• Journal of Pharmacopuncture
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• v.22 no.1
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• pp.16-27
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• 2019

Generative and vegetative parts of the cactuses have had a long-lasting position in folk medicine and their effects could partly be confirmed in scientific experiments. Nowadays, the cactus, fruits, and cladodes are the focus of many studies because of their desirable properties. Therefore, the summarized reports of valuable properties of medicinal plants may be a good way to familiarize researches with a new source of drugs with lower side effects and higher efficacy. Opuntia dillenii, a well-known member of the Cactaceae family, is used as a medicinal plant in various countries and grows in the desert, semi-desert, tropical and sub-tropical areas. It shows diverse pharmacological activities such as: antioxidant, anti-inflammatory, anti-tumor, neuroprotective, hepatoprotective, hypotensive etc. OD fruit also possesses valuable constitutes for instance: betalains, ascorbic acid, total phenol, protein as well as essential elements which suggest the significant potential of this plant as a complementary therapy against several pathological conditions. This review describes experimental evidence about pharmacological and therapeutic potential of OD in order to give the basis of its application in the prevention and treatment of some chronic diseases. More studies on OD can help better understanding of its pharmacological mechanism of action to explain its traditional uses and to identify its potential new therapeutic applications.

• The Journal of the Korea Contents Association
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• v.19 no.7
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• pp.22-35
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• 2019

The purpose of this study is to analyze the applicability and effectiveness of the Person - centered counseling program in the field of counseling service provided by the Independent Living Center for Persons with Disabilities. Thirteen participants, operating peer counseling program at the Independent Living Center who finished 9 sessions of person - centered counseling program over 3 months were interviewed. The collected data were analyzed using Consensual Qualitative Research (CQR). The results were grouped into three themes as "Acceptance as oneself", "Counselor's variables", and "Limitations and unsatisfactory points". Eight categories such as "The relationship with myself and others", "Accepting oneself though with discomfort", "changed perspective about problems", "Recognizing the parts that oneself was not aware", "Accepting one's potentials as well as limitations", "Opportunity to reflect one's life", "Attitude about life ahead" were retrieved with 23 sub-categories. Based on the results, the possibility of applying person - centered approach on peer counseling was presented. Finally, several suggestions for the development of person-centered approach for peer counseling were discussed.

• Design & Manufacturing
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• v.13 no.1
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• pp.55-60
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• 2019

Smart-phone in the recently released high-end applied to the camera module is equipped with the most features auto focusing camera module. Also, auto focusing camera module is divided into voice coil motor, encoder, and piezo according to type of motion mechanism. Auto focusing camera module is composed of voice coil motor (VCM) as an actuator and leaf spring as a guide and suspension. VCM actuator is made of magnet, yoke as a metal, and coil as a copper wire. Recently, the assembly as yoke and magnet is made by human resources. These process has a long process time and it is difficult to secure quality. Also, These process is not economical in cost, and productivity is reduced. Therefore, an automatic assembly as yoke and magnet is needed in the present process. In this paper, we have developed an automatic assembly device that can automatically assemble yoke and magnet, and performed verifying performance. Therefore, by using the developed automatic assembly device, it is possible to increase the productivity and reduce the production cost.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.43 no.4
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• pp.93-106
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• 2020

This research explores how imported automobile companies can develop their strategies to improve the outcome of their recalls. For this, the researchers analyzed patterns of recall demand, classified recall types based on the demand patterns and examined response strategies, considering plans on how to procure parts and induce customers to visit workshops, recall execution capacity and costs. As a result, recalls are classified into four types: U-type, reverse U-type, L- type and reverse L-type. Also, as determinants of the types, the following factors are further categorized into four types and 12 sub-types of recalls: the height of maximum demand, which indicates the volatility of recall demand; the number of peaks, which are the patterns of demand variations; and the tail length of the demand curve, which indicates the speed of recalls. The classification resulted in the following: L-type, or customer-driven recall, is the most common type of recalls, taking up 25 out of the total 36 cases, followed by five U-type, four reverse L-type, and two reverse U-type cases. Prior studies show that the types of recalls are determined by factors influencing recall execution rates: severity, the number of cars to be recalled, recall execution rate, government policies, time since model launch, and recall costs, etc. As a component demand forecast model for automobile recalls, this study estimated the ARIMA model. ARIMA models were shown in three models: ARIMA (1,0,0), ARIMA (0,0,1) and ARIMA (0,0,0). These all three ARIMA models appear to be significant for all recall patterns, indicating that the ARIMA model is very valid as a predictive model for car recall patterns. Based on the classification of recall types, we drew some strategic implications for recall response according to types of recalls. The conclusion section of this research suggests the implications for several aspects: how to improve the recall outcome (execution rate), customer satisfaction, brand image, recall costs, and response to the regulatory authority.

