• 생약학회지
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• 제50권3호
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• pp.175-184
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• 2019

Mast cells are crucial as effector cells in the immediate-type allergic reaction. Lentinus edodes has been the popular edible mushroom in oriental countries and reported to have immunomodulatory, anti-tumor, anti-atherogenic, anti-viral, and anti-allergic activities. However, the roles of L. edodes in mast cell-mediated anaphylactic reaction have not been fully elucidated. In this research, we have demonstrated the effects of the methanol extract of L. edodes (MELE) on mast cell-mediated anaphylaxis-like and anaphylactic reactions. MELE suppressed systemic anaphylaxis-like reaction, plasma histamine levels, and ear swelling response in mice treated with compound 48/80. MELE also suppressed passive systemic and cutaneous anaphylaxis mediated by anti-dinitrophenyl IgE. In accordance with these findings, MELE dose-dependently decreased histamine release from RPMC evoked by compound 48/80 or the antigen-antibody reaction. To clarify the mechanism of degranulation system, intracellular cAMP levels as well as calcium influx in RPMC was evaluated. In compound 48/80-treated RPMC, MELE blocked calcium uptake into the cells. In addition, MELE elevated the intracellular cAMP content and significantly attenuated compound 48/80-induced cAMP reduction in RPMC. Taken together, we propose the clinical use of MELE in mast cell-mediated immediate-type allergic diseases.

• 공업화학
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• 제5권3호
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• pp.524-536
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• 1994

생체적합성이 좋은 천연고분자인 chitosan에 수용성의 비닐계 단량체인 polyethyleneglycol monomethacrylate series를 그라프트중합시켜 그 반응조건과 물성을 검토하였다. 그라프트중합은 ethylene oxide 부가몰수에 따라 PE-90, PE-200, PE-350의 세 가지 단량체에 ceric ammonium nitrate(CAN)를 개시제로 사용하였으며, 중합에서 개시제의 농도, 단량체의 농도, 반응온도, 반응시간이 총전환율, 그라프트율, 그라프트효율에 미치는 영향을 조사하여 최적조건을 규명하였다. 반응은 개시제농도 $4{\sim}5{\times}10^{-3}M$, 단량체농도 0.5~0.6M, 반응시간 2~3시간, 반응온도 $40^{\circ}C$에서 최고의 그라프트율과 총전환율을 나타냈다. 합성한 공중합체의 열적 성질, 용해성 및 점성도를 검토한 결과 고농도의 개시제를 사용하면 그라프트 중합체는 chitosan의 특성을 급격히 감소시켰다. 고유점성도의 경우, chitosan-g-PE-90이 2.81dl/g, chitosan-g-PE-200이 3.01dl/g, chitosan-g-PE-350이 4.93d1/g으로 증가하는 경향이 나타났다. 공중합체를 막으로 성형하여 그라프트율과 polyethyleneglycol monomethacrylates의 ethylene oxide 부가몰수에 따른 공중합체의 기계적 물성과 함수율을 측정하였다. 가교화 공중합체막은 150분 이내에 함수율이 평형에 이르렀다. 공중합체의 물성은 그라프트율과 ethylene oxide 부가몰수의 영향을 받았으며 chitosan의 기계적 물성과 함수율이 공중합체에서 증가되었음을 확인하였으며 그라프트율이 증가함에 따라 vitamin $B_{12}$의 투과량도 증가하였다.

• Archives of Pharmacal Research
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• 제27권4호
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• pp.371-375
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• 2004

The silicon linker is the foremost traceless linker used in solid-phase reactions. Hydrogen fluo-ride (HF) or trifluoroacetic aicd (TFA) can remove the silicon linker with the silicon atom being replaced by a hydrogen atom. In this experiment, the linkers 1c and 2d, which are the most useful in solid-phase reactions, were synthesized, Linker 1c is composed of seven linearly linked carbons and linker 2d includes an oxygen atom in the linear carbon chain to increase the solvation capacity. The carboxylic acid component of linker 1c and 2d forms an amide or ester bond with resin. The synthesized linkers 1c and 2d could be utilized in constructing a chemical compound library that includes indole, benzodiazepine and phenothiazine (aromatic ring compounds).

