• Archives of Plastic Surgery
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• 제38권6호
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• pp.867-870
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• 2011

Purpose: The authors would like to introduce two patients who presented with velopharyngeal inadequacy. We emphasize the importance of nasaopharyngeal endoscopy in evaluating the velopharyngeal function and the usefulness of biofeedback trial therapy. Methods: Two patients visited our clinic due to velopharyngeal inadequacy. Both of the patients showed hypernasality, nasal emission and compensatory articulation such as glottal stop. During oral examination and nasopharyngeal endoscopy both showed no evidence of structural deformities. One inconsistently showed a small gap during articulation. The other showed a rather large gap during compensatory articulation. Both received a simultaneous biofeedback trial therapy using the nasopharyngeal endoscope. Results: Both patients were successfully diagnosed and treated at once using biofeedback trial therapy with nasopharyngeal endoscopy. By giving direct visual feedback to the patient, they were both able to achieve complete velopharyngeal closure during production of 2~3 nonsence syllables and hypernasality was not detected in both of them. Conclusion: The authors were able to help patients with velopharyngeal inadequacy to have velopharyngeal closure through biofeedback trial therapy. The accurate evaluation of velopharyngeal function and the possibility of closure prevented unnecessary operations.

• 말소리와 음성과학
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• 제3권3호
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• pp.3-10
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• 2011

This study examined the production of aspirated stop consonants in Korean and English words to address how the influences differed particularly in terms of proficiency in L2 English. Voice onset times (VOTs) were measured from two American monolinguals and seven Korean speakers. The results showed that VOT patterns for both L1 and L2 stops differed according to their proficiency in L2 English. In L2 English, high proficient speakers produced VOTs that were similar to those of native speakers of English whereas low proficient speakers produced VOTs that were significantly longer than those of proficient speakers. In L1 Korean and L2 English, most of the proficient speakers produced VOTs similarly. Unlike previous findings, Korean VOTs were even shorter than English counterparts. The VOT shortening of aspirated stops in Korean was found for most of the proficient speakers. The findings of the present study suggest that cross language phonetic influences as well as the ongoing VOT shortening in Korean aspirated stops may be correlated with L2 proficiency. Since this is a pilot study with a small number of subjects for each proficiency group, further quantitative study is necessary to generalize.

• 산업경영시스템학회지
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• 제37권4호
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• pp.63-71
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• 2014

As power consumption increases, more power utilities are required to satisfy the demand and consequently results in tremendous cost to build the utilities. Another issue in construction of power utilities to meet the peak demand is an inefficiency caused by surplus power during non-peak time. Therefore, most power company considers power demand management with time-based electricity rate policy which applies different rate over time. This paper considers an optimal machine operation problem under the time-based electricity rates. In TOC (Theory of Constraints), the production capacities of all machines are limited to one of the bottleneck machine to minimize the WIP (work in process). In the situation, other machines except the bottleneck are able to stop their operations without any throughput loss of the whole manufacturing line for saving power utility cost. To consider this problem three integer programming models are introduced. The three models include (1) line shutdown, (2) block shutdown, and (3) individual machine shutdown. We demonstrate the effectiveness of the proposed IP models through diverse experiments, by comparing with a TOC-based machine operation planning considered as a current model.

• 한국항만경제학회지
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• 제21권1호
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• pp.111-132
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• 2005