• Journal of Ocean Engineering and Technology
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• v.35 no.4
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• pp.266-272
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• 2021

Mooring systems are among the most important elements employed to control the motion of floating offshore structures on the sea. Considering the use of polymer material, a new method is proposed to address the creep characteristics rather than the method of using a tension load cell for measuring the tension of the mooring line. This study uses a synthetic mooring rope made from a polymer material, which usually consists of three parts: center, eye, and splice, and which makes a joint for two successive ropes. We integrate the optical sensor into the synthetic mooring ropes to measure the rope tension. The different structure of the mooring line in the longitudinal direction can be used to measure the loads with the entire mooring configuration in series, which can be defined as SMART (Smart Mooring and Riser Truncation) mooring. To determine the characteristics of the basic SMART mooring, a SMART mooring with a diameter of 3 mm made of three different polymer materials is observed to change the wavelength that responds as the length changes. By performing the longitudinal tension experiment using three different SMART moorings, it was confirmed that there were linear wavelength changes in the response characteristics of the 3-mm-diameter SMART moorings. A 54-mm-diameter SMART mooring is produced to measure the response of longitudinal tension on the center, eye, and splice of the mooring, and a longitudinal tension of 100 t in step-by-step applied for the Maintained Test and Fatigue Cycle Test is conducted. By performing a longitudinal tension experiment, wavelength changes were detected in the center, eye, and splice position of the SMART moorings. The results obtained from each part of the installed sensors indicated a different strain measurement depending on the position of the SMART moorings. The variation of the strain measurement with the position was more than twice the result of the difference measurement, while the applied external load increased step-by-step. It appears that there is a correlation with an externally generated longitudinal tensional force depending on the cross-sectional area of each part of the SMART mooring.

• Journal of Ginseng Research
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• v.46 no.4
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• pp.543-549
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• 2022

Background: In physical activity or labor, the human body is in a state of high intensity stress, and all parts or physiological functions of the body respond positively to maintain or balance the need for movement. The human body has many physiological changes in the process of movement, and fatigue is the external manifestation of various complex changes inside the human body. Fatigue is also a physiological mechanism of self-protection after the body reaches a certain level of activity, which can prevent the occurrence of life-threatening excessive functional failure. The generation of fatigue is a very complex process, and its mechanism has not been concluded yet. Therefore, it is an important work to search and screen the effective components of natural plants that have anti-fatigue effect and to explore their mechanism. Methods: This was a 8-week, randomized, double-blind, placebo-controlled clinical trial. A total of 110 subjects who passed physical examination were included according to the scheme design, and randomly divided into a test group which was given KRG and a placebo control group. The calculation is carried out according to the standard of sub-high-intensity exercise test. Results: There was no adverse effect on safety index of subjects after taking red ginseng capsule. After KRG treatment, subjective strength grade is significant lower than placebo treatment. Blood lactic acid content is significantly get lower after trial in KRG group, and significant lower than placebo group. Creatine phosphokinase(CK) content is significantly get lower after trial in KRG group, and significant lower than placebo group. Conclusion: According to the criterion in the test scheme, the result shows that KRG is helpful on relieving physical fatigue.

