• Biomedical Science Letters
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• v.8 no.3
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• pp.195-202
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• 2002

Osteoarthritis (OA), the most common form of arthritis, involves the destabilization of the normal balance between the degradation and the synthesis of articular cartilage and subchondral bone within a joint. As articular cartilage degrades over time, its smooth surface roughens and bone-against-bone contact ensues, producing the inflammation response symptomatic of this 'wear and tear' disease. Although a variety of genetic, developmental, metabolic, and traumatic factors may initiate the development of osteoarthritis, its symptoms (joint pain, stiffness, and curtailed function) typically evolve slowly, and patients experience periods of relative calm alternation with episodes of inflammation and pain. Rheumatoid arthritis (RA), an autoimmune disease of unknown etiology characterized by chronic synovitis and cartilage destruction, affect 1% of the total population. Cartilage is a specialized connective tissue in which the chondrocytes occupy only 5% of the volume. Cartilage is particularly rich in extracellular matrix, with matrix making up 90% of the dry weight of the tissue chondrocytes have cell processes that extend a short distance into the matrix, but do not touch other cells thus in cartilage, cell-matrix interactions are essential for the maintenance of the extracellular matrix. In this study, subtractive hybridization method was utilized to detect genes differentially expressed in chondrocytes treated with methylprednisolone. We have isolated 57 genes that expressed differentially in the chondreocytes by methylprednisolone. 13 clones of them were analyzed with sequencing and their homologies were searched. 8 cDNAS included KIAA 0368, upregulated during skeletal muscle growth 5 (usmg 5), ribosomal protein S 18 (RPS 18), skeletal muscle ryanodine receptor, radial spoke protein 3 (RSP 3), ribosomal protein QM, ribosomal protein L37a (RPL37A), cytochrome coxidase subunit VIII (COX8).

• Composites Research
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• v.14 no.6
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• pp.16-23
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• 2001

Analysis of mechanical behavior for a pultruded-wound hollow rod is presented. For this purpose, the pultruded-wound hollow rod is manufactured by the new winder attached to the conventional pultrusion system. And the conventional pultrusion process is newly altered to manufacture pultruded-wound specimens. A computer program, POST II, is modified to perform this study, In the nonlinear finite element formulation, the updated Lagrangian description method based on the second Piolar-Kirchhoff stress tensor and the Green strain tensor are used. For the finite element modeling of the composite hollow rod, the eight-node degenerated shell element is utilized. In order to estimate the failure, the maximum stress criterion is adopted to the averaged stress in the each layer of the finite elements. As numerical examples, the behavior of glass/up composite hollow rod is investigated from the initial loading to the final collapse. Present finite element results considering stiffness degradation and stress unload due to failure shows excellent agreement with experiments in the ultimate load, failure and deformations.

• Earthquakes and Structures
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• v.2 no.3
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• pp.233-256
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• 2011

This paper investigates the applicability of newly developed Cu-Al-Mn shape memory alloy (SMA) bars to retrofitting of historical masonry constructions by performing quasi-static tests of half-scale brick walls subjected to cyclic out-of-plane flexure. Problems associated with conventional steel reinforcing bars lie in pinching, or degradation of stiffness and strength under cyclic loading, and in their inability to restrain residual deformations in structures during and after intense earthquakes. This paper attempts to resolve the problems by applying newly developed Cu-Al-Mn SMA bars, characterized by large recovery strain, low material cost, and high machinability, as partial replacements for steel bars. Three types of brick wall specimens, unreinforced, steel reinforced, and SMA reinforced specimens are prepared. The specimens are subjected to quasi-static cyclic loading up to rotation angle enough to cause yielding of reinforcing bars. Corresponding nonlinear finite element models are developed to simulate the experimental observations. It was found from the experimental and numerical results that both the steel reinforced and SMA reinforced specimens showed substantial increment in strength and ductility as compared to the unreinforced specimen. The steel reinforced specimen showed pinching and significant residual elongation in reinforcing bars while the SMA reinforced specimen did not. Both the experimental and numerical observations demonstrate the superiority of Cu-Al-Mn SMA bars to conventional steel reinforcing bars in retrofitting historical masonry constructions.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.45 no.12
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• pp.1013-1020
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• 2017

In this study, the failure prediction of composite laminates under flexural loading is investigated. A FEA(finite element analysis) using 2D strain-based interactive failure theory. A pregressive failure analysis was applied to FEA for stiffness degradation with failure mode each layer. A three-point bending test based on the ASTM D790 are performed for cross-ply $[0/90]_8$ and quasi-isotropic $[0/{\pm}45/90]_{2s}$ laminated composites. The accuracy of the applied failure theory is verified with the experimental results and other failure criteria such as maximum strain, maximum stress and Tsai-Wu theories.

