• Journal of the Korean Society of Food Science and Nutrition
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• v.35 no.7
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• pp.823-827
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• 2006

The present study describes the preliminary evaluation of the cytotoxic effect from Styela clava (Korean name : miduduk) extracts. S. clava was treated with methanol, ethanol, acetone, and water, then cytotoxic effect of the extracts were evaluated by the MTT reduction assay. The ethanol extracts from S. clava showed the cytotoxic activity on the HT-29 human colon cancer cells. The ethanol extracts was further fractionated with n-hexane, diethyl ether, ethyl acetate, and water according to the degree of polarity. The diethyl ether fraction showed high cytotoxic activity of HT-29 cells. however, the other fractions showed low cytotoxicity. The diethyl ether layer also showed the cytotoxic activity against SW620, HeLa, and MCF-7 cells. These studies support that extracts from S. clava may be a potential candidate as a possible chemotherapeutic agent against human cancer cells.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.9 no.4
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• pp.745-754
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• 2019

As GeoWeb 2.0 technologies are widely used, various kinds of services that mashup spatial data and user data are being developed. In particular, various spatial information platforms such as Google Maps, OpenStreetMap, Daum Map, Naver Map, olleh Map, and VWorld based on GeoWeb 2.0 technologies support mashup service. The mashup service which is supported through the Open APIs of the platforms, provides various kinds of spatial data such as 2D map, 3D map, and aerial image. Also, application fields using the mashup service are greatly expanded. Recently, as user data for mashup have been greatly increased, there was a problem in mashup performance. However, the research on the mashup performance improvement is currently insufficient, even the research on the mashup performance comparison of various platforms has not been performed. In this paper, we perform comparative analysis of the mashup performance for large amounts of user data and spatial data using various spatial information platforms available in Korea. Specifically, we propose two performance analysis indexes of mashup time and user interaction time in order to analyze the mashup performance efficiently. Also, we implement a system for the performance analysis. Finally, from the performance analysis result, we propose a spatial information platform that can be efficiently applied to cases when user data increases greatly and user interaction occurs frequently.

• Journal of Korean Society on Water Environment
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• v.35 no.2
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• pp.145-151
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• 2019

The purpose of this study was to investigate treatment characteristics of diatomite filtration, that would allow water recovery from biologically-treated effluent for reuse. Diatomite, Celpure 100, and acid clay were used as filter-aids, with a support filter manufactured from polyethylene (PE), and polypropylene (PP). This pre-coating process using diatomite filter-aids, is used in the filtration range of pressure filters, and has consistently provided high-quality separation. The results showed that variations in average removal efficiency of SS, and T-P from biologically treated effluent by the diatomite-coated PE filter, were approximately 82.2 ~ 88.9 % and 4.8 ~ 21.1 %, respectively. T-P treatment efficiency of the PP filter pre-coated with diatomite and $Celpure^{(R)}100$ at $57.64g/m^2$, was approximately $24{\pm}10%$ and $40{\pm}15%$ on average, respectively. Particle size distribution of secondary effluent varied from 0.05 to $200{\mu}m$, and $d_{50}$ value was $20.76{\mu}m$. The size distribution of particles in the diatomite filtrate ranged from 1.26 to $101.1{\mu}m$ when pre-coated with diatomite filter-aid, at a content of $57.64g/m^2$. Diatomite filter aids, i.e., the particles that form the pre-coating layer, capture very fine particles as well as macromolecules, owing to their complex structure with numerous fine microscopic pores, and surface properties. The filtration process using diatomite and $Celpure^{(R)}100$ as filter aids, has been successfully applied, to recover water from sewage for reuse. The disadvantage of the process, is that the particle size of the filter-aid is spent, because of pressurization.

