• Journal of Microbiology and Biotechnology
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• 제21권5호
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• pp.449-454
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• 2011

The infection of pandemic influenza viruses such as swine flu (H1N1) and avian flu viruses to the host cells is related to the following two factors: First, the surface protein such as HA (hemagglutinin) and NA (neuraminidase) of the influenza virus. Second, the specific structure of the oligosaccharide [sialic acid(${\alpha}2$-6) galactose(${\beta}1$-4)glucose or sialic acid(${\alpha}2$-3)galactose(${\beta}1$-4)glucose] on the host cell. After recognizing the specific structure of the oligosaccharide on the surface of host cells by the surface protein of the influenza virus, the influenza virus can secrete sialidase and cleave the sialic acid attached on the final position of the specific structure of the oligosaccharide on the surface of host cells. Tamiflu (oseltamivir), known as a remedy of swine flu, has a saccharide analog structure, especially the sialic acid analog. Tamiflu can inhibit the invasion of influenza viruses (swine flu and avian flu viruses) into the host cells by competition with sialic acid on the terminal position of the specific oligosaccharide on the surface of the host cell. Because of the emergence of Tamiflu resistance, the development of new potent anti-influenza inhibitors is needed. The inhibitors with positive-charge groups have potential as antiviral therapeutics, and the strain specificity must also be resolved.

• 기술사
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• 제42권6호
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• pp.42-46
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• 2009

Every year influenza contributes to the death of 72 people in the South korea, 20,000 in the U.S. and perhaps millions worldwide. The swine fever so-called the noble flu A H1N1, a strain of the flu virus, which jumped species and burst into the human population in March and April of this year. The outbreak of 2009 novel H1N1 was the fourth in 100 years. Fortunately, it led to today's comparatively tame swine flu than the vicious 1918, which was original H1N1 pandemic flu virus, killed at least 40 million worldwide in an ongoing pandemic era. Although the 2009 H1N1 which is still in full swing, this global flu epidemic is already teaching scientists valuable lessons about pandemics. Evidence accumulated these days indicates that the 2009 H1N1 was not entirely new to all human immune systems. This article introduces only an outline for our better understanding the basic mechanisms of influenza and the vaccination about longstanding fears of that worst-case scenario engendered pandemic that are paying off today.

• 대한임상검사과학회지
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• 제42권1호
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• pp.1-15
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• 2010

Swine influenza virus (SIV) or swine-origin influenza virus (S-OIV) is endemic in swine, and classified into influenza A and influenza C but not influenza B. Swine influenza A includes H1N1, H1N2, H3N1, H3N2 and H2N3 subtypes. Infection of SIV occurs in only swine and that of S-OIV is rare in human. What human can be infected with S-OIV is called as zoonotic swine flu. Pandemic 2009 swine influenza H1N1 virus (2009 H1N1) was emerged in Mexico, America and Canada and spread worldwide. The triple-reassortant H1N1 resulting from antigenic drift was contained with HA, NA and PB1 of human or swine influenza virus, PB2 and PA polymerase of avian influenza virus, and M, NP and NS of swine influenza virus, The 2009 H1N1 enables to transmit to human and swine. The symptoms and signs in human infected with 2009 H1N1 virus are fever, cough and sore throat, pneumonia as well as diarrhea and vomiting. Co-infection with other viruses and bacteria such as Streptococcus pneumoniae can occur high mortality in high-risk population. 2009 H1N1 virus was easily differentiated from seasonal flu by real time RT-PCR which contributed rapid and confirmed diagnosis. The 2009 H1N1 virus was treated with NA inhibitors such as oseltamivir (Tamiflu) and zanamivir (Relenza) but not with adamantanes such as amantadine and rimantadine. Evolution of influenza virus has continued in various hosts. Development of a more effective vaccine against influenza prototypes is needed to protect new influenza infection such as H5 and H7 subtypes to infect to multi-organ and cause high pathogenicity.

• 설비공학논문집
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• 제22권6호
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• pp.353-360
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• 2010

Recently H1N1(swine flu) and SARS has been infected widely in the world; we have to care about germs and virus in indoor air environment. The air sterilization system investigated in this study allows occupants to turn on/off and to control the incoming air speed and direction. To predict the performance of air sterilization system without real experiment, a simulation is considered to compare and analyze the performance of the air sterilization systems in a typical office space. Multiple system parameters including volume flow rate and velocity of supply air were varied and investigated during the simulation. The investigation result shows that difference (between simulation and experiment) was about 3.5% in case of minimum air flow rate and about 0.2% in case of maximum air flow rate. The results indicate that multi-zone simulation technique can be used to predict the performance of a sterilization system in personalized office.

