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Evaluation of Neuronal Dysfunction in Schizophrenia before and after Neuroleptic Treatment by ??H MRS

  • C, Bo-Young;Paik, In-Ho;Lee, Chang-Uk;Lee, Hyoung-Koo;Suh, Tae-Suk
    • Journal of the Korean Magnetic Resonance Society
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    • v.5 no.1
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    • pp.56-65
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    • 2001
  • Localized in vivo proton magnetic resonance spectroscopy (MRS) was performed to evaluate metabolic alterations in the right and left frontal lobe before and after neuroleptic treatment of schizophrenic patients (n=24) and a group of healthy normal subjects (n=20). Proton metabolic ratios obtained from the 8㎤ yokels in the right and left frontal lobe were compared with the clinical assessment of PANSS for each subject. There was no significant difference in the metabolic ratios between the right and the left frontal lobes in either the schizophrenic group or the control group, indicating no laterality. Compared with those of the normal control group, NAA/Cr and (GABA+Glu)/Cr ratios of the schizophrenic patients showed significantly lower (p=0.023) and higher (p=0.005) value, respectively. The (GABA+Glu)/Cr ratio of the schizophrenic patients was generally decreased after neuroleptic treatment, while the NAA/Cr ratio was not changed. Significant correlation between the (GABA+Glu)/Cr ratio and the clinical symptom scores assessed by PANSS was established. The present study supports the “hypofrontality” hypothesis of schizophrenia on the basis of the altered metabolic ratios before and after neuroleptic treatment.

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Changes of the Hand Grip Strength accodring to Shoulder joint Angle (견관절의 각도에 따른 악력변화)

  • Chu Min;Hwang Byung-Deog
    • The Journal of Korean Physical Therapy
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    • v.10 no.2
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    • pp.77-86
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    • 1998
  • The shoulder joint permit ate greatest mobility of any joint area carries out the importment function of stabilization for hand use. So handgrip activity is important to evaluate while assessing shoulder load in manual work. There was an association between static handgrip and shoulder muscle activity. The purpose of this study was to find out the changes of the hand grip strength according to shouter an81e. One hundred (50 female, 50 male) college adult volunteers with no known shoulder dysfunction participated subject in three positions with elbow extension: (1) shoulder $0^{\circ}$ flexion (2) shoulder $90^{\circ}C$ flexion (3)shoulder $180^{\circ}C$ flexion. The paired t-test was used to determine the different in grip strength between right and left hand at shouter position change. All, there was significiant for all three position by right and left shoulder (p<0.001). In mon, the ANOVA results revealed not a significiant F-ratio fer all three position by right and left hand. In woman, revealed significiant (p<0.05).

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Study on the Solar Flux on Facade Variation in Apartment Housing (공동주택의 입면 변화에 따른 일사량 분석 -Skyline 변화를 중심으로-)

  • Lee, Duck-Hyung;Choi, Chang-Ho
    • Journal of the Korean Solar Energy Society
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    • v.27 no.2
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    • pp.1-9
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    • 2007
  • Recently, the point of view about housing environment in the city has changed from the traditional point of view of the center of housing to the subject of land- utilization-control for interaction of buildings. Right of light is the center of this issue in other words. Also many interests about the beauties of the city have increasing centering around Europe etc. This is to change a city design into the characteristic design from the exiting uniform design. As if reflect this situation, recently we are setting up the night illumination and constructing a building which acted as Land Mark like the Jong-Ro Tower. And Apartment Housing was being built various form deviate from a existing standardized form and skyline. Existing studies about sunshine of Apartment Housing have dealt with just about a standardized Apartment Housing form. So this study analyzed a recently increasing interest for Right of light and change of sunshine environment on Apartment Housing which have a various skyline form.

