• Korean Journal of Acupuncture
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• 제26권4호
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• pp.23-38
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• 2009

Objectives : The purpose of this study was to identify the effect of the tonification & sedation manipulation for LI4 and KI7 on lacking of sweating in cold environment. Methods: The participants were divided into 3 groups as intact group without acupuncture, acupuncture group inserting and twisting with LI4 tonificaton and KI7 sedation method(LI4-tonify KI7-purge) and acupuncture group inserting and twisting with LI4 sedation and KI7 tonificaton method(LI4-purge KI7-tonify). We obtained baseline data at cold condition with the temperature $14{\pm}1^{\circ}C$. After making the participant staying in cold condition for 10 minute, we measured sweating rate in skin surface, body temperature, oxygen saturation, pulse rate, systolic blood pressure, diastolic blood pressure, deoxy-Hb and oxy-Hb in subcutaneous. Results : After acupuncture in cold environment, the sweating rate in skin surface significantly decreased in KI7-purge LI4-tonify group comparing the intact groups. The body temperature significantly increased in LI4-tonify KI7-purge and LI4-purge KI7-tonify groups comparing the intact group. The oxygen saturation significantly increased in LI4-tonify KI7-purge group comparing the intact group. Conclusions : These findings indicated that LI4 tonificaton and KI7 sedation method(LI4-tonify KI7-purge) could be effective for production of sweating in cold condition.

• 한국축산시설환경학회지
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• 제18권2호
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• pp.91-94
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• 2012

본 실험에서는 자돈을 대상으로 비정상 체온의 판정을 위한 알고리즘 개발에 활용할 정상상황에서의 표피 (귀, 목, 머리) 및 심부 체온의 database를 구축하였다. 평균체중 46kg의 자돈 5두를 공시하여 $22.5{\pm}2.0^{\circ}C$로 설정된 이유 자돈사에 설치한 개별 케이지에 2주간 적응시킨 후, 귀, 목 및 머리의 피부온도와 심부 (피하지방) 체온, 그리고 돈사내 온도를 1 mm k-type 열전대와 National Instruments Corporation (Austin, Texas, USA)의 장치 (cDAQ-9174, NI-9214, 9214TB)를 이용하여 1분 간격으로 17일간 연속하여 측정하였다. 수집된 체온 data는 24시간 단위로 통합하여 매 시간대별 평균 및 표준편차를 산출했다. 모든 측정 site의 하루 중 체온의 변화는 오전 6시에 가장 낮은 값으로 나타났으며 이후 점점 증가하다가 14시에 가장 높은 값을 보였고 그 후 익일 오전 6시까지 서서히 떨어졌다. 이런 변화 pattern은 외부온도의 변화와 일치하였다. 심부의 체온은 $35{\sim}39^{\circ}C$의 범위로 변화가 적은 반면에 목과 머리는 각각 $32{\sim}36^{\circ}C$, $30{\sim}36^{\circ}C$이고, 귀는 $29{\sim}36^{\circ}C$로 변화 폭이 컸다. 귀의 경우 가장 낮은 값은 자돈의 활동이 가장 적은 새벽시간이었으며, 새벽시간대를 제외한다면 귀, 목, 머리의 체온은 대체적으로 같은 범위의 온도 값을, 심부는 체온의 가장 근접한 값을 나타내고 있다. 이 연구를 통해 축적된 자돈의 표피 (귀, 목, 머리)와 심부 체온의 databse는 RFID (radio frequency identification device)를 이용한 동물의 비정상 체온의 전자적 감지를 위한 알고리즘 개발에 활용 할 수 있을 것으로 사료된다.

• 대한미생물학회지
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• 제20권1호
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• pp.109-113
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• 1985

It was well known that B. pertussis cells possess protective antigen, histamine sensitizing factor, heatstable and labile toxin, hemagglutinin, agglutinogen and the others. Previous reports involving above antigenic properties of B. pertussis have been carried out for several years. However, leucocyte promoting property was not yet investigated. In this report, the results of studies on the leucocytosis, particulary the lymphocytosis, produced in mice by injecting pertussis vaccine were presented. Especially leucocyte promoting property and histamine sensitizing property of B. pertussis vaccine treated at various temperatures were compared. The relationship between the leucocyte promoting property and histamine sensitizing property was investigated. Results were as follows. 1. Although leucocytosis was significantly rised in both 0.5ml injection and 0.1ml injection of pertussis vaccine than in control, at the higher dose (0.5ml injection) an elevation in white cell count was more significant. The leucocyte responce to pertussis vaccine was greater following 0.5 ml injection than following 0.1ml injection. 2. Lymphocytosis was significantly rised in both 0.5ml injection and 0.1ml injection of pertussis vaccine than in control. At higher dose (0.5ml injection), an elevation in lymphocyte count was more significant. 3. Order of elevation in differential leucocyte counts was lymphocyte, polymorphonuclear leucocyte and monocyte. 4. The leucocyte response to pertussis vaccine was 2 fold greater following intravenous injection than following subcutaneous injection. 5. Decrease leucocyte promoting activity and histamine sensitizing activity resulted from exposure to temperature above $56^{\circ}C$. Histamine sensitizing activity of pertussis vaccine treated at various temperatures paralleled leucocyte promoting activity.