• Journal of Veterinary Science
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• v.22 no.5
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• pp.47.1-47.10
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• 2021

Background: Due to multiple similarities in the structure and physiology of human and pig skin, the pig model is extremely useful for biological drug testing after subcutaneous administration. Knowledge of the differences between subcutaneous injection sites could have a significant impact on the absorption phase and pharmacokinetic profiles of biological drugs. Objectives: This study aimed to analyze the impact of administration site on pharmacokinetics and selected biochemical and hematological parameters after a single subcutaneous administration of ustekinumab in pigs. Drug concentrations in blood plasma were analyzed by enzyme-linked immunosorbent assay. Pharmacokinetic analyses were performed based on raw data using Phoenix WinNonlin 8.1 software and ThothPro v 4.1. Methods: The study included 12 healthy, female, large white piglets. Each group received a single dose of ustekinumab given as a 1 mg/kg subcutaneous injection into the internal part of the inguinal fold or the external part of the inguinal fold. Results: The differences in absorption rate between the internal and external parts of the inguinal fold were not significant. However, the time of maximal concentration, clearance, area under the curve calculated between zero and mean residence time and mean residence time between groups were substantially different (p > 0.05). The relative bioavailability after administration of ustekinumab into the external part of the inguinal fold was 40.36% lower than after administration of ustekinumab into the internal part of the inguinal fold. Conclusions: Healthy breeding pigs are a relevant model to study the pharmacokinetic profile of subcutaneously administered ustekinumab.

• Journal of the Korean Geotechnical Society
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• v.22 no.5
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• pp.47-57
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• 2006

The shear wave velocity is related with the stiffness of granular skeleton and mass density. The shear stiffness of the granular skeleton remains unaffected by the presence of the fluid. Bender elements are convenient shear wave transducers for instrumenting soil cells due to optimal soil-transducer coupling. This study addresses the principles of the shear wave, the design and implementation of bender elements including electromagnetic coupling prevention, directivity, resonant frequency, detection of first arrival, and near field effects. It is shown that electromagnetic coupling effects can be minimized using parallel-type bender elements. Thus, the in-plane S-wave directivity is quasi-circular. The resonant frequency of bender element installations depends on the geometry of the bender element, the anchor efficiency and the soil stiffness. One of the most cumbersome parts in the bender element test is near field effects, which affect the selection of arrival time. The selection of the first arrival within the near field Is effectively solved by the multiple reflection technique and signal matching technique. Bender elements, which requires several considerations, may be effective tools for the subsurface characterization by using S-wave.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.2
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• pp.77.3-77.3
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• 2019

We present an analysis of the stellar population of compact elliptical galaxies (cEs) in various environments. Following conventional selection criteria of cEs, we created a list of cE candidates in the redshift range of z < 0.05 using SDSS DR12 catalog. We finally selected cEs with low-luminosity (Mg > 18.7 mag), small effective radius (Re < 600 pc), and high velocity dispersion (> 60 kms-1). We divide our cE sample into those inside and outside of the one virial radius of the bright (Mr < -21 mag) nearby host galaxy which is then defined as cEs with (cEw) and without (cEw/o) host galaxy, respectively. We investigated the stellar population properties of cEs based on the Hb, Mgb, Fe 5270, and Fe 5335 line strengths from the OSSY catalog. We found that cEw has a systematically higher metallicity than cEw/o. In the velocity dispersion-Mgb distribution, while cEw/o follows the relation of early-type galaxies, cEw are found to have a systematically higher metallicity than cEw/o at a given velocity dispersion. The different feature in the metallicity between cEw and cEw/o can suggest that two different scenarios can be provided in the formation of cEs. cEw would be the remnant cores of the massive progenitor galaxies that their outer parts have been tidally stripped by massive neighbor galaxies (i.e., nurture origin). On the other hand, cEw/o are likely to be faint-end of early-type galaxies maintaining in-situ evolution (i.e., nurture origin).

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.5C
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• pp.359-368
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• 2006

After construction, time-variant seepage and long-term underground motion are representative factors to understand the abnormal behavior of tunnels. In this study, numerical models have been developed to analyze the behavior of tunnels associated with seepage and long-term underground motion. Possible scenarios have been investigated to establish causes-and-results mechanisms. Various parameters such as permeability of tunnel filter, seepage condition, water table, long-term rock mass load, size of damaged zone due to excessive blasting have been investigated. These are divided into two sub-parts depending on the tunnel type and major loading mechanisms depending on the types. For the soft ground tunnels, the behavior associated with seepage conditions has been studied and the effect of permeability change in tunnel-filter and the effect of water-table change which are seldom measurable are investigated in detail. For the rock mass tunnels, tunnel behavior associated with the visco-plastic behavior of rock mass has been studied and the long-term rock mass loads as a result of relaxation and creep have been considered.