• 정신신체의학
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• 제9권1호
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• pp.93-102
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• 2001

이완반응은 갚은 휴식상태를 말하며, 소위 스트레스반응으로 불리는 투쟁-도피 반응의 생리적 변화와 반대되는 생리적 변화를 일으키게 된다. 따라서 인위적으로 이완반응을 일으킴으로써 이러한 스트레스 반응을 상쇄시킬 수 있다. 이러한 이완반응을 일으킬 수 있는 복식호흡, 명상, 점진적 근육이완기법, 자율이완훈련, 생체되먹이기법 등의 다양한 이완기법들이 제시되어 왔으며, 이들은 다양한 신체, 정신 질환뿐만 아니라 정상적인 스트레스 관리 프로그램에 있어서도 마음과 신체의 안녕을 위해 유익한 도움을 줄 수 있음이 알려져 있다. 이러한 이완기법들은 스트레스 관리를 위한 전체적 과정의 한 부분으로 이해되어야 할 것이며, 자신에 맞는 적절한 기법을 찾아 지속적인 훈련을 함으로써 효과적인 스트레스 관리 방법으로서의 역할을 할 수 있을 것이다. 이에 본 저자는 명상, 점진적 근육이완기법, 자율이완훈련 및 기타 이완기법에 대한 보다 구체적이고 실제적인 방법을 제시하고자 한다. 스트레스와 관련된 다양한 신체, 정신 질환들에 대한 치료적 접근을 함에 있어서, 전통적 치료 방법에 병합하여 이완기법을 사용함으로써 스트레스와 질병 사이의 조절자로 이용할 수 있을 것이다.

• Fisheries and Aquatic Sciences
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• 제19권4호
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• pp.18.1-18.10
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• 2016

In this study, to clarify the function of $PoPLC-{\beta}1$, in response to stress challenge, we examined the $PoPLC-{\beta}1$ expression pattern in response to external stress (pathogen-associated molecular pathogen challenge and environmental challenge including temperature and salinity). $PoPLC-{\beta}1$ expression analysis of tissue from olive flounder showed that the messenger RNA (mRNA) was predominantly expressed in the brain, heart, eye, liver, spleen, and stomach. We also tested the mRNA expression of the $PoPLC-{\beta}1$ in the spleen and kidney of olive flounder by RT-PCR and real-time PCR following stimulation with lipopolysaccharide (LPS), concanavalin A (ConA), or polyinosinic:polycytidylic acid (PolyI:C) and compared with the inflammatory cytokines IL-1b and IL-6 in the stimulated flounder tissues. Each of the spleen and kidney and mRNA transcripts of $PoPLC-{\beta}1$ were increased 30- and 10-fold than normal tissue at 1-6 h post injection (HPI) with PolyI:C when the expression of $PoPLC-{\beta}1$ transcript was similar to LPS and ConA. We also tested the expression of $PoPLC-{\beta}1$ in response to temperature and salinity stress. The expression of $PoPLC-{\beta}1$ also was affected by temperature and salinity stress. Our results provide clear evidence that the olive flounder $PLC-{\beta}1$ signal pathways may play a critical role in immune function at the cellular level and in inflammation reactions. In addition, $PLC-{\beta}1$ appears to act as an oxidative-stress suppressor to prevent cell damage in fish.

• The Korean Journal of Physiology and Pharmacology
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• 제1권5호
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• pp.523-528
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• 1997

Peripheral benzodiazepine receptor(PBR) has been indentified in various peripheral tissues including kidney. The physiological and pharmacological functions of PBR are still uncertain, althought it has been suggested that these are associated with the regulation of stress/anxiety response. Diazepam progeny, which were exposed to diazepam perinatally, was reported to be an animal model of chronic anxiety. However, PBR in the diazepam progenies are not known yet. In the present study, therefore, we examined the changes of PBR in the stress/anxiety response. Dams of rats were given injection of diazepam or vehicle during puerperium. Diazepam progenies showed increased level of anxiety on the performance of elevated plus maze, and increased Bmax of PBR. Saturation experiments followed by scatchard analysis of the results showed that the increase in the density of PBR and the affinity of the PBR remained unchanged. Forced swim stress increased anxiety on the plus maze in both groups of rats. In contrast to control, diazepam progenies did not show further upregulation of renal PBR immediately after swimming stress, but still higher than control. From the above results, it may be concluded that upregulation of renal PBR is associated with chronic anxiety as well as stress-induced response.

