• 한국학교보건학회지
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• 제19권1호
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• pp.67-78
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• 2006

Purporse : The purpose of this study was to examine the relationship between a health promoting lifestyle and body composition in university students. The study subjects were 194 university students who attended K-university located in Chungnam. Methods : The data was collected between March 2 and May 31, 2004. The instrument used for this study was the modified Health Promoting Lifestyle Profile(HPLP) developed by Walker, Sechrist, & Pender(1987). The body composition was measured by In Body 3.0, a Bioelectrical Impedance Analyzer. The data was analyzed using the SPSS/WIN 10.0 program by t-test, ANOVA and pearson correlation coefficients. Results : The results of this study are as follows: 1) The scores of the Health Promoting Lifestyle(HPL) ranged from 79 to 170, with a mean score of 110(±15.8). The mean scores of sub-categorical HPL were self-actualization 31.8(±4.9), health responsibility 17.0(±4.0), exercise 8.3(±3.2), nutrition 15.4(±3.7), interpersonal relationships 20.3(±3.5) and stress management 17.2(±3.4). 2) The HPL according to the subjects' general characteristics had significant correlation to exercise amount(F=8.09, p＜.01), drinking amount(F=6.56, p＜.01), perceived health status(F=19.2, p＜.01) and perceived health knowledge (F=15.9, p＜.01). 3) The total HPL did not significantly correlate with any categories in body composition. The exercise area of sub-categorical HPL had significant positive correlation to height (r=.199, p＜.01), weight(r=.181, p＜.05) and soft lean mass(r=.257, p＜.01), and negative correlation to percent body fat(r=-.255, p＜.01) in body composition. Conclusion : The results suggest that the exercise area of sub-categorical HPL was an important variable for an exercise program's development such as nursing intervention for the health promotion of university students.

• 대한지역사회영양학회지
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• 제13권1호
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• pp.91-99
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• 2008

The present study was conducted to examine metabolic risk factors and total antioxidant capacity (TAC) of Korean females living in Seoul and to investigate the relationship between the metabolic risk factors and serum TAC. A total of 353 females aged between 20 and 64 participated in the study. Obesity indicators, blood pressure, serum lipid profile and fasting blood glucose were measured as metabolic risk factors. Ferric reducing antioxidant power (FRAP) assay was employed to determine serum TAC of subjects. Obesity indicators such as body mass index, waist circumference and waist-hip ratio were significantly higher in the participants aged $\geq$ 50 y (older group) than in the participants aged 20-49 y (younger group) (p < 0.001). Blood pressure, serum total cholesterol (TC), triglyceride (TG) and fasting blood glucose were also significantly higher in the older group than in the younger group (p < 0.001), demonstrating significant positive correlations between age and MS risk factors. The association between FRAP and MS risk factors were also investigated. FRAP values showed significant positive correlations with age (p = 0.001), serum TG (p = 0.002) and TC (p = 0.03). A tendency of positive association between FRAP and waist circumference was observed without any significant difference (p = 0.06). Increased serum FRAP with central obesity and serum lipids may be interpreted as results of activation of antioxidant defense system against oxidative stress induced by metabolic syndrome (MS) constituent factors. However, to verify the function of FRAP as a potential biomarker of susceptibility to MS various contributors to the plasma antioxidant capacity and their biological relevance related to MS should be elucidated further.

• Nutrition Research and Practice
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• 제7권6호
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• pp.481-487
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• 2013

High-fat diet up-regulates either insulin resistance or triglycerides, which is assumed to be related to the expression of peroxisome proliferator-activated receptor (PPAR)-${\alpha}$ and PPAR-${\gamma}$. The beneficial effects of vitamin E on insulin resistance are well known; however, it is not clear if vitamin E with a high-fat diet alters the expression of PPAR-${\alpha}$ and PPAR-${\gamma}$. We investigated the effects of d-${\alpha}$-tocopherol supplementation on insulin sensitivity, blood lipid profiles, lipid peroxidation, and the expression of PPAR-${\alpha}$ and PPAR-${\gamma}$ in a high-fat (HF) diet-fed male C57BL/6J model of insulin resistance. The animals were given a regular diet (CON; 10% fat), a HF diet containing 45% fat, or a HF diet plus d-${\alpha}$-tocopherol (HF-E) for a period of 20 weeks. The results showed that the HF diet induced insulin resistance and altered the lipid profile, specifically the triglyceride (TG) and total cholesterol (TC) levels (P < 0.05). In this animal model, supplementation with d-${\alpha}$-tocopherol improved insulin resistance as well as the serum levels of TG and very-low-density lipoprotein-cholesterol (VLDL-C) (P < 0.05). Moreover, the treatment decreased the levels of malondialdehyde (MDA) in the serum and liver while increasing hepatic PPAR-${\alpha}$ expression and decreasing PPAR-${\gamma}$ expression. In conclusion, the oral administration of d-${\alpha}$-tocopherol with a high-fat diet had positive effects on insulin resistance, lipid profiles, and oxidative stress through the expression of PPAR-${\alpha}$ and PPAR-${\gamma}$ in a high-fat diet-fed male mice.

