• 한국시뮬레이션학회논문지
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• 제11권2호
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• pp.55-66
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• 2002

VHDL has been. widely used in modeling and simulation of hardware designs. However, complex relationship between components of the designs makes the VHDL modeling problem very difficult. Furthermore, after the initial creation of VHDL models, they evolve into many versions over their lifetime. To cope with such difficulties, this paper proposes a new methodology for the management of VHDL models supporting versions. Its conceptual bases are system entity structure and relational database. Within the methodology, a family of hierarchical structures of a design is organized in the form of VHDL model structure. It is, in turn, represented in the form of relational tables. Once the model structure is built in such a way, a specific simulation model which meets design objective is pruned from the model structure. The details of VHDL codes are systematically synthesized by combining it with the primitive models in a model base. These algorithms are also defined in terms of relational algebraic operations.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2005년도 추계학술대회논문집
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• pp.217-222
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• 2005

Active vibration control of smart hull structure using Macro Fiber Composite (MFC) actuator is performed. Finite element modeling is used to obtain governing equations of motion and boundary effects of end-capped smart hull structure. Equivalent interdigitated electrode model is developed to obtain piezoelectric couplings of MFC actuator. Modal analysis is conducted to investigate the dynamic characteristics of the hull structure, and compared to the results of experimental investigation. MFC actuators are attached where the maximum control performance can be obtained. Active controller based on Linear Quadratic Gaussian (LQG) theory is designed to suppress vibration of smart hull structure. It is observed that closed loop damping can be improved with suitable weighting factors in the developed LQG controller and structural vibration is controlled effectively.

• BMB Reports
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• 제56권12호
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• pp.633-644
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• 2023

Epigenetic mechanisms, primarily mediated through histone and DNA modifications, play a pivotal role in orchestrating the functional identity of a cell and its response to environmental cues. Similarly, the spatial arrangement of chromatin within the three-dimensional (3D) nucleus has been recognized as a significant factor influencing genomic function. Investigating the relationship between epigenetic regulation and 3D chromatin structure has revealed correlation and causality between these processes, from the global alignment of average chromatin structure with chromatin marks to the nuanced correlations at smaller scales. This review aims to dissect the biological significance and the interplay between the epigenome and 3D chromatin structure, while also exploring the underlying molecular mechanisms. By synthesizing insights from both experimental and modeling perspectives, we seek to provide a comprehensive understanding of cellular functions.

• 대한토목학회논문집
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• 제32권1A호
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• pp.49-53
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• 2012

해안사면의 침식을 막기 위한 해안구조물이 해저면과의 경계면에서 파랑에 의하여 세굴이 발생 할 수 있으며, 세굴에 의한 기초지반의 유실로 해안구조물의 붕괴에 이를 수 있다. 이러한 세굴 현상을 방지하기 위하여 기존의 직립식 해안구조물을 다양한 형태의 해안구조물로 개선하여 제작할 수 있다. 이러한 해안구조물의 세굴 방지 효과를 검증하기 위해서는 많은 비용이 요구되는 조파 실험이 필요하다. 조파실험에 선행하여 모델링을 수행하고 실험결과의 검증 및 추가 분석을 하는 과정을 통해서 큰 비용 절감 효과를 기대할 수 있게 된다. 본 연구에서는 조파실험 해석기법을 제안하기 위해서 유한요소해석 프로그램인 LS-DYNA를 사용하여 유체-구조 상호 작용을 고려한 조파 실험 모델링을 하고, 해안구조물과 상호작용에 의한 유체 흐름을 분석하였다. 본 연구에서는 직립형, 경사형, 계단형, 사석형의 4가지 해안구조물의 세굴이 발생 가능성이 높은 위치를 선정하여 유속을 통하여 성능을 비교 분석하였다.

• 한국전산구조공학회논문집
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• 제31권1호
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• pp.1-8
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• 2018

본 연구의 목적은 강성 개폐식 대공간 건축물의 비정형 입체트러스를 파라메트릭 기법을 적용하여 모델링을 구현하는데 있다. 개폐식 대공간 건축물은 비선형성 형상을 모델링하거나 다수의 모델을 대안별로 생성, 해석, 검토하는 과정에 많은 시간과 기술이 소요되는 것이 현 실정이다. 이러한 문제점을 해결하기 위해서 첫째로, 개발에 사용된 파라메트릭 모델링 전산도구를 소개하고, 강성 개폐식 대공간 건축물의 비정형 입체트러스를 분석하며, 개발한 입체트러스의 파라메트릭 컴포넌트로 모델링을 구현하게 된다. 따라서 지붕이 개폐되는 방식으로 구분한 입체 트러스 종류의 모델링을 구현해 낼 수 있는 컴포넌트를 형상이나 기능에 따른 각각 대안별로 개발하여 효율적인 개폐식 지붕의 모델링을 가능하게 하는 것이 추후 연구사항이다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.785-791
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• 2005

Reconfigurability of machine tools is one of the critical factors to realize the responsive manufacturing systems to satisfy the mass-customization production. This paper presents the methods to model and simulate the machine tools on Internet in response to change in the machining requirements. Specifically, a set of module combination rules and a modeling method of the structure of machine tools using connectivity graph are developed. In response to the user requirements, kinematic relations and structures of machine tools can be derived using the module combination rules and connectivity graph relationships. Internet-based simulator of machine tools is implemented and presented. The developed machine tool simulator can be used to verify the structure of machine tools derived from the user requirements.

