• Journal of Veterinary Science
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• v.23 no.6
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• pp.84.1-84.15
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• 2022

Background: Stroke is caused by disruption of blood supply and results in permanent disabilities as well as death. Chlorogenic acid is a phenolic compound found in various fruits and coffee and exerts antioxidant, anti-inflammatory, and anti-apoptotic effects. Objectives: The purpose of this study was to investigate whether chlorogenic acid regulates the PI3K-Akt-Bad signaling pathway in middle cerebral artery occlusion (MCAO)-induced damage. Methods: Chlorogenic acid (30 mg/kg) or vehicle was administered peritoneally to adult male rats 2 h after MCAO surgery, and animals were sacrificed 24 h after MCAO surgery. Neurobehavioral tests were performed, and brain tissues were isolated. The cerebral cortex was collected for Western blot and immunoprecipitation analyses. Results: MCAO damage caused severe neurobehavioral disorders and chlorogenic acid improved the neurological disorders. Chlorogenic acid alleviated the MCAO-induced histopathological changes and decreased the number of terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells. Furthermore, MCAO-induced damage reduced the expression of phospho-PDK1, phospho-Akt, and phospho-Bad, which was alleviated with administration of chlorogenic acid. The interaction between phospho-Bad and 14-3-3 levels was reduced in MCAO animals, which was attenuated by chlorogenic acid treatment. In addition, chlorogenic acid alleviated the increase of cytochrome c and caspase-3 expression caused by MCAO damage. Conclusions: The results of the present study showed that chlorogenic acid activates phospho-Akt and phospho-Bad and promotes the interaction between phospho-Bad and 14-3-3 during MCAO damage. In conclusion, chlorogenic acid exerts neuroprotective effects by activating the Akt-Bad signaling pathway and maintaining the interaction between phospho-Bad and 14-3-3 in ischemic stroke model.

• Smart Media Journal
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• v.12 no.5
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• pp.81-87
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• 2023

In this paper, accidents in high-voltage overhead distribution lines, which provide stable power supply in the power system, cause inconvenience in life and disruption of production of companies. 22.9 [kV] high-voltage overhead power distribution lines aim to improve reliability and stability, such as damage caused by rain, snow, wind, etc., or electric shock prevention. Therefore, in order to prevent wire disconnection accidents due to deterioration of electrical conductivity or tensile strength due to corrosion of overhead distribution lines, it is necessary to prevent unexpected accidents in the future through regular inspection and repair. In order to diagnose deterioration due to corrosion of distribution lines, a diagnostic system (measuring instrument) is installed on the wires to monitor the condition of the wires. The manager on the ground receives the measured data through ZigBee wireless communication, controls the diagnosis system through the diagnosis system program, and grasps the condition of the overhead distribution line through the measured data and photographed photos, and predicts the life of the wire along with the visual inspection method. developed a program.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.516-516
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• 2022

Agricultural reservoirs are critical water resources structures to ensure continuous water supplies for rice cultivation in Korea. Climate change has increased the risk of reservoir failure by exacerbating discrepancies in upstream runoff generation, downstream irrigation water demands, and evaporation losses. In this study, the variations in water balance components of 400 major reservoirs during 1973-2017 were examined to identify the reservoirs with reliable storage capacities and resilience. A conceptual lumped hydrological model was used to transform the incident rainfall into the inflows entering the reservoirs and the paddy water balance model was used to estimate the irrigation water demand. Historical climate data analysis showed a sharp warming gradient during the last 45 years that was particularly evident in the central and southern regions of the country, which were also the main agricultural areas with high reservoir density. We noted a country-wide progressive increase in average annual cumulative rainfall, but the forcing mechanism of the rainfall increment and its spatial-temporal trends were not fully understood. Climate warming resulted in a significant increase in irrigation water demand, while heavy rains increased runoff generation in the reservoir watersheds. Most reservoirs had reliable storage capacities to meet the demands of a 10-year return frequency drought but the resilience of reservoirs gradually declined over time. This suggests that the recovery time of reservoirs from the failure state had increased which also signifies that the duration of the dry season has been prolonged while the wet season has become shorter and/or more intense. The watershed-irrigated area ratio (W-I_ratio) was critical and the results showed that a slight disruption in reservoir water balance under the influence of future climate change would seriously compromise the performance of reservoirs with W-I_ratio< 5.

• Environmental and Resource Economics Review
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• v.20 no.4
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• pp.859-882
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• 2011

Since two oil crises in the 1970s, Korea has actively engaged in overseas E&P projects to increase energy diversity as well as its self-development rate of energy resources. Korea's energy self-development rate, an index that indicates the ratio of resources acquired through overseas development compared to direct imports. Currently, Korea is conducting a total of 180 promising overseas oil development projects in 36 countries as of the end of 2010. By now, it has secured a reserve of around 1.63 billion barrels and production of around 176 thousand barrels of oil per day. The self-development rate for oil rose from 2.8% in 2006 to 7.4% in 2010. Not content with these remarkable successes, the korean government is planning to raise its self-development rate in oil to 25% by 2019, by promoting the active participation of Korean companies in overseas oil development projects. This paper is concerned with estimation of the required amount of government subsidies that includes loans and financial support through state-controlled banking institutions in order to reach the target 25% rate by 2019. The estimation results shows that government subsidies of at least 268 million dollars are needed for the current rate of 7.4% in oil. However, the amount sharply increases up to 1.25 billion dollars in 2019 when domestic oil demand rises to 1.02 billion barrels.

• Journal of Wetlands Research
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• v.16 no.4
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• pp.303-318
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• 2014

Baseflow gives a significant contribution to stream function in the regions where climatic characteristics are seasonally distinct. In this regard, variable baseflow can make it difficult to maintain a stable water supply, as well as causing disruption to the stream ecosystem. Changes in land use can affect both the direct flow and baseflow of a stream, and consequently, most other components of the hydrologic cycle. Baseflow estimation depends on the observed streamflow in gauge watersheds, but accurate predictions of streamflow through modeling can be useful in determining baseflow data for ungauged watersheds. Accordingly, the objectives of this study are to 1) improve predictions of SWAT by applying the alpha factor estimated using RECESS for calibration; 2) estimate baseflow in an ungauged watershed using the WHAT system; and 3) evaluate the effects of changes in land use on baseflow characteristics. These objectives were implemented in the Gapcheon watershed, as an ungauged watershed in South Korea. The results show that the alpha factor estimated using RECESS in SWAT calibration improves the prediction for streamflow, and, in particular, recessions in the baseflow. Also, the changes in land use in the Gapcheon watershed leads to no significant difference in annual baseflow between comparable periods, regardless of precipitation, but does lead to differences in the seasonal characteristics observed for the temporal distribution of baseflow. Therefore, the Guem River, into which the stream from the Gapcheon watershed flows, requires strategic seasonal variability predictions of baseflow due to changes in land use within the region.