• Korea-Australia Rheology Journal
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• 제18권2호
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• pp.41-49
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• 2006

A modified Volume-of-Fluid (VOF) numerical method is used to predict the dynamics of a liquid drop of a low viscosity dilute polymer solution, forming in air from a circular nozzle. Viscoelastic effects are rep-resented using an Oldroyd-B model. Predicted drop shapes are compared with experimental observations. The main features, including the timing of the shape evolution and the 'bead-on-a-string' effect, are well reproduced by the simulations. The results confirm published conclusions of the third author, that the deformation is effectively Newtonian until near the time of Newtonian pinch-off and that the elastic stress becomes large in the pinch region due to the higher extensional flow there.

• 한국기계가공학회지
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• 제9권6호
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• pp.7-15
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• 2010

Recently, with the high performance and efficiency of machine, there have been required the multi-functions in various machine parts, such as the heat resistance, the abrasion resistance and the stress resistance as well as the strength. Fatigue crack growth tests were carried out to investigate the fatigue characteristics of high carbon steel (SM53C) experienced by high-frequency induction treatment. The Cam nose part of the Automobile's Cam shaft is strongly bumped with rocker arm or valve-lift. Therefore abnormal wear such as unfair wear and early wear occur in the surface. This abnormal wear causes a defect that bad timing open and close actions of the engine valve happen in the combustion chamber so the fuel gas will be combustion imperfect. Therefore, the cam shaft demands high hardness and wear resistance. In this study, high frequency heat treatment has been accomplished while wear test for material SM53C.

• Journal of Power Electronics
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• 제6권3호
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• pp.253-263
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• 2006

A high performance and low cost single switch current fed energy recovery circuit (ERC) for an alternating current (AC) plasma display panel (PDP) is proposed. Since it is composed of only one power switch compared with the conventional circuit consisting of four power switches and two large energy recovery capacitors, the ERC features a simpler structure and lower cost. Furthermore, since all power switches can be switched under soft switching operating conditions, the proposed circuit has desirable merits such as increased reliability and low switching loss. Specifically, there are no serious voltage notches across the PDP with the aid of gas discharge current compensation, which can greatly reduce the current stress of all inverter switches, and provide those switches with the turn on timing margin. To confirm the validity of proposed circuit, its operation and performance were verified on a prototype for 7-inch test PDP.

• 연구논문집
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• 통권33호
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• pp.5-16
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• 2003

Fuel distribution, combustion, and flame propagation characteristics of heavy duty engine with the liquid phase LPG injection(LPLI) were studied in a single cylinder engine. Optically accessible single cylinder engine and laser diagnostics system were built for quantifying fuel concentration by acetone PLIF(planar laser induced fluorescence) measurements. In case of Otto cycle engine with large bore size, the engine knock and thermal stress of exhaust manifold are so critical that lean burn operation is needed to reduce the problems. It is generally known that fuel stratification is one of the key technologies to extend the lean misfire limit. The formation of rich mixture in the spark plug vicinity was achieved by open valve injection. With higher swirl strength(Rs=3.4) and open valve injection, the cloud of fuel followed the flow direction and the radial air/fuel mixing was limited by strong swirl flow. It was expected that axial stratification was maintained with open-valve injection if the radial component of the swirling motion was stronger than the axial components. The axial fuel stratification and concentration were sensitive to fuel injection timing in case of Rs=3.4 while those were relatively independent of the injection timing in case of Rs2.3. Thus, strong swirl flow could promote desirable axial fuel stratification and, in result, may make flame propagation stable in the early stage of combustion.

