• 대한의생명과학회지
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• 제8권3호
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• pp.195-202
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• 2002

Osteoarthritis (OA), the most common form of arthritis, involves the destabilization of the normal balance between the degradation and the synthesis of articular cartilage and subchondral bone within a joint. As articular cartilage degrades over time, its smooth surface roughens and bone-against-bone contact ensues, producing the inflammation response symptomatic of this 'wear and tear' disease. Although a variety of genetic, developmental, metabolic, and traumatic factors may initiate the development of osteoarthritis, its symptoms (joint pain, stiffness, and curtailed function) typically evolve slowly, and patients experience periods of relative calm alternation with episodes of inflammation and pain. Rheumatoid arthritis (RA), an autoimmune disease of unknown etiology characterized by chronic synovitis and cartilage destruction, affect 1% of the total population. Cartilage is a specialized connective tissue in which the chondrocytes occupy only 5% of the volume. Cartilage is particularly rich in extracellular matrix, with matrix making up 90% of the dry weight of the tissue chondrocytes have cell processes that extend a short distance into the matrix, but do not touch other cells thus in cartilage, cell-matrix interactions are essential for the maintenance of the extracellular matrix. In this study, subtractive hybridization method was utilized to detect genes differentially expressed in chondrocytes treated with methylprednisolone. We have isolated 57 genes that expressed differentially in the chondreocytes by methylprednisolone. 13 clones of them were analyzed with sequencing and their homologies were searched. 8 cDNAS included KIAA 0368, upregulated during skeletal muscle growth 5 (usmg 5), ribosomal protein S 18 (RPS 18), skeletal muscle ryanodine receptor, radial spoke protein 3 (RSP 3), ribosomal protein QM, ribosomal protein L37a (RPL37A), cytochrome coxidase subunit VIII (COX8).

• Composites Research
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• 제14권6호
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• pp.16-23
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• 2001

인발 와인딩에 의한 섬유강화 복합재료 중공 봉의 기계적 거동해석을 수행하였다. 이 목적의 수행을 위해 새롭게 제작된 와인더를 전통적 인발 시스템에 부탁하여 시편을 제작하였다. 또한 인발-와인딩된 시편을 제작할 수 있는 새로운 공법을 개발하였다. 이 연구를 위해 유한요소 해석 프로그램 POSTII를 확장 개발하였다. 비선형유한요소 수식화에는 2차 피올라-키르히호프 응력 텐서와 그린 변형률 텐서에 기초한 업데이트된 라그란지언 표현법이 사용되었다. 복합재료 중공봉의 유한요소 모델링을 위해 8절점 응축쉘요소를 사용하였다. 파손평가를 위해 모든 유한요소의 각 단층에서의 평균응력을 최대음력 판정법에 대입하였다. 수치해석 예로서 불포화 섬유강화 복합재료 중공 봉의 기계적 거동을 초기 하중상태에서 최종 붕괴가지 조사하였다. 파손에 따른 강성저하와 응력제하를 고려한 유한요소해석 결과는 극만 하중과 파손 및 변형에서 실험치와 잘 일치하였다.

• Earthquakes and Structures
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• 제2권3호
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• pp.233-256
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• 2011

This paper investigates the applicability of newly developed Cu-Al-Mn shape memory alloy (SMA) bars to retrofitting of historical masonry constructions by performing quasi-static tests of half-scale brick walls subjected to cyclic out-of-plane flexure. Problems associated with conventional steel reinforcing bars lie in pinching, or degradation of stiffness and strength under cyclic loading, and in their inability to restrain residual deformations in structures during and after intense earthquakes. This paper attempts to resolve the problems by applying newly developed Cu-Al-Mn SMA bars, characterized by large recovery strain, low material cost, and high machinability, as partial replacements for steel bars. Three types of brick wall specimens, unreinforced, steel reinforced, and SMA reinforced specimens are prepared. The specimens are subjected to quasi-static cyclic loading up to rotation angle enough to cause yielding of reinforcing bars. Corresponding nonlinear finite element models are developed to simulate the experimental observations. It was found from the experimental and numerical results that both the steel reinforced and SMA reinforced specimens showed substantial increment in strength and ductility as compared to the unreinforced specimen. The steel reinforced specimen showed pinching and significant residual elongation in reinforcing bars while the SMA reinforced specimen did not. Both the experimental and numerical observations demonstrate the superiority of Cu-Al-Mn SMA bars to conventional steel reinforcing bars in retrofitting historical masonry constructions.

