• BMB Reports
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• v.35 no.3
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• pp.343-347
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• 2002

The human protein tyrosine kinase-6 (PTK6) polypeptide that is deduced from the cDNA sequence contains a Src homology (SH) 3 domain, SH2 domain, and catalytic domain of tyrosine kinase. We initiated biochemical and NMR characterization of PTK6 SH3 domain in order to correlate the structural role of the PTK6 using circular dichroism and heteronuclear NMR techniques. The circular dichroism data suggested that the secondary structural elements of the SH3 domain are mainly composed of $\beta$-sheet conformations. It is most stable when the pH is neutral based on the pH titration data. In addition, a number of cross peaks at the low-field area of the proton chemical shift of the NMR spectra indicated that the PTK6 SH3 domain retains a unique and folded conformation at the neutral pH condition. For other pH conditions, the SH3 domain became unstable and aggregated during NMR measurements, indicating that the structural stability is very sensitive to pH environments. Both the NMR and circular dichroism data indicate that the PTK6 SH3 domain experiences a conformational instability, even in an aqueous solution.

• International Journal of Aeronautical and Space Sciences
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• v.4 no.1
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• pp.53-62
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• 2003

In this study, nonlinear aeroelastic characteristics of an supersonic missile wing with strong shock interferences are investigated. The missile wing model has a freeplay structural nonlinearity at its pitch axis. To practically consider the effects of freeplay structural nonlinearity, the fictitious mass method is applied to structural vibration analysis based on finite element method. Nonlinear aerodynamic flows with unsteady shock waves are also considered in supersonic flow regions. To solve the nonlinear aeroelastic governing equations including the freeplay effect, a modal-based coupled time-marching technique based on the fictitious mass method is used in the time-domain. Various aeroelastic computations have been performed for the nonlinear wing structure model. Linear and nonlinear aeroelastic analyses have been conducted and compared with each other in supersonic flow regions. Typical nonlinear limit cycle oscillations and phase plots are presented to show the complex vibration phenomena with simultaneous fluid-structure nonlinearities.

• Structural Engineering and Mechanics
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• v.56 no.6
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• pp.917-938
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• 2015

The nonlinear numerical analysis of the impact response of reinforced concrete/mortar beam incorporated with the updated Lagrangian method, namely the Smoothed Particle Hydrodynamics (SPH) is carried out in this study. The analysis includes the simulation of the effects of high mass low velocity impact load falling on beam structures. Three material models to describe the localized failure of structural elements are: (1) linear pressure-sensitive yield criteria (Drucker-Prager type) in the pre-peak regime for the concrete/mortar meanwhile, the shear strain energy criterion (Von Mises) is applied for the steel reinforcement (2) nonlinear hardening law by means of modified linear Drucker-Prager envelope by employing the plane cap surface to simulate the irreversible plastic behavior of concrete/mortar (3) implementation of linear and nonlinear softening in tension and compression regions, respectively, to express the complex behavior of concrete material during short time loading condition. Validation upon existing experimental test results is conducted, from which the impact behavior of concrete beams are best described using the SPH model adopting an average velocity and erosion algorithm, where instability in terms of numerical fragmentation is reduced considerably.

• Steel and Composite Structures
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• v.23 no.6
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• pp.691-714
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• 2017

Rotating fluid induced vibration and instability of embedded piezoelectric nano-composite separators subjected to magnetic and electric fields is the main contribution of present work. The separator is modeled with cylindrical shell element and the structural damping effects are considered by Kelvin-Voigt model. Single-walled carbon nanotubes (SWCNTs) are used as reinforcement and effective material properties are obtained by mixture rule. The perturbation velocity potential in conjunction with the linearized Bernoulli formula is used for describing the rotating fluid motion. The orthotropic surrounding elastic medium is considered by spring, damper and shear constants. The governing equations are derived on the bases of classical shell theory (CST), first order shear deformation theory (FSDT) and sinusoidal shear deformation theory (SSDT). The nonlinear frequency and critical angular fluid velocity are calculated by differential quadrature method (DQM). The detailed parametric study is conducted, focusing on the combined effects of the external voltage, magnetic field, visco-Pasternak foundation, structural damping and volume percent of SWCNTs on the stability of structure. The numerical results are validated with other published works as well as comparing results obtained by three theories. Numerical results indicate that with increasing volume fraction of SWCNTs, the frequency and critical angular fluid velocity are increased.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.30 no.5 s.248
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• pp.397-404
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• 2006

