• Membrane and Water Treatment
• /
• v.14 no.3
• /
• pp.141-146
• /
• 2023

Algal organic matters (AOMs) are challenging to remove using traditional water treatment methods. Additionally, they are recognized as disinfection by product (DBP) precursors during the chlorination process. These compounds have the potential to seriously harm aquatic creatures. Despite the fact that AOMs and DBPs formed from algae can harm aquatic species by impairing their cognitive function and causing behavioral problems, only a few studies on the effects of AOMs and associated DBPs have been conducted. To assess the impact of extracellular organic materials (EOMs) produced by three different hazardous algal species and the chlorinated EOMs on zebrafish, this study used fish acute embryo toxicity (FET) and cognitive function tests. With rising EOM concentrations, the embryo's survival rate and mental capacity both declined. Of the three algal species, the embryo exposed to Microcystis aeruginosa EOM exhibited the lowest survival rate. On the other hand, the embryo exposed to EOMs following chlorination demonstrated a drop in CT values in both the survival rate and cognitive ability. These findings imply that EOMs and EOMs treated with chlorine may have detrimental effects on aquatic life. Therefore, an effective EOM management is needed in aquatic environment.

• Biomedical Science Letters
• /
• v.25 no.1
• /
• pp.32-39
• /
• 2019

Conventional high-flux hemodialysis (HD) is not as good as normal kidney function. Morbidity and mortality rates of patients receiving HD are still very high. To increase mid-to-large molecule clearance by combining diffusion and convection, on-line hemodiafiltration (HDF) is required. The objective of this study was to compare long-term survival rate of patients treated with on-line HDF to those who received conventional high-flux HD by reviewing data from Chonnam National University Hospital (CNUH). We selected patients who attended the 'CUNH dialysis center' and agreed to participate in the study. Overall, 40 patients with ESRD switched from high flux HD to on-line HDF or started on-line HDF from August 2007 to December 2009. Additionally, a total of 42 patients receiving conventional high-flux HD during the same period were enrolled. We then reviewed long-term survival rate of patients receiving on-line HDF over the next seven years. When we compared survival rates for seven years, the survival rate of the group receiving on-line HDF was 65% (26/40) while that of the group receiving the conventional high-flux HD was 54.8% (23/42). Although the number of patients was small to see survival difference clearly by one specific dialysis modality, there was somewhat difference in survival rate between the two groups. Indicators such as anemia, calcium-phosphate metabolism, nutritional status, treatment adequacy, and hospitalization were also improved in the group receiving HDF. Overall, results of our study showed beneficial effects of on-line HDF on clinical outcomes and survival in chronic HD patients.

• Journal of the Korean Statistical Society
• /
• v.33 no.2
• /
• pp.191-202
• /
• 2004

The paper considers nonparametric empirical Bayes estimation of residual survival function at age t using a Dirichlet process prior V(a). Empirical Bayes estimators are proposed for the case where both the function ${\alpha}$(0, $\chi$] and the size a(R$\^$+/) are unknown. It is shown that the proposed empirical Bayes estimators are asymptotically optimal at a rate n$\^$-1/, where n is the number of past data available for the present estimation problem. Therefore, the result of Lahiri and Park (1988) in which a(R$\^$+/) is assumed to be known and a rate n$\^$-1/ is achieved, is extended to a(R$\^$+/) unknown case.

• Journal of the Korean Data and Information Science Society
• /
• v.2
• /
• pp.45-62
• /
• 1991

In this paper we propose new nonparametric estimators of the survival function using spline function under the progressively random censoring scheme. This sampling scheme is applied in many practical situations such as clinical trials or the life testing problems. We also investigate the behaviors for some estimators in the proposed class and the performance of progressively random censoring scheme through the numerical examples and Monte Carlo simulation.

• Journal of the Korean Data and Information Science Society
• /
• v.26 no.3
• /
• pp.569-580
• /
• 2015

Log-rank is widely used for testing equality of two survival functions, and this method is efficient only under the proportional hazard assumption. However, crossing survival functions are common in practice. Therefore, many approaches have been suggested to test equality of them. This study considered several methods; Renyi type test, modified Kolmogorov-Smirnov and Cramer-von Mises test, and weighted Log-rank test, which can be applied when the survival functions cross, and simulated power of those methods. Based on the simulation results, we provide the useful information to choose a suitable approach in a given situation.

• Journal of the Korean Institute of Gas
• /
• v.25 no.3
• /
• pp.53-58
• /
• 2021

The number of patients with cardiovascular diseases who experience an out-of-hospital cardiac arrest (OHCA) are increasing among young adults as well as the aged population. An automated external defibrillator (AED) is vital in improving survival rates of OHCA victims. Survival rates of OHCA were shown to decline exponentially in time to defibrillation, yet studies in Korea are uncommon that captures the properties of their survival rates in examining optimal locations of AEDs. In this study, we worked on the maximal gradual coverage location problem (MGCLP) with exponential decay coverage function to decide on their optimal locations. The exponential decay coverage function mitigates the drawback of over-estimating survival rates of OHCA patients. It is expected that a more sophisticated facility location problem will be developed to identify the "emergent" characteristics of pedestrians who responds to the OHCA occurrence by incorporating random pedestrian locations and movement through simulation.

• Journal of the Korean Statistical Society
• /
• v.25 no.1
• /
• pp.133-144
• /
• 1996

We, in this paper, propose a nonparametric estimator of bivariate mean residual life function based on Lin and Ying's (1993) bivariate survival function estimator of paired failure times under univariate censoring and prove the uniform consistency and the weak convergence result of this estimator. Through Monte Carlo simulation, the performances of the proposed estimator are tabulated and are illustrated with the skin grafts data.

• Journal of the Korean Data and Information Science Society
• /
• v.1
• /
• pp.77-77
• /
• 1990

• Molecules and Cells
• /
• v.46 no.6
• /
• pp.345-347
• /
• 2023

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.10
• /
• pp.4387-4392
• /
• 2015

Background: Tight junctions (TJs) organise paracellular permeability and they have an important role in epithelial and endothelial cell polarity and permanence of barrier function. It has been demonstrated that the Claudin family constitutes an important component of them. In this study, we assessed expression patterns of of Claudin1, 4 and 7 and whether they have any relation with prognosis in patients with pancreatic cancer. Materials and Methods: Expression patterns of Claudin 1,4 and 7 were examined by immunohistochemistry in 25 patients with a histopathological diagnosis of pancreatic cancer using a semiquantitative scoring of the extent and intensity of staining. After grouping the staining scores as low (final score 0-2) and high (final score 3-9) the relation between expression of Claudin 1,4 and 7 and survival was evaluated. Results: There was no significant relation between expression of Claudin 1,4 and 7 and gender and stage. No statistically significant relation was found between Claudin 1 and 4 expression and survival whereas a statistically significant relation was found between decrease in Claudin 7 expression and decrease in survival. Conclusions: Claudins have important functions other than their popular function known as adhesion. Supporting this hypothesis, we found a statistically significant relationship between increased Claudin 7 expression and increased survival time, and this suggests that Claudin 7 may exert different tumorigenic effects in pancreatic cancer other than its well-known adhesion effect.