• Journal of Ginseng Research
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• 제15권3호
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• pp.167-170
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• 1991

Radiation protective fraction was Isolated and partially purified from Korean white ginseng. The effect of the fraction was studied on the cell survival of W-damaged CHO-Kl cells. As a result, it was found that the fraction increased the survival rate of damaged cells significantly within the dose range of which cytotoxicity did not appear This fraction was separated into two parts by adding butanol, namely the precipitated protein component and the butanol extract. Damaged cells were treated with each of these components and their survival rates were measured. The protein component demonstrated significant increase in the survival rates, while the butanol extract showed no such increment. These results suggest that the radiation protective effect of the ginseng fraction is originated from the butanol-precipitated protein component, not from the butanol-soluble compounds.

• 한국산업융합학회 논문집
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• 제4권3호
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• pp.267-273
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• 2001

In this study, the survival rate of fiber is investigated by nozzle size difference in injection/mold sides. The survival rate of fiber is influenced about the nozzle size differ. Also, The mechanical properties of short carbon glass fiber reinforced polypropylene are experimentally measured as functions of fiber volume fraction and nozzle size difference. These mechanical properties are compared with the survival rate of fiber and fiber volume fraction using image analysis after pyrolytic decomposition. The survival rate of fiber as well as fiber volume fraction is influenced by injection processing condition, the used materials, mold conditions and nozzle sides difference, etc, In particular, the survival rate of fiber is great influenced when injection/mold nozzle sides are different more than that of the same. Consequently, the mechanical properties of short carbon/glass fiber reinforced polypropylene arc improved as the nozzle sides are the same in injection mold sides.

• 대한기계학회논문집A
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• 제25권4호
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• pp.564-573
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• 2001

The mechanical properties of short carbon/glass fiber reinforced polypropylene are experimentally measured as functions of fiber content and nozzle diameter. Also, these properties are compared with the survival rate of reinforced fibers and fiber volume fraction using image analysis after pyrolytic decomposition. The survival rate of fiber aspect ratio as well as fiber volume fraction is influenced by injection processing condition, the used materials and mold conditions such as diameter of nozzle, etc. In this study, the survival rate of fiber aspect ratio is investigated by nozzle size variations in injection/mold sides. It is found that the survival rate of glass fiber is higher that the survival rate of glass fiber is higher than that of carbon fiber. Both tensile modulus and strength of short-fiber reinforced polypropylene are improved s the fiber volume fraction and nozzle diameter are increased.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7359-7363
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• 2015

Background: As a result of significant progress made in treatment of many types of cancers during the last few decades, there have been an increased number of patients who do not experience mortality. We refer to these observations as cure or immune and models for survival data which include cure fraction are known as cure rate models or long-term survival models. Materials and Methods: In this study we used the data collected from 438 female patients with breast cancer registered in the Cancer Research Center in Shahid Beheshti University of Medical Sciences, Tehran, Iran. The patients had been diagnosed from 1992 to 2012 and were followed up until October 2014. We had to exclude some because of incomplete information. Phone calls were made to confirm whether the patients were still alive or not. Deaths due to breast cancer were regarded as failure. To identify clinical, pathological, and biological characteristics of patients that might have had an effect on survival of the patients we used a non-mixture cure rate model; in addition, a Weibull distribution was proposed for the survival time. Analyses were performed using STATA version 14. The significance level was set at $P{\leq}0.05$. Results: A total of 75 patients (17.1%) died due to breast cancer during the study, up to the last follow-up. Numbers of metastatic lymph nodes and histologic grade were significant factors. The cure fraction was estimated to be 58%. Conclusions: When a cure fraction is not available, the analysis will be changed to standard approaches of survival analysis; however when the data indicate that the cure fraction is available, we suggest analysis of survival data via cure models.

• Advances in Traditional Medicine
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• 제4권1호
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• pp.49-52
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• 2004

The total alkaloid fraction of the methanolic extract of Solanum pseudocapsicum unripe fruits was tested for its in-vivo anticancer activity against Dalton's Lymphoma Ascites model in mice. The total alkaloid fraction at 5.0 and 10.0 mg/kg body weight showed significant increase in the mean survival time and the percentage increase in the life span of tumor bearing mice. The increase in the body weight was found to be less than that of the control. However, the treatment at 20 mg/ kg body weight was found to be toxic and showed a decrease in the mean survival time, and body weight when compared to control mice. The antitumor activity observed may be due to the cytotoxic activity of the total alkaloid fraction.

• 약학회지
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• 제29권5호
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• pp.246-252
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• 1985

Ginseng proteins were isolated and partially purified to obtain two fractions, namely GI and GII. Radioprotective effects of these fractions were examined on $\gamma$-ray irradiated ICR mice by observing 30-day survival rates after irradiation. Also investigated were the effects of GI fraction on the recovery of radiation damage. As the results, the GI fraction showed strong protection against radiation indicated by the increment of 30-day survival rates, while the GII fraction did not. The GI fraction enhanced the recovery of body and splenic weights and increased the amount of DNA in liver significantly. It also helped to recover the damage done on erythrocytes by increasing the number to normal in short period, however, it had no effect on the recovery of leukocyte counts.