Effects of surface defect distribution on flame instability during flame-surface interaction are experimentally investigated. To examine chemical quenching phenomenon which is caused by radical adsorption and recombination processes on the surface, thermally grown silicon oxide plates with well-defined defect density were prepared. ion implantation technique was used to control the number of defects, i.e. oxygen vacancies. In an attempt to preferentially remove oxygen atoms from silicon dioxide surface, argon ions with low energy level from 3keV to 5keV were irradiated at the incident angle of $60^{\circ}$. Compositional and structural modification of $SiO_2$ induced by low-energy $Ar^+$ ion irradiation has been characterized by Atomic Force Microscopy (AFM) and X-ray Photoelectron Spectroscopy (XPS). It has been found that as the ion energy is increased, the number of structural defect is also increased and non-stoichiometric condition of $SiO_x({\le}2)$ is enhanced.

• Coupled systems mechanics
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• v.6 no.1
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• pp.29-40
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• 2017

This work employed density functional theory to investigate the structural and ferroelectric properties of the Ruddlesden-Popper (RP) phase of lead titanate, $Pb_2TiO_4$, as well as its phase transitions with epitaxial strain. A wealth of novel structural instabilities, which are absent in the host $PbTiO_3$ material, were identified in the RP phase through phonon soft-mode analysis. Our calculations showed that the ground state of $Pb_2TiO_4$ is antiferroelectric, distinct from the dominant ferroelectric phase in the corresponding host material. In addition, applied epitaxial strain was found to play a key role in the interactions among the instabilities. The induction of a sequence of antiferroelectric and antiferrodistortive (AFD) phase transitions by epitaxial strain was demonstrated, in which the ferroic instability and AFD distortion were cooperative rather than competitive, as is the case in the host $PbTiO_3$. The RP phase in conjunction with strain engineering thus represents a new approach to creating ferroic orders and modifying the interplay among structural instabilities in the same constituent materials, enabling us to tailor the functionality of perovskite oxides for novel device applications.

• Structural Engineering and Mechanics
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• v.82 no.4
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• pp.517-542
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• 2022

The effect of mean angle of wind attack on the flutter critical wind speed of two generic bridge deck cross-sections, viz, one closed box type streamlined section (deck-1) and closed box trapezoidal bluff type section with extended flanges/overhangs (deck-2) type of section have been studied using Computational Fluid Dynamics (CFD) based forced vibration simulation method. Owing to the importance of the effect of the amplitude of forcing oscillation on the flutter onset, its effect on the flutter derivatives and flutter onset have been studied, especially at non-zero mean angles of wind attack. The flutter derivatives obtained have been used to evaluate flutter critical wind speeds and flutter index of the deck sections at non-zero mean angles of wind attack studied and the same have been validated with those based on experimental results reported in literature. The value of amplitude of forcing oscillation in torsional degree of freedom for CFD based simulations is suggested to be in the range of 0.5° to 2°, especially for bluff bridge deck sections. Early onset of flutter from numerical simulations, thereby conservative estimate of occurrence of instability has been observed from numerical simulations in case of bluff bridge deck section. The study aids in gaining confidence and the extent of applicability of CFD during early stages of bridge design, especially towards carrying out studies on mean incident wind effects.

