• Nuclear Engineering and Technology
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• v.54 no.3
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• pp.842-848
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• 2022

Parametric studies of heat transfer and fluid flow are very important research of interest because the design and operation of fluid flow and heat transfer systems are guided by these parametric studies. The safety of the system operation and system optimization can be determined by decreasing or increasing particular fluid flow and heat transfer parameter while keeping other parameters constant. The parameters that can be varied in order to determine safe and optimized system include system pressure, mass flow rate, heat flux and coolant inlet temperature among other parameters. The fluid flow and heat transfer systems can also be enhanced by the presence of or without the presence of particular effects including gravity effect among others. The advanced Generation IV reactors to be deployed for large electricity production, have proven to be more thermally efficient (approximately 45% thermal efficiency) than the current light water reactors with a thermal efficiency of approximately 33 ℃. SCWR is one of the Generation IV reactors intended for electricity generation. High Performance Light Water Reactor (HPLWR) is a SCWR type which is under consideration in this study. One-eighth of a proposed fuel assembly design for HPLWR consisting of 7 fuel/rod bundles with 9 coolant sub-channels was the geometry considered in this study to examine the effects of system pressure and mass flow rate on wall and fluid temperatures. Gravity effect on wall and fluid temperatures were also examined on this one-eighth fuel assembly geometry. Computational Fluid Dynamics (CFD) code, STAR-CCM+, was used to obtain the results of the numerical simulations. Based on the parametric analysis carried out, sub-channel 4 performed better in terms of heat transfer because temperatures predicted in sub-channel 9 (corner subchannel) were higher than the ones obtained in sub-channel 4 (central sub-channel). The influence of system mass flow rate, pressure and gravity seem similar in both sub-channels 4 and 9 with temperature distributions higher in sub-channel 9 than in sub-channel 4. In most of the cases considered, temperature distributions (for both fluid and wall) obtained at 25 MPa are higher than those obtained at 23 MPa, temperature distributions obtained at 601.2 kg/h are higher than those obtained at 561.2 kg/h, and temperature distributions obtained without gravity effect are higher than those obtained with gravity effect. The results show that effects of system pressure, mass flowrate and gravity on fluid flow and heat transfer are significant and therefore parametric studies need to be performed to determine safe and optimum operating conditions of fluid flow and heat transfer systems.

• Bulletin of the Korean Chemical Society
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• v.35 no.12
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• pp.3559-3566
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• 2014

Study on the unimolecular reaction for $CH_2FO$ and $CD_2FO$ is carried out. The structures, energy barriers and zero point energy of the three channels in the title unimolecular reactions are computed with the MP2/6-311++G(3df, 3pd) method. RRKM theory is used to calculate the rate constants of canonical case at temperature range of 500-5000 K and microcanonical system at total energy of 19.05-71.68 kcal/mol. The results indicate that the anharmonic effect and isotope effect are very small for the three channels, and the anharmonic rate constants, around $10^9-10^{11}s^{-1}$, are close to the experimental prediction reasonably.

• Biomolecules & Therapeutics
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• v.31 no.2
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• pp.168-175
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• 2023

Tramadol is an opioid analog used to treat chronic and acute pain. Intradermal injections of tramadol at hundreds of millimoles have been shown to produce a local anesthetic effect. We used the whole-cell patch-clamp technique in this study to investigate whether tramadol blocks the sodium current in HEK293 cells, which stably express the pain threshold sodium channel Na_v1.7 or the cardiac sodium channel Na_v1.5. The half-maximal inhibitory concentration of tramadol was 0.73 mM for Na_v1.7 and 0.43 mM for Na_v1.5 at a holding potential of -100 mV. The blocking effects of tramadol were completely reversible. Tramadol shifted the steady-state inactivation curves of Na_v1.7 and Na_v1.5 toward hyperpolarization. Tramadol also slowed the recovery rate from the inactivation of Na_v1.7 and Na_v1.5 and induced stronger use-dependent inhibition. Because the mean plasma concentration of tramadol upon oral administration is lower than its mean blocking concentration of sodium channels in this study, it is unlikely that tramadol in plasma will have an analgesic effect by blocking Na_v1.7 or show cardiotoxicity by blocking Na_v1.5. However, tramadol could act as a local anesthetic when used at a concentration of several hundred millimoles by intradermal injection and as an antiarrhythmic when injected intravenously at a similar dose, as does lidocaine.

