• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10045-10051
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• 2015

Chemotherapy is a major therapeutic approach for malignant neoplasms; however, due to the most common adverse events of nausea and vomiting, scheduled chemotherapeutic programs may be impeded or even interrupted, which severely impairs the efficacy. Aprepitants, 5-HT3 antagonists and dexamethasone are primary drugs used to prevent chemotherapy-induced nausea and vomiting (CINV). These drugs have excellent efficacy for control of acute vomiting but are relatively ineffective for delayed vomiting. Aprepitant may remedy this deficiency. Substance P was discovered in the 1930s and its association with vomiting was confirmed in the 1950s. This was followed by a period of non-peptide neurokinin-1 (NK-1) receptor antagonist synthesis and investigation in preclinical studies and clinical trials (phases I, II and III). The FDA granted permission for the clinical chemotherapeutic use of aprepitant in 2003. At present, the combined use of aprepitant, 5-HT3 antagonists and dexamethasone satisfactorily controls vomiting but not nausea. Therefore, new therapeutic approaches and drugs are still needed.

• 부모자녀건강학회지
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• 제11권2호
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• pp.115-126
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• 2008

Purpose: The purpose of this study was to identify the knowledge, attitude and experience of elementary students on smoking. Method: This study is a descriptive survey study by a self reported questionnaires and the subjects of this study were 631 students who are attending elementary schools in Seoul. Results: The results of this study are as followed : 1) 67.9% of subjects have smoking family members, 91.9% of subjects don't have good relation to their parents, 78.6% of subjects have discontented school life and 4.6% of subjects are smoking now. 2) 37.9% of subjects hardly ever experienced education of substance use. There are only 10~17% of subjects have experienced education of substance use among 3~4th grade students. 3) There is highly right answer rate in "relation between pregnant women and fetus(91.6)", "addiction of smoking((85.6%)" and "earlier smoking stronger addiction(72.9%)". 4) The attitude of smoking is mostly negative, and 3.1% of subjects have future smoking plan. 5) The subjects who have smoking parents more have future smoking plan(t=-2.28, p=.02), more positive attitude for smoking(t=-4.42, p=.00). Conclusion: There is needed systematic smoking prevention program for elementary students which fits their knowledge and attitude not later than 3rd. grade, and continual smoking prevention program for adulthood.

• 한국미생물·생명공학회지
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• 제36권4호
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• pp.285-290
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• 2008

Rahnella aquatilis AY2000 균주는 항효모성 물질(AYS)을 생산하지만, AYS가 저장 중에 활성이 감소되는 경향이 있었다. 따라서 본 연구에서는 AYS활성이 저하되는 원인을 알아보기 위하여 AYS에 다양한 이화학적인 처리를 행하였다. 그 결과 열처리가 AYS의 활성을 감소시키는 하나의 인자이며, AYS를 침전시키는 유기용매인 methanol의 사용 또한 AYS의 활성을 감소시키는 원인이었다. 또한 $\beta$-mercaptoethanol 과 dithiothreitol 등 thiol화합물 역시 AYS의 활성을 감소시키는 인자로 작용하였으나, pH, EDTA나 NaCl은 AYS의 활성저하를 가져오지 않았다. 한편, 정제과정에서 AYS의 조성분 중 다당류와 미지의 물질(230 nm)을 DEAE-cellulose 이온교환수지로 분리시키면 AYS의 활성이 완전히 소실되지만, AYS를 Sephacryl S-400 gel 여과를 행하여 이들 성분이 분리되지 않은 상태에서는 그 활성이 잘 유지되었다. 본 실험에 사용된 AYS의 MIC는 S. cerevisiae 대해 $7.8-15.6{\mu}g/mL$ 범위로 측정된다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2009년도 하계학술대회 논문집
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• pp.353-353
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• 2009

It is an important task to construct a recycling society with a low damage on the environment in our century. Magnetic separation is expected to be applied for the industrial waste treatment as an important supporting technology. In the magnetic separation of dry condition, the cohesive force between particles is strong compared with that in the wet condition's magnetic separation. The use of high magnetic field by the superconducting magnet enhances the powder's magnetic substance capture ability of the magnetic separation. In this study, the POSCO's coolant sludge of hot rolled steel was used for the superconducting magnetic separation of dry condition. Cryo-cooled NB-Ti superconducting magnet with 100 mm room temperature bore and 600 mm of height was used for magnetic separator.

• 대한의용생체공학회:의공학회지
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• 제38권5호
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• pp.242-247
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• 2017

This study presents a bio-chemical energy harvesting system which can generate electric power from bioorganic substance contained in vermicompost. It produced electricity by inoculating microbial fuel cell(MFC) with earthworm-composted food waste. The generated electricity was converted into usable voltage level for mobile electronics through power conditioning circuits. The implemented prototype showed $200{\mu}W$ of maximum output electric power, which successfully supplied a beacon device which continuously transmitted data to nearby smartphone without a battery. The proposed system can help develop portable or bio-mimetic energy supply for sustainable use with further improvement.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1990년도 한국자동제어학술회의논문집(국내학술편); KOEX, Seoul; 26-27 Oct. 1990
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• pp.602-607
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• 1990

Spent nuclear fuel is very dangerous substance emitting strong ionizing radiation which is harmful to human body. The remote handling of spent nuclear fuel is essential because people cannot access this substance without protecting radiation. To handle highly radioactive material or nuclear waste, many kinds of teleoperators such as master slave manipulator, electro mechanical manipulator, servo manipulator, mobile robot was developed. The distance and dimension of target object cannot be measured easily when highly radioactive material is handled by teleoperator because one should use lead glass or TV camera and monitor to protect radiation and see target object. During experiments on the remote handling of spent nuclear fuel by electro mechanical manipulator, we often felt that a distance and dimension measurement system is necessary to handle the objects which is in the highly radioactive environment, so we developed a system which is appropriate for this purpose.

