• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.5257-5261
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• 2012

Background: High incidence of breast cancer and its fatal effect has reached an alarming stage across the globe, including the third world countries. Many factors have been reported to be associated with the development of breast cancer but detailed structural and functional information is missing. CA 15-3 is one of the known potential tumor marker of breast cancer; however little is known about structure and functional site of this protein. Present study aims to investigate the functional role of CA 15-3 in breast cancer, especially in development and metastasis. Material and Methods: Hundred female breast cancer patients confirmed by histopathological reports were included in the study. Their physiological characters were recorded in a performa. Enzyme linked immunosorbent assay (ELISA) technique was used to estimate serum CA 15-3 level. Immunohistochemistry was done for estrogen (ER), progesterone (PR) and Her2/neu receptors expression. Results: The study revealed the details of physiological characteristics of female breast cancer. Mean age was $37.72{\pm}5.99$ and $55.05{\pm}7.28$ years and serum CA 15-3 (MUC1) level was $60.47{\pm}8.59$ and $63.17{\pm}4.58$ U/ml in pre and post-menopause respectively, and both groups of women had sedentary life style. Their receptor status especially of progesterone, estrogen and HER-2/neu were positive in 50% of premenopausal women and 65% of postmenopausal women. Conclusion: There are multiple physiological factors promoting breast cancer. High serum CA 15-3 level and hormonal imbalance of ER, PR and Her2/neu appears to be the main cause of breast cancer. It may be possible that the functional sites of these proteins may be altered which may increase the chances of metastasis in breast cancer.

• Journal of Korean Society of Steel Construction
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• v.20 no.6
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• pp.773-781
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• 2008

As buildings are becoming taller and longer-spanned, the requirements of high-strength and reliable steels are becoming increasingly stringent. Structural steels, however, acquire significantly different mechanical properties when their strength becomes higher. In this study, the mechanical properties, welding characteristics, and conformities of the 600MPa-grade high-strength steel were tested. The 600MPa-grade steel plates exhibited stable criterion strengthvalues and showed low carbon equivalents (${\mathcal{Ceq}}$) and composition (${\mathcal{Pcm}}$) as well as excellent welding hardness. In the tensile strength test, all the specimens were found to have strengths of over 600MPa. In the Sharphy impact test, the impact-absorbed energy of the V-notch specimens was shown to be 47J at the KS limit. Moreover, the maximum hardness of the specimens in the weld-heat-affected zone at a normal temperature was the same as that before welding. Their weld metal properties, however, were found not to be as good as those of high-strength steel. As such, the details of high-strength steel must be determined.

• Journal of Korean Society of Steel Construction
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• v.26 no.4
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• pp.361-373
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• 2014

As the height and beam span of buildings built in the construction market increase, increasingly higher quality is being required of the construction materials. In response to this trend, 800MPa tensile strength class steel was developed in domestic company. Currently, experiments applying flexural member, compression member, and connections are continuously conducted, but a design guideline for high strength steel has yet to be established. Among those construction materials, for the high strength steel beam-to-column connections, the evaluation of implementing ductile connections for the high strength steel beam-to-column connections is producing pessimistic results and the number of related researches is inadequate because of the high yield ratio, which is the characteristic of high strength steel. This study on implementation of ductile connections made of high strength steel was conducted using the connection detail as the variable, for the purpose of enhancing the deformation capacity of high strength steel beam-to-column connections. Cyclic loading test and nonlinear finite element analysis were conducted with full-scale mock-up connection models with the applied connection details. As a result, the structural performance of high-strength steel beam-to-column connection with presented detail was contented with demand of Special Moment Frames of KBC standard.

• Magazine of the Korean Society of Agricultural Engineers
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• v.41 no.6
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• pp.54-63
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• 1999

Considering that rural village had evolved through a long-sustained effort of harmnization with nature, there should be the wisdom not only to reflect the level of rural resident's housing demand, but also to conserve the traditional characteristics of high-valuation in the modern rural housing. In Korea , standard design proposals of rural houses had been made public three times ; in 1972 , 1984 and 1995. so , firstly, this study analysed the inner-space layouts of design proposals mentioned above, from which changes and problems in the past housing design were derived. And also, through, the positive acceptance of residents' opinion living inthe houses built by standard design proposals in 1970 ~1980's, improved design principles and an alternative model were proposed , finally. The inner-space structed of standard design proposals in 1970s was originated from small-scaled and low-priced one, basically under the " open system". In 1980s, the basic design principle changed to the 'closed system' in which the living room being the focus of indoor family life, and , in 1990s, progressively, therural housing developed to the high qualified type by the spatial enlargement and with increased equipements. However, this structural change of rural house brought about the problem of functional separatioon between farming and daily living activities. In details, limited spaces of multipurpose spaces and sanitary facility would be mentioned as problems for improvement. conclusively in this study, newoly arranged "open system" was recommended , as a basic design principle for theinner space structure formation of rural house, which easily links the constituent inner-house spaces to outer one. Based on this principle, the detailed design criterial was proposed as follows ; 1. The living room be directly linked to the front-yard and centrally placed, the addtional space of which could be secured for the special family events by the flexibleuse of its adjacent room or by the housing of male quarters(separated from main building quarter). 2. The kitchen also be directly linked to side-yard and to livng room , for the convenience of farming activities and the shortening of path flow housewife. 3. The expanded toilet-and-bathroom be placed in the directly connected left-hand side to the living room and also be allowed access through multipurpose spaces to out door. 4. The multipurpose spaces be directly connected to the kitchen and the toilet and-bathroom , of which function would be for undressing of working clothes, quickwashing and ordinary working.nd ordinary working.

