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  • Title/Summary/Keyword: Structural Flexibility

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Molecular dynamics simulations approaches for discovering anti-influenza drug

  • Cho, Sungjoon;Choi, Youngjin
    • CELLMED
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    • v.6 no.4
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    • pp.24.1-24.4
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    • 2016
  • The emergence of influenza virus and antigenic drift are potential cause of world-wide pandemic. There are some commercially available drugs in the market to treat influenza. During past decade, however, critical resistances have been raised for biological targets. Because of structural complexity and flexibility of target proteins, applying a computational modeling tool is very beneficial for developing alternative anti-influenza drugs. In this review, we introduced molecular dynamics (MD) simulations approach to reflect full conformational flexibility of proteins during molecular modeling works. Case studies of MD works were summarized for the drug discovery and drug resistance mechanism of anti-influenza pharmaceuticals.

Telerobotic operations of structurally flexible, long-reach manipulators

  • Kwon, Dong-Soo;Hwang, Dong-Hwan;Badcock, Scott-M.
    • 제어로봇시스템학회:학술대회논문집
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    • 1993.10a
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    • pp.825-829
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    • 1993
  • As a part of the Department of Energy's Environmental Restoration and Waste Management Program, long-reach manipulators are being considered for the retrieval of waste from large storage tanks. Long-reach manipulators may have characteristics significantly different from those of typical industrial robots because of the flexibility of long links needed to cover the large workspace. To avoid structural vibrations during operation, control algorithms employing various types of shaping filters were investigated. A new approach that uses imbedded simulation was developed and compared with others. In the new approach, generation of joint trajectories considering link flexibility was also investigated.

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An inverse dynamic trajectory planning for the end-point tracking control of a flexible manipulator

  • Kwon, Dong-Soo;Babcock, Scott-M.;Book, Wayne-J.
    • 제어로봇시스템학회:학술대회논문집
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    • 1992.10b
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    • pp.599-606
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    • 1992
  • A manipulator system that needs significantly large workspace volume and high payload capacity has greater link flexibility than typical industrial robots and teleoperators. If link flexibility is significant, position control of the manipulator's end-effector exhibits the nonminimum phase, noncollocated, and flexible structure system control problems. This paper addresses inverse dynamic trajectory planning issues of a flexible manipulator. The inverse dynamic equation of a flexible manipulator was solved in the time domain. By dividing the inverse system equation into the causal part and the anticausal part, the inverse dynamic method calculates the feedforward torque and the trajectories of all state variables that do not excite structural vibrations for a given end-point trajectory. Through simulation and experiment with a single-Unk flexible manipulator, the effectiveness of the inverse dynamic method has been demonstrated.

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MultiRing An Efficient Hardware Accelerator for Design Rule Checking (멀티링 설계규칙검사를 위한 효과적인 하드웨어 가속기)

  • 노길수;경종민
    • Journal of the Korean Institute of Telematics and Electronics
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    • v.24 no.6
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    • pp.1040-1048
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    • 1987
  • We propose a hardware architecture called Multiring which is applicable for various geometrical operations on rectilinear objects such as design rule checking in VLSI layout and many image processing operations including noise suppression and coutour extraction. It has both a fast execution speed and extremely high flexibility. The whole architecture is mainly divided into four parts` I/O between host and Multiring, ring memory, linear processor array and instruction decoder. Data transmission between host and Multiring is bit serial thereby reducing the bandwidth requirement for teh channel and the number of external pins, while each row data in the bit map stored in ring memory is processed in the corresponding processor in full parallelism. Each processor is simultaneously configured by the instruction decoder/controller to perform one of the 16 basic instructions such as Boolean (AND, OR, NOT, and Copy), geometrical(Expand and Shrink), and I/O operations each ring cycle, which gives Multiring maximal flexibility in terms of design rule change or the instruction set enhancement. Correct functional behavior of Multiring was confirmed by successfully running a software simulator having one-to-one structural correspondence to the Multiring hardware.

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Computationally efficient 3D finite element modeling of RC structures

  • Markou, George;Papadrakakis, Manolis
    • Computers and Concrete
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    • v.12 no.4
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    • pp.443-498
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    • 2013
  • A detailed finite element modeling is presented for the simulation of the nonlinear behavior of reinforced concrete structures which manages to predict the nonlinear behavior of four different experimental setups with computational efficiency, robustness and accuracy. The proposed modeling method uses 8-node hexahedral isoparametric elements for the discretization of concrete. Steel rebars may have any orientation inside the solid concrete elements allowing the simulation of longitudinal as well as transverse reinforcement. Concrete cracking is treated with the smeared crack approach, while steel reinforcement is modeled with the natural beam-column flexibility-based element that takes into consideration shear and bending stiffness. The performance of the proposed modeling is demonstrated by comparing the numerical predictions with existing experimental and numerical results in the literature as well as with those of a commercial code. The results show that the proposed refined simulation predicts accurately the nonlinear inelastic behavior of reinforced concrete structures achieving numerical robustness and computational efficiency.

