• Journal of Environmental Health Sciences
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• v.32 no.5 s.92
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• pp.462-468
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• 2006

Antibiotics are manufactured and used for specific physiological functions, hence they may exert adverse ecological consequences when they are in contact with nontarget organisms. In the last decade, many reports have been made on the occurrences of various antibiotic compounds in surface water, and their potential impact to the environment has become an increasing concern. This study was conducted to prioritize antibiotic substances with potential environment risk in Korea. Human use antibiotics with an EIC (Expected Introduction Concentration) value greater than $1{\mu}g/l$, US FDA's action limit criteria, were selected. In order to calculate a worst-case EIC for each substance, annual production volume (in kg) of each antibiotic substance was derived using the Korea Pharmaceutical Manufacturers Association (KPMA)'s monetary database. Sixteen substances were preliminarily selected. The EICs of the 16 antibiotic substances were refined with the excretion rate of the parent substances. Ten antibiotic substances were identified to have EIC-corrected greater than $1{\mu}g/l$, which include Amoxicillin ($15.8{\mu}g/l$), Cefaclor ($10.1{\mu}/l$), Roxithromycin ($4.2{\mu}g/l$), Cephradine ($4.5{\mu}g/l$), Cefatrizine ($2.6{\mu}g/l$), Cefadroxil ($3.3{\mu}g/l$), Aztreonam ($2.3{\mu}g/l$), Ceftazidime ($2.8{\mu}g/l$), Ribostamycin ($1.3{\mu}g/l$), and Ceftezole ($1.3{\mu}g/l$). Additional risk assessments for these antibiotic substances are suggested.

• Journal of Preventive Medicine and Public Health
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• v.57 no.1
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• pp.8-17
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• 2024

Objectives: The effectiveness and efficiency of pre-exposure prophylaxis (PrEP) in reducing the transmission of human immunodeficiency virus (HIV) among men who have sex with men (MSM) relies on how widely it is adopted and adhered to, particularly among high-risk groups of MSM. The meta-analysis aimed to collect and analyze existing evidence on various factors related to PrEP adherence in MSM, including demographic characteristics, sexual behaviors, substance use, and psychosocial factors. Methods: The meta-analysis followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The search included articles published between January 2018 and December 2022, obtained from the PubMed, ScienceDirect, and Scopus databases. The studies that were included in the analysis reported the proportion of MSM who demonstrated adherence to PrEP and underwent quality appraisal using the Newcastle-Ottawa Scale. Results: Of the 268 studies initially identified, only 12 met the inclusion criteria and were included in the final meta-analysis. The findings indicated that education (odds ratio [OR], 1.64; 95% confidence interval [CI], 1.12 to 2.40), number of sexual partners (OR, 1.16; 95% CI, 1.02 to 1.31), engaging in sexual activities with an human immunodeficiency virus-positive partner (OR, 1.59; 95% CI, 1.16 to 2.26), substance use (OR, 0.83; 95% CI, 0.70 to 0.99), and lower levels of depression (OR, 0.55; 95% CI, 0.37 to 0.82) were associated with higher rates of PrEP adherence among MSM. Conclusions: Despite these findings, further research is necessary to investigate PrEP adherence more comprehensively. The findings of this meta-analysis can be utilized to inform interventions aimed at improving PrEP adherence among MSM and provide directions for future research in this area.

• Proceedings of the KIEE Conference
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• 1999.07e
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• pp.2453-2455
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• 1999

We propose that we use a porous-Si for a new spatial walk-off polarizing material with a large split angle. The beam-split an91e f is determined by the filling factor g(or porosity p) of the columnar dielectric substance and the slant angle $\theta$. Theoretically, by the assuming that $n_2$=3.5, and $n_1$=1 one can predict that a large split angle, up to $27^{\circ}$, is possible if one can construct such films with $Si.^{[3]}$ To accomplish this, we use porous-Si. As a result of theoretical simulation, the best structural parameters for attaining the maximum split angle $\phi$=$27.5^{\circ}$ are $\theta$=$58.7^{\circ}$ and p=57.6%.

