• Title/Summary/Keyword: Supply Disruption

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An Experimental Study for Substitutability of Sand Mat with Precious Slag Ball (풍쇄 슬래그의 샌드매트 대체 가능성에 대한 실험적 연구)

  • Shin, Eun-Chul;Lee, Woon-Hyun;Kang, Jeong-Ku
    • Journal of the Korean Geosynthetics Society
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    • v.9 no.2
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    • pp.1-9
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    • 2010
  • At present, the sand mat method is actively used for improvement of soft ground. But, there are some problems related with sand mat which has been used as a way to accelerate consolidation settlement. First of all, insufficiency of sand due to imbalances in market supply and demand is the one of the biggest problems, which makes price high of sand and delays a term of total construction work. Moreover, it is necessary to preserve integrity of environment from natural disruption caused by indiscreet quarrying and dredging operation to supply sand for soil improvement construction site. This paper presents the feasibility study to use of Precious Slag Ball instead of sand mat as the replacing material through the basic soil property tests, the medium of discharge capacity test and analysis of settlement property. It is also evaluates the performance of Precious Slag Ball as a sand mat in terms of discharge capacity, ground settlement by the K-Embank program based on field experimental work.

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AMP-activated protein kinase: implications on ischemic diseases

  • Ahn, Yong-Joo;Kim, Hwe-Won;Lim, Hee-Jin;Lee, Max;Kang, Yu-Hyun;Moon, Sang-Jun;Kim, Hyeon-Soo;Kim, Hyung-Hwan
    • BMB Reports
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    • v.45 no.9
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    • pp.489-495
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    • 2012
  • Ischemia is a blockage of blood supply due to an embolism or a hemorrhage in a blood vessel. When an organ cannot receive oxygenated blood and can therefore no longer replenish its blood supply due to ischemia, stresses, such as the disruption of blood glucose homeostasis, hypoglycemia and hypoxia, activate the AMPK complex. LKB1 and $CaMKK{\beta}$ are essential activators of the AMPK signaling pathway. AMPK triggers proangiogenic effects through the eNOS protein in tissues with ischemic conditions, where cells are vulnerable to apoptosis, autophagy and necrosis. The AMPK complex acts to restore blood glucose levels and ATP levels back to homeostasis. This review will discuss AMPK, as well as its key activators (LKB1 and $CaMKK{\beta}$), as a central energy regulator and evaluate the upstream and downstream regulating pathways of AMPK. We will also discuss how we can control this important enzyme in ischemic conditions to prevent harmful effects in patients with vascular damage.

Commissioning result of the KSTAR in-vessel cryo-pump

  • Chang, Y.B.;Lee, H.J.;Park, Y.M.;Lee, Y.J.;Kwag, S.W.;Song, N.H.;Park, D.S.;Joo, J.J.;Moon, K.M.;Kim, N.W.;Yang, H.L.;Oh, Y.K.
    • Progress in Superconductivity and Cryogenics
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    • v.15 no.4
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    • pp.53-58
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    • 2013
  • KSTAR in-vessel cryo-pump has been installed in the vacuum vessel top and bottom side with up-down symmetry for the better plasma density control in the D-shape H-mode. The cryogenic helium lines of the in-vessel cryo-pump are located at the vertical positions from the vacuum vessel torus center 2,000 mm. The inductive electrical potential has been optimized to reduce risk of electrical breakdown during plasma disruption. In-vessel cryo-pump consists of three parts of coaxial circular shape components; cryo-panel, thermal shield and particle shield. The cryo-panel is cooled down to below 4.5 K. The cryo-panel and thermal shields were made by Inconel 625 tube for higher mechanical strength. The thermal shields and their cooling tubes were annealed in air environment to improve the thermal radiation emissivity on the surface. Surface of cryo-panel was electro-polished to minimize the thermal radiation heat load. The in-vessel cryo-pump was pre-assembled on a test bed in 180 degree segment base. The leak test was carried out after the thermal shock between room temperature to $LN_2$ one before installing them into vacuum vessel. Two segments were welded together in the vacuum vessel and final leak test was performed after the thermal shock. Commissioning of the in-vessel cryo-pump was carried out using a temporary liquid helium supply system.

