• 제목/요약/키워드: Sulodexide

검색결과 1건 처리시간 0.013초

Sulodexide inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy

  • Jo, Hyoung;Jung, Sang Hoon;Kang, Jun;Yim, Hye Bin;Kang, Kui Dong
    • BMB Reports
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    • 제47권11호
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    • pp.637-642
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    • 2014
  • Sulodexide is a mixed glycosaminoglycan composed of heparin and dermatan sulfate. In this study, the anti-angiogenic effect of sulodexide was investigated using an oxygen-induced retinopathy (OIR) mouse model. The retinas of sham-injected OIR mice (P17) had a distinctive central area of nonperfusion, and this area was significantly decreased in sulodexide-injected mice. The number of neovascular tufts measured by SWIFT_NV and mean neovascular lumen number were significantly decreased in sulodexide-injected mice. Hyperbaric oxygen exposure resulted in increased levels of VEGF, MMP-2 and MMP-9, and when mice were treated with sulodexide, a dose-dependent reduction in VEGF, MMP-2 and MMP-9 levels was observed. Our results clearly demonstrate the anti-angiogenic effect of sulodexide and highlight sulodexide as a candidate supplementary substance to be used for the treatment of ocular pathologies that involve neovascularization.