• 한국항공우주학회지
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• 제45권12호
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• pp.1013-1020
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• 2017

본 연구에서는 굽힘 하중을 받는 복합재료 적층판에 대한 파손 강도를 예측하기 위하여 2D 변형률 기반의 파손 이론을 적용한 유한요소 해석을 수행하였다. 복합재료 적층판 내각 층의 파손 모드에 따른 강성저하를 고려하기 위해 점진적 파손 해석 방법을 적용하였다. 크로스 플라이와 준등방성 복합재 적층판에 대하여 3점 굽힘 시험을 수행하였다. 최대응력 이론, 최대 변형률 이론, 그리고 Tsai-Wu 파손 이론을 적용한 유한요소 해석을 수행하였다. 시험 및 파손 이론에 따른 해석 결과 비교를 통하여 2D 변형률 파손 이론의 정확성을 검증하였다.

• Steel and Composite Structures
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• 제22권2호
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• pp.449-472
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• 2016

This paper studies the seismic behavior of reinforced concrete (RC) walls with encased cold-formed and thin-walled (CFTW) steel truss, which can be used as an alternative to the conventional RC walls or steel reinforced concrete (SRC) composite walls for high-rise buildings in high seismic regions. Seven one-fourth scaled RC wall specimens with encased CFTW steel truss were designed, manufactured and tested to failure under reversed cyclic lateral load and constant axial load. The test parameters were the axial load ratio, configuration and volumetric steel ratio of encased web brace. The behaviors of the test specimens, including damage formation, failure mode, hysteretic curves, stiffness degradation, ductility and energy dissipation, were examined. Test results indicate that the encased web braces can effectively improve the ductility and energy dissipation capacity of RC walls. The steel angles are more suitable to be used as the web brace than the latticed batten plates in enhancing the ductility and energy dissipation. Higher axial load ratio is beneficial to lateral load capacity, but can result in reduced ductility and energy dissipation capacity. A volumetric ratio about 0.25% of encased web brace is believed cost-effective in ensuring satisfactory seismic performance of RC walls. The axial load ratio should not exceed the maximum level, about 0.20 for the nominal value or about 0.50 for the design value. Numerical analyses were performed to predict the backbone curves of the specimens and calculation formula from the Chinese Code for Design of Composite Structures was used to predict the maximum lateral load capacity. The comparison shows good agreement between the test and predicted results.

• 한국지진공학회논문집
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• 제3권1호
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• pp.55-66
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• 1999

이연구에서는 반복적인 횡하중이 작용하고 있는 철근콘크리트 기둥의 비선형 이력거동 및 파괴거동을 해석적으로 예측할 수 있는 기법을 제시하였다 하중의 단계에 따라 수반하게 되는 콘크리트의 균일 및 철근의 항복 이로 인한 부착 효과와 골재의 맞물림 현상 및 강도의 감소 등과 같은 특성을 고려한 재료적 비선형성을 고려하였고 기둥부재에 일반적으로 배치되는 구속철근으로 인한 강도의 증가효과를 고려하였다. 여기서 철근콘크리트의 응력-변형도 관계는 분산균열모델에 기초하여 평균값으로 표현된다. 비교적 큰 압축하중과 함께 지진하중과 같이 큰 규모의 횡하중으로 인한 대변위 문제를 고려할 수 있도록 total Lagrangian formulation에 의한 기하학적인 비선형성을 고려하였다. 본 연구에서 작성한 유한요소 해석 프로그램에 의한 결과를 다른 연구자의 실험 결과와 비교함으로써 본 연구에서 제시한 해석기법의 타당성을 검증하였다.