Effect of Dietary Soybean Protein on Cerebral Infarction Size and Antioxidant Enzyme Activities in Rat Focal Brain Ischemia Model (쥐의 대두 단백질 섭취가 국소 뇌허혈/재관류 후 뇌경색 크기와 항산화효소 활성도에 미치는 영향)

  • Lee, Hee-Joo
    • Journal of Korean Biological Nursing Science
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    • v.10 no.1
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    • pp.1-10
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    • 2008
  • Purpose: The purpose of this study was to investigate the cerebral infarction size, antioxidant enzyme activities and lipid peroxidation changes after 6 weeks of dietary soybean protein intake in a rat focal brain ischemia model. Method: Weaning Sprague-Dawley rats were fed with either modified AIN-93G diet containing casein 20% (control), 20% soybean protein isolate-based diet (S20), or 40% of soybean protein isolate-based diet (S40) for 6 weeks. The animals were subject to right middle cerebral artery occlusion for 2 hr. After 24 hr of recirculation, the rats were sacrificed. Antioxidant enzymes activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and thiobarbituric acid reactive substance (TBARS) level in the right brain were also measured. Result: There were no significant differences in the right cortical infarction volume, TBARS level, SOD and CAT activities among the three groups whereas the GPx activities of the S20 group were significantly higher than those of the control group (p=.02). Conclusion: Our results suggest that 20% of soybean protein may have a modulating effect on GPx and possibly have some protective effect against oxidative stress although it may enough to decrease cerebral infarction volume in rat focal brain ischemia model.

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A Dynamic Model of the Human Lower Extremity (하지의 동역학 모델)

  • Choi, Gi-Young;Son, Kwon;Jung, Min-Geun
    • Proceedings of the ESK Conference
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    • 1993.04a
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    • pp.1-9
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    • 1993
  • A human gait study is required for the biomechanical design of running shoes. A tow-dimensional dynamic model was developed in order to analyze lower extremity kinematics and loadings at the right ankle, knee, and hip joints. The dynamic model consists of three segments, the upper leg, the lower leg, and the foot. Each segment was assumed to be a rigid body with one or two frictionless hinge joints. The lower extremity motion was assumed to be planar in the sagittal plane. A young male subject was involved in the gait test and his anthropometric data were measured for the calculation of segement mass and moment of inertia. The experimental data were obtained from three trials of walking at 1.2m/s. The foot-floor reaction data were measured from a Kistler force plate. The kinematic data were acquired using a three-dimensional motion measurement system (Expert Vision) with six markers, five of which were placed on the right lower extremity segments and the rest one was attached to the force plate. Based on the model and experimental data for the stance phase of the right foot, the calculated vertical forces reached up to 492, 540, and 561 N at the hip, knee, ankle joints, respectively. The flexion-extension moments reached up to 155, 119, and 33 Nm in magnitude at the corresponding joints.

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Case of Vocal Cord Paralysis And Upper Limb Motor Paralysis Caused by Herpes Zoster (대상포진에 의해 발생한 성대마비 및 상지운동신경마비 1례)

  • Yeo, Eun-Ju;Park, Kyung-Mi;Cho, So-Hyun;Chun, Hea-Sun
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.25 no.2
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    • pp.322-325
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    • 2011
  • Motor paralysis by herpes zoster is rare. The incidence of herpetic motor involvement was reported to be between 0.5-31%. This case was reported to evaluate the effects of oriental medicine therapy on vocal cord paralysis and upper limb motor paralysis caused by herpes zoster. The subject was a 48-year-old man who suffering from hoarseness, right upper limb paralysis, right upper limb weakness, right post ear pain, headache. After our treatment, clinical symptoms were improved and VAS score significantly decreased. This study suggests that herbal medicine and acupuncture complex therapy is probably effective in the treatment of vocal cord paralysis and upper limb motor paralysis.

Perception of discrepancy in the upper midline position in conjunction with the gingival display according to various occupations in Iran

  • Hooman Zarif Najafi;Taraneh Estedlal;Maryam Saki;Maryam Azadi
    • The korean journal of orthodontics
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    • v.53 no.3
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    • pp.163-174
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    • 2023
  • Objective: This study evaluated the influence of various gingival displays on the esthetic perception in the presence of upper dental midline discrepancy. Methods: A smiling image of a male subject was altered digitally to produce five image series: normal smile (series A), decreased tooth show (series B), increased gingival show (series C), maxillary cant (series D), and asymmetric upper lip elevation (series E). In each image series, the midline was deviated to the right and left incrementally. A total of 210 raters (four professional groups and laypersons, n = 42 in each group) determined the midline deviation threshold and the attractiveness of midline position in each series. Results: The right and left thresholds were statistically similar for the symmetrical series (A, B, and C), while for series D, the right threshold was significantly lower. In most rater groups, the mean threshold order was: B > A > E > C > D. In all the series, the raters selected the coincident midline as the most attractive series except for series D, for which 1-2-mm deviations to the left were selected as the most attractive by almost all the groups. Conclusions: It is crucial to establish the coincident midline position in a symmetrical smile, especially when a gummy smile exists. In the asymmetrical gingival show, a coincident midline might not be the most esthetic midline position.

