• 한국실내디자인학회논문집
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• 제21호
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• pp.89-93
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• 1999

A museum architecture has been developed as important representation of a specific period in architectural history. Modern concept of museum architecture has started by Karl Fredrich van Schinkel(1781-1841) through das Altes Museum(1823-1830) back in early 20th century and it continues to be the model for museum architecture for over 30 years. By middle of the 20th century, the movement of redefining new model for the new era on the subject of museum architecture was developed. This development was lead by the three masters of the modern architecture at the time. F.L. Wright, Corbusier, Mies and they were responsible and very active in creating new concepts. Their works in museum design became the prototype and they tried hard to make sure their new concepts to be the stepping stone for further development. This study is to compare the three different museums designed by those masters of the modern architecture, particularly on the issue of the exhibition spaces. The purpose of the study will be focused on the point of interior architecture such as the matters of layout and design characteristics of the exhibition spaces. And it will reveal the impact made by those masters on the advanced development of the current generations of museum designers as well as to describe the prototype of exhibition space. The analyzation was done on FLW's Guggenheim Museum in New York, Corbusier's the National Museum of Western Art in Tokyo, and Mies' Die Neue National Galerie in Berliv. Comparable materials were collected through site visits and reference documents from various publications. It will be ideal if this study can be used for further development in new museum design in this country.

• 한국자동차공학회논문집
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• 제6권2호
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• pp.12-20
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• 1998

Exter ballistics of a typical high-speed projectile is studied through a flow-visualization experiment and an unstructured grid Navier-Srokes computation. Experiment produced a schlieren photograph that adequately shows the characteristic features of this complex flow, namely two kinds of oblique cone shocks and turbulent wake developing into the downstream. A hybrid scheme of finite volume-element method is used to simulate the compressible Reynolds-Averaged Navier-Stok- es solution on unstructured grids. Osher's approximate Riemann solver is used to discretize the cinvection term. Higher-order spatial accuracy is obtained by MUSCL extension and van Albada ty- pe flux limiter is used to stabilize the numerical oscillation near the solution discontinuity. Accurate Gakerkin method is used to discretize the viscous term. Explict fourth-order Runge-Kutta method is used for the time-stepping, which simplifies the application of MUSCL extension. A two-layer k-$\varepsilon$ turbulence model is used to simulate the turbulent wakes accurately. Axisymmetric folw and two-dimensional flow with an angle of attack have been computed. Grid-dependency is also checked by carrying out the computation with doubled meshes. 2-D calculation shows that effect of angle of attack on the flow field is negligible. Axi-symmetric results of the computation agrees well with the flow visualization. Primary oblique shock is represented within 2-3 meshes in numerical results, and the varicose mode of the vortex shedding is clearly captured in the turbulent wake region.

• 한국한의학연구원논문집
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• 제13권2호통권20호
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• pp.75-81
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• 2007

The need for the study of the revealing Sasang constitution at scientific term is increasing as the application of this discipline to the patient produces more accurate result. To obtain scientific evidence of Sasang constitution, it is crucial to analyze accumulated clinical information and associate them to the biological indices that may classify Sasang constitution. Thus, the analysis of clinical information is the most important stepping stone to go toward to the stage of developing model and decision support system (DSS) for classifying Sasang constitution. This study is a preliminary analysis of 1,109 samples collected with 171 clinical indices. To find meaningful clinical indices for classifying Sasang constitutional medicine, we applied decision tree model for them. The skin of 66.5% within whole Taeeumin is thick and non feeble. In the case of 69.8% within whole Soyangin, the skin is non feeble and slippery. In the case of 64.4% within whole Soeumin. they have feeble skin. Therefore, the property of skin can be suggested to be more important than any other index for the classification of Sasang constitution.

• Coupled systems mechanics
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• 제1권4호
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• pp.361-379
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• 2012

This paper presents a fully coupled three-dimensional solver for the analysis of interaction between pulsatile flow and large deformation structure. A partitioned time marching algorithm is employed for the solution of the time dependent coupled discretised problem, enabling the use of highly developed, robust and well-tested solvers for each field. Conservative transfer of information at the fluid-structure interface is combined with an effective multi-predict-correct iterative scheme to enable implicit coupling of the interacting fields at each time increment. The three-dimensional unsteady incompressible fluid is solved using a powerful implicit time stepping technique and an ALE formulation for moving boundaries with second-order time accurate is used. A full spectrum of total variational diminishing (TVD) schemes in unstructured grids is allowed implementation for the advection terms and finite element shape functions are used to evaluate the solution and its variation within mesh elements. A finite element dynamic analysis of the highly deformable structure is carried out with a numerical strategy combining the implicit Newmark time integration algorithm with a Newton-Raphson second-order optimisation method. The proposed model is used to predict the wave flow fields of a particular flow-induced vibrational phenomenon, and comparison of the numerical results with available experimental data validates the methodology and assesses its accuracy. Another test case about three-dimensional biomedical model with pulsatile inflow is presented to benchmark the algorithm and to demonstrate the potential applications of this method.