• 대한한의학방제학회지
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• 제26권4호
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• pp.307-318
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• 2018

Objectives : Endoplasmic reticulum (ER) stress designates cellular responses to the accumulation of misfolded and unfolded proteins in ER, which is related to a variety of liver diseases. Present study investigated the inhibitory effects of Litsea japonica flesh water extract (LJE) aganist ER stress. Methods : After HepG2 cells were pretreated with LJE and subsequently exposed to tunicamycin (Tm) or thapsigargin (Tg), expression of C/EBP homologous protein (CHOP), glucose regulated protein 78 kDa (GRP78), asparagine synthetase (ASNS), and endoplasmic reticulum DnaJ homologue 4 (ERDJ4) were determined by immunoblot and real-time PCR analysis. Three canonical signaling pathways in response to ER stress were examined to explore molecular mechanisms involved. Results : Pretreatment of 1 mg/mL LJE inhibited Tm- or Tg-induced CHOP expression, while L. japonica fruit water extract did not. In addition, LJE decreased the levels of GRP78, ASNS, and ERDJ4 mRNA by Tm. Moreover, phosphorylations of eukaryotic translation initiation factor $2{\alpha}$ and inositol-requiring enzyme 1, expression of nuclear form of activating transcription factor $6{\alpha}$, and transactivation of ER stress response element- and unfolded protein response element-harboring luciferase activities were inhibited by LJE pretreatment. Conclusions : Present results suggest that LJE would be a candidate to prevent or treat ER stress-mediated liver injuries.

• Animal Bioscience
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• 제34권1호
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• pp.134-142
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• 2021

Objective: To understand the athletic characteristics of Thoroughbreds, high-throughput analysis has been conducted using horse muscle tissue. However, an in vitro system has been lacking for studying and validating genes from in silico data. The aim of this study is to validate genes from differentially expressed genes (DEGs) of our previous RNA-sequencing data in vitro. Also, we investigated the effects of exercise-induced stress including heat, oxidative, hypoxic and cortisol stress on horse skeletal muscle derived cells with the top six upregulated genes of DEGs. Methods: Enriched pathway analysis was conducted using the Database for Annotation, Visualization, and Integrated Discovery (DAVID) tool with upregulated genes in horse skeletal muscle tissue after exercise. Among the candidates, the top six genes were analysed through geneMANIA to investigate gene networks. Muscle cells derived from neonatal horse skeletal tissue were maintained and subjected to exercise-related stressors. Transcriptional changes in the top six genes followed by stressors were investigated using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Results: The inflammation response pathway was the most commonly upregulated pathway after horse exercise. Under non-cytotoxic conditions of exercise-related stressors, the transcriptional response of the top six genes was different among types of stress. Oxidative stress yielded the most similar expression pattern to DEGs. Conclusion: Our results indicate that transcriptional change after horse exercise in skeletal muscle tissue strongly relates to stress response. The qRT-PCR results showed that stressors contribute differently to the transcriptional regulation. These results would be valuable information to understand horse exercise in the stress aspect.

• 사물인터넷융복합논문지
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• 제7권2호
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• pp.31-40
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• 2021

본 연구는 간호대학생의 임상실습중 경험하는 언어폭력, 감정반응, 간호전문직관, 임상실습 스트레스 정도를 파악하고 임상실습 스트레스에 영향을 미치는 요인들을 확인하기 위하여 시도되었다. 연구 대상은 4년제 간호대학 4학년에 재학중인 간호대학생 106명이였으며 측정 도구는 언어폭력, 감정반응, 간호전문직관, 임상실습스트레스에 관한 문항으로 구성되었다. 언어폭력, 감정반응, 간호전문직관, 임상실습스트레스 정도는 기술통계로 분석하였고 언어폭력, 감정반응, 간호전문직관, 임상실습스트레스간의 상관관계는 Pearson correlation coefficients, 임상실습스트레스에 영향을 미치는 요인은 다중 선형 회귀분석(Multiple linear regression)을 적용하였다. 임상실습스트레스는 언어폭력, 감정반응과 유의한 정적상관성이 있는 것으로 나타났다(r=.683, r=.573). 유의미한 영향요인으로 언어폭력(𝛽=.487), 감정반응(𝛽=.240)순으로 임상실습스트레스의 49%를 설명하였다. 본 연구의 결과를 토대로 간호대학생들이 임상실습중 언어폭력에 대처하고 임상실습스트레스를 관리하기 위한 전략개발에 기초자료를 제공하고자 한다.

