• 제목/요약/키워드: Stress hormone

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삽수(挿穗)의 Leaf Water Potential의 변화(變化) (Diurnal Changes of Leaf Water Potential in Cuttings)

  • 홍성천
    • 한국산림과학회지
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    • 제38권1호
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    • pp.27-32
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    • 1978
  • 토양(土壤)의 Water potential(${\psi}_s$)을 몇 단계 다르게 설정(設定)한 경우(境遇) 삽수(揷穗)의 Leaf water potential(${\psi}_l$)은 일일중(一日中) 어떻게 변화(變化)하며, 삽목후(揷木後) 시간(時間)의 경과(經過)와 수종간(樹種間), 삽수(揷穗)의 형태적(形態的) 요인별(要因別), Hormone 처리(處理)의 경우(境遇) 삽수(揷穗)의 ${\psi}_l$변화(變化) pattern은 어떻게 변화(變化)하고 있는 가를 밝혀 삽상(揷床)의 수분영리(水分營理) 지침(指針)의 기초적(基礎的) 자료(資料)를 만들기 위하여 본실험(本實驗)을 하였다. 그 결과(結果)를 요약(要約)하면 다음과 같다. 1. Leaf water potential(${\psi}_l$)의 변화(變化)에 있어 아왜나무, 서향나무의 삽수(揷穗)의 경우(境遇) ${\psi}_s$가 0 bar일때는 토성(土性)에 관계(關係)없는 변화(變化) pattern을 나타내었다. ${\psi}_s$가 -0.01bar 이상(以上)일때는 L.S.가 S.C.보다 -1bar 정도(程度)의 간격(間隔)으로서 최고치(最高値)에 도달(到達)하였다. 2. 일일중(一日中)의 ${\psi}_l$의 변화(變化)는 삽목후(揷木後) 시간(時間)의 경과(經過)와 ${\psi}_s$별(別)로 차이(差異)가 있으나, 최고치(最高値)는 0.2~0.6시(時)에 나타났으며, 아왜나무와 서향나무의 경우(境遇) ${\psi}_s$가 -0.01~-0.02bar이상(以上)일때는 -3bars, -0.03bar 이하(以下)일때는 -4bars를 나타내었으며, 최소치(最小値)는 -20~-22bars 정도(程度)였다. 15일(日)째에 있어서는 5일(日)째보다 최고치(最高値)에 머무르는 시간(時間)이 1/2정도(程度)에 지나지 않았고, ${\psi}_l$의 증가(增加)의 경우(境遇) 시간당(時間當) -1~-2bars정도(程度) 늦게 최고치(最高値)에 도달(到達)하였고, 일일중(一日中)의 ${\psi}_l$의 변화(變化) pattern은 온도(溫度)와 상대습도(相對濕度)의 변화(變化)에 따라 민감(敏感)하게 변화(變化)하고 있다. 3. 아왜나무 삽수(揷穗)의 경우(境遇) IAA 50ppm 처리구(處理區)는 무처리구(無處理區)에 비교(比較)하여 삽목후(揷木後) 15일(日)째에 있어 -2~-3bars 늦게 최고치(最高値)에 도달(到達)하였으며, 최고치(最高値)에 머무르는 시간(時間)도 1/2정도(程度)에 지나지 않았다. 4. 아왜나무는 본실험(本實驗) 조건내(條件內)에서 4엽(葉)을 가진 삽수(揷穗)가 2엽(葉)을 가진 삽수(揷穗)보다 시간당(時間當) -2~-3bars 늦게 최고치(最高値)에 도달(到達)하며 그 발근량(發根量)도 많았다. (Table. 1) 5. 회양목 삽수(揷穗)의 ${\psi}_l$의 변화(變化) pattern은 8엽(葉)이 4엽(葉)보다 시간당(時間當) -2~-3bars 늦게 최고치(最高値)에 도달(到達)하나 발근량(發根量)이 적은 것을 고려(考慮)하면(Table. 2) 발근(拔根)의 생리적(生理的) 저항외(抵抗外)에 상대습도(相對濕度)의 부족(不足)으로 인(因)한 삽수내(揷穗內)의 수분부족(水分不足)에 의한 세포(細胞)의 활력(活力) 쇠퇴(衰退)에 기인(基因)한 저항(抵抗)의 증대(增大)로 인(因)한 변화(變化) pattern임을 예측(豫測)할 수 있다.

