symptom complex of dyspnea are Ginseng Radix, Poria, Glycyrrhizae Radix, Aconiti Iateralis Preparata Radix, Atractylodis Macrocephalae Rhizoma, Dioscoreae Rhizoma, Angelicae Gigantis Radix, Rehmanniae Radix Preparat, Pinelliae Rhizoma, Zingiberis Rhizoma Recens are mostly used. Nature of herb properties used for symptom complex of dyspnea and symptom complex of wheezing asthma are herbs that are warm properties. When the symptom complex of dyspnea and the symptom complex of wheezing asthma were treated. if the patient felt tenderness at Pyesu, doctors conducted pricking blood around the opposite Pyesu or Sipseon acupoint. when the patient didn't have tenderness at Pyesu by soft press, pricking blood was performed both sidees, right and left Pyesu. In case of the treatment of symptom complex of dyspnea and symptom complex of wheezing asthma, when they got treatment, when the symptom complex of disease is severe, a doctor cauterized the opposite Pyesu while the other Pyesu felt tenderness, and decided how the above treatment is performed whether the degree of the symptom compolex of disease is severe or not. In case of the treatment of symptom complex of dyspnea and symptom complex of wheezing asthma, if the person felt tenderness at Pyesu and is caught by the Wind-Cold pathogen, slight acupuncture is treated at relevant Pyesu with Fire needling. When patient with symptom complex of dyspnea and symptom complex of wheezing asthma cannot hawk sputum up from the oral and laryngopharynx, suction method is treated. Conclusion : With this study, actual traditional and clinical pattern identification form and characteristics of symptom complex of dyspnea and symptom complex of wheezing asthma were recognized. Modern case report utilizing in clinical application need to be secured and an incurable disease asthma need to be diagnosed and improvement for treatments have to be searched through other case records.

• Journal of Korean Academy of Nursing
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• v.33 no.8
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• pp.1127-1134
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• 2003

Background. Although there have been a great number of research studies based on the model of uncertainty in illness, few studies have considered the appraisal portion of model. Purpose. The purpose of this study was to test the mediating effect of appraisal in the model of uncertainty in illness. Additionally, this study aimed to examine the relationships among uncertainty, symptom severity, appraisal, and anxiety in patients newly diagnosed with atrial fibrillation. Methods. This study employed a descriptive correlational and cross-sectional survey design using a face-to-face interview method. Patients diagnosed with atrial fibrillation within the previous 6 months prior to data collection were interviewed by Mishel Uncertainty in Illness Scale-Community Form, appraisal scale, Symptom Checklist-Severity V.3, and State Anxiety Inventory. Results. A total of 81 patients with atrial fibrillation were recruited from two large urban medical centers in Cleveland, Ohio, U.S.A.. Symptom severity was the significant variable in explaining uncertainty ($\beta$=0.34). Individuals with greater symptom severity perceived more uncertainty. Uncertainty was appraised as a danger rather than opportunity, and those with greater uncertainty appraised a greater danger (p<.0l). While the appraisal of opportunity had the negative relationship with anxiety (r=-0.25), the appraisal of danger was positively associated with anxiety (r=0.78). The measure of goodness of fit (Q) of the model was .7863, and the significant test (X$^2$) for the Q was statistically significant (df =3, p<.00l). Accordingly, the overall mediating model of uncertainty in illness was proven not to be fit to the empirical data of patients with atrial fibrillation. Consequently, the mediating effect of appraisal was not supported by the empirical data of this study. Conclusion. The findings of this study were discussed in terms of their relevance compared with those of previous studies or theoretical framework and the plausible explanations on study findings. Lastly, in order to expand the present body of knowledge on uncertainty in illness model, recommendations for the future nursing studies were included.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.17 no.2
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• pp.90-111
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• 2013

Objectives Migratory pathogenic factor(六淫) occupies an important position in the etiology of Korean Medicine. This paper shows how Dampness, one of Migratory pathogenic factor(六淫), is explained in Donguibogam(東醫寶鑑). And, based on this, we will figure out how to make a judgement of Dampness through diagnosis. Method 1. Collect parts of Dampness mentioned in Donguibogam(東醫寶鑑). 2. From the collection, extract contents about mechanism and symptom of Dampness, which is considered necessary for diagnosis. 3. Put all the extraction together, suggest the diagnosis element which can be criteria of judgement of Dampness through diagnosis. Result & Conclusions The occurrence of Dampness come from a wet climate and environment externally, and overeating of greasy food and digestive disorder internally. There are many different kinds of symptoms throughout the body cause of poor circulation. Dampness is classed as Cold-dampness, Damp-heat, and Dampness-phlegm depending on characteristic symptoms, and mainly shows musculoskeletal disease and digestive troubles. Typical symptoms are pitting edema, distention and fullness, moderate and thready pulse, volume of perspiration increase, loose feces, urine volume decrease, pain of joint and muscle, restriction of movement, etc.