• Korean Journal of Clinical Pharmacy
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• v.3 no.1
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• pp.89-104
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• 1993

The use of drug or substance for altering consciousness among adolescence is a practice in modern society, especially in Korea. The choice and pattern of use are strongly influenced by the user6s personality and expectations. The goverment and society institute must be declared the emergency of Drug abuse, for the purpose of protecting adolescence from pscychotropic agents.

• Proceedings of the KIEE Conference
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• 1999.07d
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• pp.1919-1921
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• 1999

AlN thin films were fabricated by sputter for the application of MIS device with Al/AlN/Si structure. We controled that sub-temperature room-temperature. Sputtering pressure 5 mTorr, flow ratio Ar:$N_2$=1:1(4sccm:4sccm), and appended hydrogen gas $0{\sim}5%$. AlN thin films thickness fabricated to maintain $2700{\AA}$ time control. Before the experiment remove to the contaminated material use the Ultrasonic every 10 minute use the acetone and ethanol, then use the HF remove oxide-substance at 10 second. To analyze characteristic of the $H_2$ gas addition period, C-V and I-V characteristic make and experiment $H_2$ gas at addition period progressive capability of I-V and C-V characteristic.

• Health Policy and Management
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• v.31 no.4
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• pp.409-422
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• 2021

The growing use of prescription analgesic opioids has rapidly escalated the treatment of chronic pain since the 1990s; however, it is also highly needed to control opioid-related issues, including opioids misuse, abuse, and addiction. In 2018, Organization for Economic Cooperation and Development (OECD) secretariat administered the survey on opioids use and policies to OECD countries and presented it at the Health Committee meeting of December 2018. This study aimed to review the opioids use in OECD countries and their policies to prevent and reduce associated harms, also seek the available policy lessons from OECD countries. More recently, opioids prescribing rate have been increased 14.7% between 2011-2013 and 2014-2016 and steadily focused on the main substance misused and abused in Korea. In addition, policy efforts have contributed to developing a guideline for prescribing opioids to steer the appropriate use of prescription analgesic opioids since 2000 in Korea, so it is not enough to control opioids compared with other OECD countries. Therefore, taking a people-centered and public health perspective, it will consider the health system policies and interventions at a national level to improve their preparation and approach to control opioid-related issues.

• Journal of Life Science
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• v.17 no.1 s.81
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• pp.125-131
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• 2007

Amino acid and fatty acid compositions of the physiological activity substance in the seed and pulpy substance of feral peach (Prunus persica Batsch var. davidiana Max.) were analyzed for the use as an biohealth functional processed products. The proximate compositions in the vacuum freeze dried seed and pulpy substance of feral peach were carbohydrate 63.92% and 75.11%, crude protein 27.85% and 12.77%, moisture 3.61% and 4.69%, crude fat 1.21% and 4.80%, crude ash 3.41% and 2.63%, respectively. Total amino acid contents in the protein of feral peach seed were 3,444.35 mg%, and the major amino acids were aspartic acid(681.10 mg%), glutamic acid(495.48 mg%), alanine(283.66 mg%), serine(251.36 mg%), proline(229.80 mg%), lysine(192.31 mg%) and leucine(191.34 mg%), respectively. Total amino acid contents in the protein of feral peach pulpy substance were 1,064.02 mg%, and the major amino acids followed aspartic acid(250.15 mg%), glutamic acid(129. 63 mg%), lysine, proline, leucine, alanine and serine, in a decreasing order. The richest total amino acid content contained in feral peach seed and pulpy substance was aspartic acid, followed by glutamic acid. The amount of free amino acids of feral peach seed were 6,215.34 ms%, and the major free amino acids were glutamic acid(827.25 mg%), threonine, valine and $\beta-aminobutyric$ acid, respectively. Free amino acid contents of pulpy substance were 683.82 mg%, and the major free amino acids were glutamic acid(339.49 mg%), serine proline, alanine and $\gamma-amino-n-butyric$ acid. Especially, in the case of glutamic acid, it was highest. The compositions of major total fatty acid in the lipid feral peach (Prunus persica Batsch var. davidiana Max.) seed and pulpy sabstance were linoleic acid($C_{18:2}$, n-6) and linolenic acid($C_{18:3}$, n-3), particularly.