A RADIOGRAPHIC STUDY ON CRANIOFACIAL ASYMMETRY BY POSTERO-ANTERIOR CEPHALOMETRY (Postero-Anterior Cephalometry를 이용한 안모의 비대칭에 관한 연구)

  • Ko Jae Kyeung;Kim Jae Duk
    • Journal of Korean Academy of Oral and Maxillofacial Radiology
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    • v.17 no.1
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    • pp.249-258
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    • 1987
  • The purpose of this article was to determine the amount of cranio-facial asymmetry in normal subject before the analysis of the cranio-facial asymmetry as the result of internal derangement in T.M.J. dysfunction. The author has conducted analysis using Cephalometric P-A reviews of 54 males and 51 females. Following the Grayson's method of measurement, the standard value of cranio-facial asymmetry in normal subject was obtained. The following results were obtained: 1. Compared with right and left width, asymmetry could be identified in normal subject, although the degree of the difference appears to be small. 2. In male, asymmetric value of contact point of the upper central incisors is 0.76±0.84㎜ that of the lower central incisors is 0.86±0.86㎜, and that of center of genial tubercle is 0.87±1.06㎜. In female, asymmetric value of contact point of the upper central incisors is 1.03±1.29㎜, that of lower incisors is 1.11 ±1.18㎜, and that of center of genial tubercle is 1.45±2.15㎜. 3. Cranio-facial saymmetry in female is somewhat greater than that of male.

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Effects of TENS and Inhibitive Techniques on Spasticity in Cerebral Palsy: A Single-Subject Study (경피신경자극치료와 경직억제기술이 뇌성마비의 경직에 미치는 효과)

  • Kim, Won-Ho
    • Physical Therapy Korea
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    • v.4 no.1
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    • pp.70-77
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    • 1997
  • An A-B-A-C single subject research design was used to assess the effectiveness of transcutaneous electrical nerve stimulation(TENS) and inhibitive techniques on spasticity in a 10-year-old girl with cerebral palsy. Stimulation electrodes were placed over the sural nerve of the right leg. The standard method of cutaneous stimulation, TENS with impulse frequency of 100 Hz, was applied. Inhibitive techniques including stretch, antagonist contraction, and weight bearing were used. The tonus of the leg muscle was measured by means of a surface-EMG biofeedback unit. Visual analysis of data indicate that the child showed clinically significant reduction of spasticity in passive ankle movement following 30 minutes of TENS and inhibitive techniques application, respectively. The effect of TENS on spasticity inhibition was similar to that of inhibitive techniques. This result suggests that for this child with cerebral palsy, the application of TENS to the sural nerve may induce short-term post-stimulation inhibitory effects on the spasticity of cerebral palsy. Replication of this study with a more complex single-subject design involving more subjects is recommended to confirm this result.

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A Study on the Buyer's Right of Reducing the Price in International Sale of Goods (국제물품매매에서 매수인의 대금감액권에 관한 고찰)

  • HA, Kang-Hun
    • THE INTERNATIONAL COMMERCE & LAW REVIEW
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    • v.71
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    • pp.37-58
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    • 2016
  • CISG Article 50 contains the remedy of price reduction but limits it if the seller has a right to cure. Reduction of price presupposes that the seller delivers non-conforming goods, and that the buyer decides to accept them nevertheless. The remedy of price reduction differs from all other remedies provided in CISG with regard to it effects and to the time-limits. As to the time-limits, unlike Articles 46 and 49, Article 50 does not contain the element within a reasonable time. CISG imposes no period of time for his reducing the price. The buyer's right to declare a reduction of the price is expressly subject to the seller's right to remedy any failure to perform his obligations pursuant to Articles 37 and 48. The problem lies in determining from where to take the figures for comparing the value of the goods contracted and of those delivered. The price level in this place will usually determine his considerations as to resale or repair of the defective goods. The buyer must examine the goods, or cause them to be examined, within, as short a period as is practicable in the circumstances. The buyer loses the right to rely on a lack of conformity of the goods if he does not give notice to the seller specifying the nature of the lack of conformity within a reasonable time after he has discovered it or ought to have discovered it.

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