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산수유 추출물에 의한 testosterone으로 유발된 양성 전립선 비대증의 개선 (Extract of Fructus Corni Ameliorates Testosterone-induced Benign Prostatic Hypertrophy in Sprague Dawley Rats)

  • 지선영;김민영;황보현;이혜숙;홍수현;김태희;윤선혜;김현진;정하은;김성연;김태중;김민지;김성옥;최영현
    • 생명과학회지
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    • 제31권6호
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    • pp.550-558
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    • 2021
  • 양성 전립선 비대증(BPH)의 발병은 노화에 따른 남성 호르몬 수치의 변화와 연관된 내분비 기능 저하와 밀접한 관련이 있는 것으로 알려져 있다. 현재 BPH 치료를 위해 임상적으로 사용되는 약물은 다양한 부작용을 나타내므로 효과적인 대체 식의약 소재의 개발을 시급히 요구된다. 산수유나무의 열매인 산수유(Fructus Corni)는 오랫동안 다양한 질병의 예방 및 치료에 사용되어왔으며 최근 BPH의 진행을 억제할 수 있음이 밝혀졌다. 본 연구에서는 BPH에 대한 산수유 열수 추출물(CF)의 추가 효능을 평가하기 위해 비거세 및 거세 동물 모델에서 TP에 의한 BPH 유도에 미치는 효과를 조사하였으며, BPH 억제를 위한 양성대조군으로 FINA를 사용하였다. 본 연구의 결과에 의하면 CF 투여는 대조군 및 FINA 처리 그룹에 비하여 비거세 및 거세군 모두에서 전립선의 과도한 발달을 억제하였다. BPH에 대한 CF의 억제 효과는 BPH 유도에 관여하는 testosterone과 DHT의 발현 감소뿐만 아니라 HIF-1α, 5α-reductase type 2, SRC1, AR 및 PSA 발현의 과도한 발현 억제와 관련이 있었다. 또한, 스트레스 호르몬인 cortisol의 혈청 수준은 비거세 및 거세군 모두에서 TP에 의한 BPH 유도 동안 증가하였지만 CF 투여에 의하여 유의하게 감소되었다. 그러나 BPH 유도군에서 insulin 및 IGF-1은 증가되지 않았으며 CF에 의한 효과적인 결과는 나타나지 않았다. 이러한 결과는 AR 신호 전달 경로 활성의 억제를 통해 BPH에 대한 CF의 유익한 효과를 시사하며, 산수유가 BPH의 예방과 치료에 잠재적인 가능성을 가지고 있음을 시사한다.

계획된 간호 정보가 수면량에 미치는 영향에 관한 연구 -개심술 환자를 중심으로- (The Effect of Structured Information on the Sleep Amount of Patients Undergoing Open Heart Surgery)

