• Quality Improvement in Health Care
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• v.2 no.1
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• pp.86-109
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• 1995

Clinical trials of drugs on humans is the final and most important stage in evaluating the safety and efficacy of the drugs. Good Clinical Practice(GCP) standards were announced in 1987 to protect testees' rights as well as to ensure validity of the clinical trial results, but its implementation has been delayed until now. The purpose of this study is to evaluate the preparedness of the designated institutions to abide by GCP standards during clinical trials, and thereby to determine GCP implementability at the institutions. Survey on the status of clinical trials was conducted for the designated 83 clinical trial hospitals. Response rate was 95.2%. Donabedian's quality assessment model was applied as the basic framework for the study. And the relative - weights for the evaluation items were determined by expert's evaluation. Among the designated 83 hospitals, 39 conducted clinical trials to obtain drug manufacturing approval from 1990 to 1994. Only 19 institutions are found to be able to meet the requirements of KGCP. Structure variables - manpower, organization, and facility -, which are the basic elements for GCP, are evaluated as unsatisfied in many hospitals. Institutions which established IRB accounted for 41 or 51.9%, but those who have a protocol evaluation guideline, or Adverse Drug Reaction(ADR) reporting system were only 12 and 21 institutions, respectively. Also, the institutions providing educational programs on conducting clinical trials are few - 20. The study results indicates that the level of conducting KGCP is unsatisfactory. However, more institutions are expected to be able to meet the standards soon because GCP standards does not require so much regulation on facilities, but stress importance on research methodology and human right. At present as the institutions for clinical trials are primarily training hospitals with residency programs, such efforts as education will accelerate the implementability of GCP in Korea. Institutions must build the appropriate infrastructure and government must prepare to strongly enforce KGCP before it can successfully take place.

• Journal of Nutrition and Health
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• v.35 no.9
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• pp.952-961
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• 2002

The purpose of this study was to compare nutrient intakes and the serum iron status of 74 Food and Nutrition major, and 45 non-major, female students at a university in Incheon. This cross-sectional survey was conducted using a self-administered questionnaire and the data were analyzed by the SPSS 10.0 program. The nutrient intake data collected from three-day dietary recalls were analyzed by the Computer Aided Nutritional Analysis Program. Anthropometric data and hematological indices of iron in the blood were measured. Average heights, weights, body fat and mid-upper arm circumference of Food and Nutrition major and non-major female students were 160.3 cm, 53.5kg, 25.8%, 23.7cm and 159.8cm, 55.5kg, 28.9%, 24.8cm, respectively. There were significant differences in body fat percentage and mid-upper arm circumference between the major and non-major students. In all subjects, daily dietary intakes of nutrients- except protein, vitarrlin B1, vitamin C and phosphorus - were lower than the Korean RDA. In particular, calcium and iron intakes of all subjects were under 60% of the Korean RDA. Values of RBC (red blood cell) count, Hb (hemoglobin), Hct (hematocrit), MCV (mean cell volume), MCH (mean cell hemoglobin), and MCHC (mean corpuscular hemoglobin concentration) of the non-major students were significantly higher compared to those of the major students. The diastolic blood pressure of the major students was negatively correlated with MCV, MCH, TS, and serum iron levels. Triceps skinfold thickness, mid-upper arm circumference and waist-to-hip ratios of the non-major students were negatively correlated with TIBC. Fat intake was positively correlated with RBC, Hb, Hct, and TIBC (total iron binding capacity) in the major students. Vitamin C intake was positively correlated with serum iron in the major students. Carbohydrate intake was positively correlated with Hb, Hct, and MCHC in the non-major students. Niacin and iron intakes were positively correlated with Hb and Hct in the non-major students. Therefore, nutrition education is necessary for female university students to improve nutritional status and to practice optimal nutrition strategies. (Korean J Nutrition 35(9) : 952~961, 2002)

• Journal of Nutrition and Health
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• v.44 no.3
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• pp.212-221
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• 2011