• 통합자연과학논문집
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• 제4권3호
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• pp.202-209
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• 2011

Tuberculosis is a major health problem in humans because of its multidrug resistance and discovering new treatments for this disease is urgently required. The synthesis of isoprenoids in Mycobacterium tuberculosis has been reported as an interesting pathway to target. In this context, 2C-methyl-D-erythritol 4-phosphate (MEP) pathway of M. tuberculosis has drawn attention. The MEP pathway begins with the condensation of glyceraldehyde 3-phosphate and pyruvate forming 1-deoxy-D-xylulose 5-phosphate (DXP) which is catalyzed by 1-deoxy-D-xylulose 5-phosphate synthase (DXS). As there is no X-ray structure was reported for this target, comparative modeling was used to generate the three dimensional structure. The structure was further validated by PROCHECK, VERIFY-3D, PROSA, ERRAT and WHATIF. Molecular docking studies was performed with the substrate (Thiamine pyrophosphate) and the reported inhibitor 2-methyl-3-(4-fluorophenyl)-5-(4-methoxy-phenyl)-4H-pyrazolol[1,5-a]pyrimidin-7-one) against the developed model to identify the crucial residues in the active site. This study may further be useful to provide structure based drug design.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 2004년도 추계학술대회 논문집
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• pp.382-387
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• 2004

As the increasing needs in the industrial filed, many studies for the 3D CAD system are carried out. There are two types of 3D CAD system. One is manifold modeler, the other is non-manifold modeler. In the manifold modeler only 3D objects can be modeled. In the non-manifold modeler 3D, 2D, 1D, and 0D objects can be modeled in a unified data structure. Recently there are many studies on the non-manifold modeler. Most of them are focused on finding unknown topological entities and representing all kinds of topological entities found. In this paper, efficient data structure is selected. The boundary information on a face and an edge is included in this data structure. The boundary information on a vertex is excluded considering the frequency of usage. Because the disk cycle information is not required in most case of modeling. It is compact. It stores essential non-manifold information such as loop cycle and radial cycle. A suitable Euler-Poincare equation is studied and selected. Using the efficient data structure and the selected Euler-Poincare equation, 18 basic Euler operators are implemented. Several 3D models are created using the implemented modeler. A non-manifold modeling can be carried out using the implemented 3D CAD system. The results of this paper could be used in the further studies such as an implementation of Boolean operators, and a translation of 2D CAD drawings to 3D models.

• 한국지구물리탐사학회:학술대회논문집
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• 한국지구물리탐사학회 2007년도 공동학술대회 논문집
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• pp.297-302
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• 2007

Recently, electrical resistivity survey is used in the various fields and applied to urban area with many electrical noises. Therefor it's necessary to observe the electrical noise effect of the geological structure. The physical scale modeling was conducted for measuring the electric noise effect of the two geological models at various distances, depths and diameters of the electric noise objects. The results are as following. 1. When conductive noise object was vertical to the strike of geological structure and moved to the strike direction, the effect of conductive noise object at various separated distances to the measurement line was disappeared at a half distance measurement line length regardless of electrode arrays. 2. When conductive noise object was vertical to the strike of geological structure and moved to the strike direction, the effect of conductive noise object at various depths was disappeared at 4unit apart from the measurement line regardless of electrode arrays. 3. When conductive noise object was vertical to the strike of geological structure and moved to the strike direction, the effect of conductive noise object at various diameters was disappeared at 4unit apart from the measurement line regardless of electrode arrays.

• Bulletin of the Korean Chemical Society
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• 제28권6호
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• pp.941-946
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• 2007

Bacillus halodurans O-methyltransferase (BhOMT) is a S-adenosylmethionine (SAM or AdoMet) dependent methyltransferase. Three dimensional structure of the BhOMT bound to S-adenosyl-L-homocysteine (SAH or AdoHcy) has been determined by comparative homology modeling. BhOMT has 40% sequence identity with caffeoyl-CoA 3-O-methyltransferase (CCoAOMT) from alfalfa. Based on x-ray structure of CCoAOMT, three dimensional structure of BhOMT was determined using MODELLER. The substrate binding sites of these two proteins showed slight differences, but these differences were important to characterize the substrate of BhOMT. Automated docking study showed that four flavonoids, quercetin, fisetin, myricetin, and luteolin which have two hydroxyl groups simultaneously at 3'- and 4'-position in the B-ring and structural rigidity of Cring resulting from the double bond characters between C2 and C3, were well docked as ligands of BhOMT. These flavonoids form stable hydrogen bondings with K211, R170, and hydroxyl group at 3'-position in the Bring has stable electrostatic interaction with Ca2+ ion in BhOMT. This study will be helpful to understand the biochemical function of BhOMT as an O-methyltransferase for flavonoids.