• Asian-Australasian Journal of Animal Sciences
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• 제26권2호
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• pp.211-217
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• 2013

A herd of polish lowland local sheep was divided into two equal groups: the first group was kept under an overhead shelter, and the second group was kept in a warm barn. The effect of maintenance on ewe's reproductive performance, survival as well as the growth rate of lambs, and their carcasses quality was investigated. The lack of differences in fertility and prolificacy of ewes as well as in the survival and growth rate between the groups confirmed a good adaptation of $\dot{Z}$ela$\acute{z}$nie$\acute{n}$ska sheep to low temperature. Harsh environmental conditions did not cause a significant decrease of the body weight growth; however, they brought in an (insignificant) reduction of subcutaneous fat thickness and meatiness of the loin part of a lamb's body. The fat content of carcasses obtained from lambs reared under the overhead shelter was significantly lower, with no differences of meat and bones contribution between the groups.

• 생약학회지
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• 제16권1호
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• pp.31-35
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• 1985

Intraperitoneal administration of ginseng butanol fraction(GBF) to chronic morphinization in male Sprague-Dawley rats inhibited the development of tolerance to the analgesic effect and hyperthermic action of morphine. Rats were rendered tolerant to morphine by subcutaneous multiple morphine injections for a period of 8 days. The development of tolerance was evidenced by the decreased analgesic response to morphine and inhibition of tolerance by the greater analgesic response. Concomitant administration of morphine with GBF blocked the tolerance to the hyperthermic effect of morphine as evidenced by elevation of body temperature by morphine. Dopamine receptor sensitivity was enhanced in morphine tolerant rats as measured by apomorphine induced in spontaneous motor activity. GBF administration also blocked dopamine receptor supersensitivity induced by chronic morphinization.

• 대한골관절종양학회지
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• 제18권1호
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• pp.41-44
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• 2012

사구종은 피부와 피하 인접부위에 위치하는 피부의 온도를 조절하는 사구체에서 발생하는 혈관종의 일종으로 대개 조갑하 부위에서 발생하는 양성 종양이다. 수지 이외의 부위에서 발생하는 경우가 상대적으로 흔하나 말초 신경에서 생기는 경우는 비교적 드문 것으로 알려져 있다. 본 교실에서는 일반적으로 호발하는 부위가 아닌 상완신경총에서 발생한 사구종 1예를 경험하였기에 이에 대해 보고하고자 한다.

• Journal of Yeungnam Medical Science
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• 제39권3호
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• pp.262-265
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• 2022

Penile Mondor disease (MD) is a palpable, painful, subcutaneous induration caused by superficial dorsal penile vein thrombosis. We report a case of penile MD that was suspected to be related to prolonged oral sildenafil use. A 46-year-old man visited our emergency department with sustained penile pain and swelling that began 7 hours after sexual intercourse. He had used oral sildenafil intermittently for 11 years and engaged in sexual intercourse the previous night after taking sildenafil. Examination revealed no evidence of intercourse-related trauma to the genital area or an increase in penile skin temperature. However, penile swelling and tenderness over the protruding dorsal penile vein were noted. A color Doppler ultrasound examination was performed immediately, which showed hyperechoic thrombosis in the right superficial dorsal penile vein that was dilated, with soft tissue swelling and no detectable flow signal in the thrombotic lesion. The patient was diagnosed as having penile MD. The patient was treated conservatively. Some reports have indicated the involvement of sildenafil in thrombogenesis. Physicians should be aware that prolonged oral sildenafil use may be associated with penile MD.

