• Journal of Mechanical Science and Technology
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• v.19 no.7
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• pp.1460-1468
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• 2005

Two possible shape memory processes, austenite to detwinned martensite transformation and twinned martensite to detwinned martensite transformation of a shape memory alloy have been modeled and examined. Eshelby's equivalent inclusion method with Mori-Tanaka's mean field theory is used for modeling of the shape memory processes of TiNi shape memory alloy reinforced aluminum matrix composite. The shape memory amount of shape memory alloy, plastic strain and residual stress in the matrix are computed and compared for the two processes. It is shown that the shape memory amount shows differences in a small prestrain region, but the plastic strain and the residual stress in the matrix show differences in the whole prestrain region. The shape memory process with initially martensitic state of the shape memory alloy would be favorable to the increase in the yield stress of the composite owing to the large compressive residual stress and plastic strain in the matrix.

• Biomolecules & Therapeutics
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• v.26 no.4
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• pp.368-373
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• 2018

Rapid eye movement (REM) sleep has an essential role in the process of learning and memory in the hippocampus. It has been reported that linalool, a major component of Lavandula angustifolia, has antioxidant, anti-inflammatory, and neuroprotective effects, along with other effects. However, the effect of linalool on the cognitive impairment and behavioral alterations that are induced by REM-sleep deprivation has not yet been elucidated. Several studies have reported that REM-sleep deprivation-induced memory deficits provide a well-known model of behavioral alterations. In the present study, we examined whether linalool elicited an anti-stress effect, reversing the behavioral alterations observed following REM-sleep deprivation in mice. Furthermore, we investigated the underlying mechanism of the effect of linalool. Spatial memory and learning memory were assessed through Y maze and passive avoidance tests, respectively, and the forced swimming test was used to evaluate anti-stress activity. The mechanisms through which linalool improves memory loss and behavioral alterations in sleep-deprived mice appeared to be through an increase in the serotonin levels. Linalool significantly ameliorated the spatial and learning memory deficits, and stress activity observed in sleep-deprived animals. Moreover, linalool led to serotonin release, and cortisol level reduction. Our findings suggest that linalool has beneficial effects on the memory loss and behavioral alterations induced by REM-sleep deprivation through the regulation of serotonin levels.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.4
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• pp.515-523
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• 2003

Shape memory is physical phenomenon which a platically metal is restored to its original shape by a solid state phase change by heating. TiNi alloy the most effective material in the shape memory alloy(SMA). To study(measure) recovery stress of intelligent composite. Ti50-Ni50 shape memory matrix with prestrain SMA fiber. When SMA fiber of the intelligent composite is heated over austenite starting temperature(As) by electric heating. a recovery stress are generated. The recovery stress of the intelligent composite was measured by strain gage or photoelastic experiment. Measuring method of recovery stress by photoelastic experiment was developed in this research. It was certified that photoelastic experiment was more effective and more precise than strain gage method in the measurement of recovery stress.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.1
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• pp.55-59
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• 2014

Dehydroevodiamine HCl (DHED) has been reported to prevent memory impairment and neuronal cell loss in a rat model with cognitive disturbance. We investigated the effect of DHED on memory impairment and behavioral abnormality caused by stress. We demonstrated that DHED can improve stress-induced memory impairments and depression-like behaviors by using open-field test, Y-maze test and forced swimming test. DHED treatment significantly recovered the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability. Our results suggested that DHED is a potential drug candidate for neuronal death, memory impairment and depression induced by stress.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.5
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• pp.345-352
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• 2010

The present study was undertaken to explore the potential of erythropoietin in memory deficits of mice. Memory impairment was produced by scopolamine (0.5 mg/kg, $i.p.$) and intracerebroventricular streptozotocin (i.c.v STZ, 3 mg/kg, $10{\mu}l$, $1^{st}$ and $3^{rd}$ day) in separate groups of animals. Morris water-maze test was employed to assess learning and memory. The levels of brain thio-barbituric acid reactive species (TBARS) and reduced glutathione (GSH) were estimated to assess degree of oxidative stress. Brain acetylcholinesterase enzyme (AChE) activity was also measured. Scopolamine/streptozotocin administration induced significant impairment of learning and memory in mice as indicated by marked decrease in Morris water-maze performance. Scopolamine/streptozotocin administration also produced a significant enhancement of brain AChE activity and brain oxidative stress (an increase in TBARS and a decrease in GSH) levels. Treatment of erythropoietin (500 and 1,000 IU/Kg i.p.) significantly reversed scopolamine- as well as streptozotocin-induced learning and memory deficits along with attenuation of those-induced rise in brain AChE activity and brain oxidative stress levels. It may be concluded that erythropoietin exerts a beneficial effect in memory deficits of mice possibly through its multiple actions including potential anti-oxidative effect.