• Journal of Animal Science and Technology
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• 제63권4호
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• pp.766-777
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• 2021

Bezafibrate, a fibrate drug used as a lipid-lowering agent to treat hyperlipidemia, is a pan-agonist of peroxisome proliferator-activated receptor alpha. It can enhance mitochondrial fatty acid oxidation, oxidative phosphorylation, and mitochondrial biogenesis. After ovulation, oocytes may get arrested at the metaphase II (MII) stage until fertilization beyond optimal timing, which is termed as post-ovulatory aging. Post-ovulatory aging is a disease that degrades DNA, mitochondria, and oxidative system, and has a negative impact on embryo development and quality; however, the impact of bezafibrate during post-ovulatory aging has not been fully defined. In the present study, we assessed the ability of bezafibrate to prevent the progression of aging in in vitro conditions as well as the underlying mechanisms in pigs. An appropriate concentration of this drug (50 µM) was added, and then oxidative stress, reactive oxygen species downstream, mitochondrial biogenesis, and mitochondrial function were analyzed via immunofluorescence staining and real-time polymerase chain reaction. Bezafibrate significantly alleviated reactive oxygen species and ameliorated glutathione production simultaneously in oocytes and embryos. Moreover, it diminished H2A.X and attenuated CASPASE 3 expression produced by oxidative stress in oocytes and embryos. Furthermore, bezafibrate remarkably improved the mitochondrial function and blastocyst quality as well as markedly reduced the mitochondria/TOM20 ratio and mtDNA copy number. The elevated PARKIN level indicated that mitophagy was induced by bezafibrate treatment after post-ovulatory aging. Collectively, these results suggest that bezafibrate beneficially affects against porcine post-ovulatory oocyte aging in porcine by its antioxidant property and mitochondrial protection.

• 한국기계가공학회지
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• 제20권1호
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• pp.80-87
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• 2021

Most container ships are currently being constructed as Ultra-Large Container Ships. Hence, the equipment of the ships is also becoming relatively large. In particular, propellers, rudders, and rudder stocks are large in the stern structure, and in relation, efficient design of the hull structures to safely secure these parts is important. The bottom shell plate surface of a stern skeg is a perforated plate from which the rudder stock penetrates, so it is an important component for the stern structure. In this paper, to determine the critical buckling of the shell plate, an interaction curve equation for the two-axis compression of the shell plate was derived using the maximum value of the static structural stress multiplier in a load multiplier mode. This equation predicts the timing of the buckling occurrence. By analyzing this interaction curve equation, the buckling behavior of the plates subjected to a combination load was determined and the usefulness of applying it to ship building was investigated.

• Journal of Photoscience
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• 제9권2호
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• pp.146-149
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• 2002

Oxidative stress evoked hy Ultraviolet (UV) exposure has been suggested to be involved in UV-induced skin carcinogenesis. In this study, the role of oxidative stress in UV-carcinogenesis was evaluated by applying N-Acetylcysteine (NAC) in animal model of hairless-mouse. NAC is known to be a precursor of glutathione, which was converted to glutathione in cytoplasm, acting as an intracellular free radical scavenger. The glutathione levels in hairless mouse skin after one time application of NAC increased significantly. With and without the pre-treatment of NAC, hairless-mice were exposed to UVB three times a week, at total dose 274.4 kJ in 80 times, and the timing of tumor-development, incidence of skin tumor and the histopathology of tumors were observed. 8-hydroxy-2'-deoxyguanosine (8-0HdG), a typical form of oxidative damage in DNA has been also investigated in the course of experiment. The decrease of 8-0HdG formation of UVB- exposed skin compared to controls was observed in the early stage of experiment in the NAC-treated mice. In addition, initial tumor development delayed significantly in NAC-treated group. Finally the number of the tumor developed in the NAC-treated mice was fewer though not significant. These results suggest that antioxidants may have inhibitory effect in the initial step of UVB-induced carcinogenesis of hairless mice.

