• Journal of Veterinary Clinics
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• v.37 no.5
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• pp.261-269
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• 2020

The purpose of this study is to investigate the clinical effects of carboxymethyl chitosan (CMC) and adipose-derived mesenchymal stem cells (MSCs) on osteoarthritis (OA). Thirty New Zealand white rabbits were used as cranial cruciate ligament transection and partial meniscectomy models. The rabbits were divided into five groups (n = 6) according to the intra-articular injection materials: the control group with PBS, the HA group with hyaluronic acid, the CMC group with CMC, the MSC group with MSCs emerged in PBS, and the MSC+CMC group with CMC and MSCs. Knee thickness, extension angle, gross morphology, histopathology and immunohistochemistry were performed to evaluate the effects of CMC and MSCs on rabbit OA. On the morphologic and histologic examination, the articular surfaces of the femur and tibia were markedly damaged in control group with higher Mankin score and lower cartilage surface thickness. However, OA related cartilage defects were alleviated by the treatment of MSC and/or CMC. The expressions of apoptotic and inflammatory cytokines were decreased and cartilage extracellular matrix (ECM) related collagens I and II were enhanced by the treatment of MSC and/or CMC. In conclusion, this study showed that CMC and MSC treatments have a beneficial effects on OA via the protection of cartilage damage, the stimulation of ECM, and the inhibition of inflammatory and apoptotic reaction.

• The Journal of Korean Medicine
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• v.26 no.1 s.61
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• pp.1-10
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• 2005

Objective: We examined the antimetastatic effect of Curcuma zedoaria Roscoe (CZ) on pulmonary metastasis of B 16 cells. Methods: For 6 weeks, Zedoariae Rhizoma made from dried CZ were dissolved in distilled water and administered to mice 2 weeks before they were injected with B]6 melanoma cells. Mice were given CZ at doses of 250 and 500 mg/kg, and were compared for lung weight, survival days, and NO production. Results: Intake of CZ throughout the experiment extended the average survival time. Intake after B16 cell injection slightly prolonged survival time, but intake before B]6 cell injection did not influence life span. We examined the effect of CZ on macrophage function by measuring NO production. After the macrophages were given CZ for 6 weeks, the amount of NO generated by the macrophages stimulated with LPS in culture medium increased. NO generated by the macrophages also served as a cytotoxic factor against B16 melanoma cells. B16 melanoma-conditioned medium reduced NO production by macrophages. However, CZ treatment reversed the reduction in NO production by the conditioned medium significantly. Conclusion : These findings may suggest that macrophage function-modulating activity by CZ appears to underlie its antimetastatic activity, which leads to a decrease in the number of lung metastatic surface nodules and the extension of life span.

• Journal of the Korean Academy of Clinical Electrophysiology
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• v.8 no.2
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• pp.7-12
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• 2010

Purpose : The purpose of this study was to determine the effects of hip adduction using a ball on the activation of the vastus medialis oblique (VMO) and the vastus lateralis (VL) during dynamic semisquat exercises. Methods : Twenty seven participants performed three repetitions of a double-leg semisquat and squeeze semisquat (semisquat with hip adduction using a ball) at $60^{\circ}$ knee flexion. The activation of the VMO and the VL was recorded at dominant leg during both semisquat exercises using surface electromyography (MP 100). EMG data were normalized to the maximal voluntary isometric contraction (MVIC) of the quadriceps produced during seated, isometric knee extension. Results : Results of paired t-test analyses revealed that there were no differences between activity of the VMO and the VL in both double-leg semisquat and squeeze semisquat. The activity of the VMO was significantly increased in squeeze semisquat whereas there was no difference in activity of the VL between double-leg semisquat and squeeze semisquat. Conclusion : Combining hip adduction using a ball with semisquat at $60^{\circ}$ knee flexion preferentially increases the activity of the VMO. We can conclude that semisquat at $60^{\circ}$ knee flexion with hip adduction using a ball selectively recruits the VMO. Rehabilitation for quadricep imbalance should consider these findings when selecting exercises which could preferentially activate the VMO.