With the globalization of economy, there is keen competition among countries to be a logistics hub and companies are striving to be first in establishing logistics system centering on advantageous sites, especially airport and seaports, to perform supply, production and distribution. Korea competing with Northeast Asia countries is also working out strategies in order to make Korea penninsula a logistics center of Northeast Asia taking advantage of its geographical strength. Gwangyang port has designated as Free Economic Zone together with Pusan and Jinhae, Incheon from October 24th, 2003. However, the introduction of Free Economic Zone in Korea lagged behind other major countries and it has a lot of operational problems. Approximately 600 areas worldwide are designated and operated as a Free Economic Zone and Gwangyang port and its surrounding area has several points to be settled as one of FEZ. First one is its limited functions and related laws on Gwangyang Bay. Next is imperfection on development, investment and management system of the FEZ. Lack of promotion activities could be one of the problems. If we want to activate the FEZ, we must induce investment at Gwangyang Bay. This paper analyzes the above problems and presents various measures to activate Gwangyang Free Economic Zone by inducing investment for innovation cluster as follows Benchmarking to promote Gwangyang Free Economic Zone as follows Benchmarking other countries' system, governmental support, introduction & logistics functions, early development of the hinterland, supply ofeffective one-stop service, investment attraction into the area and diversified promotion & marketing activities.

• 한국컴퓨터정보학회논문지
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• 제19권2호
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• pp.117-124
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• 2014

본 논문에서는 소셜 영상과 컬러 마케팅기법을 결합하여 전략적이고 효과적인 영상 기법을 제안함으로써, 기업의 관점에서 효과적인 마케팅적 효과를 얻는 것을 목표로 한다. 연구 방법으로는 흑백 영상과 컬러 추출된 스톱모션기법의 이미지의 결합 기법을 구현하고 구체적인 프로세스를 분석하는 것을 연구 범위로 삼았다. 기대 효과로는 기업 및 브랜드의 효과적인 소셜 영상 마케팅을 위한 구체적인 영상 구현 및 새로운 영상 기법을 제안함으로써 소셜 영상 마케팅 발전 및 활성화에 기여할 수 있다는 것이다. 이를 통해 기업의 관점에서는 자사의 핵심 메시지를 담은 컬러를 통해 사용자(대중)에게 일관된 이미지를 심어줄 수 있기 때문에 긍정적이고 효과적이다.

• 한국인쇄학회지
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• 제26권2호
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• pp.79-89
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• 2008

Eco printing offers the perfect balance between getting all our printing jobs done without endangering the environment. It is important to realize that the printing industry is no exception to this rampant destruction of the planet's natural resources. In fact, surprisingly enough, its effect on the environment is an extremely harmful one. Like most other production operations, printing houses also produce harmful waste products that pollute the air we breathe in. They also put a great drain on precious natural resources. Printing houses emit what are known as volatile organic compounds (VOCs), caused by the use of petroleum-based inks, laminates, varnishes and adhesives. Studies show that these compounds, when inhaled, greatly increase the risk of asthma attacks. Eco printing, however, has a larger scope than is apparent. Eco printing has a dual essence. In order to understand what it is really all about, the issue of conservation is no less important than the need to stop polluting the environment.

• 마이크로전자및패키징학회지
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• 제28권2호
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• pp.1-12
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• 2021

3차원 인쇄 기술은 제품의 설계를 3차원으로 하여 조립없이 제품의 생산까지의 시간을 획기적으로 줄이고 복잡한 구조도 구현할 수 있어 미래의 기술로 각광받고 있다. 본 논문은 3차원 인쇄기술을 이용한 전자소자에 대한 최근 연구동향을 알아보면서 구성품, 전원공급장치와 회로에서의 연결과 3차원 인쇄기술 PCB의 응용한 연구논문들을 소개하고 있다. 3차원 인쇄기술로 제작한 전자소자는 원스톱으로 전자소자, 솔더링(soldering), 스태킹(stacking), 회로의 봉지막(encapsulation)까지 제작함으로써 생산설비의 단순화와 전자기기를 개인 맞춤형을 할 수 있는 가능성을 보여주었다.