• 한국지능시스템학회논문지
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• 제22권1호
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• pp.119-125
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• 2012

본 논문은 친환경 교통수단인 일반적인 체인형 자전거(Bicycle)를 대신할 수 있는 무체인(Chainless) 지능형 파워 보조 시스템(Power Assistant System)을 설계하여 자전거 운전상태에 맞추어 필요한 동력을 지원할 수 있는 전기자전거 모델을 제안 하고자 한다. 무체인 지능형 파워 보조 시스템의 답력 센서(sensor)를 통하여 자전거의 운전상태를 지능적으로 파악 할 수 있는 퍼지제어 알고리즘을 설계하고, 자전거 운전상태에 대한 파워 보조 시스템의 보조 동력을 제어하도록 하였다. 본 논문에서는 사람의 답력에만 의존하는 일반 자전거 시스템에 보조동력을 제공하는 무체인 지능형 전기자전거 모델을 설계하여 제시하였다.

• 디지털융복합연구
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• 제18권10호
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• pp.403-408
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• 2020

본 연구는 대학 원격강의의 질을 높이기 위한 연구의 발판이 되도록 현재 사용되는 대표적인 두 개의 화상 미팅서비스의 사용성 평가를 하는 것이다. 기능을 중심으로 분석하기 위해 카노모델(Kano)을 기반으로 한 질문지를 설계하여 반구조적 심층면담을 실시해 정성적인 접근을 꾀하였다. 두 서비스의 1차원적 기능인 화면공유 기능이 중요하게 여겨지고 있었고 매력적인 기능들은 비교적 다양한 방향성을 갖고 있었다. 꼭 있어야 할 기능인 카메라, 마이크의 경우 사용자에 따른 장비로 인해 질의 격차가 컸다. 대체할 타 플랫폼이 존재하는 업로드/다운로드 기능과 교육적 목적과 거리가 있는 예약하기, 전화걸기 기능들은 활용가치가 낮았다. 웹엑스는 전체적인 노후 된 UI가, 줌은 일방적인 음소거 기능이 원치 않는 기능으로 조사되었다. 그리고 이러한 결과를 분석해서 도출한 결론으로 개발 방향성을 다섯 가지로 제시하였다. 코로나-19에 따른 장기적인 교육 운영 방식을 고민해야 하는 상황에서 본 연구가 이러한 화상미팅 서비스가 교육용으로 개발되는 발판이 되도록 지속적인 연구로 이어져야 할 것이다.

• 한국항공우주학회지
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• 제40권5호
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• pp.395-404
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• 2012

본 논문에서는 전산유체역학을 이용하여 3차원 비행체 형상에 대한 동안정 미계수를 예측하였다. 피치에 대한 미계수는 피치방향의 조화진동운동을 통하여 계산하였고 롤 감쇠계수는 비관성 좌표계에 대한 정상해석을 통하여 계산하였다. 계산은 Basic Finner와 SDM 형상에 대해 수행했으며 다른 연구자의 실험적/수치적 결과와 비교하였다. 유동 계산을 위해 비관성 좌표계와 관성 좌표계에서 모두 사용할 수 있는 3차원 Euler 해석자를 개발하였다. 시간 정확성을 유지한 비정상 해석을 위해 이중시간적분법을 적용하였다. 동안정 미계수계산 결과는 다른 수치 및 실험적 연구 결과들과 잘 일치하는 것을 알 수 있었다.