• 한국식품영양과학회:학술대회논문집
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• 한국식품영양과학회 2001년도 International Symposium on Food,Nutrition and Health for 21st Century
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• pp.22-37
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• 2001

Melatonin is secreted during the hours of darkness and is thought to influence the circadian and seasonal timing of a variety of physiological processes. Serotonin N-acetyltransferase (AA-NAT) which is found to be expressed in pineal gland, retina, and various tissues, catalyses the conversion of serotonin to N-acetylserotonin and is known as the rate-limiting enzyme in the biosynthetic pathway of melatonin. The compounds that modulate the activity of AA-NAT can be used to treat serotonin-and melatonin-related diseases such as insomnia, depression and seasonal affective disorders (SAD). Several assay methods have been developed by which to measure AA-NAT activity. We have also developed a simple, rapid and sensitive AA-NAT assay method that takes advantage of differences in the organic solubilities between acetyl CoA and N-acetyltryptamine. We screened modulators of AA-NAT activity from the water extracts of the medicinal plants. We found MNP1005 which strongly inhibited the activity of AA-NAT ($IC_{50}$=2.2$\mu$M). Enzyme inhibitory kinetic studies revealed that MNP1005 exhibited a noncompetitive inhibition toward tryptamine. The antidepressant effect of MNP1005 was investigated on behavioral despair test so called forced swimming test (FST). MNP1005 significantly increased swimming behavior by reducing immobility with treatment of 10 mg/kg when compared to the vehicle-treated control group (P < 0.05). This suggests that MNP1005 possesses antidepressant activity. The influence of chronic MNP1005 treatment on the expression of brain-derived neurotrophic factor (BDNF) was examined by in situ hybridization and Northern blot. Chronic treatment of MNP1005 blocked the downregulation of BDNF mRNA in the frontal cortex and other cortex regions in response to restraint stress.

• 한국건축시공학회지
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• 제19권2호
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• pp.123-130
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• 2019

환경부하저감 및 동절기 시공의 효율을 위해 환경부하저감형 한중콘크리트 시공기술로서 고로슬래그시멘트와 내한촉진제를 병용한 콘크리트에 있어 열화의 기점이 되는 수축균열에 관해 검토했다. 그 결과, 고로슬래그시멘트 및 내한촉진제를 첨가함으로서 자유수축변형량 및 동일재령에 있어서 균열포텐셜은 증가하는 경향으로 구속조건하에서의 균열의 발생도 빠른 것을 확인할 수 있었다. 이것은, 자유수축변형량의 증가와 함께 크리프에 의한 응력 이완량의 감소나 구속도의 증가 등이 원인으로서 생각할 수 있으며, 동절기 시공에 있어서 고로슬래그 및 내한촉진제를 적용할 때는 수축에 의한 균열발생에 대해 검토할 필요가 있다고 판단된다.

• 한국농공학회논문집
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• 제66권3호
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• pp.25-37
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• 2024

Global warming-induced drought inflicts significant socio-economic and environmental damage. In Korea, the persistent drought in the southern region since 2022 has severely affected water supplies, agriculture, forests, and ecosystems due to uneven precipitation distribution. To effectively prepare for and mitigate such impacts, it is imperative to develop proactive measures supported by early monitoring systems. In this study, we analyzed the spatiotemporal changes of multiple evapotranspiration-based drought indices, focusing on the flash drought event in the southern region in 2022. The indices included the Evaporative Demand Drought Index (EDDI), Standardized Precipitation Evapotranspiration Index (SPEI) considering precipitation and temperature, and the Evaporative Stress Index (ESI) based on satellite images. The Standardized Precipitation Index (SPI) and SPEI indices utilized temperature and precipitation data from meteorological observation stations, while the ESI index was based on satellite image data provided by the MODIS sensor on the Terra satellite. Additionally, we utilized the Evaporative Demand Drought Index (EDDI) provided by the North Oceanic and Atmospheric Administration (NOAA) as a supplementary index to ESI, enabling us to perform more effective drought monitoring. We compared the degree and extent of drought in the southern region through four drought indices, and analyzed the causes and effects of drought from various perspectives. Findings indicate that the ESI is more sensitive in detecting the timing and scope of drought, aligning closely with observed drought trends.