This study was conducted to identify differences in growth based on the obesity index in sixth grade. Heights and weights of 141 students from first to sixth grades were collected from school records. Other information was gathered by survey, and the weight length index (WLI) was calculated. Subjects were classified into three groups: underweight (n = 57, UG), normal (n = 53, NG), and obese (n = 31, OG) using the WLI. Differences in weight, height, and growth velocity were compared among the three groups from the first to sixth grades. With regard to growth, the past physical status of the three groups was maintained. More than 50% of the OG was in the overweight range when they were in the third to fifth grades. Approximately 60% of NG was in the normal weight range between the first and fifth grades. More than 70% of UG was in the underweight range when they were in the first to fifth grades (p < 0.001). Growth velocity was faster in OG than that in NG and UG (p < 0.001). The annual growth rate of children was the highest when they moved from the third to the fourth grade (p < 0.001). The results indicate that general balanced diet education should be implemented in lower grades, because physical growth formed in lower grades tended to be maintained in senior grades. It would be better to educate students about diet to prevent obesity before the fifth grade when a major change in body structure has occurred.

• Journal of Nutrition and Health
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• v.33 no.3
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• pp.324-331
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• 2000

A deteriorating North Korean economy, coupled with a devastating natural disaster such as flooding and drought in recent years, brought about a severe food shortage and malnutrition problem which caused a migration of its population including young children to neighboring countries. We conducted a nutritional survey on a total of 436 children, aged 4-19 years old, who migrated to the China side of the border from July to September, 1999. The study subjects were interviewed by Korean-Chinese interviewers who were trained for anthropometric measurements and dietary surveys. Heights, weights, and chest circumference of the subjects were 70-90% of the South Korean reference values for the corresponding age and sex. Dietary intakes of the subjects were found to be extremely poor-the average number of food, mostly of plant origin, consumed in a day was 2.8, and the proportion of the subject who reported to take all three meals in a day while residing in North Korea was as low as 36.2%. Ninety five percent of the subjects had at least one clinical symptom related to malnutrition, 68.6% had 2-4 symptoms, and 15.1% had 5 or more symptoms. The results of this study provided an objective data for the first time on the severity of the food crisis and malnutrition problem that afflicted North Korean older children and adolescents as well as children aged 7 or under as previously reported elsewhere. the wasted and stunted children and youths prevailing in North Korea could exert a negative influence on the country's health and economy. More researches are needed in the future to investigate on the impact of malnutrition in North Korean children on the country's social, economic, and cultural state as well as on the health and nutrition situation.

• Korean Journal of Clinical Pharmacy
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• v.19 no.2
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• pp.153-158
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• 2009

Background: Patients with chronic myeloid leukemia(CML) have different health status according to their disease conditions such as chronic phase(CP), accelerated phase(AP), blast crisis(BC), stage with MCyR(Major Cytogenetic Response); therefore, every patient has different quality of life related to their disease condition. Objectives: To measure the quality of life, this study compared and analyzed the utility weight in patients with CML. This study also evaluated the utility weight in order to view comparisons between the quality of life in a patient with CML to a patient with diabetes, which is a representative chronic disease. Methods: The disease scenario described 5 symptoms of the CP, AP, BC of the CML, the CML which gets the MCyR and the diabetes. Utility weight was developed using the EQ-5D method. All statistical data were analyzed by STATA 10.0 Results: 57 nurses(95%) out of 60 answered the questionnaire. In CP, the utility weight was 0.7946. In AP, it was 0.5301. and in BC, it was -0.2793. Survey data indicate that the worse the condition of a disease, the lower the utility weight. In case of the CML which gets the MCyR, the result was 0.7731(95% CI : 0.7384 - 0.8079). The general diabetes which has no complicating disease, the utility weight was 0.7481(95% CI : 0.6983 - 0.7978). Based on the result, it is evident that those with MCyR are not significantly different from people with general diabetes (p=0.4096) in views of the quality of life.

• Journal of the Korea Convergence Society
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• v.11 no.11
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• pp.25-31
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• 2020

This study is to study a method of applying weights for quality characteristics in software test evaluation. The weight application method analyzes the text of the test report and uses the ratio according to the frequency of the text as a weight for the quality characteristics of the software test score. The feasibility review of the results of this study was conducted by comparing the results of the questionnaire survey, which made the developers and users to evaluate the importance of software, and the results of the frequency analysis of text analysis. When measuring quality based on the eight quality characteristics presented in ISO/IEC 25023, the result of this study is the software quality measurement result considering software characteristics, whereas the result of this study is the software quality measurement result by applying the same weight when measuring quality.