• Journal of the Korean Data Analysis Society
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• v.20 no.6
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• pp.2873-2881
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• 2018

It is very important to obtain objective and credible information through election polls in order to contribute to the correct voting behavior of the voters or to establish appropriate election strategies for candidates or political parties. Therefore, many related organizations such as political parties, media organizations, and research institutions have been making efforts to improve the accuracy of the results of the polls and the election prediction. Kim et al. (2017) analyzed whether the non-response group responded that there is no support candidate in the election survey to increase the accuracy of the estimation of the vote rate. As a result, it has been confirmed that the accuracy of the estimation of the vote rate can be significantly improved by performing an appropriate classification on the non-response layer. In this study, we propose a method to estimate the turnout by each strata (sex, age group) under the condition that the total turnout rate is given for a specific district (region) and propose a procedure to predict the vote rate by reflecting the turnout. In addition, case studies were conducted using data gathered through telephone interviews for the 20th National Assembly elections in 2016.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.26 no.1
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• pp.49-61
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• 2021

The repeated shipboard measurements that have been conducted by the National Institute of Fisheries Science (NIFS) for more than a half century, provide the valuable long-term hydrographic data with high spatial-temporal resolution. However, this unprecedent dataset has been rarely used for oceanic climate sciences because of its reliability issue. In this study, temporal variability of salinity error in the NIFS data was quantified by means of extremely small variability of salinity in the deep layer of the south-western East Sea, in order to contribute to studies on long-term variability of the East Sea. The NIFS salinity errors estimated on the isothermal surfaces of 1℃ have a remarkable temporal variation, such as ~0.160 g/kg in the year of 1961~1980, ~0.060 g/kg in 1981~1994,~0.020 g/kg in 1995~2002, and ~0.010 g/kg in 2003~2014 on average, which basically represent bias error. In the recent years, even though the quality of salinity has been improved, there still remain relatively large bias errors in salinity data presumably due to failure of salinity sensor managements, especially in 2011, 2013, and 2014. On the contrary, the salinity in the year of 2012 was very accurate and stable, whose error was estimated as about 0.001 g/kg comparable to the salinity sensor accuracy. Thus, as long as developing proper data quality control procedures and sensor management systems, I expect that the NIFS shipboard hydrographic data could have good enough quality to support various studies on ocean response to climate variabilities. Additionally, a few points to improve the current NIFS shipboard measurements were suggested in the discussion section.

• The Korean Journal of Applied Statistics
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• v.35 no.4
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• pp.543-552
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• 2022

When frost occurs, crops are directly damaged. When crops come into contact with low temperatures, tissues freeze, which hardens and destroys the cell membranes or chloroplasts, or dry cells to death. In July 2020, a sudden sub-zero weather and frost hit the Minas Gerais state of Brazil, the world's largest coffee producer, damaging about 30% of local coffee trees. As a result, coffee prices have risen significantly due to the damage, and farmers with severe damage can produce coffee only after three years for crops to recover, which is expected to cause long-term damage. In this paper, we tried to predict frost using frost generation data and weather observation data provided by the Korea Meteorological Administration to prevent severe frost. A model was constructed by reflecting weather factors such as wind speed, temperature, humidity, precipitation, and cloudiness. Using XGB(eXtreme Gradient Boosting), SVM(Support Vector Machine), Random Forest, and MLP(Multi Layer perceptron) models, various hyper parameters were applied as training data to select the best model for each model. Finally, the results were evaluated as accuracy(acc) and CSI(Critical Success Index) in test data. XGB was the best model compared to other models with 90.4% ac and 64.4% CSI, followed by SVM with 89.7% ac and 61.2% CSI. Random Forest and MLP showed similar performance with about 89% ac and about 60% CSI.

