• Archives of Pharmacal Research
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• 제19권2호
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• pp.168-170
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• 1996

• Bulletin of the Korean Chemical Society
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• 제28권10호
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• pp.1645-1650
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• 2007

This paper describes a racemic and stereoselective synthetic route for a novel cyclohexenyl carbocyclic adenine analogue. The required stereochemistry of the target compound was controlled using a stereoselective glycolate Claisen rearrangement followed by α-chelated carbonyl addition. The introduction of 6-chloropurine was achieved using Mitsunobu conditions, and further modifications of the corresponding heterocycle gave the target cyclohexenyl nucleoside.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.169-170
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• 2002

It has been well known for the stereoselectivity in pharmacodynamic effects of many xenobiotics including therapeutic agents, which have lead to the development of enantiomer drugs. Compared to pharmacodynamic stereoselectivity, stereoselective pharmacokinetics of each enantiomer has not been seriously considered in the development of enantiomer drugs although many reports have been demonstrated the stereoselective absorption and metabolism of racemic drug (e.g verapamil). (omitted)

• 약학회지
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• 제41권6호
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• pp.714-717
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• 1997

Stereoselective synthesis of the optically active bicyclo [4.2.0] octanone 5 was accomplished using intramolecular olefin-keteniminium salt[2+2]cycloaddition of the amide 4 as a key step. This important chiral synthon was prepared starting from readily available L-glutamic acid via an efficient 8-step sequence.

• Bulletin of the Korean Chemical Society
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• 제23권12호
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• pp.1695-1696
• /
• 2002

• Bulletin of the Korean Chemical Society
• /
• 제23권8호
• /
• pp.1173-1176
• /
• 2002

• Archives of Pharmacal Research
• /
• 제17권3호
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• pp.207-208
• /
• 1994

• Bulletin of the Korean Chemical Society
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• 제22권7호
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• pp.661-662
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• 2001

• Archives of Pharmacal Research
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• 제5권2호
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• pp.107-108
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• 1982

Some examples of stereoselective epoxidation of acyclic allylic and homoallylic systems will be presented.

• 대한화학회지
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• 제48권1호
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• pp.115-118
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• 2004