• Imaging Science in Dentistry
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• 제45권2호
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• pp.109-115
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• 2015

Central odontogenic fibroma (COF) is a rare benign tumor that accounts for 0.1% of all odontogenic tumors. A case of COF (simple type) of the mandible in a four-year-old boy is described in this report. The patient showed asymptomatic swelling in the right inferior border of the lower jaw for one week. A panoramic radiograph showed a poorly-defined destructive unilocular radiolucent area. Cone-beam computed tomography showed expansion and perforation of the adjacent cortical bone plates. A periosteal reaction with the Codman triangle pattern was clearly visible in the buccal cortex. Since the tumor had destroyed a considerable amount of bone, surgical resection was performed. No recurrence was noted.

• Macromolecular Research
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• 제15권4호
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• pp.379-384
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• 2007

Sulfonation of polyetheretherketones (PEEK) was carried out in order to fabricate commercial perfluorosulfonic acid membrane alternatives, which were characterized in terms of their ion exchange capacity, ionic conductivity, water swelling, methanol crossover and electrochemical performance in their direct application as a methanol fuel cell. A high ion exchange capacity, 1.88, was achieved with a sulfonation reaction time of 8 h, with a significantly low methanol crossover low compared to that of Nafion. However, the morphological stability was found to deteriorate for membranes with sulfonation reaction times exceeding 8 h. Electrochemical cell tests suggested that the fabrication parameters of the membrane electrode assembly based on the sulfonated PEEK membranes should be optimized with respect to the physicochemical properties of the newly prepared membranes.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제44권5호
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• pp.207-211
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• 2018

Among different graft materials for craniofacial reconstruction, calcium phosphate cements have the advantages of alloplastic grafts and wide use. The authors report a case of foreign body reaction following frontal reconstruction with JectOS (an injectable calcium orthophosphate cement; Kasios) and reviewed the literature on complications of this material after craniofacial reconstruction from 2002 to 2017. Complications were categorized into two groups: immunologic reactions (consisting of seroma collection, chronic sinus mucosa swelling, and foreign body reaction) and non-immune events (infection, fragmentation, and ejection). It is wise to use calcium phosphate-based material only in selected cases with small defects, and long-term follow-up is needed to observe their consequences.

• 한국식품위생안전성학회지
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• 제14권1호
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• pp.84-89
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• 1999

Octenylscuccinated corn starches prepared by reaction of corn starch with 1-octenylsuccinic anhydride(OSAn) and their degree of substitution (DS), reaction efficiency(RE), residual octenylsuccinic acid (OSA), and physicochemical properties were compared with those of the native corn starch. DS increased with increase of OSAn and RE was much nearly the same regardless of increased of OSAn. The content of residual of residual OSA was significantly lower than that of regulation of food additives. And as washing frequency of dispersion of the reactant was increased, the content of residual OSA of octenylsuccinated starch was decreased. Raid Visco-Analyzer initial pasting temperature and setback of octenylsuccinated starches decreased whereas peak viscosity and breakdown increased. When DS of octenylsuccinated starches increased, temperature of initial gelatinization of octenylscuccinated starches drastically decreased. The octenylsuccinated starches also formed clearer pastes. The solubility was much nearly the same regardless of increase of DS at 7$0^{\circ}C$ but the swelling power increased 1.2~1.7 times higher than that of native corn starch at 7$0^{\circ}C$. The water binding capacity of octenylsuccinated starches also decreased.

