• Title/Summary/Keyword: Stimulation condition

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Effects of Hydrogen Peroxide on Neuronal Excitability and Synaptic Transmission in Rat Substantia Gelatinosa Neurons

  • Son, Yong;Chun, Sang-Woo
    • International Journal of Oral Biology
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    • v.32 no.4
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    • pp.153-160
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    • 2007
  • The superficial dorsal horn, particularly substantia gelatinosa (SG) in the spinal cord, receives inputs from small-diameter primary afferents that predominantly convey noxious sensation. Reactive oxygen species (ROS) are toxic agents that may be involved in various neurodegenerative diseases. Recent studies indicate that ROS are also involved in persistent pain through a spinal mechanism. In the present study, whole cell patch clamp recordings were carried out on SG neurons in spinal cord slice of young rats to investigate the effects of hydrogen peroxide on neuronal excitability and excitatory synaptic transmission. In current clamp condition, tert-buthyl hydroperoxide (t-BuOOH), an ROS donor, depolarized membrane potential of SG neurons and increased the neuronal firing frequencies evoked by depolarizing current pulses. When slices were pretreated with phenyl-N-tert-buthylnitrone (PBN) or ascorbate, ROS scavengers, t-BuOOH did not induce hyperexcitability. In voltage clamp condition, t-BuOOH increased the frequency and amplitude of spontaneous excitatory postsynaptic currents (sEPSCs), and monosynaptically evoked excitatory postsynaptic currents (eEPSCs) by electrical stimulation of the ipsilateral dorsal root. These data suggest that ROS generated by peripheral nerve injury can modulate the excitability of the SG neurons via pre- and postsynaptic actions.

The Immediate Effects of Kinesio Taping on Quadriceps Induced Fatigue by Short-term Squat (단시간의 스쿼트 운동으로 피로 유발된 대퇴사두근에 대한 키네시오 테이핑의 즉각적 효과)

  • Ahn, Ick-keun;Jeon, Jae-guk;Kim, Dong-ya
    • The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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    • v.21 no.1
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    • pp.21-28
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    • 2015
  • Background: The purpose is to investigate the immediate effects of kinesio taping on quadriceps induced fatigue by short-term squat. Methods: This research is cross-over designed study and conducted as a single-blind. Eleven students (Age: $18.91{\pm}0.49yrs$, height: $167.09{\pm}8.46cm$, $62.55{\pm}11.32kg$) were participated in this study. All the participants were applied short-term squat for inducing fatigue, and then intervented all three conditions (kinesio taping applied condition, placebo taping applied condition, non-taping applied condition). The interval of each intervention was at least a seven days to prevent carry-over effects. The participants were tested peak torque (isometric contracture) and active joint position sense (active JPS) pre-post intervention. A paired t-test was used to find the significance of pre-post intervention results and one-way ANOVA was used to find the significance between interventions with significant level as .05. Results: Peak torque was significantly increased on KT condition (p<.05). But there were no significant effects on active JPS. Because kinesio taping facilitates Ia afferent by tactile stimulation with stretched skin, reduced muscle power by short term squat which induce muscle fatigue was increased. But kinesio taping does not affect mechanoreceptor in muscles, induced active JPS by short-term squat had no changes.

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A study on the Dielectric Characteristics of Polyimide Organic Ultra Thin Films (폴리이미드 유기초박막의 유전특성에 관한 연구)

  • Chon, D.K.;Lee, K.S.
    • Proceedings of the KIEE Conference
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    • 1999.07d
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    • pp.1744-1746
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    • 1999
  • In this paper, we give pressure stimulation into organic ultra thin films and detected the induced displacement current properties, and then manufacture a device under the accumulation condition. In processing of a device manufacture, we can see the process is good from the change of a surface pressure and transfer ratio of area per molecule of organic ultra thin films. The structure of manufactured device is MIM(Au/polyimide LB films/AU), the number of accumulated 19 layers. I-V characteristic of the device is measured from -5[V] to +5[V]. The maximum value of measured current is increased as the number of accumulated layers are decreased. The insulation of a thin film is better as the interval between electrodes is larger, and the insulation properties of a thin film is better as the distance between electrodes is larger.

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A Study on the Deposition Transfer state of Organic Thin Films(Arac.acid) (유기박막(Arac.acid)의 누적전이상태에 관한 연구)

  • Chung, Hun-Sang;Song, Jin-Won;Lee, Kyung-Sup;Jun, Yon-Su;Chon, Woo-Gi
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2001.05a
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    • pp.57-60
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    • 2001
  • The characterization of organic Metal/Insulator/Metal(MIM) devices were investigated from LB films. The physicochemical properties of the LB films were by UV absorption spectrum and AFM. We give pressure stimulation into organic thin films and then manufacture a device under the accumulation condition that the state surface pressure is 2, 10, 30[mN/ml The stable images are probably due to a strong interaction between the monolayer film and glass substrate. We are unable to obtain molecule resolution in images of the films but did see a marked contrast between images of the bare substrate and those with the network structure film deposited onto it.