• Journal of the Korea Convergence Society
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• v.10 no.12
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• pp.337-343
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• 2019

The need for preparation for old life has been further increased due to the increase of the elderly population and changes in economic conditions today. The purpose of this study is to analyze the relationship between income instability and the degree of preparation for old life and satisfaction of current life. The key variables were extracted through prior study review. And the data collected through the survey were statistically analyzed with a structural equation model. The analysis found that the indirect effect of the current income risk on the satisfaction of current life through the preparation for old life had a significant negative effect under the statistically significant level of 0.05. However, it was found that the direct effects of current income risk on the satisfaction of current life were not statistically significant. An additional analysis was conducted by dividing the age, the number of dependents by two groups respectively. To summarize the results, preparation for old life played a significant role as a prerequisite for improving the satisfaction of current life. And the variability(risk) of current income played an important role in preparing for old life. At this time, the degree of relevance between the factors(potential variables) differed somewhat between the two groups. The results of this analysis will be meaningful in providing basic source of data to prepare for a satisfactory life in each individual's current situation. This study, meanwhile, has limitations that have only been done with cross-sectional analysis and would like to analyze time-series changes in the future.

• Journal of Korean Neurosurgical Society
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• v.65 no.2
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• pp.287-296
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• 2022

Objective : Although radiotherapy (RT) is recommended for multiple myeloma (MM) involving spine, the treatment of choice between reconstructive surgery with RT and RT alone for pathologic vertebral fractures (PVFs) associated with structural instability or neurologic compromises remains controversial. The purpose of this study was to evaluate the clinical efficacies of reconstructive surgery with adjuvant RT for treatment of MM with PVFs by comparing with matched cohorts treated with RT alone. Methods : Twenty-eight patients underwent reconstructive surgery followed by RT between 2008 and 2015 in a single institution, for management of PVFs associated with structural instability of the spine and/or neurologic compromises (group I). Twenty-eight patients were treated with RT alone (group II) after propensity score matching in a 1-to-1 format based on instability of the spine, as well as age and performance. Clinical outcomes including the overall survival rates, duration of independent ambulation, neurological status, and numeric rating scale (NRS) for back pain were compared. Results : Clinical and radiological features before treatment were similar in both groups. The median survival period was similar between the two groups. However, the mean duration of independent ambulation was significantly longer in group I (88.8 months; 95% confidence interval [CI], 66.0-111.5) than in group II (39.4 months; 95% CI, 25.2-53.6) (log rank test; p=0.022). Deterioration of Frankel grade (21.4% vs. 60.7%, p=0.024) and NRS for back pain (2.7±2.2 vs. 5.0±2.7, p=0.000) at the last follow-up were higher in the group II. Treatment-related complications were similar in both groups. Conclusion : In patients with unstable PVFs due to MM, reconstructive surgery may yield superior clinical outcomes compared with RT alone in maintaining independent ambulation and neurological status, as well as pain control despite similar median survival and complications.

• Journal of the Society of Naval Architects of Korea
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• v.61 no.2
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• pp.115-124
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• 2024

To detect and prevent structural damage caused by various loads on marine structures and ships, structural health monitoring procedure is essential. Estimating loads acting on the structures which are measured by sensors that are mounted properly are crucial for structural health monitoring. However, attaching an excessive number of sensors to the structure without consideration can be inefficient due to the high costs involved and the potential for inducing structural instability. In this study, we introduce a method to determine the optimal number of sensors and their optimized locations for strain measurement sensors, allowing for accurate load estimation throughout the structure using model expansion method. To estimate the loads exerted on the entire structure with minimal sensors, we construct a strain-load interpolation matrix using the strain mode shapes of the finite element (FE) model and select the optimal sensor locations by applying D-Optimal Design and the row exchange algorithm. Finally, we estimate the loads exerted on the entire structure using the model expansion method. To validate the proposed method, we compare the results obtained by applying the optimal sensor placement and model expansion method to an FE model subjected to arbitrary loads with the loads exerted on the entire FE model, demonstrating efficiency and accuracy.