• Journal of Applied Reliability
• /
• v.7 no.4
• /
• pp.163-172
• /
• 2007

Phenomenon, such as hardening, cracking or breaking etc.. of PVC tape for wiring harness by aging were detected on driven automobile in field. Hardening or cracking of PVC tape were confirmed decline of elongation by surrounding stress. The accelerated heat aging test was carried out applying temperature most important factor of aging, and then deduced an equation of useful life using arrhenius model. Prediction method of useful life of PVC tape was developed using miner rule calculating damage value by thermal energy classified temperature by matching deduced equation of useful life and measured temperature value on driven automobile in field.

• Structural Engineering and Mechanics
• /
• v.17 no.1
• /
• pp.29-50
• /
• 2004

A total life model was developed to assess the service life of aging aircraft. The primary focus of this paper is the development of crack growth life projection using the response surface method. Crack growth life projection is a necessary component of the total life model. The study showed that the number of load cycles N needed for a crack to propagate to a specified size can be linearly related to the geometric parameter, material, and stress level of the component considered when all the variables are transformed to logarithmic values. By the Central Limit theorem, the ln N was approximated by Gaussian distribution. This Gaussian model compared well with the histograms of the number of load cycles generated from simulated crack growth curves. The outcome of this study will aid engineers in designing their crack growth experiments to develop the stochastic crack growth models for service life assessments.

• Elastomers and Composites
• /
• v.42 no.1
• /
• pp.32-46
• /
• 2007

Mechanical properties of rubber material are very important in design procedure to assure the safety and reliability of the rubber components. In this paper, the material test and accelerated heat aging test were carried out. In order to investigate the effects of heat-aging on the material properties, hardness, elongation, stress-strain curves and dynamic characteristics were obtained from various test conditions. Also, rubber material coefficients were determined by both the uniaxical and equi-biaxial tensile tests.

• The Korean Journal of Physiology and Pharmacology
• /
• v.21 no.6
• /
• pp.633-641
• /
• 2017

The aim of this study is to investigate the effects of intermittent ladder-climbing exercise training on mitochondrial biogenesis and ER stress of the cardiac muscle in high fat diet-induced obese middle-aged rats. We induced obesity over 6 weeks of period in 40 male Sprague-Dawley rats around 50 weeks old, and were randomly divided into four experimental groups: chow, HFD, exercise+HFD, and exercise+chow. The exercising groups underwent high-intensity intermittent training using a ladder-climbing and weight exercise 3 days/week for a total of 8 weeks. High-fat diet and concurrent exercise resulted in no significant reduction in body weight but caused a significant reduction in visceral fat weight (p<0.05). Expression of $PPAR{\delta}$ increased in the exercise groups and was significantly increased in the high-fat diet+exercise group (p<0.05). Among the ER stress-related proteins, the expression levels of p-PERK and CHOP, related to cardiac muscle damage, were significantly higher in the cardiac muscle of the high-fat diet group (p<0.05), and were significantly reduced by intermittent ladder-climbing exercise training (p<0.05). Specifically, this reduction was greater when the rats underwent exercise after switching back to the chow diet with a reduced caloric intake. Collectively, these results suggest that the combination of intermittent ladder-climbing exercise training and a reduced caloric intake can decrease the levels of ER stress-related proteins that contribute to cardiac muscle damage in obesity and aging. However, additional validation is required to understand the effects of these changes on mitochondrial biogenesis during exercise.

• Journal of the Korea institute for structural maintenance and inspection
• /
• v.25 no.6
• /
• pp.103-110
• /
• 2021

Elastomeric bearings composed of flexible rubber materials and steel reinforcement plates are widely used for seismic retrofit of bridges due to their excellent vertical stiffness and flexible lateral stiffness. Especially, it has the advantages of simple construction and low cost. Chloroprene rubber, a type of rubber material, has greater resistance to aging than natural rubber, but its performance is also degraded due to various deterioration factors. Although these aging characteristics are not reflected in the seismic design standards and seismic performance evaluation guidelines, it is reasonable to reflect this when related studies are accumulated. For chloroprene rubber, accelerated heat aging test was performed with variables of heating temperatures and exposure time to analyze shear characteristics. As aging progresses the maximum shear stress and shear strain decrease. Also, the shear stiffness is greatly increased at the same shear strain.

• Elastomers and Composites
• /
• v.53 no.4
• /
• pp.213-219
• /
• 2018

The degradation mechanism and physical properties of an FKM O-ring were observed with thermal aging in this experiment. From X-ray photoelectron spectroscopy (XPS) analysis, we could observe carbon (285 eV), fluoro (688 eV), and oxygen (531 eV) peaks. Before thermal aging, the concentration of fluoro atoms was 51.23%, which decreased to 8.29% after thermal aging. The concentration of oxygen atoms increased from 3.16% to 20.39%. Under thermal aging, the FKM O-ring exhibited debonding of the fluoro-bond by oxidation. Analysis of the C1s, O1s, and F1s peaks revealed that the degradation reaction usually occurred at the C-F, C-F2, and C-F3 bonds, and generated a carboxyl group (-COOH) by oxidation. Due to the debonding reaction and decreasing mobility, the glass transition temperature of the FKM O-ring increased from $-15.91^{\circ}C$ to $-13.79^{\circ}C$. From the intermittent CSR test, the initial sealing force was 2,149.6 N, which decreased to 1,156.2 N after thermal aging. Thus, under thermal aging, the sealing force decreased to 46.2%, compared with its initial state. This phenomenon was caused by the debonding reaction and decreasing mobility of the FKM O-ring. The S-S curve exhibited a 50% increase in modulus, with break at a low strain and stress state. This was also attributed to the decreasing mobility due to thermal aging degradation.

