• The Journal of the Korea Contents Association
• /
• v.21 no.3
• /
• pp.33-46
• /
• 2021

Using news big data analysis, this study was aimed to examine the suicide phenomena in Korean society, and to evaluate whether suicide prevention policies reflect social phenomena appropriately. For this purpose, 9,142 news titles with suicide as the keyword were collected from eight central newspapers between 2000 to 2018. Nouns were extracted, and data was refined for network analysis. The total period was divided into 4 periods based on the 1st and 2nd suicide prevention policies, and the characteristics of suicide phenomena in each period were identified through the top 50 frequent main words and the clusters. As a result, period 1 (2000~2003) with 6 clusters (military, internet environment, economic problems, pessimism, school, corruption), period 2 (2004~2008) with 8 clusters (high social class, school, economic problems, suicide attempts, family issues, social problems, military, responsibilities), period 3 (2009~2013) with 6 clusters (school, family issues, suicide attempts, occupation, military, investigation), and period 4 (2014~2018) with 8 clusters (military, suicide insurance money, family issues, suicide attempts, occupation, job stress, celebrity, corruption) were identified. Study results suggested the characteristics of suicide phenomena in our society. Further, the appropriateness of the implementation of suicide prevention policies was discussed.

• English & American cultural studies
• /
• v.13 no.1
• /
• pp.83-103
• /
• 2013

This paper focuses on the function of suicidal images in the history of art including literature. Death has been romanticized or repoliticized into an existential act of defiance and rebellion in literary works, so questions remain about the correlation between literary suicide and the essence of suicide. Although Jacques Ranciere insists that the order of art contrasts with the order of common people whose acts and gestures can express either their specific purposes nor the rationalities of their frustration, literary suicide reflects the outside life of readers. In fact, images of suicide produces the order of things about the real world. William Shakespeare's Hamlet handled two oppositional self-murder significantly. As Ron M. Brown pointed out, Hamlet, by choosing confrontation, seeks out an end which is voluntary, thus he avoids self-destruction and feels triumph of heroic fashion. Ophelia's self-chosen death stems from loss, frailty and the disintegration of reason, which demeans the act and diminishes her from the tragic to the pathetic(16). In the $19^{th}$ century, the resurrection of Ophelia acted as the context for later periods where life itself is fictionalized from the differing periods of network of signifier and texts. Finally, in Ophelia's case, fiction became life(Brown 285). Her suicidal image was fixed in the Victorian Culture whose visual discourse was strikingly similar to that of the men. Likewise, the ambiguities of the suicide became intertwined with the social, cultural issues of a certain period, and the paradigm of suicide was conformed to the changing needs of successive generations. However, if literary art understands that a European culture grappled with the almost impossible task and coming to terms with this strangest and most persistent of phenomena, it will be able to focus on of the multi-layered suicide by recognizing the inherent instability of the verbal sign which cannot reveal the design and grammar of truth.

• The Journal of the Korea Contents Association
• /
• v.22 no.5
• /
• pp.518-526
• /
• 2022

The extension of life expectancy due to modernization means an extension of the benefit time for elderly care and disease. However, compared to the increase in the elderly, the attitude of children toward parental responsibility is gradually weakening. These social phenomena bring alienation, hopelessness, and stress to life in old age, and the resulting sense of helplessness leads to suicidal thoughts or intentional death (suicide), becoming a social problem. The intentional death (suicide) of the elderly is a social phenomenon that often occurs around them, and the reality can be seen through the movie. In this study, the main character 'Soyoung' in the movie 'The Woman Who Kills' and the surrounding characters 'Song Old Man', 'Jongsu', and 'Jaewoo' in conversations with the elderly problem and death factors were analyzed in the Matrix. ), and then applied to the 'flow chart of problems in the elderly due to modernization' compiled by Byeong-Woo Lim (2019), to explore the factors of intentional death (suicide). As a result of the analysis, the four elderly were exposed to problems of the elderly such as disease, alienation and loneliness, poverty, and loss. (Suicide) was analyzed.