• Journal of Internet Computing and Services
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• v.9 no.5
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• pp.141-151
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• 2008

In the paper, we analyze the performance of random access channels in multi-service multi-user OFDMA systems. The resource of the random access channels in OFDMA systems are available sub-channels and PN-codes. For given available sub-channels and PN-codes,' we analyze the performance of the random access channels of OFDMA systems in terms of the access success probability, the blocking probability, the access delay and the throughput per each service class. Further, we find the feasible region of the access probability of each service class in which the allowable minimum access success probability, the allowable maximum blocking probability and the allowable maximum access delay are satisfied. The results also can be used to find proper region of the access probabilities of each service class for differentiated quality of service(QoS)s, and for the system operations in multi-service multi-user OFDMA systems.

• Molecules and Cells
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• v.25 no.2
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• pp.242-246
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• 2008

To assess the role of $\alpha_{1G}$ T-type $Ca^{2+}$ channels in neuropathic pain after L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking $Ca_{V}3.1$ (${\alpha}_{1G}{^{-/-}}$), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increased threshold for paw withdrawal in response to mechanical stimulation were observed in these mice. The ${{\alpha}_{1G}}^{-/-}$ mice also showed attenuated thermal hyperalgesia in response to both low-(IR30) and high-intensity (IR60) infrared stimulation. Our results reveal the importance of ${\alpha}_{1G}$ T-type $Ca^{2+}$ channels in the development of neuropathic pain, and suggest that selective modulation of ${\alpha}_{1G}$ subtype channels may provide a novel approach to the treatment of allodynia and hyperalgesia.

• Journal of Ginseng Research
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• v.37 no.2
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• pp.201-209
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• 2013

Ginsenoside, one of the active ingredients of Panax ginseng, has a variety of physiologic and pharmacologic effects. The purpose of this study was to explore the effects of ginsenoside Rd (G-Rd) on melastatin type transient receptor potential 7 (TRPM7) channels with respect to the proliferation and survival of AGS and MCF-7 cells (a gastric and a breast cancer cell line, respectively). AGS and MCF-7 cells were treated with different concentrations of G-Rd, and caspase-3 activities, mitochondrial depolarizations, and sub-G1 fractions were analyzed to determine if cell death occurred by apoptosis. In addition, human embryonic kidney (HEK) 293 cells overexpressing TRPM7 channels were used to confirm the role of TRPM7 channels. G-Rd inhibited the proliferation and survival of AGS and MCF-7 cells and enhanced caspase-3 activity, mitochondrial depolarization, and sub-G1 populations. In addition, G-Rd inhibited TRPM7-like currents in AGS and MCF-7 cells and in TRPM7 channel overexpressing HEK 293 cells, as determined by whole cell voltage-clamp recordings. Furthermore, TRPM7 overexpression in HEK 293 cells promoted G-Rd induced cell death. These findings suggest that G-Rd inhibits the proliferation and survival of gastric and breast cancer cells by inhibiting TRPM7 channel activity.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.2
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• pp.135-144
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• 2022

An antidiabetic drug, rosiglitazone is a member of the drug class of thiazolidinedione. Although restrictions on use due to the possibility of heart toxicity have been removed, it is still a drug that is concerned about side effects on the heart. We here examined, using Chinese hamster ovary cells, the action of rosiglitazone on Kv1.5 channels, which is a major determinant of the duration of cardiac action potential. Rosiglitazone rapidly and reversibly inhibited Kv1.5 currents in a concentrationdependent manner (IC₅₀ = 18.9 μM) and accelerated the decay of Kv1.5 currents without modifying the activation kinetics. In addition, the deactivation of Kv1.5 current, assayed with tail current, was slowed by the drug. All of the results as well as the usedependence of the rosiglitazone-mediated blockade indicate that rosiglitazone acts on Kv1.5 channels as an open channel blocker. This study suggests that the cardiac side effects of rosiglitazone might be mediated in part by suppression of Kv1.5 channels, and therefore, raises a concern of using the drug for diabetic therapeutics.