• BMB Reports
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• 제56권3호
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• pp.202-207
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• 2023

We investigated the neuroprotective effects of deca nano-graphene oxide (daNGO) against reactive oxygen species (ROS) and inflammation in the human neuroblastoma cell line SH-SY5Y and in the 6-hydroxydopamine (6-OHDA) induced Parkinsonian rat model. An MTT assay was performed to measure cell viability in vitro in the presence of 6-OHDA and/or daNGO. The intracellular ROS level was quantified using 2',7'-dichlorofluorescein diacetate. daNGO showed neuroprotective effects against 6-OHDA-induced toxicity and also displayed ROS scavenging properties. We then tested the protective effects of daNGO against 6-OHDA induced toxicity in a rat model. Stepping tests showed that the akinesia symptoms were improved in the daNGO group compared to the control group. Moreover, in an apomorphine-induced rotation test, the number of net contralateral rotations was decreased in the daNGO group compared to the control group. By immunofluorescent staining, the animals in the daNGO group had more tyrosine hydroxylase-positive cells than the controls. By anti-Iba1 staining, 6-OHDA induced microglial activation showed a significantly decrease in the daNGO group, indicating that the neuroprotective effects of graphene resulted from anti-inflammation. In conclusion, nano-graphene oxide has neuroprotective effects against the neurotoxin induced by 6-OHDA on dopaminergic neurons.

• Journal of Korean Neurosurgical Society
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• 제56권5호
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• pp.383-389
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• 2014

Objective : Neural tissue transplantation has been a promising strategy for the treatment of Parkinson's disease (PD). However, transplantation has the disadvantages of low-cell survival and/or development of dyskinesia. Transplantation of cell aggregates has the potential to overcome these problems, because the cells can extend their axons into the host brain and establish synaptic connections with host neurons. In this present study, aggregates of human brain-derived neural stem cells (HB-NSC) were transplanted into a PD animal model and compared to previous report on transplantation of single-cell suspensions. Methods : Rats received an injection of 6-OHDA into the right medial forebrain bundle to generate the PD model and followed by injections of PBS only, or HB-NSC aggregates in PBS into the ipsilateral striatum. Behavioral tests, multitracer (2-deoxy-2-[$^{18}F$]-fluoro-D-glucose ([$^{18}F$]-FDG) and [$^{18}F$]-N-(3-fluoropropyl)-2-carbomethoxy-3-(4-iodophenyl)nortropane ([$^{18}F$]-FP-CIT) microPET scans, as well as immunohistochemical (IHC) and immunofluorescent (IF) staining were conducted to evaluate the results. Results : The stepping test showed significant improvement of contralateral forelimb control in the HB-NSC group from 6-10 weeks compared to the control group (p<0.05). [$^{18}F$]-FP-CIT microPET at 10 weeks posttransplantation demonstrated a significant increase in uptake in the HB-NSC group compared to pretransplantation (p<0.05). In IHC and IF staining, tyrosine hydroxylase and human ${\beta}2$ microglobulin (a human cell marker) positive cells were visualized at the transplant site. Conclusion : These results suggest that the HB-NSC aggregates can survive in the striatum and exert therapeutic effects in a PD model by secreting dopamine.

• 물과 미래
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• 제29권6호
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• pp.179-188
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• 1996

수자원의 주공급원인 강수는 현상의 발생여부에 따라 건조일과 습윤일이 교대로 반복되는 과정으로 구성되어 있으며, 특히, 일강수계열의 습윤일에 발생되는 강수량의 크기는 매우 다양한 형태를 지니고 있어 이 과정을 모형화 하는데는 복잡한 확률과정이 수반된다. 본 연구에서는 일강수계열의 발생과정을 건조일, 습윤일로 구분하고 습윤일의 강수량을 상태별로 분류하여 각 상태별 천이확률을 계산함으로써 이를 장래에 발생 가능한 강수사상의 모의발생에 이용하였다. 본 모형은 수문사상의 발생과 비발생만을 구분하던 2-state Markov 연쇄모형에 강수의 발생시 강수량의 크기에 따라 상태를 여러 개로 구분하여 강수량을 추정할 수 있도록 수정한 것으로 간헐 수문사상인 일강수계열의 구성성분인 건조일과 습윤일, 건조, 습윤 지속기간 및 습윤일의 강수량을 Markov 연쇄에 의해 동시에 발생있도록 한 것이며 다른 모형에 비해 사용이 비교적 용이하다. 본 연구에서 제안한 multi-state Markov 연쇄모형의 적용 가능성을 검토하기 위하여 비교적 장기간의 자료를 보유하고 있는 관측소의 강수자료를 이용하였으며 그 결과를 강수량, 건조, 습윤일수 및 건조, 습윤계속기간의 분포를 실제자료와 비교하여 모형의 적합도를 평가하였다. 이를 토대로 홍수 및 한발기간의 추정과 모의발생에 의한 자료 확장으로 중장기 수자원 계획 및 운영에 효율적으로 이용될 수 있을 것으로 판단된다.