• Journal of the Korea Concrete Institute
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• v.29 no.1
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• pp.43-51
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• 2017

As per current seismic design codes, diagonally reinforced coupling beams are restricted to coupling beams having aspect ratio below 4. However, a grouped diagonally reinforcement detail makes distribution of steel bars in the beam much harder, furthermore it may result in poor construction quality. This paper describes the experimental results of concrete coupling beam reinforced with high-strength steel bars (SD500 & SD600 grades). In order to improve workability for fabricating coupling beams, a headed large diameter steel bar was used in this study. Two full-scale coupling beams were fabricated and tested with variables of reinforcement details and aspect ratio. To reflect real behavior characteristic of the beam coupling shear walls, a rigid steel frame system with linked joints was set on the reaction floor. As a test result, it was noted that cracking and yielding of reinforcement were initially progressed at the coupling beam-to-shear wall joint, and were progressed to the mid-span of the coupling beam, based on the steel strain and failure modes. It was found that the coupling beams have sufficient deformation capacity for drift ratio of shear wall corresponding to the design displacement in FEMA 450-1. In this study, the headed horizontal steel bar was also efficient for coupling beams to exhibit shear performance required by seismic design codes. For detailed design for coupling beam reinforced with high-strength steel, however, research about the effect of variable aspect ratios on the structural behavior of coupling beam is suggested.

• Journal of the Korean Society of Hazard Mitigation
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• v.9 no.1
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• pp.41-47
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• 2009

Transverse rib web of orthotropic steel decks is highly susceptible to stress concentration due to out-of-plane and oil canning deformation caused by longitudinal rib distortion. In particular, stress concentrations are observed in the crossing point of longitudinal rib-transverse rib-deck plate, and cutout parts of transverse rib. The main objective of this study is to improve structure performance and to reduce the stress concentration of aforementioned susceptible parts. It is known that the installation of diaphragm alleviates stress concentrations between crossing point ant cutout. The influence of transverse rib placement and cutout width on stress concentrations was thoroughly investigated through numerical analyses. The numerical result showed that diaphragms produce the structural details for improved structure performance, when the transverse rib was placed in the same location with diaphragms. In any case, it is certain that the installation of diaphragms has more advantageous than the case without diaphragms in terms of structure performance of orthotropic steel decks. In this study, the distance ratio($y_i/y_{total}$) is defined as the ratio of the distance($y_{total}$) between the deck plate and longitudinal rib bottom to the distance($y_i$) between the deck plate and crossing point of longitudinal rib-transverse rib in cutout part. It has been found that the optimal distance ratio was 0.85 from the numerical simulation.

• Korean Journal of Heritage: History & Science
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• v.45 no.4
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• pp.74-91
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• 2012

This study puts its focus on Honjeon space which relatively small number of precedent studies chose as a subject of a study. The objective is to analyze Honjeon space's spatial relationship and palaces that consist Honjeon through analysis of spatial configuration and elements that affected construction of Honjeon space. The Royal Funeral, among other ceremonies of Joseon Dysnasty, carries religious characteristic along with functional and structural characteristics. By analyzing "National Five Rites", "Uigwe for the State Funeral 魂殿都監儀軌", and "Annals of Joseon Dynasty", the study organized elementary details about Honjeon space and surrounding spaces to determine the symbolism of Honjeon space's location at each palace and compared them to see if any systematical features existed between Honjeon spaces of each palace. Through this study, it was apparent the king mainly used Jaseongdang Hall of Gyeongbokgung in the early period of Joseon Dynasty and he mainly used Sunjeongjun of Changdeokgung while the queen used Munjeongjun of Changgyeonggung as the time reached the later period of Joseon Dynasty. Also in determination of Honjeon space, the study found that there were records of avoiding Pyeonjeon space in need for political space. The study also determined that places other than Pyeonjeon space was intended to be used for Honjeon space through the analysis which indicates that spaces that were initially used as Pyeonjun in the early Joseon Dynasty and simultaneously as Honjeon space were moved due to changes made in terms of theirs usages. Through the study, it could be also known that primary spaces of Honjeon was composed accordingly to "National Five Rites" and constant pattern of spaces existed among buildings near Honjeon which were arranged according to each palace's characteristic.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.12
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• pp.65-76
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• 2018