• Journal of the Korean Society of Safety
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• v.29 no.4
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• pp.28-33
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• 2014

Recently, the actuator worked by the driving recovery-force of the thermo elastic martensitic transformation of shape memory alloys(SMA) has been studied. This paper presents a study on the fatigue life of shape memory alloy (SMA) actuators undergoing thermally induced martensitic phase transformation under various stress levels. shape memory recoverable stress and strain of Ti-44.5at.%Ni-8at.%Cu alloys were by means of constant temperature tensile tests. Differential scanning calorimetry (DSC) was employed in order to investigate the transformation characteristics of the alloy before the tests. the results were summarized as follows. The martensite inducing stress incerased with the increasing of the Cu-contents. The fatigue life decreased with the increasing of the test load and the Cu-content. The data acquired will be very useful during the design process of an SMA NiTiCu element as a functional part of an actuator.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.6
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• pp.1543-1548
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• 2007

Recent experiments investigating the analgesic or anti-stress effects of electro-acupuncture provide extensive evidence that opioid or stress hormone system is involved in those effects, respectively. It has been also suggested that opioid or stress hormones modulate long-term memory consolidation or retrieval in animals and human subjects. This article reviews the possibilitythat electroacupuncture can modulate memory consolidation or retrieval. The release of serum cortisol is enhanced or reduced by high-frequency or low-frequency electroacupuncture, respectively. Also the release of beta endorphin and enkephalin is enhanced by low-frequency electroacupuncture and the release of dynorphin is enhanced by high-frequency electroacupunture. The memory consolidation is enhanced by post-training injection of Glucocorticoids, Naloxone or Dynorphin. So this review suggests strongly that memory consolidation can be modulated by electroacupuncture.

• Proceedings of the KSME Conference
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• 2001.11a
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• pp.186-191
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• 2001

Tensile residual stress happen by difference of coefficients of thermal expansion between fiber and matrix is one of the serious problems in metal matrix composite(MMC). In this study, TiNi alloy fiber was used to solve the problem of the tensile residual stress as the reinforced material. TiNi alloy fiber improves the tensile strength of composite by occurring compressive residual stress in matrix using shape memory effect of it. Pre-strain was added to generate compressive residual stress inside TiNi/A16061 shape memory alloy(SMA) composite. It was also evaluated the effect of compressive residual stress corresponding to pre-strains variation and volume fraction of TiNi alloy. AE technique was used to clarify the microscopic damage behavior at high temperature and the effect of pre-strain difference of TiNi/A16061 SMA composite. In addition, two dimensional AE source location technique was applied to inspect the crack initiation and propagation in composite.

• Proceedings of the KSME Conference
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• 2001.06a
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• pp.72-77
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• 2001

Tensile residual stress happen by difference of coefficients of thermal expansion between fiber and matrix is one of the serious problems in metal matrix composite(MMC). In this study, TiNi fiber was used to solve the tensile residual stress as the reinforced material. TiNi fiber improves the tensile strength of composite by occurring compressive residual stress in matrix using shape memory effect of it. Pre-strain was added to generate compressive residual stress inside TiNi/A16061 composite. It was also evaluated the effect of compressive residual stress corresponding to pre-strains variation. AE technique was used to clarify the microscopic damage behavior at high temperature and the effect of pre-strain difference of TiNi/A16061 shape memory alloy composite.

• Korean Journal of Psychosomatic Medicine
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• v.4 no.1
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• pp.124-137
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• 1996

As the society becomes more industrialized and modernized, we have more chances to experience a serious traumatic event. Post-traumatic stress disorder (PTSD) has 3 major categories of symptoms such as memory disturbance, hyperarousal and avoidance or numbness. I reviewed the psychobiological evidences in 3 main categories of symptoms and the biological treatment after a brief review of the epidemiology, psychosocial etiology and diagnosis of PTSD. The memory disturbance of PTSD might be developed by the potentiation of the memory pathway mediated by norepinephrine. PTSD induces HPA axis abnormality, it might also develop hippocampal dysfunction, which might contribute to the memory disturbance. The kindling effect develops desensitization, which might develop reexperiencing of the traumatic events and hyperarousal state. Chronic aroused state of locus ceruleus with resultant chronic maladaptive state of norepinephrine system, might develop hyperarousal state. Social avoidance and physical numbing state in PTSD might be caused by serotnin or opiate system. Stress induced analgesia might be developed by opiate reliesed against the acute stress. The biologic research results would help the selective treatment of PTSD.