• 한국수소및신에너지학회논문집
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• 제20권4호
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• pp.309-316
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• 2009

The effect of gas diffusion layers (GDLs) on the freeze/thaw condition durability in polymer electrolyte fuel cells (PEFCs) were investigated. For this purpose, three kinds of GDLs, such as, felt, paper and cloth types with different basic properties have been first prepared, then the changes in the properties and performance of cells was observed during the freeze/thaw cycles ranging from -30 to $70^{\circ}C$. The performance evaluations were conducted by using the single cells consisting of different GDLs. The performance degradation and the cell resistance increase could be directly correlated. The physical destruction of electrode was shown by SEM analysis. The mechanically supporting ability on the interface between the cell components can help enhancing the durability of PEFCs in the freeze/thaw condition.

• 항공우주기술
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• 제8권1호
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• pp.42-48
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• 2009

복합재 항공기의 경우 인증 시 여러 가지 요소를 고려해야한다. 금속과는 달리 복합재구조물의 감항성은 운용 및 제작 중 발생하는 손상 등에 의해 큰 영향을 받는다. 그러므로 예상 가능한 여러 가지 손상에 대해 정적강도, 강성, 플러터 및 손상허용강도 등을 입증하여 야한다. 복합재료의 기계적물성은 환경조건에 영향을 받는다. 특히 압축강도는 수지의 영향이 지배적이고 수지가 온도와 습도의 영향을 많이 받으므로 설계/해석 시 고려하여야한다. 복합재 항공기의 경우 육안으로 탐지가 어려운 손상에 대한 정적강도를 입증하여야하고, 육안으로 보이는 큰 손상에 대해서는 발견 즉시 수리하도록 규정되어있다. 본 논문에서는 복합재 구조물의 설계/해석에 필요한 규정을 분석하고 해석방법 등에 대해 검토하려한다.

• 한국해양공학회지
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• 제28권2호
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• pp.133-139
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• 2014

Offshore wind turbines have been constructed extensively throughout the world. These turbines are subjected to approximately $10^8$ horizontal load cycles produced from wind, waves, and current during their lifetimes. Therefore, the accumulated displacement of the foundation under horizontal cyclic loading has significant effects on the foundation design of a wind turbine. Akili(2006) and Achmus et al.(2009) performed cyclic triaxial tests on dry sands and proposed an empirical model for predicting the accumulated plastic strain of sands under long-term cyclic loading. In this study, cyclic triaxial tests were performed to analyze the cyclic loading behaviors of dry sands. A total of 27 test cases were performed by varying three parameters: the relative density of the sands, cyclic load level, and confining stress. The test results showed that the accumulated plastic strain increased with an increase in the cyclic load level and a decrease in the relative density of the sand. The confining stress had less effect on the plastic strain. In addition, the plastic strain at the 1st loading cycle was about 57% of the accumulated strain at 1,000 cycles. Finally, the input parameters of the empirical models of Akili(2006) and Achmus et al.(2009) were evaluated by using the relative density of the sand and the cyclic load level.

• 한국소음진동공학회논문집
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• 제25권5호
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• pp.313-320
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• 2015

A 2-axis gimbal-type X-band antenna has been widely used to effectively transmit the high resolution image data from the observation satellite to the desired ground station. However, a discontinuous stepper motor activation for rotating the pointing mechanism in azimuth and elevation directions induces undesirable micro-vibration disturbances which can result in the image quality degradation of a high-resolution observation satellite. To enhance the image quality of the observation satellite, attenuating the micro-vibration induced by an activation of the stepper motor for rotational movements of the antenna is important task. In this study, we proposed a low-rotational-stiffness blade gear applied to the output shaft of the stepper motor to obtain the micro-vibration isolation performance. The design of the blade gear was performed through the structure analysis such that this gear is satisfied with the margin of safety rule under the derived torque budget. In addition, the micro-vibration isolation performance of the blade gear was verified through the micro-vibration measurement test using the dedicated micro-vibration measurement device proposed in this study.