• Membrane Journal
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• v.32 no.2
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• pp.116-125
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• 2022

In this experiment, an α-Al₂O₃ ceramic hollow fiber was used as a support, and a hydrogen membrane plated with Pd and Pd-Ag was manufactured through electroless plating. The Pd-Ag membrane was annealed at 500℃ for 10 h to form an alloy of Pd and Ag. It was confirmed that it became a Pd-Ag alloy through EDS (Energy Dispersive X-ray Spectroscopy) analysis. Also, the thickness of the Pd, Pd-Ag plating layer was measured to be about 8.98 and 9.29 ㎛ through SEM (Scanning Electron Microscope) analysis respectively. Hydrogen permeation experiment was performed using the H₂ gas and mixed gas (H₂ and N₂) in the range of 350~450℃ and 1-4 bar using the prepared hydrogen membrane. Under the H₂ gas condition, the Pd and Pd-Ag membrane has a flux of up to 21.85 and 13.76 mL/cm²·min and also separation factors of 1216 and 361 were obtained in the mixed gas at 450℃ and 4 bar conditions respectively.

• Structural Engineering and Mechanics
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• v.90 no.6
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• pp.551-568
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• 2024

The present study deals with static and dynamic behaviors including forced vibrations of an elastic rectangular nano plate on the two-parameter foundation. Firstly, the rectangular plate is assumed to be subjected to uniformly distributed and eccentrically applied concentrated loads. The governing equations of the problem are derived by considering the dynamic response of the plate, employing a series of the Chebyshev polynomials for the displacement function and applying the Galerkin method. Then, effects of the non-essential boundary conditions of the plate, i.e., the boundary conditions related to the shearing forces, the bending moments and the corner forces, are included in the governing equation of motion to compensate for the non-satisfied boundary conditions and increase the accuracy of the Galerkin method. The approximate numerical solution is accomplished using an iterative process due to the non-linearity of the unilateral property of the two-parameter foundation. The plate under static concentrated load is investigated in detail numerically by considering a wide range of parameters of the plate and the foundation stiffnesses. Numerical treatment of the problem in the time domain is carried out by assuming a stepwise variation of the concentrated load and the linear acceleration procedure is employed in the solution of the system of governing differential equations derived from the equation of motion. Time variations of the contact region and those of the displacements of the plate are presented in the figures for various numbers of the two-parameter of the foundation, as well as the classical and nano parameters of the plate particularly focusing on the non-linearity of the problem due to the plate lift-off from the unilateral foundation. The effects of classical and nonlocal parameters and loading are investigated in detail. Definition of the separation between the plate and the two-parameter foundation is presented and applied to the given problem. The effect of the lift-off on the static and dynamic behavior of the rectangular plate is studied in detail by considering various loading conditions. The numerical study shows that the effect of nonlocal parameters on the behavior of the plate becomes significant, when nonlinearity becomes more profound, due to the lift-off of the plate. It is seen that the size effects are significant in static and dynamic analysis of nano-scaled rectangular plates and need to be included in the mechanical analyses. Furthermore, the corner displacement of the plate is affected more significantly from the lift-off, whereas it is less marked in the time variation of the middle displacement of the plate. Several numerical examples are presented to examine the sensibility of various parameters associated with nonlocal parameters of the plate and foundation. Both stiffening and softening nonlocal parameters behavior of the plate are identified in the numerical solutions which show that increasing the foundation stiffness decreases the extent of the contact region, whereas the stiffness of the shear layer increases the contact region and reduces the foundation settlement considerably.

• Journal of Ginseng Research
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• v.47 no.5
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• pp.627-637
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• 2023