• KIEAE Journal
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• 제4권4호
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• pp.3-10
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• 2004

If move in in the new apartment usually, do that hundreds hazardous substance among air floats and is broken-down. In the case of the floor, organic compound turns in adhesives that is bitter when attach the reinforcement floor and material lumber and hazardous substance is exhausted much wallpaper and concrete. Therefore, to reveal maximum this research to apply on interior of building to live function of charcoal, at non combustible material two faces that can promise safety from fire, strong and satisfy light performance, and it is thing about development of sheathing that use recycling material for barren land of multi-function and surface treatment of charcoal board as well as can keep healthy indoor environment.

• Architectural research
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• 제26권2호
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• pp.21-29
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• 2024

The use of clay bricks dates back to ancient Egypt. From the stamped clay tablets to the works of contemporary buildings, clay was significant building material for both cultural and pragmatic reasons. In the making of modern architecture in Egypt, Hassan Fathy employed clay as primary substance for building. This study demonstrates the use of clay bricks in ancient Egypt and in the works of Hassan Fathy. This study further exemplifies that the use of clay bricks is still valid in contemporary architecture in Upper Egypt and Siwa Oasis. The use of clay bricks provides structural durability and efficient insulation in the arid regions, and it also adheres to the vernacular building traditions. This paper proves that the use of clay bricks plays a crucial role in the making of modern architecture in Egypt for its pertinence in the historic continuity and practicality.

• 대한간호학회지
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• 제49권6호
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• pp.701-712
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• 2019

Purpose: Despite the high drinking rates and the complexity of drinking behaviors in adolescents, insufficient attention has been paid to their drinking patterns. Therefore, we aimed to identify patterns of adolescent drinking behaviors and factors predicting the distinct subgroups of adolescent drinking behaviors. Methods: We analyzed nationally representative secondary data obtained in 2017. Our final sample included 24,417 Korean adolescents who had consumed at least one glass of alcohol in their lifetime. To investigate patterns of drinking behaviors, we conducted a latent class analysis using nine alcohol-related characteristics, including alcohol consumption levels, solitary drinking, timing of drinking initiation, and negative consequences of drinking. Furthermore, we investigated differences in demographics, mental health status, and characteristics of substance use across the latent classes identified in our study. To do so, we used the PROC LCA with COVARIATES statement in the SAS software. Results: We identified three latent classes of drinking behaviors: current non-drinkers (CND), binge drinkers (BD), and problem drinkers (PD). Compared to the CND class, both BD and PD classes were strongly associated with higher academic year, lower academic performance, higher levels of stress, suicidal ideation, lifetime conventional or electronic cigarette use, and lifetime use of other drugs. Conclusion: Health professionals should develop and implement intervention strategies targeting individual subgroups of drinking behaviors to obtain better outcomes. In particular, health professionals should consider different characteristics across subgroups of adolescent drinking behaviors when developing the interventions, such as poor mental health status and other substance use among binge and problem drinkers.

• Journal of Dairy Science and Biotechnology
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• 제34권2호
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• pp.99-116
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• 2016

본 시험은 sialic acid가 7%를 함유하도록 제조한 유청가수분해단백분말제제(whey protein of hydrolysis)의 기능성 식품원료로 개발을 위한 동물안전성을 평가함에 연구목표를 두었다. GMP를 원료로 제조한 시험물질은 sialic acid 7%(v/v)와 원료인 GMP 가수분해 단백질이 93%로 구성되어 있었다(시험명: 7%-GNANA). 시험물질의 독성 유무는 한국식품의약안전청(KFDA, 2014)과 OECD(2008)의 의약품 등의 독성시험 기준에 따라 실시하였다. 평가방법으로서, 시험물질의 투여용량을 0, 1,250, 2,500 및 5,000 mg/kg/day로 하여 SPF Sprague-Dawley 계열 암수 랫드에 90일 동안 반복경구투여하였을 때 나타나는 독성 여부를 평가하였다. 평가항목으로서는 사망률, 일반증상관찰, 체중 변화, 사료 섭취량 측정, 안검사, 요검사, 혈액학적 및 혈액생화학적 검사, 부검 시 장기의 중량측정, 부검 시 육안적 검사 및 조직병리학적 검사 등을 평가하였다. 90일 반복경구투여 실험결과로서, 시험물질투여 및 관찰기간 동안 사망동물은 발생하지 않았다. 또한 일반증상, 체중 변화, 사료섭취량, 안과학적 검사, 요검사 그리고 혈액학적 및 혈액이화학적 이상 및 혈액응고검사에서 대조군 대비 특이한 변화는 관찰되지 않았다(p<0.05). 부검 및 병리조직학적 평가 결과, 암수 모두에서 시험물질-유래 중요한 변화 없이 시험물질-유래 경미한 변화(non-adverse effect)만인 5,000 mg/kg/day에서 확인되었다. Weight-based classification(독성 강도에 따른 분류)을 적용한 최종 독성평가 결과, 수컷의 경우 NOEL(No Observed Effect Level)은 5,000 mg/kg/day 그리고 암컷의 경우는 NOAEL(No Observed Adverse Effect Level)은 5,000 mg/kg/day로 최종 확인되었다. 따라서, 암수 모두에서 시험물질의 NOAEL은 투여최대용량인 5,000 mg/kg/day로 확인되었다. 결론적으로, GMP를 원료로 하여 제조한 7%-GNANA(유청가수분해단백분말)는 투여가능 최대용량에서도 독성이 없는 안전한 천연물이라는 것을 확인하였고, 의약품이나 기능성 식품으로서의 개발 가능성을 확인하였다.