• 한국전산구조공학회논문집
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• 제25권3호
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• pp.203-209
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• 2012

본 논문에서는 상온 및 방사선 경화 복합재 풍력 블레이드의 구조성능을 비교하기 위하여 단면 강성, 정적응력 및 동적 고유 진동수를 해석하였다. 먼저 상온 및 방사선 경화공정에 의한 복합재료 시편의 탄성계수 등 물성 값을 적용하였다. 블레이드의 단면 강성 값은 고형 복합재료 보 이론을 적용하여 유한요소 적분법으로 계산하였다. 허브 체결부위를 포함한 소형 풍력 블레이드를 상용 유한요소 프로그램으로 모델링하여 최대 변위와 응력분포 등을 확인하였다. 또한, 풍력 블레이드의 회전속도에 따른 원심력 효과를 고려하여 고유 진동수 해석을 병행하였다. 이와 같은 일련의 해석결과를 상호 비교함으로써, 상온 및 방사선 경화 복합재료의 물성 값 차이에서 기인하는 풍력 블레이드의 구조성능 변화를 정량적으로 분석하였다.

• 항공우주기술
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• 제5권2호
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• pp.227-239
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• 2006

신뢰성 예측은 설계안 중 하나를 선택하거나, 적용되는 부품의 품질 수준, 부하경감(derating) 정도, 기존의 입증기술 또는 최신기술의 채택여부 등과 같은 사항을 설계시 결정하는 데에 합리적인 근거를 제공할 수 있으므로, 우주 시스템의 개발과정에 있어서 필수적인 사항으로 인식되고 있다. 신뢰성의 정량적인 표현을 위해서는 수치적인 정보와 그 정보를 생성하기 위한 기법의 정확성이 확보되어야 하며, 설계에 대한 평가를 돕고, 신뢰성 요구조건 할당, 시정조치 우선순위 결정 등의 기초자료로 적용하기 위하여 개념설계 초기 단계에서부터 수행되어야 한다. 대상품의 설계, 환경 요구조건, 운용환경 데이터, 고장률 데이터 또는 운용 프로파일의 변경이 발생할 때마다 업데이트되어야 한다. 본 논문에서는 우주시스템 개발과정에서 수행되는 신뢰성 예측을 위한 세부절차, 정량적 데이터의 도출 및 적용기법 등에 대하여 검토하였다.

• Steel and Composite Structures
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• 제34권1호
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• pp.91-105
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• 2020

Steel-concrete composite beam with profiled steel sheet has gained its popularity in the last two decades. Due to the ageing of these structures, retrofitting in terms of flexural strength is necessary to ensure that the aged structures can carry the increased traffic load throughout their design life. The steel ribs, which presented in the profiled steel deck, limit the use of shear connectors. This leads to a poor degree of composite action between the concrete slab and steel beam compared to the solid slab situation. As a result, the shear connectors that connects the slab and beam will be subjected to higher shear stress which may also require strengthening to increase the load carrying capacity of an existing composite structure. While most of the available studies focus on the strengthening of longitudinal shear and flexural strength separately, the present work investigates the effect of both flexural and longitudinal shear strengthening of steel-concrete composite beam with composite slab in terms of failure modes, ultimate load carrying capacity, ductility, end-slip, strain profile and interface differential strain. The flexural strengthening was conducted using carbon fibre reinforced polymer (CFRP) or steel plate on the soffit of the steel I-beam, while longitudinal shear capacity was enhanced using post-installed high strength bolts. Moreover, a combination of both the longitudinal shear and flexural strengthening techniques was also implemented (hybrid strengthening). It is concluded that hybrid strengthening improved the ultimate load carrying capacity and reduce slip and interface differential strain that lead to improved composite action. However, hybrid strengthening resulted in brittle failure mode that decreased ductility of the beam.

• Genomics & Informatics
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• 제11권4호
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• pp.245-253
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• 2013

A radioresistant cell line was established by fractionated ionizing radiation (IR) and assessed by a clonogenic assay, flow cytometry, and Western blot analysis, as well as zymography and a wound healing assay. Microarray was performed to profile global expression and to search for differentially expressed genes (DEGs) in response to IR. H460R cells demonstrated increased cell scattering and acidic vesicular organelles compared with parental cells. Concomitantly, H460R cells showed characteristics of increased migration and matrix metalloproteinase activity. In addition, H460R cells were resistant to IR, exhibiting reduced expression levels of ionizing responsive proteins (p-p53 and ${\gamma}$-H2AX); apoptosis-related molecules, such as cleaved poly(ADP ribose) polymerase; and endoplasmic reticulum stress-related molecules, such as glucose-regulated protein (GRP78) and C/EBP-homologous protein compared with parental cells, whereas the expression of anti-apoptotic X-linked inhibitor of apoptosis protein was increased. Among DEGs, syntrophin beta 2 (SNTB2) significantly increased in H460R cells in response to IR. Knockdown of SNTB2 by siRNA was more sensitive than the control after IR exposure in H460, H460R, and H1299 cells. Our study suggests that H460R cells have differential properties, including cell morphology, potential for metastasis, and resistance to IR, compared with parental cells. In addition, SNTB2 may play an important role in radioresistance. H460R cells could be helpful in in vitro systems for elucidating the molecular mechanisms of and discovering drugs to overcome radioresistance in lung cancer therapy.

