• 대한치과교정학회지
• /
• 제26권1호
• /
• pp.83-94
• /
• 1996

Substance P는 교정력이 가해진 치아의 치주인대 중 인장력을 받는 부위에 많이 분포하는 neuropeptide중의 하나이며, 또한 여러 조직에서 neurogenic inflammation을 야기하는 neuropeptide중의 하나로도 알려져 있다. 그러나 중요한 세포외 단백기질인 교원질의 생성에 대한 Substance P의 효과는 잘 알려져 있지 않다. 따라서 이 연구의 목적은 배양치주인대 세포에서 교원질 생성에 대한 Substance P의 효과를 평가하는 것이었다. collagenase-digestion method로 교원질 생성을 평가하였고 mRNA 수준에서 작용효과를 평가하기 위하여 Northern blot hybridization을 시행하였다. 이 연구는 또한 교원질 생성에 대한 prostaglandin과 gelatinase 생성도 포함하였으며 변성된 교원질의 분해를 평가하기 위하여 zymography를 이용하였다. 비교원성 단백질, 교원성 단백질, 상대교원질에 대한 dose-dependent effect를 보면 Substance P는 비교원성 단백질 합성을 증가시켰으나 교원성 단백질 합성은 감소시킨다. 그리하여 총 단백합성에 대한 상대적인 교원질 생성을 나타내는 상대교원질은 $7\%$에서 $3.6\%$로 감소시켰다. 세포를 indomethacin과 동시에 처리할 때 substance P의 교원질 합성 억제효과는 나타나지 않았다. 이것은 Substance P의 교원질 합성 억제효과가 prostaglandin의 생성 때문이라는 것을 의미한다. Substance P의 교원질 합성 억제효과가 procollagen mRNA의 정상(steady-state)수준에 부합하는가를 평가하기 위하여 northern blot hybridization을 시행한 결과 Substance P는 ${\alpha}1(1)$ procollagen mRNA의 양적 변동을 일으키지 않았다. Substance P의 교원질 생성 억제효과는 전사이후의 어떤 단계에서 이루어지는 현상임을 나타낸다. 치주인대세포에서 gelatinase 생성에 대한 Substance P의 효과를 알아보기 위하여 zymography를 이용하였다. zymogram 을 보면 Substance P는 치주인대세포에서 gelatinase 생성에는 아무 효과도 나타내지 않음들 알 수 있다. Substance P의 교원질 생성 억제효과가 치주인대세포에 대해 선택적인가 아닌가를알아보기 위하여 MC3T3-E1세포를 이용하였는데 Substance P는 MC3T3-E1세포의 교원질 합성에는 영향을 미치지 않았다. 이상에서 Substance P는 인간의 치주인대세포에서 교원질 합성을 억제하였다. 이 효과는 procollagen mRNA와 gelatinase 생성의 정상(steady-state) 수준의 변화 때문이 아니라 prostaglandin 생성과 연관이 있음을 알았다.

• 한국양식학회지
• /
• 제12권1호
• /
• pp.63-69
• /
• 1999

A series of experiments were conducted to examine on what stimulus giant danio (Danio malabaricus) were mainly responsible for detecting alarm substance. When 0.15 ml alarm substance (10 ppm) was introduced into the tank, fish showed no notable change in swimming pattern. However, the introduction of 1.5 ml alarm substance (100 ppm) could induce fright reaction about in 6 minutes. Further, when 15 ml alarm substance (1,000 ppm) was introduced into the tank, fish showed the following fright reaction in a few seconds; suppressing to feed diet, no swimming, strong chasing, and visual alertness. In detecting alarm substance, fish were mainly depending on the chemical stimulus (nares) rather than the vision stimulus (eyes) because fish detected alarm substance by the chemical cue showed the significantly stronger fright reaction than by the visual cue. The time for fish to show the initial fright reaction after detecting alarm substance by the chemical cue was shorter than by the visual cue. Also after alarm substance was introduced into the tank, olfaction-deprived fish showed significantly weaker fright reaction and less frequency of chasing than the normal fish which detected alarm substance by both olfaction and gustation stimulus. These results indicated that chemical stimulus, especially olfaction might be the primary sensory modality used in the detection of the alarm substance for giant danio.