• Journal of Forest and Environmental Science
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• v.30 no.1
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• pp.152-160
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• 2014

The purpose of this study is to investigate and analyze the physical characteristics and tranquility of the valleys located in Gangwon region. For this study we analyzed the field survey data 135 valleys using GIS. The elements for measurement of tranquility were divided into visual elements including terrain, objects, forest, water and auditory elements including noise. These elements were divided further into positive and negative factors. The weight of each element and item was calculated by applying the AHP method. The results of this study are as follows. The length of the valley ranged from 126 m to 17 km, and the elevation ranged from 40 m to 1,800 m. Type of mixed forest was common in the valleys. The depth of the water was over 20 cm in 83% of the total area and most of the water was in good condition in visual quality. Regarding the positive factors of tranquility, the weighted scores of the objects, waterfall sounds and visual transparence of the water were of relatively high value. Relatively high values were also shown in closed and curved topography in the landform, forest type and natural forests. In the negative factors, the weights of the objects and forest elements had high values. Within the facility groups, facility of the river produced a considerable negative. After applying the index of tranquility, the natural physical attributes affected the tranquility value, more than the manmade structures to a much greater degree.

• Journal of the Korea Society of Computer and Information
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• v.22 no.3
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• pp.107-113
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• 2017

Most of online bookstores are providing a user with the bibliographic book information rather than the concrete information such as thematic words and atmosphere. Especially, thematic words help a user to understand books and cast a wide net. In this paper, we propose an efficient extraction method of thematic words from book text by applying the compound noun and noun phrase synthetic method. The compound nouns represent the characteristics of a book in more detail than single nouns. The proposed method extracts the thematic word from book text by recognizing two types of noun phrases, such as a single noun and a compound noun combined with single nouns. The recognized single nouns, compound nouns, and noun phrases are calculated through TF-IDF weights and extracted as main words. In addition, this paper suggests a method to calculate the frequency of subject, object, and other roles separately, not just the sum of the frequencies of all nouns in the TF-IDF calculation method. Experiments is carried out in the field of economic management, and thematic word extraction verification is conducted through survey and book search. Thus, 9 out of the 10 experimental results used in this study indicate that the thematic word extracted by the proposed method is more effective in understanding the content. Also, it is confirmed that the thematic word extracted by the proposed method has a better book search result.

• Journal of Korean Medicine for Obesity Research
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• v.8 no.1
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• pp.53-61
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• 2008

Objectives We have investigated a questionnaire on syndrome differentiation pertaining to obesity. To calculate data from this questionnaire, we can simply sum up the degree of symptoms. However, this does not reflect the difference in contribution of syndrome differentiation. In order to improve the level of precision of this questionnaire, we gather the weight of each symptom from experts and apply them to overweight persons. Method Nine Experts from The Society of Korean Medicine for Obesity Research nominated weights for the symptoms. We created a program based on weight survey results and applied to 1487 overweight persons and 26 oriental medical doctors. The concordance rate between the result obtained from the oriental medical doctors and that obtained using three methods was analyzed. Results 1. The reliability of this questionnaire is very high (Cronbach' ${\alpha}$=0.963). 2. The concordance level between diagnosis by oriental medical doctors and the result of general calculation is 0.347, between diagnosis by oriental medical doctors and the result of weighted calculation by syndrome differentiation is 0.362, between diagnosis by oriental medical doctors and the result of weighted calculation by symptoms is 0.1. Conclusions Weighted calculation by syndrome differentiation is relative more appropriate among three methods studied.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.10
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• pp.69-76
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• 2016

In this paper, an efficient image denoising method using non-local means (NL-means) method in the transform domain is proposed. Survey for various image denoising methods has been given, and the performances of the image denoising method using NL-means method have been analyzed. We propose an efficient implementation method for NL-means method by calculating the weights for NL-means method in the DCT and LiftLT transform domain. By using the proposed method, the computational complexity is reduced, and the image denoising performance improves by using the characteristics of images in the tranform domain efficiently. Moreover, the proposed method can be applied efficiently for performing image denoising and image rescaling simultaneously. Extensive computer simulations show that the proposed method shows superior performance to the conventional methods.