• 보건행정학회지
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• 제20권1호
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• pp.64-86
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• 2010

Korea has had problems with the price and supply of essential drugs such as Gleevec for leukemia, Fuzeon for HIV/AIDS, and Tamiflu for both avian flu and swine flu. The shortage or refusal of patented drugs supply is imposing a heavy burden in not only developing countries but also developed countries. Thinking over the serious results, we need to concern about the limited access to patented drugs by multinational drug companies' patent monopoly especially for pandemic and life threatening diseases. The effective response regarding to pandemic and life threatening diseases. The effective response regarding to pandemic situation requests collaborative and unbiased provisions of all countries in the world, however, sometimes patent monopoly may hinder the efforts. Compulsory licensing has been considered to be a useful alternative to the abuse of patent rights. However, the Korean experiences of compulsory licensing have left some controversial issues in connection with the availability of it in Korea. 'Flexibility' allowed in TRIPS and Doha Declaration has not come into effect in Korea for several reasons. Although the situation shows the limitations of compulsory licensing as a pharmaceutical supply policy, it is clear that compulsory licensing still has the possibilities of enhancing the access to medicines of all countries in need. Through searching the institutionalization process and experiments of compulsory licensing in Korea, this article explores the possibilities and the limits.

• Journal of Microbiology and Biotechnology
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• 제20권1호
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• pp.63-70
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• 2010

Novel influenza A (H1N1) is a newly emerged flu virus that was first detected in April 2009. Unlike the avian influenza (H5N1), this virus has been known to be able to spread from human to human directly. Although it is uncertain how severe this novel H1N1 virus will be in terms of human illness, the illness may be more widespread because most people will not have immunity to it. In this study, we compared the codon usage bias between the novel H1N1 influenza A viruses and other viruses such as H1N1 and H5N1 subtypes to investigate the genomic patterns of novel influenza A (H1N1). Totally, 1,675 nucleotide sequences of the hemagglutinin (HA) and neuraminidase (NA) genes of influenza A virus, including H1N1 and H5N1 subtypes occurring from 2004 to 2009, were used. As a result, we found that the novel H1N1 influenza A viruses showed the most close correlations with the swine-origin H1N1 subtypes than other H1N1 viruses, in the result from not only the analysis of nucleotide compositions, but also the phylogenetic analysis. Although the genetic sequences of novel H1N1 subtypes were not exactly the same as the other H1N1 subtypes, the HA and NA genes of novel H1N1s showed very similar codon usage patterns with other H1N1 subtypes, especially with the swine-origin H1N1 influenza A viruses. Our findings strongly suggested that those novel H1N1 viruses seemed to be originated from the swine-host H1N1 viruses in terms of the codon usage patterns.

• 한국콘텐츠학회논문지
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• 제13권3호
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• pp.352-361
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• 2013

본 연구는 거시경제 및 비 거시경제변수가 항공운송업의 경영성과에 미치는 영향을 분석하여 경영자에게 유용한 정보를 제공하는데 그 목적이 있다. 이를 위해 1991년부터 2011년까지의 거시경제지표인 회사 채수익률, 유가, 실업률, 통화량, 무역수지, 원/달러 환율, 소비자물가지수, 산업생산성지수와 경영성과 지표인 총자산순이익률을 사용하여 선형회귀분석을 실시하였다. 그 결과 환율 변동은 정의 유의적인 영향을, 소비자물가지수 증가율은 부의 유의적인 영향을 총자산순이익률 변동에 미친 것으로 나타났다. 또한 거시경제변수의 위험성을 통제하는 비 거시경제변수의 영향력을 파악하기 위해 비 거시경제변수로 대만 대지진, 아시아 경제 위기, 미국 911테러, 이라크 전쟁, 베이징 올림픽, 신종 플루 발병, 대통령 선거(1차), 대통령 선거(2차)을 축출하여 유의적인 영향을 미치는 것으로 나타난 환율 변동과 소비자물가지수 증가율을 함께 사용하여 선형회귀분석을 실시하였다. 분석 결과 아시아 경제 위기와 신종 플루 발병은 총자산순이익률 변동에 부의 유의적인 영향을 미친 것으로 나타났다. 그 외에 대만 대지진, 미국 911테러, 이라크 전쟁, 베이징 올림픽, 1,2 차 대통령 선거는 총자산순이익률 변동에 통계적으로 유의적인 영향을 미치지 않는 것으로 나타났으나 이라크 전쟁을 제외한 다른 변수들은 부의 관계가 있는 것으로 나타났다. 항공운송업의 경영자들은 거시경제변수가 통제가 어려운 변수이긴 하지만 거시경제변수와 거시경제변수의 위험성을 통제하는 비 거시경제변수의 변화를 주의 깊게 관찰하고 분석한다면 경영성과를 극대화 시키는데 도움이 될 것이다.