• 폴리머
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• 제29권6호
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• pp.599-604
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• 2005

생체적합성이 우수한 히아루론산과 생분해성이 우수한 폴리락타이드의 이량체인 락타이드를 결합하여 인체내에서 분해속도를 조절할 수 있는 생체적합성이 우수한 생체재료를 제조하였다. 냉동 건조법을 이용하여 히아루론산과 락타이드를 가교제 1-ethyl-3-(3-dimethyl aminopnpyl) carbodiimide(EDC)로 가교시켰다. 생성된 막을 핵자기 공명분광법으로 분석하여 젖산기 반응도와 EDC 반응도를 결정하였다. 히아루론산에 대한 락타이드의 몰비가 5부터 13까지 증가함에 따라 젖산기 반응도와 EDC 반응도는 증가하였다. 몰비가 커서 젖산기가 많이 첨가되면 팽윤도는 감소하고 취성이 강해졌다. 또 가교제 농도를 증가시키거나 가교 온도를 감소시키면 젖산기가 더욱 첨가되어 팽윤도는 감소하고 탄성률은 증가하였다. 서로 다른 가교도를 가진 막에 대해 약물 방출 실험을 한 결과 막의 가교도가 증가함에 따라 약물의 투과도는 감소하였다. 몰비가 커 젖산기가 많이 첨가된 고분자일수록 늦게 분해되었다. 몰비, 온도, 가교제 농도 등의 운전 변수를 조절하여 막의 기계적 물성과 분해 속도가 적절히 조절될 수 있었다.

• Fisheries and Aquatic Sciences
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• 제7권3호
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• pp.115-121
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• 2004

Experiments were carried out to investigate Cd accumulation, elimination and cell response in juvenile rockfish (Sebastes schlegeli) exposed to sub-chronic dietary Cd (0, 0.5, 5, 25 and 125 mg/kg) for 60 days and depuration periods of 30 days. Cd accumulation in the kidney of cock fish increased with exposure periods and concentrations for the 60 days of dietary Cd exposure. After the end of the dietary Cd exposure, Cd accumulation values in the kidney were $52.9{\pm}9.94\;{\mu}g/g$ and $90.6{\pm}15.7\;{\mu}g/g$ for those exposed to 25 mg/kg and 125 mg/kg Cd, respectively. The accumulation factors increased with the exposure period in the kidney. Cd elimination in the kidney of rockfish did not vary significantly and remained constant after the cessation of the dietary Cd exposure. In the primary exposure periods, the effect of kidney tissue in the rockfish exposed to dietary Cd was observed the swelling of capillary of the glomerulus. In addition, there was also hydropic swelling within the pyknotic nuclei, some of hyaline droplet accumulation and the microvilli showed a positive reaction to alcian blue in the tubular cells. While exposure time and concentrations were increased, there was a lot of hyaline droplet accumulation and the microvilli showed a positive reaction to alcian blue in the tubular cells. Fused renal tubule and its necrosis were observed after 60 days at l25 mg/kg.

• 폴리머
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• 제33권5호
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• pp.463-468
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• 2009

입자 분포가 균일하며, 마이크론 크기를 가지는 중공 유기 안료에 대한 합성 방법을 연구하였다. 코어-쉘 합성 방법에 의해 다양한 크기의 중공 유기 안료를 합성할 수 있었으며, 각각의 코어 크기 및 분자량에 따른 최종 입자 크기 변화 및 반응 중 코어의 중화 시간에 따른 은폐율 변화에 대한 실험을 진행하였다. 그 결과 사용한 코어 크기가 클수록 최종 입자 크기는 증가되며, $1.0{\mu}m$ 이상의 마이크론 크기를 가지는 중공 유기 안료를 합성하기 위해서는 적어도 200 nm 이상의 코어를 사용해야 함을 알 수 있었다. 또한, 사용한 코어 크기가 클수록 중공 부피비가 증가되나, 은폐율을 높이기 위해서는 코어의 분자량을 줄이거나, 코어의 알카리 팽윤 단계에서 중화 시간을 증가시켜 주어야 한다. 그리고, 반응 중 교반 속도 및 합성 고형분이 마이크론 크기의 중공 유기 안료 합성에 끼치는 영향을 알아보았다.