• 제목/요약/키워드: Structural characterization

검색결과 968건 처리시간 0.028초

Recent advances in NMR-based structural characterization of αB-crystallin and its potential role in human diseases

  • Muniyappan, Srinivasan;Kim, Jin Hae
    • 한국자기공명학회논문지
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    • 제23권1호
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    • pp.26-32
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    • 2019
  • ${\alpha}B$-crystallin (${\alpha}BC$) is a member of a small heat-shock protein (sHSP) superfamily and plays a predominant role in cellular protein homeostasis network by rescuing misfolded proteins from irreversible aggregation. ${\alpha}BC$ assembles into dynamic and polydisperse high molecular weight complexes containing 12 to 48 monomers; this variable stereochemistry of ${\alpha}BC$ has been linked to quaternary subunit exchange and its chaperone activity. The chaperone activity of ${\alpha}BC$ poses great potential as therapeutic agents for various neurodegenerative diseases. In this mini-review, we briefly outline the recent advancement in structural characterization of ${\alpha}BCs$ and its potential role to inhibit protein misfolding and aggregation in various human diseases. In particular, nuclear magnetic resonance (NMR) spectroscopy and its complimentary techniques have contributed much to elucidate highly-dynamic nature of ${\alpha}BCs$, among which notable advancements are discussed in detail. We highlight the importance of resolving the structural details of various ${\alpha}BC$ oligomers, their quaternary dynamics, and structural heterogeneity.

Structural glass panels: An integrated system

  • Bidini, G.;Barelli, L.;Buratti, C.;Castori, G.;Belloni, E.;Merli, F.;Speranzini, E.
    • Smart Structures and Systems
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    • 제30권3호
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    • pp.327-332
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    • 2022
  • In building envelope, transparent components play an important role. The structural glazing systems are the weak element of the casing in terms of mechanical resistance, thermal and acoustic insulation. In the present work, new structural glass panels with granular aerogel in interspace were investigated from different points of view. In particular, the mechanical characterization was carried out in order to assess the resistance to bending of the single glazing pane. To this end, a special instrument system was built to define an alternative configuration of the coaxial double ring test, able to predict the fracture strength of glass large samples (400 × 400 mm) without overpressure. The thermal and lighting performance of an innovative double-glazing façade with granular aerogel was evaluated. An experimental campaign at pilot scale was developed: it is composed of two boxes of about 1.60 × 2 m2 and 2 m high together with an external weather station. The rooms, identical in terms of size, construction materials, and orientation, are equipped with a two-wing window in the south wall surface: the first one has a standard glazing solution (double glazing with air in interspace), the second room is equipped with the innovative double-glazing system with aerogel. The indoor mean air temperature and the surface temperature of the glass panes were monitored together with the illuminance data for the lighting characterization. Finally, a brief energy characterization of the performance of the material was carried out by means of dynamic simulation models when the proposed solution is applied to real case studies.

핵연료집합체 기계적특성 시험시설 구축과 기능시험 (Construction and Functional Tests of Fuel Assembly Mechanical Characterization Test Facility)

  • 이강희;강흥석;윤경호;양재호
    • 한국압력기기공학회 논문집
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    • 제12권1호
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    • pp.11-16
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    • 2016
  • Fuel assembly's mechanical characterization test facility (FAMeCT) in KAERI was constructed with upgraded functional features such as increased loading capacity, underwater vibration testing and severe earthquake simulation for extended fuel design guideline. This facility is designed and developed to provide out-pile fuel data for accident analysis model and fuel licensing. Functional tests of FAMeCT were performed to confirm functionality, structural integrity, and validity of newly-built fuel assembly mechanical test facility. Test program includes signal check of data acquisition system, load delivering capacity using real-sized fuel assemblies and a standard loading cylindrical rigid specimen. Fuel assembly's lateral bending test was carried out up to 30 mm of pull-out displacement. Limit case axial compression loading test up to 33 kN was performed to check structural integrity of UCPS (Upper Core Plate Simulator) support frame. Test results show that all test equipment and measurement system have acceptable range of alignment, signal to noise ratio, load carrying capacity limit without loss of integrity. This paper introduces newly constructed fuel assembly's mechanical test facility and summarizes results of functional test for the mechanical test equipment and data acquisition system.