• Tuberculosis and Respiratory Diseases
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• 제44권4호
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• pp.756-765
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• 1997

연구배경 : 종양세포 성장의 역동학적 성상은, 종양의 분열능을 직접적으로 반영하므로 종양의 예후 예견에 임상적 의의가 있다. PCNA는 DNA 합성에 관여하는 36KD의 핵단백질로서, 종양 조직에서 면역조직화학적 방법으로, 그 발현 정도를 계측하여 종양세포 증식정도의 반영으로서 이용하고 있다. 이에 저자들은 폐암의 조직에서 면역조직화화적 방법으로 PCNA의 세포의 분열능을 반영하는 다른 분자생물학적 인자 즉 S-주기비율과의 관계를 확인하고, PCNA의 발현정도에 따른 폐암환자들의 생존률을 검색하였다. 방 법 : 대상군은 원발성 비소세포 폐암으로 확진 받고, 외과적 절제술 후 파라핀에 보관된 57례의 폐암 조직을 사용하여 면역조직화학 염색법으로 PCNA의 암세포형, TNM 병기, 세포 분화도, S-주기 비율과 생존률과의 관계를 분석하였다. 결 과 : 본 병원에서 외과적 절제술을 시행한 57례중 남녀비는 43 : 14였고, 평균연령은 60세였다. PCNA의 발현 정도는 25%를 기준으로 하여 +, ++, +++, ++++로 구분하였다. PCNA의 발현은 편평상피암에서 선암보다 강하게 발현되었으며, TNM 병기에 따른 PCNA 발현의 차이는 없었다. 세포의 분화도에 따라서 미분화일수록 PCNA의 발현 정도는 높았으나, 유의한 차이는 없었다. S-주기 비율은 -17.9%, +18.3(${\pm}9.7$)%, ++18.6(${\pm}11.1$)%, +++19.6(${\pm}9.0$)%, ++++24.7(${\pm}8.2$)% 였으나 서로간의 유의성있는 차이는 없었다. PCNA의 발현 정도에 따른 2년 생존률과 중간 생존기간은 -50% 13.0개월, +75% 41.3개월, ++73% 33.6개월, +++67% 29.0개월, ++++25% 9개월로서 서로간에 유의한 차이를 보여주고 있다(P<0.05, Kaplan-Meier법, generalized Wilcox). 결 론 : 비소세포 폐암에서 PCNA의 발현정도는 편평상피암에서 선암보다 높았고, TNM 병기와 세포분화도에 따른 차이는 없었다. PCNA 발현정도에 따라 S-주기 비율은 증가한 듯하나 유의성은 없었다. PCNA 발현이 높을수록 2년 생존률과 중간 생존기간은 유의하게 불량하였다. 즉 결과적으로 PCNA 염색법은 비소세포폐암의 예후인자로서의 이용이 가능하리라 생각된다.

• 생약학회지
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• 제42권3호
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• pp.282-287
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• 2011

This study was presented to the anti-cancer activity from different fraction of Zanthoxylum schnifolium fruits. The values for human colon cancer cell(HT-29) survival rate of 0.3 mg/mL of 70% EtOH and 70% MeOH ethyl acetate fraction extracts were 7.62${\pm}$0.173%, 7.66${\pm}$0.037%, respectively. It was shown that human colon cancer cell(HT-29) survival rate was in a dose-dependent manner. The percentages of cells were increased in the sub-G0 and G0/G1 phase region, meaning that cell proliferation was decreased. The RT-PCR demonstrated that 70% EtOH and 70% MeOH ethyl acetate fraction extracts were down-regulated the expression of Bcl-2 and survivin genes in HT-29 cells. We examined that 70% EtOH and 70% MeOH ethyl acetate fraction extracts anti-cancer activities initiated through ROS generation suggesting that HT-29 cells treated with ethyl acetate fraction extracts induced ROS generation. Our results revealed that the Zanthoxylum schnifolium fruit may expect for anti-cancer activities in HT-29 cells.

• 생약학회지
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• 제26권1호
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• pp.74-77
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• 1995

Several coumarins isolated from Angelica sp. were described to show inhibitory effects against human platelet aggregation. The anti-thrombotic and anti-platelet potential was evaluated, in this paper, with the BuOH soluble fraction of Angelica dahurica root. The BuOH fraction was divided into five subfractions fr. A - E and tested in the mouse model of thrombosis. Survival was enhanced to 35% with fr. A or fr. E treated (500 mg/Kg, p.o.) group of mice compared with 5% survival of the control group. However, none of the 8 coumarin glycosides obtained from fr. A, at the conc. of 0.5 mg/ml, showed inhibitory effects against rat platelet aggregation induced by ADP or collagen.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.131.2-132
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• 2003

Artemisia Folium is a preparation of dried leaves from Artemisia species and has been used traditionally to prevent or treat various kinds of woman's diseases. A similar preparation called Chinese Moxa has been used to treat rheumatism by moxibustion in Chinese medicine. A small carbohydrate fraction of approximately 1,000 dlaton from the water-soluble extract of the Artemisia Folium promoted survival of the mouse thymocytes in culture. A mouse gene array study suggested that the fraction might modulate Fas/FasL dependent apoptotic cell death and thus had influence on the survival of the thymocytes in culture. (omitted)