• The Journal of the Korea Contents Association
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• v.8 no.11
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• pp.217-224
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• 2008

Is trend that treatment that use isotope of radioactive substance increases from 1964 to now steadily. Bursting tube state solidified accordingly. But, do not establish treatment ward in presence at a sickbed by means that present regulation and system escape this as well as possession that exert negative impact in treatment action preferably is and is treating by radioactivity of small quantity, treatment air by that do not detain many sickers without equaling the institution although there is treatment ward keeps fair death anniversary and is in reservation stand-by status. To possess about 10 therapy rooms including existing sickroom in the institute of nuclear energy recently is looked but is waiting for an opportunity for treatment during suitableness time yet indeed even as that operate 57 radiation isotope therapy rooms all in about 28 hospitals in present domestic state is solveded. Therefore, radiation safety supervision by medical treatment action that treat as radioactive substance may need more active effort. Make mandatory to equipment that hospital which correspond to present the third medical examination and treatment must equip, or effort about more active system improvement may have to be about equipment that enforce this.

• Journal of Environmental Health Sciences
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• v.49 no.6
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• pp.312-323
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• 2023

Background: Environmental concentrations of substances can be estimated by K-CHESAR based on main, industrial, and use categories (MC/IC/UC) and ECETOC TRA based on environmental or specific environmental categories (ERC or spERC). Objectives: Three different systems for estimating environmental concentrations were compared to figure out their order with possible reasons along with relationship of regional predicted environmental concentrations (PEC_regional) and final PEC_local for various uses of a substance. Methods: Typical uses of the case substance and their corresponding ERCs were selected from the webpage of the European Chemical Agency. Proper MC/IC/UC and spERC were assigned to each ERC. Emission fractions were compared for each assessment code from the available database. PECs were calculated by three estimating systems: K-CHESAR using MC/IC/UC, ECETOC TRA using ERC, and ECETOC TRA using spERC with their default values for input parameters. Percentage of PEC_regional to PEC_local were manually calculated for each use. Results: Emission factors decreased in the order of ERC > MC/IC/UC > spERC. Values of the final PEC_local derived as sum of PEC_regional and Clocal decreased in the order of calculations using ECETOC TRA-ERC>KCHESAR with MC/IC/UC>ECETOC TRA-spERC for all environmental media. Percentages of PEC_{regional,water} to PEC_local,water ranged from 0 to 10.3% in industrial uses calculated with MC/IC/UC and ERC but 96.3 to 100% in wide dispersive uses of ERC and spERC where values of C_local,water are estimated to be very low. Conclusions: ECETOC TRA generated the most refined PNEC values with spERC and the least with ERC, while K-CHESAR with MC/IC/UC generated values between the two results. The ratio of PEC_regional to PEC_local can be a good measure for performing suitable estimation of PNECs according to use.

• Journal of Pharmacopuncture
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• v.22 no.4
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• pp.225-230
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• 2019

Objectives: This study was to discuss the research trend of dementia treatment using cannabis for the purpose of providing the basis of cannabis use for medical purposes in the future. Methods: This study searched publications, which were registered to databases or published by Aug 22, 2019, and targeted the full-text or abstracts of these publications. We selected the final nine studies met all selection criteria. Results: These results implied that the CBD components of cannabis might be useful to treat and prevent AD because CBD components could suppress the main causal factors of AD. Moreover, it was suggested that using CBD and THC together could be more useful than using CBD or THC alone. Conclusion: We hope that there will be a solid foundation to use cannabis for medical use by continuously evaluating the possibility of using cannabis for clinical purposes as a dementia treatment substance and cannabis can be used as a positive tool.