• 대한간호학회지
• /
• 제33권8호
• /
• pp.1161-1170
• /
• 2003

Purpose. The purpose of this study was to examine the effects of a rehabilitation program on hope and self-efficacy in a sample of homeless adolescent substance abusers at a halfway house in Seoul, Korea. Methods. Five residents of a halfway house were provided with a 16-week rehabilitation program based on a cognitive-behavioral approach. To evaluate the effectiveness of the program, this study used a single-case experimental design with the variables - hope and self-efficacy - being measured at pre-, post-, and follow-up tests. Results. While three participants showed considerable positive changes in hope and self-efficacy after the program, two participants did not show any positive changes. Despite this lack of consistent patterns in the effectiveness of the rehabilitation program, there was a qualitative change in social status (such as academic and work status) for the participants at the follow-up test. Conclusion. A rehabilitation program based on a cognitive-behavioral approach may improve the hope and self-efficacy of homeless adolescent substance abusers at a halfway house and help them to reintegrate into society.

• Nuclear Engineering and Technology
• /
• 제55권5호
• /
• pp.1671-1676
• /
• 2023

The influence of adding iodine as a contrast substance to elevate radiation in a tumor is studied using simulation techniques of Monte-Carlo. The study is carried on a brain cancer by adopting an unsophisticated head phantom. The ionizing radiation source is an external beam of x-rays with energy range of a few tens of keV. The expected radiation dose increment due to adding the iodine is investigated by comparing the radiation in the tumor after and before adding the iodine and calculating the ratio between the two doses. Several concentrations of the contrast substance are used to quantify its impact. The change of the dose increment with the source energy is also examined. It is found that the radiation elevation in the tumor tends to saturate with increasing the iodine concentration, and for the studied domain of energies (30 keV-100 keV), the radiation dose enhancement factors (RDEF) for the different iodine concentrations (1%-9%) show peaked curves, with the peak occurring between 60 keV and 70 keV. For the highest concentration studied, 9%, the peak value is almost 7.

• 대한한방내과학회지
• /
• 제34권4호
• /
• pp.362-374
• /
• 2013

Objectives : This study was carried out to investigate the inhibitory effect of Banhasasim-tang on early reflux esophagitis by control of gastric peristalsis and the lower esophageal sphincter in mice. Methods : Experimental mice were classified into three groups. The normal group were mice with no inflammation. The control group were mice with gastroesophageal reflux elicited by alcohol. The sample group were mice administered Banhasasim-tang after gastroesophageal reflux elicitation. We observed morphological change and production of ghrelin, substance P, and inducible nitric oxide synthase (iNOS) in gastroesophageal junction mucosa. In addition, we examined change of epithelial junction in esophageal mucosa and change of lower esophageal sphincter distribution. Results : The migration of inflammation-related cells in lamina propria of gastroesophageal junction decreased more in the sample group than in the control group. The positive reaction of ghrelin, substance P, and iNOS significantly decreased more in the sample group than in the control group (p<0.05). Injury of the epithelial junction in the esophageal mucosa and outer oblique layer in the lower esophageal sphincter were significantly mitigated by Banhasasim-tang administration in the sample group (p<0.05). Conclusions : According to the above results, it is supposed that Banhasasim-tang inhibits early reflux esophagitis by controlling not only gastric peristalsis and acid secretion through ghrelin, and substance P but also the lower esophageal sphincter through iNOS.

• Restorative Dentistry and Endodontics
• /
• 제9권1호
• /
• pp.7-14
• /
• 1983

The purpose of this study was to investigate pulpal responses to tricalcium phosphate and durapatite which recently introduced as a bone substitute. Tricalcium phosphate and durapatite were placed on the amputated pulp tissue in the dog's teeth. Animals were sacrificed after 1, 2, 3 and 4 weeks and specimens were decalcified, embedding, sectioned and stained routinly. Microscopic examination reveals as follows; 1. Tricalcium phosphate: Severe inflammatory change was seen in the all cases and calcified masses were seen at 2 weeks. Calcified masses were enlarged according to the time elapsed. 2. Durapatite: Severe inflammatory change and pus cavities were found at 1 week. There was no evidence of healthy cell component in the remaining pulp tissue and degenerative change was obvious at 2, 3 and 4 weeks. 3. Dentin bridge was not formed in the both cases. In the case of tricalcium phosphate osteoblasts were observed unevenly around the calcified masses which were composed of hematophilic substance in central portion and eosinophilic substance in peripheral region of the masses.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2004년도 추계학술대회 논문집 전기물성,응용부문
• /
• pp.171-176
• /
• 2004