• Steel and Composite Structures
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• v.22 no.2
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• pp.449-472
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• 2016

This paper studies the seismic behavior of reinforced concrete (RC) walls with encased cold-formed and thin-walled (CFTW) steel truss, which can be used as an alternative to the conventional RC walls or steel reinforced concrete (SRC) composite walls for high-rise buildings in high seismic regions. Seven one-fourth scaled RC wall specimens with encased CFTW steel truss were designed, manufactured and tested to failure under reversed cyclic lateral load and constant axial load. The test parameters were the axial load ratio, configuration and volumetric steel ratio of encased web brace. The behaviors of the test specimens, including damage formation, failure mode, hysteretic curves, stiffness degradation, ductility and energy dissipation, were examined. Test results indicate that the encased web braces can effectively improve the ductility and energy dissipation capacity of RC walls. The steel angles are more suitable to be used as the web brace than the latticed batten plates in enhancing the ductility and energy dissipation. Higher axial load ratio is beneficial to lateral load capacity, but can result in reduced ductility and energy dissipation capacity. A volumetric ratio about 0.25% of encased web brace is believed cost-effective in ensuring satisfactory seismic performance of RC walls. The axial load ratio should not exceed the maximum level, about 0.20 for the nominal value or about 0.50 for the design value. Numerical analyses were performed to predict the backbone curves of the specimens and calculation formula from the Chinese Code for Design of Composite Structures was used to predict the maximum lateral load capacity. The comparison shows good agreement between the test and predicted results.

• Journal of the Earthquake Engineering Society of Korea
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• v.3 no.1
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• pp.55-66
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• 1999

This paper presents an analytical prediction of the hysteresis behavior of reinforced concrete long column with rectangular section under the cyclic loading state. The mechanical characteristic of cracked concrete and reinforcing bar in concrete has been modeled, considering the bond effect between reinforcing bar and concrete, the effect of aggregate interlocking at crack surface and the stiffness degradation after the crack has taken place. The strength increase of concrete due to the lateral confining reinforcement has been also taken into account to model the confined concrete. The formulation of these models for concrete and reinforcing bar has been based on the smeared crack concept that the stress-strain relationship of reinforced concrete element would be defined using the average values. In addition to the material nonlinear properties, the algorithm for large displacement problem that may give an additional deformation has been formulated using total Lagrangian formulation. The analytically predicted behavior was compared with test result and they showed good agreement in overall behavior.

• Journal of Hydrogen and New Energy
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• v.20 no.4
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• pp.309-316
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• 2009

The effect of gas diffusion layers (GDLs) on the freeze/thaw condition durability in polymer electrolyte fuel cells (PEFCs) were investigated. For this purpose, three kinds of GDLs, such as, felt, paper and cloth types with different basic properties have been first prepared, then the changes in the properties and performance of cells was observed during the freeze/thaw cycles ranging from -30 to $70^{\circ}C$. The performance evaluations were conducted by using the single cells consisting of different GDLs. The performance degradation and the cell resistance increase could be directly correlated. The physical destruction of electrode was shown by SEM analysis. The mechanically supporting ability on the interface between the cell components can help enhancing the durability of PEFCs in the freeze/thaw condition.

• Aerospace Engineering and Technology
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• v.8 no.1
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• pp.42-48
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• 2009

There are a number of factors affecting the continued airworthiness of composite structure. Unlike metal structure, damages made in manufacturing processes or maintenance repair procedures need to be considered. The different levels of degradation and damage, which may occur, must be considered for structural substantiation of static strength, stiffness, flutter, and damage tolerance. This can start with an evaluation of environmental effects for the particular composite material. Matrix-dominated composite properties, such as compressive strength, are most sensitive to moisture absorption and temperatures. Static strength substantiation includes the smaller damages that will not be detected in production or maintenance inspection while damage tolerance addresses larger damages that need to be repaired once discovered. In this paper, we intend to list the airworthiness regulations and advisory circular that are deemed closely related to the certification of composite airplanes.

• Journal of Ocean Engineering and Technology
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• v.28 no.2
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• pp.133-139
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• 2014

Offshore wind turbines have been constructed extensively throughout the world. These turbines are subjected to approximately $10^8$ horizontal load cycles produced from wind, waves, and current during their lifetimes. Therefore, the accumulated displacement of the foundation under horizontal cyclic loading has significant effects on the foundation design of a wind turbine. Akili(2006) and Achmus et al.(2009) performed cyclic triaxial tests on dry sands and proposed an empirical model for predicting the accumulated plastic strain of sands under long-term cyclic loading. In this study, cyclic triaxial tests were performed to analyze the cyclic loading behaviors of dry sands. A total of 27 test cases were performed by varying three parameters: the relative density of the sands, cyclic load level, and confining stress. The test results showed that the accumulated plastic strain increased with an increase in the cyclic load level and a decrease in the relative density of the sand. The confining stress had less effect on the plastic strain. In addition, the plastic strain at the 1st loading cycle was about 57% of the accumulated strain at 1,000 cycles. Finally, the input parameters of the empirical models of Akili(2006) and Achmus et al.(2009) were evaluated by using the relative density of the sand and the cyclic load level.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.25 no.5
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• pp.313-320
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• 2015

A 2-axis gimbal-type X-band antenna has been widely used to effectively transmit the high resolution image data from the observation satellite to the desired ground station. However, a discontinuous stepper motor activation for rotating the pointing mechanism in azimuth and elevation directions induces undesirable micro-vibration disturbances which can result in the image quality degradation of a high-resolution observation satellite. To enhance the image quality of the observation satellite, attenuating the micro-vibration induced by an activation of the stepper motor for rotational movements of the antenna is important task. In this study, we proposed a low-rotational-stiffness blade gear applied to the output shaft of the stepper motor to obtain the micro-vibration isolation performance. The design of the blade gear was performed through the structure analysis such that this gear is satisfied with the margin of safety rule under the derived torque budget. In addition, the micro-vibration isolation performance of the blade gear was verified through the micro-vibration measurement test using the dedicated micro-vibration measurement device proposed in this study.