• 한국해안해양공학회지
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• 제8권1호
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• pp.28-36
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• 1996

조류와 취송류의 비선형 상호작용에 대한 연직확산계수의 영향을 점모형을 이용하여 살펴보았다. q$^2$-q$^2$1 난류모형을 난류운동에너지의 생성과 감쇄가 균형을 이룬다는 가정 하에 단순화한 0-방정식 난류모형을 도입하고 마찰수심의 영향을 적절히 반영하도록 수정하여 연직확산계수를 산정하였다. 0-방정식 난류모형의 유도과정과 전향력 항이 포함됨으로써 공진이 발생될 수 있음을 제시하였다. 왕복성 수면경사력과 바람응력이 복합된 경우, 고려된 바람응력에 의한 조류 진폭의 변화는 무시할만한 크기였으나, 왕복성 수면경사력만에 의해서는 발생되지 않았던 2배조의 조류 성분이 파생되었다. 취송류의 연직구조는 조류에 의한 배경난류가 지배적인지의 여부에 따라 상당한 차이를 보였다. 따라서 황해와 같이 강한 조류가 존재하는 해역의 취송순환을 파악함에 있어 조류에 의한 배경난류를 무시할 경우는 실제와는 상당히 다른 결과가 나타날 수 있다.

• 한국발생생물학회지:발생과생식
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• 제24권3호
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• pp.197-205
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• 2020

Diabetes mellitus is a common heterogeneous metabolic disorder, characterized by deposition of extracellular matrix, oxidative stress, and vascular dysfunction, thereby leading to gradual loss of function in multiple organs. However, little attention has been paid to gene expression changes in the lung under hyperglycemic conditions. In this study, we found that diabetes inuced histological changes in the lung of streptozotocin-induced diabetic mice. Global gene expression profiling revealed a set of genes that are up- and down-regulated in the lung of diabetic mice. Among these, expression of Amigo2, Adrb2, and Zbtb16 were confirmed at the transcript level to correlate significantly with hyperglycemia in the lung. We further evaluated the effect of human umbilical cord-derived perivascular stem cells (PVCs) on these gene expression in the lung of diabetic mice. Our results show that administration of PVC-conditioned medium significantly suppressed Amig2, Adrb2, and Zbtb16 upregulation in these mice, suggesting that these genes may be useful indicators of lung injury during hyperglycemia. Furthermore, PVCs offer a promising alternative cell therapy for treating diabetic complications via regulation of gene expression.

• Molecular & Cellular Toxicology
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• 제2권1호
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• pp.21-28
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• 2006

Gadolinium chloride ($GdCl_{3}$) was known to block Kupffer cells and generally its toxicity study based on blocking these cells. Therefore, $GdCl_{3}$ frequently used to study toxic mechanisms of hepatotoxicants inducing injury through Kupffer cells. We also tried to investigate the effect of $GdCl_{3}\;on\;CCl_{4}$ toxicity, typical hepatotoxicants. Administration of $GdCl_{3}$ to mice significantly suppressed AST (asparatate amino transferase), ALT (alanine amino transferase) levels which were increased by $CCl_{4}$ treatment. However, $GdCl_{3}$ didn't inhibit the phagocytotic activity of Kupffer cells. Malondialdehyde (MDA) is a good indicator of the degree of lipid peroxidation. In this study, MDA increased by $GdCl_{3}$ administration not by $CCl_{4}$. To understand the toxicity of $GdCl_{3}$, we analyzed global gene expression profile of mice liver after acute $GdCl_{3}$ injection. Four hundred fifty two genes were differentially expressed with more than 2-fold in at least one time point among 3 hr, 6 hr, and 24 hr. Several genes involved in fibrogenesis regulation. Several types of pro-collagens (Col1a2, Col5a2, Col6a3, and Col13a1) and tissue inhibitor of metal-loproteinase1 (TIMP1) were up regulated during all the time points. Genes related to growth factors, chemokines, and oxidative stress, which were known to control fibrogenesis, were significantly changed. In addition, $GdCl_{3}$ induced abnormal regulation between lipid synthesis and degradation related genes. These data will provide the information about influence of $GdCl_{3}$ to hepatotoxicity.