• 보건행정학회지
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• 제28권3호
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• pp.301-307
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• 2018

The development of transport is being easily shared with people all over the world. It is necessary to appropriately and effectively revise the domestic quarantine law because the fatal infectious diseases are at risk of being easily shared. Today, Korea has an advanced quarantine system approved by World Health Organization, but it maintains partnerships with related ministries (Ministry of Foreign Affairs, Ministry of Justice, local medical institutions) and to introduce new medical technology (electronic quarantine) is important. And since the prevention of quarantine infectious diseases and prevention of the spread, in order to maintain international cooperation with the International Health Regulations, the quarantine law and the system should be amended and improved effectively and it is also a way to prepare for the outbreak of new quarantine infectious diseases. In the past, Korea has experienced great confusion during the past outbreak of swine flu and Middle East respiratory syndrome coronavirus. To prevent similar cases from recurring in the past, the revision of the quarantine law and the improvement of the system should be done to cope with the changing environment (new infections, increased number of overseas travelers, etc.).

• Journal of Information Science Theory and Practice
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• 제1권1호
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• pp.42-53
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• 2013

Timely access to quality healthcare information during an outbreak plays an important role in curtailing its spread. The aim of this study was to investigate the information needs and seeking behavior of the general public in Singapore during the H1N1 pandemic. A pre-tested questionnaire was used for data collection. The convenience snowball sampling method was used and 260 working adults and tertiary-level students participated in this study. The most crucial information needs of a majority of the participants were: symptoms of H1N1, causes of the infection, preventive measures, and possible treatments. Data analysis also revealed that mass media such as television, newspapers, and radio were most frequently used for seeking the needed information. The use of human information sources was also quite high while only a small number of the respondents accessed online news and healthcare websites. About three-quarters of the participants indicated that the gathered information helped them to stay vigilant and take necessary precautionary measures. A major problem identified by the participants in using H1N1 information was the lack of understanding of certain terms used in public communications. This paper suggests certain measures for strengthening health information communication during future outbreaks.

• 기술혁신연구
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• 제28권4호
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• pp.127-150
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• 2020

세계보건기구(WHO)는 홍콩독감과 신종플루 이후 역사상 세 번째 팬데믹을 선언했다. 코로나19의 발생으로 국가 간 교류는 극도로 위축되는 한편 빠른 전염성으로 국가별 경기변동의 시간차를 만들어 냈다. 2020년 1월 미·중 무역 분쟁은 합의국면으로 접어들었으나 코로나19로 발생한 경제 디커플링 현상은 중국이 미국과의 무역균형을 맞추기 어렵게 만들었고 미·중 무역 분쟁 합의 조건을 지키기 어렵게 만들었다. 트럼프 대통령은 코로나19 확산의 책임을 중국에 돌렸고 경기 침체의 원인도 중국의 영업비밀 침해, 불법복제품 등으로 지목하면서 보호주의가 대두되었다. 이에 중국은 거세게 반발하면서 미국과 갈등이 깊어졌다. 미국은 중국 반도체 굴기의 핵심기업인 화웨이와 SMIC에 무역재제를 선언했고 미·중 간 반도체 밸류체인 단절 위험을 예고하고 있다. 반도체 산업의 밸류체인 분리는 특정 국가와 기업이 가치사슬에 고도로 전문화되어 독점하는 구조인 반도체 산업에 큰 충격을 줄 가능성이 있다. 본 논문은 코로나19로 인해 재점화된 미·중 간 반도체 밸류체인 단절 위험과 반도체 글로벌 산업 가치사슬의 충격과 변화, 한국 반도체 기업의 대응전략을 다루고자 한다.