• Proceedings of the Korean Biophysical Society Conference
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• 2001.06a
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• pp.36-36
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• 2001

Small conductance $Ca^{2＋}$-activated $K^{+}$ channels (or S $K_{Ca}$ channels) are a group of $K^{＋}$-selective ion channels activated by sub-micromolar concentrations of intracellular $Ca^{2＋}$ independent of membrane voltage. We expressed a cloned S $K_{Ca}$ channel, rSK2, in Xenopus oocytes and investigated the monovalent cation selectivity of the channels. We have used site-directed mutagenesis and macro-channel recordings to identify amino acid residues influencing the ion selectivity.(omitted)d)

• Korean Journal of Acupuncture
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• v.30 no.4
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• pp.305-318
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• 2013

Objectives : The aim of this study was to examine the effect of electroacupuncture(EA) at an acupoint, HT8(Sobu), on normal humans by using power spectral analysis. We examined the effect on the Heart Rate Variability(HRV), and the balance of the autonomic nervous system. Methods : Thirty-two healthy volunteers participated in this study. EEG(Electroencephalogram) power spectrum exhibits site-specific and state-related differences in specific frequency bands. A thirty-two channel EEG study was carried out on thirty-two subjects(14 males; mean age=23.5 years old, 18 females; mean age=21.5 years old). HRV and EEG were simultaneously recorded before and after acupuncture. Results : In the ${\alpha}$(alpha) band, during the HT8-acupoint treatment, the power values in the ${\alpha}$(alpha) band significantly decreased(p<0.05) at 28 channels. In the ${\beta}$(beta) band significantly decreased(p<0.05) at 26 channels. In ${\delta}$(delta) band significantly decreased(p<0.05) at 18 channels. In ${\theta}$(theta) band significantly decreased(p<0.05) at 20 channels. ${\alpha}/{\beta}$ values were increased at 6 channels and decreased at 10 channels.${\beta}/{\theta}$ values were increased at 10 channels and decreased at 19 channels. Mean-RR(RR-interval), Complexity, RMSSD(Root mean square of successive differences), SDSD(Standard deviations differences between adjacent normal R-R intervals), norm HF showed a significantly increased and mean-HRV, norm LF, LHR(LF/HF Ratio) showed a significantly decreased after HT8-acupoint treatment(p<0.05). Conclusions : These results suggest that EA at the HT8 mostly causes significant changes on alpha(28 channels), beta(26 channels), delta(18 channels), theta(20 channels) bands and mean-HRV, mean-RR, complexity, RMSSD, SDSD, norm LF, norm HF and LHR. If practicing EA at the HT8, it will regulate the function of the cerebral cortex, decrease activity of the sympathetic and increase parasympathetic nervous activity.

• Proceedings of the IEEK Conference
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• 2003.07e
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• pp.2052-2055
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• 2003

본 논문은 MDC의 전송 중 발생한 에러를 검출하고, 그 에러를 정정하는 알고리즘을 제안한다. 이 알고리즘은 기존의 MDC 와 같이 약간의 redundancy를 가지는 두 개의 sub-bitstream 을 생성하는데, 한쪽 sub-bitstream에 에러가 발생하였을 때, 다른 한쪽의 sub-bitstream을 이용하여, 발생한 비트 에러를 정정한다. 제안된 알고리즘에 대한 BER-SNR실험은 Generalized Gaussian source를 임의적으로 발생시켜서 결과를 얻어내었다. sub-bitstream에서 에러가 발생하였을 때 우리가 제안한 알고리즘은 BER<10/sup -3/에서 기존 알고리즘보다 약 12㏈ 높은 성능을 얻을 수 있었다.