Background: Damage to the healthy intestinal epithelial layer and regulation of the intestinal immune system, closely interrelated, are considered pivotal parts of the curative treatment for inflammatory bowel disease (IBD). Plant-based diets and phytochemicals can support the immune microenvironment in the intestinal epithelial barrier for a balanced immune system by improving the intestinal microecological balance and may have therapeutic potential in colitis. However, there have been only a few reports on the therapeutic potential of plant-derived exosome-like nanoparticles (PENs) and the underlying mechanism in colitis. This study aimed to assess the therapeutic effect of PENs from Panax ginseng, ginseng-derived exosome-like nanoparticles (GENs), in a mouse model of IBD, with a focus on the intestinal immune microenvironment. Method: To evaluate the anti-inflammatory effect of GENs on acute colitis, we treated GENs in Caco2 and lipopolysaccharide (LPS) -induced RAW 264.7 macrophages and analyzed the gene expression of proinflammatory cytokines and anti-inflammatory cytokines such as TNF-α, IL-6, and IL-10 by real-time PCR (RT-PCR). Furthermore, we further examined bacterial DNA from feces and determined the alteration of gut microbiota composition in DSS-induced colitis mice after administration of GENs through 16S rRNA gene sequencing analysis. Result: GENs with low toxicity showed a long-lasting intestinal retention effect for 48 h, which could lead to effective suppression of pro-inflammatory cytokines such as TNF-α and IL-6 production through inhibition of NF-κB in DSS-induced colitis. As a result, it showed longer colon length and suppressed thickening of the colon wall in the mice treated with GENs. Due to the amelioration of the progression of DSS-induced colitis with GENs treatment, the prolonged survival rate was observed for 17 days compared to 9 days in the PBS-treated group. In the gut microbiota analysis, the ratio of Firmicutes/Bacteroidota was decreased, which means GENs have therapeutic effectiveness against IBD. Ingesting GENs would be expected to slow colitis progression, strengthen the gut microbiota, and maintain gut homeostasis by preventing bacterial dysbiosis. Conclusion: GENs have a therapeutic effect on colitis through modulation of the intestinal microbiota and immune microenvironment. GENs not only ameliorate the inflammation in the damaged intestine by downregulating pro-inflammatory cytokines but also help balance the microbiota on the intestinal barrier and thereby improve the digestive system.

• Journal of the Korean Institute of Landscape Architecture
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• v.43 no.3
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• pp.77-91
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• 2015

This study aims to suggest adequate soil management through the analysis of physicochemical properties of soil in the planting grounds of Incheon International Airport, which was constructed on a massive land reclamation site. Study areas were 5 sites at the international business complex, the passenger terminal, the airport support complex, the free trade zone, and the access road. Soil profile analysis showed that 9 plots out of the 27 plots were hardpan and heterospere within 80cm from the soil surface. The earth laid on the ground was categorized as gravel based soil(4 plots), dredged soil from the sea bottom and mixed reclamation materials(2 plots), clay with poor permeability(3 plots) and waste construction material(1 plot). Average soil hardness was $11.5kg/cm^2$ and soil textures were sandy soil, sandy loam and loamy sand. Average soil pH was 6.7 and average organic matter content was 0.7%. Electrical conductivity was 0.0dS/m and exchangeable cation concentrations were $Ca^{2+}$ 3.4cmol/kg, $Mg^{2+}$ 1.5cmol/kg, $K^+$ 0.3cmol/kg and $Na^+$ 1.0cmol/kg. Average cation exchange capacity was 11.0cmol/kg. Although average figures in Solum mostly meet the landscape design criteria, properties of each soil layer showed various values sometimes over the limit. Base saturations were $Ca^{2+}$ 29.9%, $Mg^{2+}$ 13.3% and $K^+$ 3.7% for lower soil, $Ca^{2+}$ 33.3%, $Mg^{2+}$ 17.0% and $K^+$ 2.7% for mid-soil and $Ca^{2+}$ 32.6%, $Mg^{2+}$ 12.2% and $K^+$ 1.9% for upper soil. Exchangeable sodium percentages were 16.4% for lower soil, 7.5% for mid-soil and 4.7% upper soil. Sodium adsorption rates were 0.8 for lower soil, 0.3 for mid-soil and 0.2 for upper soil. Factors affecting to the vegetation growth were heterogeneity and poorness of solum, disturbance of dredged soils, high soil hardness including hardpan in the subsurface soil layer and shallow effective soil depth, high soil acidity, imbalance of base contents, low organic matter content and low available phosphate levels in the soil.