Correlation Between Mandibular Condylar Process Fracture and Temporomandibular Joint (하악 과두 골절과 측두하악관절과의 관계)

  • Moon, Chul-Woong;Kim, Su-Gwan;Oh, Ji-Su
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.32 no.5
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    • pp.488-492
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    • 2010
  • This review evaluates the literature on the relationship between mandibular condylar process fracture and temporomadibular joint (TMJ). The topic of condylar fracture generated more discussion and controversy than any other field of maxillofacial trauma associated with TMJ. Disturbance of occlusal function, devia-tion of mandible, internal derangements of TMJ, and ankylosis of the joint with resultant inability to move the jaw are sequelae of condylar process fracture. Thus it is necessary to understand how the masticatory system adapts to the structural alterations that accompany fractures of the mandibular condyle. Treatment of condylar process fracture include two methods ; closed treatment and open treatment. If one chooses totreat closed, one must understand that adaptations in the musculature, skeleton, and dentition will be necessary. Open treatment of condylar process fractures probably requires fewer adaptations within the masticatory system to provide a favorable functional outcome. However, one must weigh the risk of open surgery against the possible improvement in outcome. The risks are not just surgical risk, but biological risk as well, such as disruption of the blood supply to the condyle. This review presents relevant aspects of change of TMJ associated with condylar process fracture.

The primary cilium as a multiple cellular signaling scaffold in development and disease

  • Ko, Hyuk-Wan
    • BMB Reports
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    • v.45 no.8
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    • pp.427-432
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    • 2012
  • Primary cilia, single hair-like appendage on the surface of the most mammalian cells, were once considered to be vestigial cellular organelles for a past century because of their tiny structure and unknown function. Although they lack ancestral motility function of cilia or flagella, they share common ground with multiciliated motile cilia and flagella on internal structure such as microtubule based nine outer doublets nucleated from the base of mother centrioles called basal body. Making cilia, ciliogenesis, in cells depends on the cell cycle stage due to reuse of centrioles for cell division forming mitotic spindle pole (M phase) and assembling cilia from basal body (starting G1 phase and maintaining most of interphase). Ciliary assembly required two conflicting processes such as assembly and disassembly and balance between these two processes determines the length of cilia. Both process required highly conserved transport system to supply needed substance to grow tip of cilia and bring ciliary turnover product back to the base of cilia using motor protein, kinesin and dynein, and transport protein complex, IFT particles. Disruption of ciliary structure or function causes multiple human disorder called ciliopathies affecting disease of diverse ciliated tissues ranging from eye, kidney, respiratory tract and brain. Recent explosion of research on the primary cilia and their involvement on animal development and disease attracts scientific interest on how extensively the function of cilia related to specific cell physiology and signaling pathway. In this review, I introduce general features of primary cilia and recent progress in understanding of the ciliary length control and signaling pathways transduced through primary cilia in vertebrates.

The Optimal Pyloric Procedure: A Collective Review

  • Kim, Dohun
    • Journal of Chest Surgery
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    • v.53 no.4
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    • pp.233-241
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    • 2020
  • Vagal damage and subsequent pyloric denervation inevitably occur during esophagectomy, potentially leading to delayed gastric emptying (DGE). The choice of an optimal pyloric procedure to overcome DGE is important, as such procedures can lead to prolonged surgery, shortening of the conduit, disruption of the blood supply, and gastric dumping/bile reflux. This study investigated various pyloric methods and analyzed comparative studies in order to determine the optimal pyloric procedure. Surgical procedures for the pylorus include pyloromyotomy, pyloroplasty, or digital fracture. Botulinum toxin injection, endoscopic balloon dilatation, and erythromycin are non-surgical procedures. The scope, technique, and effects of these procedures are changing due to advances in minimally invasive surgery and postoperative interventions. Some comparative studies have shown that pyloric procedures are helpful for DGE, while others have argued that it is difficult to reach an objective conclusion because of the variety of definitions of DGE and evaluation methods. In conclusion, recent advances in interventional technology and minimally invasive surgery have led to questions regarding the practice of pyloric procedures. However, many clinicians still perform them and they are at least somewhat effective. To provide guidance on the optimal pyloric procedure, DGE should first be defined clearly, and a large-scale study with an objective evaluation method will then be required.