• Current Optics and Photonics
• /
• v.6 no.3
• /
• pp.227-235
• /
• 2022

To investigate the aging-related physiological functions of organic light-emitting diodes (OLEDs), we examined mRNA expression changes in aging-related genes due to oxidative stress inhibition by 630-nm red light OLEDs. As a result of irradiating 630-nm OLED with an intensity of 5 mW/cm² for 15 min, the viability of dermal fibroblasts significantly increased by 1.3-fold. In addition, reactive oxygen species generated by H₂O₂ were significantly reduced about 4.9-fold by irradiation with 630-nm OLED. Quantitative reverse-transcription polymerase chain reaction results showed that 630-nm OLEDs altered aging-related gene mRNA expression levels through antioxidant activity. The mRNA expression levels of matrix metalloproteinase1 (MMP1) and MMP9 decreased significantly, by about 2.2- and 2.5-fold, compared to the control group, whereas those of collagen, type I, and alpha 1 increased significantly, by 4.9-fold. The mRNA expression levels of cancer suppression genes p16 and p53 in dermal fibroblasts were also significantly reduced by 630-nm OLED irradiation, by about 1.4- and three-fold, respectively, compared to the control. Overall, it was confirmed that 630-nm OLED irradiation lowered the level of ROS formation induced by H₂O₂ in dermal fibroblasts, and that this antioxidant effect could regulate the mRNA expression levels of aging- and tumor suppression-related genes. This study shows a link between 630-nm OLED irradiation and anti-aging physiological functions such as antioxidant function, and suggests the potential of OLEDs as a useful light source for skin care.

• Journal of Ginseng Research
• /
• v.46 no.4
• /
• pp.536-542
• /
• 2022

Background: In aged skin, reactive oxygen species (ROS) induces degradation of the extracellular matrix (ECM), leading to visible aging signs. Collagens in the ECM are cleaved by matrix metalloproteinases (MMPs). Syringaresinol (SYR), isolated from Panax ginseng berry, has various physiological activities, including anti-inflammatory action. However, the anti-aging effects of SYR via antioxidant and autophagy regulation have not been elucidated. Methods: The preventive effect of SYR on skin aging was investigated in human HaCaT keratinocytes in the presence of H₂O₂, and the keratinocyte cells were treated with SYR (0-200 ㎍/mL). mRNA and protein levels of MMP-2 and -9 were determined by real-time PCR and Western blotting, respectively. Radical scavenging activity was researched by 2,2 diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) assays. LC3B level was assessed by Western blotting and confocal microscopy. Results: SYR significantly reduced gene expression and protein levels of MMP-9 and -2 in both H₂O₂-treated and untreated HaCaT cells. SYR did not show cytotoxicity to HaCaT cells. SYR exhibited DPPH and ABTS radical scavenging activities with an EC₅₀ value of 10.77 and 10.35 ㎍/mL, respectively. SYR elevated total levels of endogenous and exogenous LC3B in H₂O₂-stimulated HaCaT cells. 3-Methyladenine (3-MA), an autophagy inhibitor, counteracted the inhibitory effect of SYR on MMP-2 expression. Conclusion: SYR showed antioxidant activity and up-regulated autophagy activity in H₂O₂-stimulated HaCaT cells, lowering the expression of MMP-2 and MMP-9 associated with skin aging. Our results suggest that SYR has potential value as a cosmetic additive for prevention of skin aging.

• Proceedings of the KSME Conference
• /
• 2003.04a
• /
• pp.1915-1918
• /
• 2003

Atherosclerosis, which is a degenerate disease, is believed to occur in the vascular system due to deposition of cholesterol and low density lipoprotein(LDL) or thrombosis on the blood vessel. Atherosclerosis narrows arterial lumen, which is known as stenosis phenomenon of blood vessel. Pathogenesis of atherosclerosis is thought to occur mainly by aging. Restenosis phenomenon is observed in the same site of insertion of a stent and balloon angioplasty after treatment of interventional theraphy. Several hypothetical theories related to the generation of atherosclerosis have been reported: high shear stress theory, low shear stress theory, high shear stress gradient theory, flow separation and turbulence theory and high pressure theory. However, no one theory clearly explains the causes of atherosclerosis. In the present study the generation of atherosclerosis in the left coronary artery is investigated. The hypotheses are verified by using the computer simulation.

• Nuclear Engineering and Technology
• /
• v.40 no.3
• /
• pp.239-250
• /
• 2008

If there is a water flow with a range of temperature inside a pipe, the wanner water tends to float on top of the cooler water because it is lighter, resulting in the upper portion of the pipe being hotter than the lower portion. Under these conditions, such thermal stratification can play an important role in the aging of nuclear power plant piping because of the stress caused by the temperature difference and the cyclic temperature changes. This stress can limit the lifetime of the piping, even leading to penetrating cracks. Investigated in this study is the effect of thermal stratification on the structural integrity of the pressurizer surge line, which is reported to be one of the pipes most severely affected. Finite element models of the surge line are developed using several element types available in a general purpose structural analysis program and stress analyses are performed to determine the response characteristics for the various types of top-to-bottom temperature differentials due to thermal stratification. Fatigue analyses are also performed and an allowable environmental correction factor is suggested.