• Journal of Biomedical Engineering Research
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• v.38 no.1
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• pp.43-48
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• 2017

Chemotherapy, radiation therapy, and surgery are major methods to treat cancer. However, current cancer treatments report severe side effects and high recurrences. Recent studies about engineering nanoparticles as a drug carrier suggest possibilities in terms of specific targeting and spatiotemporal release of drugs. While many nanoparticles demonstrate lower toxicity and better targeting results than free drugs, they still need to improve their performance dramatically in terms of targeting accuracy, immune responses, and non-specific accumulation at organs. One possible way to overcome the challenges is to make precisely controlled nanoparticles with respect to size, shape, surface properties, and mechanical stiffness. Here, we demonstrate $500{\times}200nm$ discoidal polymeric nanoconstructs (DPNs) as a drug delivery carrier. DPNs were prepared by using a top-down fabrication method that we previously reported to control shape as well as size. Moreover, DPNs have multiple payloads, poly lactic-co-glycolic acid (PLGA), polyethylene glycol (PEG), lipid-Rhodamine B dye (RhB) and Salinomycin. In this study, we demonstrated a potential of DPNs as a drug carrier to treat cancer.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.11
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• pp.697-704
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• 2017

This study was carried out to investigate and alleviate the vibration problem of commercial high-speed trains. First, the measurement of the carbody vibration was performed, in order to determine the vibration level of the high-speed train. The measurement result showed that the vibration level of the driver cab was higher than that of the passenger car and that the vibration became bigger toward the trailing end of the train. The vertical vibration of the driver cab and passenger car was larger than the transverse vibration, and the maximum value of the vibration in the ballast section was larger than that in the concrete section. A dynamic analysis was carried out to improve the vibration of the KTX-Sancheon train. The results of the analysis showed that it is necessary to reduce the vibration of the driver cab and both ends of the passenger cars. To reduce the vibration of the driver cab, it was recommended that the stiffness of the secondary coil spring be reduced and the damping coefficient of the secondary vertical damper be increased. It was found that the failure of the suspension system could be the origin of the vibration problem of the high-speed train. The proper management of wheel wear plays an important role in the improvement of the operation efficiency and reduction of the carbody vibration of high-speed trains, and research is underway to change the present wheel profile to increase the mileage between wheel turning.

• Journal of the Korean Geotechnical Society
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• v.21 no.6
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• pp.101-115
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• 2005

For the site characterization at two inland areas, Gyeongju and Hongsung, which represent geomorphic and geologic characteristics of inland region in Korea, in-situ seismic tests containing borehole drilling investigations and resonant column tests were peformed and site-specific seismic response analyses were conducted using equivalent linear as well as nonlinear scheme. The soil deposits in Korea were shallower and stiffer than those in western US, from which the site coefficients and site classification system in Korea were derived. Most sites were categorized as site classes C and D based on the mean shear wave velocity $(V_s)$ of the upper 30 m $(V_s30)$, ranging between 250 and 650 m/s. According to the acceleration response spectra determined from the site response analyses, the site coefficients specified in the current Korean seismic design guide underestimate the ground motion in the short-period band and overestimate the ground motion in mid-period band. These differences can be explained by the differences in the bedrock depth and the soil stiffness profile between Korea and western US. The site coefficients, $F_a$ for short-period and $F_v$ for mid-period, were re-evaluated and the site classification system, in which sites C and D were subdivided according to $V_s20,\;V_s15,\;and\;V_s10$ together with the existing $V_s30$ was introduced accounting for the local geologic conditions at inland region of the Korean peninsula. The proposed site classification system in this paper is still rudimentary and requires modification.

• Restorative Dentistry and Endodontics
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• v.25 no.3
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• pp.381-389
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• 2000

Lateral condensation with gutta-percha and sealer has been shown to provide an excellent apical seal; however, the lateral condensation technique has demonstrated less favorable apical leakage results in curved canals when compared with straight canals. Placement of endodontic spreaders to within 1 to 2mm of the root canal working length has been advocated for optimum gutta-percha obturation. Due to their stiffness, stainless-steel(SS) spreaders will often fail to achieve this position in curved canals. Newly marketed nickel-titanium(NT) spreaders may offer an advantage in this regard due to the increased flexibility of these instruments. The purpose of this study was to evaluate the effect of NT finger spreader on the sealing ability in lateral condensation technique, compared with conventional SS finger spreader. Twenty four standardized resin models simulating curved canals(30 degree) were randomly placed into 2 groups and instrumented to a #30 master apical file size with Ni-Ti Profile .04 taper series using step down technique. Each groups was obturated with standardized gutta-percha cone by standard lateral condensation technique using SS finger spreader, NT finger spreader. And then, each model was sectioned horizontally with microtome at 1, 2, 3, 4, 5mm levels from the apex. At each of 5 levels, ratio of the area of gutta-percha was obtained by calculating the area of gutta-percha to the total area of the canal. The data collected were then analyzed statistically using a t test for independent samples. The results as follows ; 1. The total mean ratio of area of gutta-percha was 89.20${\pm}$7.00(%) for SS spreader group. 92.20${\pm}$5.17(%) for NT spreader group. There was statistically significant difference between each group(p<0.05). 2. At 3mm level, the mean ratio of area of gutta-percha was 88.32${\pm}$5.41(%) for SS spreader group, 95.25${\pm}$2.60(%) for NT spreader group. There was statistically significant difference between each group(p<0.05). At 1,2,4mm levels, NT spreader group showed greater mean ratio of area of gutta-percha than SS spreader group, too. But there was no statistically significant difference. 3. At 5mm level, the mean ratio of area of gutta-percha was 91.83${\pm}$3.42(%) for SS spreader group, 87.91${\pm}$3.68(%) for NT spreader group. There was statistically significant difference between each group(p<0.05). This study concluded that the NT spreader demonstrated somewhat favorable apical sealing effect than SS spreader in prepared curved canals. The clinical use of NT spreaders may enhance our ability to create better apical seals in curved canals, but further studies in this area will help clarify some of the remaining areas with which practitioners are concerned, such as compaction forces exerted by NT spreaders.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.11
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• pp.1581-1586
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• 2010