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Deposition Transfer and Electrical Properties of Arachidic Acid Multilayer Manufacture by LB Method (LB법으로 제작한 Arachidic Acid 다층막의 누적전이와 전기특성)

  • Song, Jin-Won;Lee, Kyung-Sup
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2001.05a
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    • pp.11-14
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    • 2001
  • We give pressure stimulation into organic thin films and then manufacture a device under the accumulation condition that the state surface pressure is 30[mN/m]. LB layers of Arac. acid deposited by LB method were deposited onto slide glass as Y-type film. The physicochemical properties of the LB films were examined by UV absorption spectrum, SEM and AFM. The structure of manufactured device is Au/arachidic acid/Al. the number of accumulated layers are 3~9. Also. we then examined of the MIM device by means of I-V. The I-V characteristic of the device is measured from -3 to +3[V]. The insulation property of a thin film is better as the distance between electrodes is larger.

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Experimental Study of Acid-Base Balance and Variations of Heart Rate, Fluid and Electrolyte by Electrical Stimulation according to the Physical Constitutions (체질에 따른 산.염기평형과 전기자극에 의한 맥박수 및 체액전해질의 변동에 관한 실험적 고찰)

  • 조봉관;배종일
    • Journal of Biomedical Engineering Research
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    • v.14 no.4
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    • pp.349-354
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    • 1993
  • To investigate the relations between the physical constitutions, the acid-base balance, and the autonomic nervous function, the blood gas, the heart rate and the concentrations of Na, K of serum were measured pre-and poststimulation. As the result, it is shown that in the normal condition the macro-negative(strong liver- weak lung type) is the metabolic alkalosis, the macro-positive (strong lung-weak liver type) is the metabolic acidosis, the micro-negative(strong kidney-weak spleen type) is the alkalosis and the micro-positive (strong spleen-weak kidney type) is the acidosis. And the ntacro-positive and micro-positive are the sympathetic lead, the macro-negative and micro-negative are the parasympathetic lead. In the macro-positive and micro-positive subjects, the concentration of K in serum is relatively high. This si coincided with the acidosis. But in the macro-negative and micro-negative subjects, the concentration of K in serum is relatively low. This is coincided with the alkalosis.

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Infraorbital Nerve Block with Pure Ethyl Alcohol for Treatment of Trigeminal Neuralgia - A case report - (안와아래 신경 차단술에 의한 위 작은 어금니 및 위 송곳니 부위에 발생한 삼차신경통의 치험 - 증례 보고 -)

  • Chung, Chong-Kweon;Lee, Kyung-Min;Kim, Chan
    • The Korean Journal of Pain
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    • v.5 no.1
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    • pp.76-79
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    • 1992
  • Trigeminal neuralgia is a condition characterized by excruciating paroxysms of pain in lips, gums, cheek, or chin, and very rarely, in the distribution of the ophthalmic division of the trigeminal nerve. There are many treatments of trigeminal neuralgia, such as, medical treatment, electrical stimulation, radiation therapy and ablative procedures. Infraorbital nerve block with pure ethyl alcohol is an ablation procedure for trigeminal neuralgia. We injected pure ethyl alcohol into the infraorbital foramen for pain control. The results were as follows; 1) The infraorbital nerve block with pure alcohol was an a simple and an effective method. 2) Complication, included a mild sensory deficit and mild edema over the infraorbital area.

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Chronic pelvic pain arising from dysfunctional stabilizing muscles of the hip joint and pelvis

  • Lee, Dae Wook;Lim, Chang Hun;Han, Jae Young;Kim, Woong Mo
    • The Korean Journal of Pain
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    • v.29 no.4
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    • pp.274-276
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    • 2016
  • Chronic pelvic pain in women is a very annoying condition that is responsible for substantial suffering and medical expense. But dealing with this pain can be tough, because there are numerous possible causes for the pelvic pain such as urologic, gynecologic, gastrointestinal, neurologic, or musculoskeletal problems. Of these, musculoskeletal problem may be a primary cause of chronic pelvic pain in patients with a preceding trauma to the low back, pelvis, or lower extremities. Here, we report the case of a 54-year-old female patient with severe chronic pelvic pain after a transcutaneous electrical nerve stimulation (TENS) accident that was successfully managed with image-guided trigger point injections on several pelvic stabilizing muscles.

Design and Synthesis of Thioureas as Capsaicin Receptor Antagonist

  • Kim, Hee-Doo;Ryu, Chong-Hyon;Park, Young-Ho;Park, Hyeung-Geun;Suh, Young-Ger;Oh, Uh-Taek
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.339.3-340
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    • 2002
  • Capsaicin is hot taste ingredient of chili pepper and was isolated in 1876 and in 1919 its structure is sympathized compound. induces pain and when persistently dosed. the fact will bring insensible condition to other chemical and mechanical thermal stimulation by incapacitating sensory neuron is known. The analgesic effect by desensitization of such capsaicin is differ from the mechanism by analgesic action by opiate receptor of the existing analgesia or by prostaglandin mediation and the efficacy was known as similar with morphine. (omitted)

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Structural Characteristics of Fatty Acid Thin films (유기절연박막의 알킬체인 길이에 따른 전기적 특성)

  • Jung, Jong-Chul;Choi, Yong-Sung;Hwang, Jong-Sun;Lee, Kyung-Sup
    • Proceedings of the KIEE Conference
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    • 2009.04a
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    • pp.37-39
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    • 2009
  • The physicochemical properties of the fatty acid monomolecular Arachidic Acid, Stearic Acid films surface structure has been studied by AFM. We give pressure stimulation into organic thin films and then manufacture a device under the accumulation condition that the state surface pressure is gas state, liquid state, solid state. Formation that prevent when gas phase state and liquid phase state measure but could know organic matter that molecules form equal and stable film when molecules were not distributed evenly, and accumulated in solid state only.

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