Dynamic Analysis of a 4-Axis Nano Imprinting Stage Mechanism considering Flexibility (유연성을 고려한 4축 나노임프린팅 스테이지의 동적 해석)

  • Park, Sung-Bin;Jeong, Jae-I.;Yim, Hong-Jae
    • Proceedings of the KSME Conference
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    • 2008.11a
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    • pp.844-849
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    • 2008
  • A nano-imprinting stage has been widely used in various fields of nano-technology. In this study, A 4-axis nano-imprinting stage is modeled with using the 3D-CAD Tool. Structural components such as an upper-plate, bearings and cross-roller-guides are modeled with finite elements to analyze flexibility effect during the precision stage motion. In addition, Dynamic analysis is executed to reproduce actual motion of 4-axis nano imprinting stage.

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Fabrication of Organic-Inorganic Nanohybrid Semiconductors for Flexible Electronic Device

  • Han, Gyu-Seok;Jeong, Hui-Chan;Gwon, Deok-Hyeon;Seong, Myeong-Mo
    • Proceedings of the Korean Vacuum Society Conference
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    • 2011.02a
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    • pp.114-114
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    • 2011
  • We report a high-performance and air-stable flexible and invisible semiconductor which can be substitute for the n-type organic semiconductors. N-type organic-inorganic nanohybrid superlattices were developed for active semiconducting channel layers of thin film transistors at low temperature of 150C by using molecular layer deposition with atomic layer deposition. In these nanohybrid superlattices, self-assembled organic layers (SAOLs) offer structural flexibility, whereas ZnO inorganic layers provide the potential for semiconducting properties, and thermal and mechanical stability. The prepared SAOLs-ZnO nanohybrid thin films exhibited good flexibility, transparent in the visible range, and excellent field effect mobility (> 7cm2/Vs) under low voltage operation (from -1 to 3V). The nanohybrid semiconductor is also compatible with pentacene in p-n junction diodes.

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Current Issues of Healthcare Research and Development in Korea (한국 보건의료 연구개발의 현황과 과제)

  • Kim, Kwangjum
    • Health Policy and Management
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    • v.28 no.3
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    • pp.280-287
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    • 2018
  • There has been much efforts to facilitate healthcare innovation and many desirable outcomes were produced in Korea. However, some structural deficiencies were found. They are misalignment of research and development (R&D) subjects with healthcare system, lack of flexibility of current healthcare system to accommodate the radically innovative products, and lack of cooperation among innovation agent. Some suggestions to correct these deficiencies are discussed. The suggestions are as follows: relating Korean healthcare R&D to healthcare system, enhancement of institutional flexibility to allow innovative application of new technology, improvement of the R&D process, and reexamination of the role of academic medical centers.

Dynamic Response Characteristics of Tension Leg Platforms with Flexibility Variations in Waves (굽힘강성 변화에 따른 인장계류식 해양구조물의 동적응답 특성)

  • Lee, Chang-Ho;Choi, Chan-Moon;Hong, Bong ki
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.32 no.2
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    • pp.191-204
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    • 1996
  • The dynamic response characteristics with flexibility variations are examined for presenting the basic data for design of Tension Leg Platforms(TLPs)in waves. A numerical approach is based on the dynamic response analysis theory, in which the superstructure of TLPs is assumed flexible instead of the rigid body assumption used in two-step analysis method. The hydrodynamic interactions among TLP members, such as columns and pontoons are not included in the motion and structural analyse. The equations of motion of a whole structure are formulated using element-fixed coordinate systems which have the origin at the node of the each hull element.

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Experimental investigation of reinforced concrete columns retrofitted with polyester sheet

  • Chang, Chunho;Kim, Sung Jig;Park, Dongbyung;Choi, Sunghun
    • Earthquakes and Structures
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    • v.6 no.3
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    • pp.237-250
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    • 2014
  • This paper experimentally investigates the seismic performance of RC columns retrofitted with Super Reinforcement with Flexibility (SRF), which is a polyester fiber reinforced polymer. A total of three specimens with a scale factor of 1/2 were constructed and tested in order to assess the structural behavior of the retrofitted RC columns. One specimen was a non-seismically designed column without any retrofit, while others were retrofitted with either one or two layers of the polyester belt with urethane as the adhesive. Static cyclic testing with a constant axial load was conducted to assess the seismic performance of the retrofitted RC columns. It is concluded that the SRF retrofitting method increases the strength and ductility of the RC columns and can also impact on the failure mode of the columns.