Haptic-aided design (HAD) involves the use of a haptic simulator in place of physical prototypes in the design and development of products with which human beings interact physically. The development time and cost can be significantly reduced by adopting this HAD scheme. Although both physical and emotional factors are equally important, only the emotional factors were taken into consideration in the previous HAD process. Consequently, the design of the products was sometimes unsatisfactory from the viewpoint of ergonomics, even though users were emotionally satisfied with the products. To overcome this problem, in this study, we propose a new human-oriented design methodology that is enhanced by taking the physical factors into consideration. The HAD scheme was verified by using a haptic chair simulator to design a tilt mechanism of an office chair for which the stiffness of the backrest can be adjusted; then, the design was simulated using MADYMO. The results show that the proposed method can reflect both the physical and emotional factors to modify the design in real-time.

• The Journal of the Convergence on Culture Technology
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• v.8 no.5
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• pp.515-524
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• 2022

The turnout system of the sleeper floating tracks (STEDEF) on urban transit is a Anti-vibration track composed of a wooden sleeper embedded in a concrete bed and a sleeper resilience pad under the sleeper. Therefore, deterioration and changes in spring stiffness of the sleeper resilience pad could be cause changes in sleeper support conditions. The damage amount of manganese crossings that occurred during the current service period of about 21 years was investigated to be about 17% of the total amount of crossings, and it was analyzed that the damage amount increased after 15 years of use (accumulated passing tonnage of about 550 million tons). In this study, parameter analysis (wheel position, sleeper support condition, and dynamic wheel load) was performed using a three-dimensional numerical model that simulated real manganese crossing and wheel profile, to analyze the damage type and cause of manganese crossing that occurred in the actual field. As a result of this study, when the voided sleeper occurred in the sleeper around the nose, the stress generated in the crossing nose exceeded the yield strength according to the dynamic wheel load considering the design track impact factor. In addition, the analysis results were evaluated to be in good agreement with the location of damage that occurred in the actual field. Therefore, in order to minimize the damage of the manganese crossing, it is necessary to keep the sleeper support condition around the nose part constant. In addition, by considering the uniformity of the boundary conditions under the sleepers, it was analyzed that it would be advantageous to to replace the sleeper resilience pad together when replacing the damaged manganese crossing.

• Journal of Korean Tunnelling and Underground Space Association
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• v.11 no.1
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• pp.57-70
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• 2009

Considerable advance has been made on research on effect of steel pipe Umbrella Arch Method (UAM) and mechanical reinforcement mechanism through numerical analyses and experiments. Due to long analysis time of three-dimensional analysis and its complexity, un-quantitative two-dimensional analysis is dominantly used in the design and application, where equivalent material properties of UAM reinforced area and ground are used, For this reason, development of reasonable, theoretical, quantitative and easy to use design and analysis method is required. In this study, both field UAM tests and laboratory tests were performed in the residual soil to highly weathered rock; field tests to observe the range of reinforcement, and laboratory tests to investigate the change of material properties between prior to and after UAM reinforcement. It has been observed that the increase in material property of neighboring ground is negligible, and that only stiffness of steel pipe and cement column formed inside the steel pipe and the gap between steel pipe and borehole contributes to ground reinforcement. Based on these results and concept of Convergence Confinement Method (CCM), two dimensional axisymmetric analyses have been performed to obtain the longitudinal displacement profile (LDP) corresponding to arching effect of tunnel face, UAM effect and effect of supports. In addition, modified load distribution method in two dimensional plane-strain analysis has been suggested, in which effect of UAM is transformed to internal pressure and modified load distribution ratios are suggested. Comparison between the modified method and conventional method shows that larger displacement occur in the conventional method than that in the modified method although it may be different depending on ground condition, depth and size of tunnel, types of steel pipe and initial stress state. Consequently, it can be concluded that the effect of UAM as a beam in a longitudinal direction is not considered properly in the conventional method.