• The Journal of Society for e-Business Studies
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• v.15 no.4
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• pp.33-47
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• 2010

Web records is valuable information to preserve, because it can be used as a legal evidence about business or e-commerce of a public institution, but it is easily disappeared because of its volatile characteristic. Therefore, archival information package should be defined for long-term preservation. Web records can be stored in the archival information package for electronic records, because web records is a kind of electronic records. However, the NEO(NARS Encapsulation Object), the archival information package for electronic records in Korea, can't able to store web records, because it was developed without consideration of the characteristic of web records. In this paper, we define extended NEO based on the analysis of KoSurWeb and KoDeWeb, that archival information package for document of surface and deep web as well as the NEO. Web records can be preserved and utilized along with electronic records by using the extended NEO. Also it can be used for record and legal evudence by archiving web records of public institution about e-commerce.

• Journal of the Korean Recycled Construction Resources Institute
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• v.6 no.3
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• pp.153-159
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• 2018

Many researches have been carried out on carbonation, a representative deterioration in underground structure. The carbonation of RC (Reinforced Concrete) structure can cause steel corrosion through pH drop in concrete pore water. However extension of service life in RC structures can be obtained through simple surface protection. Unlike the conventional deterministic maintenance technique, probabilistic technique can consider a variation of service life but it deals with only normal distributions. In the work, life time-probability distributions considering not only normal but also log distributions are induced, and repair cost estimation technique is proposed based on the induced model. The proposed technique can evaluate the repair cost through probabilistic manner regardless of normal or log distribution from initial service life and extended service life with repair. When the extended service life through repair has log distribution, repair cost is effectively reduced. The more reasonable maintenance strategy can be set up though actual determination of life-probability distribution based on long term tests and field investigations.

• Journal of Dental Rehabilitation and Applied Science
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• v.32 no.3
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• pp.214-223
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• 2016

Implant-assisted removable partial denture (Implant-assisted RPD, IARPD), posterior edentulous extension areas of which obtains additional support and retention from implants, is attracting increasing interest. This case report presents a successful treatment on a partially edentulous patient with a severely canted occlusal plane resulted from a long-term use of posterior extended RPD. The full mouth was rehabilitated through a fixed prosthesis on maxilla and IARPD with zirconia occlusal surface on mandible, which allowed to achieve an esthetic occlusal plane with long-term stability and, ultimately, functionally satisfying outcome.

• Journal of the Korean Ceramic Society
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• v.48 no.3
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• pp.217-221
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• 2011

Glass-ceramic materials, which consist of glass matrix phase containing crystalline ${\beta}-Ca_3(PO_4)_2$ and ${\beta}-Ca_2P_2O_7$, have been prepared by heating at $750-900^{\circ}C$ of calcium phosphate invert glasses in the silica-free $CaO-P_2O_5-TiO_2-Na_2O$, system. With increasing heating temperature from 750 to $900^{\circ}C$, the crystallite size of precipitated ${\beta}-Ca_3(PO_4)_2$ in glass with $55CaO{\cdot}35P_2O_5{\cdot}3TiO_2{\cdot}7Na_2O$ (mol%) composition increased from 48 to 91 nm. With the extension of the immersion time in dilute acetic acid solution (pH = 5) to ${\geq}$200 min, the degree of dissolution of $Ca^{2+}$ and $P^{5+}$ ions in the glass-ceramics was linearly increased and the solution was constantly maintained at pH = ~7. Biomimetic nanostructured (62-88 nm in average dia.), sphere-shaped hydroxyapatite was homogeneously formed on the surface of the glass-ceramics when socked for 7-14 days in a Hanks' solution, indicating bioactivity of the prepared glass-ceramics.