  • 이소우
    • 대한간호학회지
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    • 제12권2호
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    • pp.1-26
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    • 1982
  • The main purpose of this study was to test the effect of the structured information on the sleep amount of the patients undergoing open heart surgery. This study has specifically addressed to the Following two basic research questions: (1) Would the structed in formation influence in the reduction of sleep disturbance related to anxiety and Physical stress before and after the operation? and (2) that would be the effects of the structured information on the level of preoperative state anxiety, the hormonal change, and the degree of behavioral change in the patients undergoing an open heart surgery? A Quasi-experimental research was designed to answer these questions with one experimental group and one control group. Subjects in both groups were matched as closely as possible to avoid the effect of the differences inherent to the group characteristics, Baseline data were also. collected on both groups for 7 days prior to the experiment and found that subjects in both groups had comparable sleep patterns, trait anxiety, hormonal levels and behavioral level. A structured information as an experimental input was given to the subjects in the experimental group only. Data were collected and compared between the experimental group and the control group on the sleep amount of the consecutive pre and post operative days, on preoperative state anxiety level, and on hormonal and behavioral changes. To test the effectiveness of the structured information, two main hypotheses and three sub-hypotheses were formulated as follows; Main hypothesis 1: Experimental group which received structured information will have more sleep amount than control group without structured information in the night before the open heart surgery. Main hypothesis 2: Experimental group with structured information will have more sleep, amount than control group without structured information during the week following the open heart surgery Sub-hypothesis 1: Experimental group with structured information will be lower in the level of State anxiety than control group without structured information in the night before the open heart surgery. Sub-hypothesis 2 : Experimental group with structured information will have lower hormonal level than control group without stuctured information on the 5th day after the open heart surgery Sub-hypothesis 3: Experimental group with structured information will be lower in the behavioral change level than control group without structured information during the week after the open heart surgery. The research was conducted in a national university hospital in Seoul, Korea. The 53 Subjects who participated in the study were systematically divided into experimental group and control group which was decided by random sampling method. Among 53 subjects, 26 were placed in the experimental group and 27 in the control group. Instruments; (1) Structed information: Structured information as an independent variable was constructed by the researcher on the basis of Roy's adaptation model consisting of physiologic needs, self-concept, role function and interdependence needs as related to the sleep and of operational procedures. (2) Sleep amount measure: Sleep amount as main dependent variable was measured by trained nurses through observation on the basis of the established criteria, such as closed or open eyes, regular or irregular respiration, body movement, posture, responses to the light and question, facial expressions and self report after sleep. (3) State anxiety measure: State Anxiety as a sub-dependent variable was measured by Spi-elberger's STAI Anxiety scale, (4) Hormornal change measure: Hormone as a sub-dependent variable was measured by the cortisol level in plasma. (5) Behavior change measure: Behavior as a sub-dependent variable was measured by the Behavior and Mood Rating Scale by Wyatt. The data were collected over a period of four months, from June to October 1981, after the pretest period of two months. For the analysis of the data and test for the hypotheses, the t-test with mean differences and analysis of covariance was used. The result of the test for instruments show as follows: (1) STAI measurement for trait and state anxiety as analyzed by Cronbachs alpha coefficient analysis for item analysis and reliability showed the reliability level at r= .90 r= .91 respectively. (2) Behavior and Mood Rating Scale measurement was analyzed by means of Principal Component Analysis technique. Seven factors retained were anger, anxiety, hyperactivity, depression, bizarre behavior, suspicious behavior and emotional withdrawal. Cumulative percentage of each factor was 71.3%. The result of the test for hypotheses show as follows; (1) Main hypothesis, was not supported. The experimental group has 282 minutes of sleep as compared to the 255 minutes of sleep by the control group. Thus the sleep amount was higher in experimental group than in control group, however, the difference was not statistically significant at .05 level. (2) Main hypothesis 2 was not supported. The mean sleep amount of the experimental group and control group were 297 minutes and 278 minutes respectively Therefore, the experimental group had more sleep amount as compared to the control group, however, the difference was not statistically significant at .05 level. Thus, the main hypothesis 2 was not supported. (3) Sub-hypothesis 1 was not supported. The mean state anxiety of the experimental group and control group were 42.3, 43.9 in scores. Thus, the experimental group had slightly lower state anxiety level than control group, howe-ver, the difference was not statistically significant at .05 level. (4) Sub-hypothesis 2 was not supported. . The mean hormonal level of the experimental group and control group were 338 ㎍ and 440 ㎍ respectively. Thus, the experimental group showed decreased hormonal level than the control group, however, the difference was not statistically significant at .05 level. (5) Sub-hypothesis 3 was supported. The mean behavioral level of the experimental group and control group were 29.60 and 32.00 respectively in score. Thus, the experimental group showed lower behavioral change level than the control group. The difference was statistically significant at .05 level. In summary, the structured information did not influence the sleep amount, state anxiety or hormonal level of the subjects undergoing an open heart surgery at a statistically significant level, however, it showed a definite trends in their relationships, not least to mention its significant effect shown on behavioral change level. It can further be speculated that a great degree of individual differences in the variables such as sleep amount, state anxiety and fluctuation in hormonal level may partly be responsible for the statistical insensitivity to the experimentation.

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