• Structural Engineering and Mechanics
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• 제26권4호
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• pp.393-408
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• 2007

The effects of material nonhomogeneity and nonisothermal conditions on the stress response of pressurized tubes are assessed by virtue of a computational model. The modulus of elasticity, the Poisson's ratio, the yield strength, and the coefficient of thermal expansion, are assumed to vary nonlinearly in the tube. A logarithmic temperature distribution within the tube is proposed. Under these conditions, it is shown that the stress states and the magnitudes of response variables are affected significantly by both the material nonhomogeneity and the existence of the radial temperature gradient.

• Wind and Structures
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• 제15권4호
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• pp.301-311
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• 2012

This paper presents results from the structural monitoring of a steel wind tower characterized and presented in Part I of the paper. Monitoring period corresponds to about fifteen months of measurements. Results presented refer to stress distribution on shell and in bolts at different heights, stress fatigue spectra, section forces along height evaluated from the stress measurements and comparison with design forces, dynamic response in terms of accelerations, stresses, deflections and rotations.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제16권2호
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• pp.261-269
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• 2005

연구 목적 : 본 연구는 가벼운 비행을 저지른 '훈방대상 비행청소년'을 대상으로 분노, 분노대처, 스트레스반응 각각의 특성과 이들의 성별, 학년에 따른 차이를 파악하기 위하여 시행되었다. 방법 : 본 연구의 대상자는 서울시 '사랑의 교실' (비행예방 프로그램)에 참석한 비행청소년 285명과 서울시내 일반청소년 391명(남 : 377명, 여 : 299명/중 346명, 고 : 330명)이었으며, 이들에게 한국판 상태-특성분노표현척도와 사건충격척도를 실시하였다. 결과 : 1) 비행청소년은 일반청소년에 비해서 상태분노, 특성분노, 전체분노 분노표출은 높았고 분노억제, 분노조절, 스트레스반응은 낮았다. 2) 남자 비행청소년이 여자 비행청소년보다 분노조절과 스트레스반응이 더 높았고 분노에서는 유의미한 차이가 없었다. 3) 고등학교 비행청소년에서 중학교 비행청소년에 비해서 특성분노와 분노조절이 더 높았고, 고등학교 일반청소년이 중학교 일반청소년에서보다 스트레스반응이 더 높았다. 결론 : '훈방대상 비행청소년'은 일반청소년과는 분노, 분노대처, 스트레스반응에서 차이를 보였으며, 학년과 성별에 따라서도 차이를 보였다. 이러한 특성들은 이들을 대상으로 하는 프로그램에 더욱 쉽고 효과적으로 적용 될 수 있다.

• 대한간호학회지
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• 제33권6호
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• pp.693-704
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• 2003

Purpose: The purpose of this study was to determine whether a relaxing music was effective in reducing stress response of patients admitted to a coronary care unit with the diagnosis of acute myocardial infarction. Method: The research design was the chosen convenience sample of a randomized control group pre-posttest quasi-experimental design. Forty patients, 20 for an experimental group and another 20 for control group. The study was to provide the patients three different kinds of relaxing music. The experimental group listened to relaxing music for a 20-minute one time a day for 3days. The control group was just provided with a 20-minute period of rest. Test for hypothesis was done by repeated measured ANOV A. Result: The experimental group which received relaxing music showed a significantly lower level of electrodermal response, myocardial oxygen consumption and respiration rate, and a higher level of peripheral skin temperature than the control group. The experimental group which received relaxing music showed a significant reduction in state anxiety than the control group. Conclusion: The results showed that relaxing music is an effective nursing intervention for reducing physiologic and psychologic stress response of the patients with acute myocardial infarction in a critical intensive care unit.