• Genomics & Informatics
• /
• v.6 no.2
• /
• pp.84-86
• /
• 2008

The Tetrahymena group I intron has been shown to employ a trans-splicing reaction and has been modified to specifically target and replace human telomerase reverse transcriptase (hTERT) RNA with a suicide gene transcript, resulting in the induction of selective cytotoxicity in cancer cells that express the target RNA, in animal models as well as in cell cultures. In this study, we evaluated the target RNA specificity of trans-splicing phenomena by the group I intron in mice that were intraperitoneally inoculated with hTERT-expressing human cancer cells to validate the anti-cancer therapeutic applicability of the group I intron. To this end, an adenoviral vector that encoded for the hTERT-targeting group I intron was constructed and systemically injected into the animal. 5'-end RACE-PCR and sequencing analyses of the trans-spliced cDNA clones revealed that all of the analyzed products in the tumor tissue of the virus-infected mice resulted from reactions that were generated only with the targeted hTERT RNA. This study implies the in vivo target specificity of the trans-splicing group I intron and hence suggests that RNA replacement via a trans-splicing reaction by the group I intron is a potent anti-cancer genetic approach.

• 중국학논총
• /
• no.58
• /
• pp.91-119
• /
• 2018

As for the various pathological phenomena of the society which is getting worse without any improvement, the film paints the phenomenon nakedly with the cold and cynical gaze on the basis of realism. These attempts originated in the Chinese art world, and they cynically sketched a Chinese society that lost hope after 6·4. The cynicism of the art world contains meanings such as instruction, meanness, passion, indifference, and mockery. In particular, the distrust of the social system after 6·4 and the collapse of the Soviet and Eastern European socialist nations gave the Chinese people a skeptical view of socialism. This situation of the times has a cynical viewpoint to face as it is instead of prudent criticism. This cynical view was embraced by filmmakers who were not silent on The pathological phenomenon of society, and they were directed to films. is a film about the love, separation, suicide, frustration and reconciliation of youth in the era of identity confusion after 6·4. The characters in the film did not mention a single word about the state power that made them do it. based on the characteristics of women in northeast China and the murder that occurred around a woman with a beauty that was not like a laundry employee. Centered around the unresolved slice murder case, expressed human moral ambiguity that does not distinguish good fortune from human instinct for struggle for survival, and portrayed the scenery of a very cold northeast small city. But it does not show any criticism of the crime. Based on the true story of the 2000s, the portrays the uncomfortable aspects of China that established Chinese socialism. A film composed of four short episodes conveys the destiny set by God.

• Journal of Oriental Neuropsychiatry
• /
• v.29 no.2
• /
• pp.99-109
• /
• 2018

Objectives: To analyze the reports of qualitative research about depressed mood and suicidal ideation of Korean Seniors. Methods: Eleven published qualitative research studies were selected for analysis. We extracted common topics and factors of each stage, Selected factors were paralleled and synthesized to make a flow chart of the phenomena. Results: Depressed mood arousals of Korean seniors are categorized by causation factors, which include economic, psychosomatic, and social factors, and positive-negative coping strategies, which include cognitive-behavioral factors. Suicidal experiences are categorized as ideation, suicidal attempt, and after-suicide stage. In the latter, participants reported three types of lifestyles by their enthusiasm for 'being alive'. Conclusions: Through the qualitative synthesis of research, we could analyze and categorize major factors and coping strategies of participants who exhibited a depressed mood or suicidal ideation.

• Journal of Life Science
• /
• v.31 no.12
• /
• pp.1120-1127
• /
• 2021

Depression has a negative impact on social functioning due to its high prevalence and increased suicide rate, and is a disease with a high economic burden. Depression is related to diverse brain-related phenomena, such as neuroinflammation, synaptic dysfunction, and cognitive deficit. As antidepressant drugs used in clinical trials have shown poor therapeutic effects, antidepressant drugs that show rapid efficacy urgently need to be developed. Although studies on various genes, proteins, and signaling pathways related to depression have been conducted, the pathogenesis of depression has not been clearly elucidated. Sirtuin 1 is a nicotinamide-adenine dinucleotide- (NAD+-) dependent histone deacetylase and is involved in cell differentiation, apoptosis, autophagy, and cancer metabolism. Recent genetic studies found that sirtuin 1 is a potential target gene for depression. In addition, preclinical studies reported that sirtuin 1 signaling affects depression-like behavior. In this review, we attempt to present up-to-date knowledge of depression and sirtuin 1. We describe the various roles of sirtuin 1 in the regulation of glial activation, circadian rhythm, neurogenesis, and cognitive function and the effects of its expression on depression. Further, we discuss the effect of sirtuin 1 on the impairment of neural plasticity, one of the key mechanisms of depression, and the associated mechanisms of sirtuin 1.