• Journal of Hydrogen and New Energy
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• v.22 no.5
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• pp.569-578
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• 2011

The $SiO_2$ membranes for polymer electrolyte membrane fuel cell (PEMFC) are preapared by electrospinning method. It leads to high porosity and surface area of membrane to accommodate the proton conducting materials. The composite membrane was prepared by impregnating of Nafion ionomer into the pores of electrospun $SiO_2$ membranes. The $SiO_2$:heteropolyacid (HPA) nano-particles as a inorganic proton conductor were prepared by microemulsion process and the particles are added to the Nafion ionomer. The characterization of the membranes was confirmed by field emission scanning electron microscope (FE-SEM), thermogravimetry analysis (TGA), and single cell performance test for PEMFC. The Nafion impregnated electrospun $SiO_2$ membrane showed good thermal stability, satisfactory mechanical properties and high proton conductivity. The addition of the $SiO_2$:HPA nano-particle improved proton conductivity of the composite membrane, which allow further extension for operation temperature in low humidity environments. The composite membrane exhibited a promising properties for the application in high temperature PEMFC.

• Physical Therapy Rehabilitation Science
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• v.6 no.1
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• pp.33-38
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• 2017

Objective: This study tried to examine the muscle activity of the neck and trunk according to head posture changes during use of laptops. Design: Cross-sectional study. Methods: This study included nineteen young men and women. All subjects maintained each posture while practice typing on laptops for ten minutes with a 5-minute break between each posture. For the neutral head posture, the subjects practiced typing while pulling their chins down towards the Adam's apple and were able to look at their knees while having their external auditory meatus, acromion, and greater trochanter vertical to the ground. For the natural head posture, they practiced typing while balancing their posture between extension and flexion of the cervical vertebrae by themselves without any guidelines. While a forward head posture was created by having their heads face the front horizontal to the rope hanging from the ceiling, they practiced typing with their external auditory meatus located in the place which was 5 cm in front of the vertical plane. The subjects used general word process but practiced typing with accuracy and high speed. Muscle activities were randomly measured using surface electromyography according to each postures. Results: The research result had found that muscle activity with the natural head posture was more significantly reduced than that of the forward head posture in the sternocleidomastoid muscle, upper trapezius, cervical vertebral spinae, and thoracic vertebrae spinae muscles (p<0.05) and that the neutral head posture was more significantly reduced than that of forward head posture in the upper trapezius, cervical vertebral spinae, and thoracic vertebrae spinae muscle activity (p<0.05) with significant increases in lumbar spinae muscle activity (p<0.05). Also, muscle activity with the neutral head posture significantly increased more in the sternocleidomastoid muscle and lumbar spinae than that of the natural posture (p<0.05). Conclusions: Our study results suggest that in order to prevent musculoskeletal pain, the neutral head posture with use of laptops is effective in reducing load to the shoulders and vitalizing the postural muscles.

• Physical Therapy Rehabilitation Science
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• v.7 no.1
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• pp.41-47
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• 2018

Objective: To investigate the effect of performing three different toe touch (TT) task condition on the activities of four different muscles using surface electromyography (sEMG) in healthy young adults. Design: Cross-sectional study. Methods: A total of 20 healthy young adults (6 males, 14 females) voluntarily participated in this study. All subject randomly performed three different TT task conditions as follows: general toe-touch (GTT) task, one side toe touch (TT) task during weight bearing, and one side foward toe touch (FTT) task during weight bearing. The muscle activities of erector spinae (ES), gluteus maximus (GM), hamstring (HAM), tibialis anterior (TA) muscles during the TT task were measured using sEMG. Subject performed each of the three conditions three time in random order and mean values were obtained. Results: With the trunk flexion period, the TT and FTT showed significantly greater muscle activity in the GM, HAM and TA compared to the GTT task (p<0.05). The TT position showed significantly greater HAM muscle activity than the GTT position. The dominant and nondominant ES muscle activity was significantly greater in the FTT compared to the GTT position (p<0.05). The dominant GM, HAM, and TA was significantly greater in the TT and FTT compared to the GTT position (p<0.05). Although the dominant ES was significantly greater in the TT and FTT compared to the GTT position (p<0.05), the dominant GM muscle activity was signifcantly greater in the TT compared with the GTT position (p<0.05). Conclusions: These findings may be applicable within the clinical field for selective trunk and lower extremity muscle activation and basic biomechanics purpose.