• 디자인학연구
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• 제18권1호
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• pp.59-68
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• 2005

시대변화에 따라 제품에 대한 소비자의 구매 결정기준과 제품 공급방법은 끊임없는 변화가 거듭되었다. 디지털기술을 응용한 on-line 시스템이 상품에 대한 정보를 전달하고 생산과 구매가 동시적으로 일어나는 시장체제가 형성하게 되었다. 그 결과 소비자 중심의 브랜드 구축이 중요한 과제가 되고 있다. 따라서 실증조사를 통하여 경제 사회 환경 변화에 따른 소비자의 의식구조를 파악하고, 이 변화에 따른 소비자의 구매결정 기준을 이해하고자 한다. 소비자의 구매태도를 만족, 선호, 재구입, 추천으로 기준을 설정하고, 이들 4개의 기준에 미칠 수 있는 브랜드 이미지의 요인들의 영향을 파악하였다. 브랜드 이미지의 효율적 형성을 위하여서 생성되는 소비자(고객) 중심의 브랜드 가치는 실증분석을 통하여 얻어진 결과를 보면 사회생활가치, 정서가치, 개성적가치 수용하여 브랜드이미지에 적용하는 것이 효과적인 것으로 나타났다. 연구결과에서 도출된 브랜드 이미지의 공통적 요인으로는 차별성가 고객 중심의 일관성 및 개성적, 감성적 요인들을 부각 시를 수 있는 행태로 브랜드 이미지화를 도모할 필요가 있다는 결과가 나타났다. 따라서 본 연구는 미래 지향적이고, 소비자에게 인지 연상되는 기능을 보다 효과적으로 증대시킬 수 있도록 고객 중심의 브랜드 창출을 위한 가이드라인을 제시하였다.

• Biomolecules & Therapeutics
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• 제18권2호
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• pp.184-190
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• 2010

Clinical cases of pure red cell aplasia (PRCA) have been reported during the recombinant human erythropoietin (EPO) therapy for the anemia patients. PRCA is a rare hematological disorder leading to a severe anemia due to an almost complete stop of red blood cell production. Antibody (Ab)-associated PRCA is caused by the EPO-neutralizing Abs that eliminate the biological activity of EPO. In order to detect anti-EPO Abs in human sera, we performed conventional ELISA, directly coated bridging ELISA, and streptavidin coated bridging ELISA, and compared their sensitivity and specificity. Some false positive results were obtained in the conventional ELISA. One positive sample was detected successfully by streptavidin coated bridging ELISA, which was not appeared in the directly coated bridging ELISA. In conclusion, streptavidin coated bridging ELISA was substantially sensitive and specific format and one out of sixty-eight serum samples was proved to be anti-EPO positive.

• 동의신경정신과학회지
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• 제18권3호
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• pp.55-82
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• 2007

Ohjective: This research investigates the effect of the DJR on Alzheimer's disease. Method: 1.The effects of the DJR extract on IL.-$1{\beta}$, IL-6, TNF-${\alpha}$, cox-2, and NOS-II mRNA of BV2 microglia cell line treated with LPS; 2. the behavior: 3. the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with ${\beta}$A were investigated. Result: 1. The DJR extract suppressed the expression of IL-$1{\beta}$, IL-6 and TNF-${\alpha}$ mRNA in BV2 microglia cell line treated with LPS. 2. The DJR extract suppressed the expression of IL-$1{\beta}$, IL-6, and TNF-${\alpha}$ protein production in BV2 microglia cell line treated with LPS. 3. For the DJR extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by .${\beta}$A in the Moms water maze experiment, which measured stop-through latency, and distance movement-through latency. 4. The DJR extract suppressed the over-expression of IL-$1{\beta}$ protein, TNF-${\alpha}$ protein and CD68/CD11b, in the mice with Alzheimer's disease induced by ${\beta}$A 5. The DJR extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by ${\beta}$A. 6. The DJR extract reduced the tau protein, GFAP protein, and presenilin1/2 protein (immunohistochemistry) of hippocampus in the mice with Alzheimer's disease induced by ${\beta}$A. Conclusion: These results suggest that the DJR extract may he effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the DJR extract for Alzheimer's disease of suggested for future research.