• 한국축산식품학회지
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• 제21권3호
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• pp.192-199
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• 2001

The objective of this study was to investigate the effects of hot- and cold-boning on sarcomere length, drip loss and protein solubility of post-rigor porcine longissimus muscle. A total of ten pigs(borrow, 100$\pm$5 kg) were randomly selected at a commercial plant and the carcasses were split in half after slaughter. The longissimus muscle of the left side was dissected and chilled at 0$^{\circ}C$ after trimming of subcutaneous fat whereas the right side carcasses were served for cold-boning after chilling for 24 hrs. The temperature, pH and sarcomere length of porcine longissimus muscle were measured at postmortem 1, 3, 6, 12 and 24 hours. Drip loss, cooking loss, Minolta L*a*b*, shear force and protein solubility were measured at postmortem 24 hrs. The pH of cold-boning samples was rapidly decreased whereas temperature and sarcomere length of hot-boning samples were rapidly decreased during 24 hrs of chilling. Hot-boning muscles showed significantly (P<0.05) higher pHu and shorter sarcomere compared with cold boning muscles because of cold shortening. However, there were no significant differences in drip loss, cooking loss and shear force value between hot- and cold boned samples. The samples of hot-boning showed lower Minolta L* value and higher sarcoplasmic protein solubility compared with cold boned samples. These results suggest that the pale color changing of porcine longissimus muscle could be inhibited by hot-boning due to rapid chilling of the muscle although sarcomere length could be shortened because of cold shortening. Also these results show that hot-boning of porcine carcass could have a high protein solubility without negative effects of drip loss or tenderness of porcine longissimus muscle.

• 대한한의학방제학회지
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• 제20권2호
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• pp.29-35
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• 2012

Objectives : To provide the information of preservation method for herbal decoction, we evaluated the anti-inflammatory effects according to preservation temperature and period of Pyungwi-san (PWS, Ping wei-san) decoction. Methods : The anti-inflammatory activity of PWS was investigated by carrageenin-induced paw edema in SD rats. At 0 month, PWS extract was administrated 100, 300 and 1000 mg/kg/day orally for seven days prior to induction of edema. Edema was induced by subcutaneous injection of 1% carrageenin into the right hind paw. The paw volume was measured at 4 hr following carrageenin-induced paw edema in rats. At 6 and 12 months, PWS extracts according to preservation temperatures (room temperature, $4^{\circ}C$ and $-20^{\circ}C$) were administrated in rats and then carrageenin-induced paw edema volume was measured. Results : PWS showed inhibitory effect on carrageenin-induced paw edema in rats and the optimal dose was 1000 mg/kg/day at 0 month of storage. At 6 month of storage, PWS storaged at $4^{\circ}C$ and $-20^{\circ}C$ were inhibited paw edema but that storaged at room temperature was not reduced paw edema in rats. Conclusions : These results suggest that PWS decoction pouch has anti-inflammatory activities at both $4^{\circ}C$ and $-20^{\circ}C$ during 6 month storage.

• 대한한방내과학회지
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• 제19권1호
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• pp.57-72
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• 1998

This study has been carried out to investigate the effects of Ukgansan(UGS) extract on anti-convulsive, antipyretic, analgesic, sedative and GABAergic system of experimental animals. The results of this study were as follows : 1. UGS extract prolonged significantly the beginning time to convulsion and death induced by strychnine. 2. UGS extract prolonged significantly the time to death induced by electrical shock of ECT unit.(3 sec, 200 F, 25 mA) 3. On the experiment of hypothermic effects of UGS extract on the rectal temperature of mouse, UGS extract decreased significantly the rectal temperature of mouse 4. On the experiment of antipyretic effects of UGS extract on the febrile induced by the subcutaneous injection of $150\;{\mu}g/kg$ endotoxin in mouse, UGS extract decreased significantly the rectal temperature of mouse. 5. On the experiment of analgesic effects of UGS extract on the writhing syndrome induced by intraperitoneal injection 0.7% acetic acid 1 ml/100g in mouse, the writhing syndrome induced by acetic acid was reduced significantly by administration of UGS extract. 6. On the experiment of effects of UGS extract on spontaneous motor activity measured by wheel cage method in mice, the spontaneous motor activity was reduced significantly by administration of UGS extract. 7. On the experiment of effects of UGS extract on the activity of GABA-transaminase(GABA-T) in mouse brains after 21 days of oral administration of UGS extract. the activity of GABA-T was reduced significantly by administration of UGS extract. 8. On the experiment of effects of UGS extract on the activity concentration of GABA in mouse brain after 21 days of oral administration of UGS extract, the activity concentration of GABA was reduced significantly by administration of UGS extract. 9 On the experiment of effect of UGS water extract on the activity of GAD in mouse brain after 21 days of oral administration of UGS extract, the activity of GAD was reduced significantly by administration of UGS extract. According to the these results, Ukgansan extracts reveal the effects on the anti-convulsive, antipyretic, analgesic, sedative and GABAergic system.