• Title/Summary/Keyword: Stereoselective

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Stereoselective Synthesis of a Novel Cyclohexene Version of Carbovir

  • Li, Hua;Hong, Joon-Hee
    • Bulletin of the Korean Chemical Society
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    • v.28 no.10
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    • pp.1645-1650
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    • 2007

  • This paper describes a racemic and stereoselective synthetic route for a novel cyclohexenyl carbocyclic adenine analogue. The required stereochemistry of the target compound was controlled using a stereoselective glycolate Claisen rearrangement followed by α-chelated carbonyl addition. The introduction of 6-chloropurine was achieved using Mitsunobu conditions, and further modifications of the corresponding heterocycle gave the target cyclohexenyl nucleoside.

  • https://doi.org/10.5012/bkcs.2007.28.10.1645 인용 PDF KSCI

Chiral Relevance of Stereoselective Disposition of Proton Pump Inhibitors: Comparision of Lansoprasole to Omeprazole and Pantoprazole

  • Shin, Jae-Gook
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.169-170
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    • 2002

  • It has been well known for the stereoselectivity in pharmacodynamic effects of many xenobiotics including therapeutic agents, which have lead to the development of enantiomer drugs. Compared to pharmacodynamic stereoselectivity, stereoselective pharmacokinetics of each enantiomer has not been seriously considered in the development of enantiomer drugs although many reports have been demonstrated the stereoselective absorption and metabolism of racemic drug (e.g verapamil). (omitted)

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Synthesis of The Optically Active Bicyclo [4.2.0. ] octanone by Stereoselective Intramolecular [2+2] Cycloaddition (입체선택적인 분자내 [2+2] 환화반응을 이용한 광학활성 Bicyclo[4.2.0.]octanone의 합성)

  • Shim, Pil-Jong;Kim, Hee-Doo
    • YAKHAK HOEJI
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    • v.41 no.6
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    • pp.714-717
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    • 1997

  • Stereoselective synthesis of the optically active bicyclo [4.2.0] octanone 5 was accomplished using intramolecular olefin-keteniminium salt[2+2]cycloaddition of the amide 4 as a key step. This important chiral synthon was prepared starting from readily available L-glutamic acid via an efficient 8-step sequence.

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Acyclic eposidations (I)

  • Kim, Deuk-Joon
    • Archives of Pharmacal Research
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    • v.5 no.2
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    • pp.107-108
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    • 1982

  • Some examples of stereoselective epoxidation of acyclic allylic and homoallylic systems will be presented.

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