Characterization of both adhesion and interfacial interaction between optical fiber coating and structural

  • Brotzu, A.;Felli, F.;Fiori, L.;Caponero, M.A.
    • Smart Structures and Systems
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    • 제4권4호
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    • pp.439-448
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    • 2008
  • Optical fiber sensors are by now broadly accepted as an innovative and reliable device for structural health monitoring, to be used either embedded into or bonded on structures. The accuracy of the strain measurement achievable by optical fiber sensors is critically dependent on the characteristics of the bonding of the various interface layers involved in the sensor bonding/embedding (structure material and gluing agent, fiber coating and gluing agent, fiber coating and fiber core). In fact, the signal of the bonded/embedded optical fiber sensor must correspond to the strain experienced by the monitored structure, but the quality of each involved interface can affect the strain transfer. This paper faces the characterization, carried on by both mechanical tests and morphological analysis, of the strain transfer function resulting with epoxidic and vinylester gluing agent on polyimide and acrylate coated optical fibers.

An experimental study on strength of hybrid mortar synthesis with epoxy resin, fly ash and quarry dust under mild condition

  • Sudheer, P.;Muni Reddy, M.G.;Adiseshu, S.
    • Advances in materials Research
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    • 제5권3호
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    • pp.171-179
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    • 2016
  • Fusion and characterization of bisphenol-A diglycidyl ether based thermosetting polymer mortars containing an epoxy resin, Fly ash and Rock sand are presented here for the Experimental study. The specimens have been prepared by means of an innovative process, in mild conditions, of commercial epoxy resin, Fly ash and Rock sand based paste. In this way, thermosetting based hybrid mortars characterized by a different content of normalized Fly ash and Rock sand by a homogeneous dispersion of the resin have been obtained. Once hardened, these new composite materials show improved compressive strength and toughness in respect to both the Fly ash and the Rock sand pastes since the Resin provides a more cohesive microstructure, with a reduced amount of micro cracks. The micro structural characterization allows pointing out the presence of an Interfacial Transition Zone similar to that observed in cement based mortars. A correlation between micro-structural features and mechanical properties of the mortar has also been studied.

방사선조사에 따른 원전 저압케이블용 절연재료의 특성분석 (Characterization of Insulation Materials for Low Voltage Cables in a Nuclear Power Plant with ${\gamma}$-Ray Irradiation)

  • 박정기;이우선;한재홍
    • 한국전기전자재료학회논문지
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    • 제14권5호
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    • pp.397-404
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    • 2001
  • This study describes the effect of γ-ray irradiation on the properties of insulation materials for low voltage cables in a nuclear power plant. The radiation effects were characterized by measuring OIT, FTIR, electrical properties of the irradiated specimens. As a result, they showed the decrease of OIT and the increase of chemical structural defects with the increase of γ-ray amount. Also, the electrical properties such as dielectrical constant, tan $\delta$ and current were changed by aging. These changes may come from the increase of chemical structural defects by $\delta$-ray irradiation.

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평균FRF를 이용한 장대교량의 동특성 (A Dynamic Characterization of Long Span Bridge Using Mean FRF)

  • 허광희;최만용;안병익
    • 한국구조물진단유지관리공학회 논문집
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    • 제4권1호
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    • pp.77-83
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    • 2000
  • 구조물의 동특성은 대형구조물을 상시감시 할 수 있는 장점으로 인하여 널리 활용된다. 상시감시를 위해 계측된 랜덤 데이터는 FFT를 통한 구조물의 동적 고유특성을 분석함으로써 이루어진다. 이 과정에서 Input Data와 Response Data사이에서 FFT Analyzer를 통하여 FRF가 측정된다. 특히 랜덤 데이터의 계측은 여건과 환경에 따라 발생하는 Noise로부터 가능한 정확한 FRF를 계측해야만 성공적인 구조물의 고유의 동적특성을 파악하게 된다. 랜덤 데이터에서 발생할 가능성이 높은 입력, 출력 Noise를 동시에 최소화 할 수 있는 새로운 개념의 FRF측정 알고리즘을 제안한다. 이 알고리즘에 의하여 장대형 모형교량으로부터 Modal 실험을 수행하여 계측된 동특성을 FE 해석 결과와 비교 평가하여 유용성을 제시한다.

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