Due to the rapid demographic and structural changes, Korea has faced a variety of social issues and quickly entered the aged society since the 2000s. In order deal with this reality, diverse types of welfare policies are emerging in the society as a whole. The government began to supply domestic public silver housing in 2016 to provide against the quickly growing aged society and now, the government is planning to supply approximately 50,000 housing by 2022 for quantitative growth of aged society, by selecting 1st and 2nd designated areas for the project additionally. This public retirement(silver) housing combines 'space' with 'service'. The lower floors are a public silver welfare Facilities and the upper floors are a housing spaces. This type of housing is to deal with requirements of rental housing residents by combining physical space with supporting service. Based on barrier-free design, the complex and unit house have safety handles and alarm bells in the bathroom, undulating washstands, bathroom sliding doors, corridor safety handles, and emergency safety exit lamps in each housing unit so the aged and the disabled can use easily and conveniently. Also, hand rails are installed and stepped pulleys are removed to promote convenience. Currently, the government is planning to increase the supply, focusing on low-income groups, such as beneficiaries of national basic livelihood and the working poor. Recognizing that the public retirement(silver) housing project is at its early stage, this study examined satisfaction, based on evaluations of real residents. This study aimed to obtain more empirical research data and apply them to public retirement(silver) house space analysis. For analysis, this study targeted Wirye public retirement(silver) housing and Magnolia public retirement(silver) housing that are in operation, and literature review, previous research review, and field survey were conducted to examine the present state. Using the questionnaires consisting of four large classification items; Block Layout, Housing Unit, Welfare Facilities, and Barrier-free Design, and sub-details, a survey was conducted to analyze residents' satisfaction. In conclusion, it is anticipated that this study would serve as basic research data about public retirement(silver) housing to increase continuously in future by analyzing public retirement(silver) housing spaces, on the basis of the analyzed data.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.1A
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• pp.183-190
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• 2006

Minimizing the self weight of long-span deck slabs is one of the key factors for the practical and economic design of a composite two-girder bridge. In this paper, the minimum design thickness and rebar details of prestressed concrete deck slabs for composite two-girder bridges with girder span length from 4 m to 12 m are studied based on the safety and serviceability. The bridge deck slab with minimum thickness is designed as a one-way slab considering orthotropic behavior. Then fatigue safety of the deck slab is examined. Serviceability requirements for the deck slab such as deflection and crack width limits are also examined. The result shows that rebars with diameter less than 16 mm is recommended for the improved fatigue behavior, and, for the deck slab with span length longer than 8 m, the deflection limit governs the minimum design thickness. The result also shows that, for the deck slab with span length longer than 4 m, the distribution rebar requirement in the current Korea Highway Bridge Design Code is not sufficient to maintain the structural continuity in bridge axis as expected from the deck slab with span length shorter than 3 m.

• Earthquakes and Structures
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• v.23 no.4
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• pp.373-384
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• 2022

To improve the seismic performance of suspended ceiling structures, various vibration-damping devices have been developed. However, the devices made of metals have a limit in that they cause large deformation and seriously damages the exterior of the suspended ceiling structure from the wall. As a results, their strengthening effect of the suspended ceiling structure was minimal. Thus, this study employed a spring and vibration-proof rubber effectively controlled vibrations without increasing horizontal seismic loads on the ceiling to enhance the seismic resistance of suspended ceiling structures. The objective of the study is to examine the dynamic properties of a seismic damping-isolation unit (SDI) with various details developed. The developed SDI was composed of a spring, embossed rubbers, and prestressed bolts, which were the main factors enhancing the damping effect. The shaking table tests were performed on eight SDI specimens produced with the number of layers of embossed rubber (n_s), presence or absence of a spring, prestressed force magnitude introduced in bolts (f_ps), and mass weight (W_m) as the main parameters. To identify the enhancement effect of the SDI, the dynamic properties of the control specimen with a conventional hanger bolt were compared to those of the SDI specimens. The SDI specimens were effective in reducing the maximum acceleration (A_{c max}), acceleration amplification factor (α_p), relative displacement (δ_R), and increasing the damping ratio (ξ) when compared to the control specimen. The A_{c max}, α_p, and δ_R of the SDI specimens with two rubbers, spring, and f_ps of 0.1f_by, where f_by is the yielding strength of the screw bolt were 57.8%, 58.0%, and 61.9% lower than those of the conventional hanger bolt specimens, respectively, resulting in the highest ξ (=0.127). In addition, the α_p of the SDI specimens was 50.8% lower than those specified in ASCE 7 and FEMA 356. Consequently, to accurately estimate the α_p of the SDI specimens, a simple model was proposed based on the functions of f_ps, stiffness constant of the spring (K), W_m, and n_s.