• Bulletin of the Korean Chemical Society
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• v.32 no.1
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• pp.208-212
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• 2011

In this work, the calculated nuclear quadrupole coupling constants of $^{17}O$ in some styrylquinoline conformers were presented. The calculations were carried out to find the relationships between the charge distribution of styrylquinolines and their pharmaceutical behavior and to explore the differences among the electronic structures of some conformers of these potent HIV IN inhibitors. Furthermore, the HIV IN inhibitory of R1 and R2 rotamers was compared. On the basis of our results: - Charge density on oxygen atoms of carboxyl moiety has a dominant role in the drug activity. - The a conformer in which a divalent hydrogen atom is a link, has more capability in antiviral drug treatment. - The R1 conformer, as a $Mg^{+2}$ chelating agent, is better than R2 conformer and thus it is more inhibitor of HIV IN.

• Applied Biological Chemistry
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• v.41 no.4
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• pp.261-264
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• 1998

Differently substituted styrylquinoline derivatives (6-9) were synthesized by condensation of quinaldine (1) and corresponding substituted benzaldehydes (2-5). Their relative configuration at C11-C12 and coupling patterns were determined by NMR techniques.

• Bulletin of the Korean Chemical Society
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• v.27 no.11
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• pp.1888-1890
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• 2006