• Journal of Korean Neurosurgical Society
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• 제37권2호
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• pp.129-136
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• 2005

Objective: Currently available therapies for human malignant gliomas have limited efficacy. Toxoplasma gondii, an obligate intracellular protozoan parasite, and Quil-A are nonspecific, potent immune stimulants. T. gondii is shown to have antitumor activity in some types of cancers. Therefore, this study is undertaken to evaluate the antitumor effect of Toxoplasma lysate antigen (TLA), alone or in combination with Quil-A, on human glioma U373MG and U87MG cells. Methods: The in vitro effects of TLA alone or in combination with Quil-A on the proliferation, invasion, and apoptosis of glioma cells were tested using MTT, Matrigel invasion, and DNA fragmentation assays, and the in vivo effects on the growth of gliomas were evaluated in athymic nude mice transplanted with glioma cells. Results: Treatment with TLA resulted in the suppressed proliferation and invasion of both U373MG and U87MG cells, in a dose-dependent manner. In addition, at high concentration, TLA induced glioma cell apoptosis. When TLA was administered in the mouse glioma model, malignant glioma growth was decreased. The combined treatment of TLA with Quil-A significantly inhibited the proliferation and invasion of cultured cells as well as tumor mass of implanted mice. Conclusion: TLA inhibits the proliferation and invasion of glioma cells in vitro and in vivo, and these antitumor effects of TLA are significantly enhanced by the addition of Quil-A.

• 대한생식의학회:학술대회논문집
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• 대한생식의학회 2007년도 제53차 추계학술대회 초록집
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• pp.98.2-99
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• 2007

• The Korean Journal of Pain
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• 제19권2호
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• pp.197-201
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• 2006

Background: There are cases in which shoulder pain persists long after shoulder joint surgery and this pain can not be reduced by intravenous patient controlled analgesia (IVPCA). Our purpose was to evaluate the effect of stellate ganglion block (SGB) on postoperative shoulder pain and also to investigate the effect of preventive SBG on complex regional pain syndrome (CRPS). Methods: Forty patients, who were evaluated to ASA class 1 and 2 and who were scheduled for shoulder joint surgery under general anesthesia, were randomly divided into 2 groups. The experimental group of patients (n = 20) received SGB with 0.5% mepivacaine 8 ml after induction of general anesthesia. The control group of patients (n = 20) received only general anesthesia. Their postoperative pain was assessed using the visual analog scale (VAS) at 30 min, 1, 2, 6, 12, 24 and 48 hours postoperatively. Whenever patients wanted supplemental analgesia, diclofenac sodium 75 mg was injected intramuscularly and the need for supplemental analgesia was recorded. Results: The experimental group of patients had significantly lower pain scores at 30 min, 1, 2 and 6 hours and also significantly lower analgesic requirement at 1, 2 and 6 hours. Conclusions: We found SGB was effective for controlling postoperative pain after shoulder joint surgery. Also, we could expect that SGB reduced the incidence of CRPS.

• 대한생식의학회:학술대회논문집
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• 대한생식의학회 2007년도 제53차 추계학술대회 초록집
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• pp.141-141
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• 2007

• 한국독성학회:학술대회논문집
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• 한국독성학회 2003년도 춘계학술대회 논문집
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• pp.55-55
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• 2003

The Bupleuri Radix, called as "Siho" in Korea has been widely used in Korea, China, and Japan as Traditional Herbal Medicine since ancient times and currently. Although saikosaponins isolated from the Bupleuri Radix had metabolic and anti-inflammatory action, it's toxicity was not screened completely. Recently, many herbal medicines are imported from China but safety of these was not evaluated. (omitted) (omitted)

• Journal of Chest Surgery
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• 제31권3호
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• pp.336-338
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• 1998

다한증은 감염이나 일부 종양 등에서 볼 수 있으나, 원인질환이 없이 원발성으로 발생하는 경우도 있다. 원발성 다한증의 경우 땀이 많이 나는 부위는 주로 손바닥이며 안면부에서 땀이 과다하게 나는 경우도 있다. 최근 흉강경을 이용한 흉부교감신경절제술이 다한증의 외과적 치료로 이용되고 있는데, 안면부다한증의 경우에는 성상신경절의 일부를 절제하기 때문에 호너증후군 등의 합병증 발생 가능성이 높다. 저자들은 최근 안면부다한증 3례의 환자에서 흉강경을 이용하여 성상신경절의 일부를 포함한 흉부교감신경절제술를 시행하였다. 수술후 모두에서 증상호전이 있었으며 호너증후군 등의 합병증은 없었다.

• Clinical and Experimental Pediatrics
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• 제46권10호
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• pp.1032-1035
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• 2003

저자들은 미숙아에서 이학적 검사상 AHO를 동반하지 않고, 생화학 검사에서는 저칼슘혈증, 고인산혈증, 혈청 PTH의 증가와 24시간 소변의 기저 cAMP의 증가를 보이면서, 대퇴골의 자발골절을 동반했던 가성부갑성선 기능저하증 1례를 문헌 고찰과 함께 보고하는 바이다.

• 응용통계연구
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• 제20권2호
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• pp.373-385
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• 2007

선형모형에서 최소자승법에 의한 정규방정식의 해는 유일하지 않은 경우도 있는데 문헌에 따르면 일반화 역행렬을 정의하여, 그 해를 SAS IML로 취급하고 있다. 본 논문에서는 이것에 대한 이론을 보다 체계화하여 교육 및 연구에 도움을 주고자 하는데 그 목적이 있다.

• 천문학회지
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• 제39권2호
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• pp.51-56
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• 2006

We report the development of a semi-VLBI observation system operating at 21 cm and present the measurement of visibility function toward the sun using this system. The system consists of two 2.3 meter antennas with a maximum separation of 35 meter, a conventional high speed data acquisition system, and a set of programs for software correlation. Since two local oscillators of receiver modules are independent, data had to be fringe-fitted to yield the visibility amplitude. It is found that the visibility amplitude decreases and then bounces back as baseline increases. We confirm that solar disk with brighter limb best explains the measured visibility amplitude.

• Tuberculosis and Respiratory Diseases
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• 제45권3호
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• pp.636-642
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• 1998

저자들은 항마이코플라스마 항체와 한냉 응집소 검사로 진단된 마이코플라스마 폐렴에서 급성 호흡곤란 증후군과 한냉 응집소용혈성 빈혈, 그리고 간염이 발생된 전격성 M. þneumoniae 감염이 스테로이드 투여로 임상 증상 및 X-선 소견 그리고 한냉 응집소 용혈성 빈혈이 호전되었던 1예를 치험하였기에 문헌 고찰과 함께 보고하는 바이다.