A Study on the Application of Ultrasonic Testing for The Interface Integrity Evaluation between Iron and Cement of Porcelain Insulator Cap (자기애자 캡의 금구-시멘트 계면 건전성 평가를 위한 초음파법 활용에 대한 연구)

  • Yoon, Young Geun;Choi, In Hyuk;Son, Ju Am;Oh, Tae Keun
    • Journal of the Korean Society of Safety
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    • v.33 no.6
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    • pp.58-65
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    • 2018
  • The life span of the porcelain insulator was made to be 30 years, but currently many of the 154kV NGK porcelain insulators using in Korea are found to have passed the production life. Accidents caused by aged mechanical breakdown can lead to disruption of power supply in some areas, large economic losses, and casualties. Therefore, ultrasonic method, which is one of the non - destructive test methods, is applied as a method for evaluating the integrity of porcelain insulators. In this study, the experiment on the interface of cap was conducted and the difference between the energy difference and the attenuation coefficient of the reflected wave was derived according to the interface state of the steel - cement. The results of this study are expected to be used as the basic data of the ultrasonic testing to evaluate the interface condition of the porcelain insulator cap.

The Awareness and Usage of School Meals Excluding Food Hazards by Nutrition Teachers and Dieticians - Focusing on the 5 Hazard-free Meals Project of the Seoul Metropolitan Office of Education - (식품 위해요인 배제 급식에 대한 영양교사 및 영양사의 인식 및 사용실태 - 서울시교육청 '5무(無) 급식' 사업 중심으로 -)

  • Lee, Hye-ri;Park, Young Il;Joo, Nami
    • The Korean Journal of Food And Nutrition
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    • v.35 no.1
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    • pp.51-61
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    • 2022
  • This study aimed at elementary, middle, and high school dietitians who purchase ingredients for school meals. Therefore, for the study, the awareness and usage of nutritional information by 108 teachers and dieticians on 5 hazard-free meals using multivariate analysis of variance were investigated during May 18~21, 2021. Among the five questions that asked the general perceptions of school meal dietitians of 5 hazard-free meals, the perception that the "5 hazard-free foods can be easily distinguished" was the lowest. Problems were associated with using the 5 hazard-free meals such as "expensive price," "no variety in items," "disruption in the supply and demand," "inconsistent quality," and "lack of taste," in that order. Therefore, to improve 5 hazard-free school meal service, it is necessary to not only lower the price burden by providing subsidies to schools but also improve the development and distribution structure of various 5 hazard-free foods.

Hazard-Consistent Ground Displacement Estimation for Seismic Input of Underground Utility Tunnels in Korea (국내 재해도에 상응하는 공동구의 지반변위 산정)

  • Kim, Dae-Hwan;Lim, Youngwoo;Chung, Yon-Ha;Lee, Hyerin
    • Journal of the Korean Geotechnical Society
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    • v.37 no.12
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    • pp.7-23
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    • 2021
  • Underground utility tunnels, which contribute to supply of electricity, communication, water and heat, are critical lifelines of an urban area. In case service is discontinued or functional disruption happens, there will be a huge socio-economic impact. For the improved seismic design and evaluation of underground structures, this study proposes a ground displacement measure when the site is subjected to a scenario earthquake based on hazard-consistent source spectra and site amplification/attenuation. This measure provides a rational estimation of ground displacement and can be an alternative to existing response displacement methods.

New proposal for skin grafts on tendon-exposed wounds

  • Um, Jung Hwan;Jo, Dong In;Kim, Soon Heum
    • Archives of Plastic Surgery
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    • v.49 no.1
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    • pp.86-90
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    • 2022
  • Performing a skin graft is not feasible for tendon-exposed defect reconstruction because tendons are fibrous connective tissues with relatively poor blood supply. This study proposes a method to effectively perform skin graft surgery in tendon-exposed wounds. A 48-year-old male patient with diabetes mellitus had a very large left dorsal foot defect (8×8 cm). The wound bed had healthy granular tissue, with tendon exposure. The tendons were turned over so that the posterior side would behave as the anterior side. The edge of the paratenon was then fixed together to the surrounding granulation tissue or dense remnant fascia using absorbable sutures, and the close granulation tissue was approximated and buried. A split-thickness skin graft was performed after 1 week. The graft site was stably taken on postoperative day 3. A small disruption was then observed at the graft site within 1 week postoperatively, but conservative treatment was continued for 1 month, after which the defect site was completely restored. This technique can increase the success rate of skin grafts for defects with tendon exposure.