An electric power efficiency of electrodeless fluorescent lamp has big relative propertye of gas in lamp, gas pressure, lamp formation, ingredients of magnetic substance and shape and action frequency etc. We used magnetic substance that open self-examination material of electrodeless fluorescent lamp antenna. Ferrite that is used in this experiment was Mn-Zn type. Coill turn was changed from 13th to 15th turn to recognize brightness change of lamp by winding number. Optical equipment that used in an experiment was used to measure brightness (LS-100). When an electrodeless fluorescent lamp was made using and T company's PE22, was it showed the highest brightness. As number of winding is increased the brightness increased, and starting characteristic became good.

• Applied Biological Chemistry
• /
• 제35권3호
• /
• pp.202-209
• /
• 1992

청국장 발효시 생산되는 점질물에 대하여 연구하기 위하여 볏짚으로부터 점질물 생성능이 우수하고 좋은 풍미의 청국장 재조균 SB-1를 분리하여 Bacillus sp.로 동정하였다. 이들 균주들은 $42^{\circ}C$에서 48시간때에 가장 많은 점질물을 생산했으며, M.S.G.의 첨가시 점질물 및 아미노태질소와 암모니아태질소의 성분에는 큰 변화가 없었으나, Sucrose 첨가시 점질물과 아미노태질소의 생산량은 증가한 반면 암모니아태질소는 오히려 감소하였다. 점질물의 분자량은 $15,000{\sim}65,000$ 정도로 추정되었다. 점질물은 G.C.와 HPLC의 분석결과 주로 glutamate와 fructose로 구성된 것으로 나타났으며, 배지조성의 차이에 따라 다른 고분자물질이 검출되었다.

• 한국산림과학회지
• /
• 제84권3호
• /
• pp.361-368
• /
• 1995

표고버섯 원목(原木) 재배(栽培)에 있어서 골목화 기간을 단축하여 해균(害菌)의 침입을 막고 생산량 증대를 위한 방법으로 생리활성화물질(生理活性化物質)이 표고버섯 골목화에 미치는 영향을 실험분석하였다. 생리활성화물질은 파(Allium fistulosm), 보리(Hordeum vulagare var. hexastichon), 표고버섯(Lentinus edodes), 당근(Daucus carota var. sativa), 유자(Citrus junos)를 사용하였는데 그 중 파(Allium fistulosm)의 추출액이 제일 유효하였으며, 생리활성화물질(生理活性化物質)에 효과가 높은 수종(樹種)은 굴참나무(Quercus variabilis)로 나타났다.

• 한국과학교육학회지
• /
• 제10권1호
• /
• pp.95-118
• /
• 1990

This students ideas in science are diverse and unique It is realized that children's preconceptions and misconceptions established before lessoning hgve a crucial in fluence on the following education. so it is meaningful to analyse the children's concept of temperature for the better teaching strategy in this study. This survey of the Elementary school children's concept is designed for the subtopics of temperature as the relation between heat and temperature, He relation between volume(size) and temperature, the temperature of change of state on water, the temperature of substances in the condition of thermal equilibrium. Using Clinical method, this research was executed to 306 children at elementary school. The network method or the analyse of questionnaires were used to analyse the children's response. Findings of this survey are as follow. Students are already familiar with such concept as this increase of temperature by geating, but they think every substance is not the case. Many students appears to believe that the temperature of an object(substance) is related to its size(vloume) Qualitative tasks are difficult than qualitative ones. This trend appear highly in the low grade students. Don't know the temperature of change of state on water and it's stability They think that the temperature is determined by the heating time(period) and the temperature of heating source. Students think, in general that temperature of substance in the condition of thermal equilibrium is different.